Abstract:
:Short-acting β2-agonists (SABA) are widely used in the emergency department (ED) to treat patients with decompensated chronic obstructive pulmonary disease (COPD). We sought to model the effectiveness of nebulized SABA (terbutaline) on clinically relevant parameters associated with a reduction in work of breathing or respiratory muscle fatigue in decompensated COPD patients admitted to the ED.Forty consecutive decompensated COPD patients (having received at least one dose of nebulized terbutaline during their stay in the ED) were included in an observational cohort study. The terbutaline dose received at time t was expressed as cumulative dose and as a rate (mg/day). The associations between the terbutaline dose and time-dependent outcome parameters (respiratory rate, heart rate, arterial blood gases, and, as a marker of terbutaline's systemic effect, serum potassium) were analyzed using a nonlinear, mixed-effects model. The effect of various covariates influencing terbutaline's effectiveness (baseline characteristics and concomitant treatments) was assessed on the model.Among the investigated patients, a total of 377 time-dependent observations were available for analysis. Neither the cumulative dose nor the dose rate at time t significantly influenced the arterial blood gas parameters or heart rate. The cumulative dose of terbutaline was associated with a lower serum potassium level (P < 0.001) and, less significantly, a lower respiratory frequency (P = 0.036). In a tertile analysis, the need for post-ED hospitalization was not associated with the cumulative dose or dose rate of terbutaline.Overall, the results of our modeling study strongly suggest that terbutaline dose did not influence time-dependent outcomes other than serum potassium, and thus call into question the systematic administration of inhaled SABA to patients admitted to the ED for decompensated COPD.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Gueho F,Beaune S,Devillier P,Urien S,Faisy Cdoi
10.1097/MD.0000000000004553subject
Has Abstractpub_date
2016-08-01 00:00:00pages
e4553issue
32eissn
0025-7974issn
1536-5964pii
00005792-201608090-00046journal_volume
95pub_type
杂志文章相关文献
MEDICINE文献大全abstract::Patients with drug-susceptible tuberculosis (TB) show good tolerance of the medications used and have few side effects. However, medications used to treat multidrug-resistant tuberculosis (MDR-TB) have many known side effects. Here, we studied the occurrence of side effects due to treatment of patients with MDR-TB.We ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007482
更新日期:2017-07-01 00:00:00
abstract:RATIONALE:Patients with, or who develop, metastatic breast cancer have a 5-year relative survival of about 25%. Endocrine therapy clearly improves outcomes in patients with estrogen receptor-positive breast cancer. In the metastatic setting, the primary goal of treatment is to maintain long-term disease control with go...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020396
更新日期:2020-06-12 00:00:00
abstract:INTRODUCTION:The purpose of this paper is to evaluate the efficacy and safety of moxibustion in infertility females/women undergoing in vitro fertilization and embryo transfer (IVF-ET). METHODS AND ANALYSIS:We will electronically search PubMed, Medline, Embase, Web of Science, the Cochrane Central Register of Controll...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017560
更新日期:2019-11-01 00:00:00
abstract:RATIONALE:PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms characterized by small round cells of neuroepithelial origin. They usually involve bone and soft tissues, and have a higher incidence in childhood. PATIENT CONCERNS:In this case report, we describe the obstetric and oncologic...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000009505
更新日期:2018-01-01 00:00:00
abstract:STUDY OBJECTIVE:Computed tomography (CT) is an important imaging modality in diagnosing a variety of disorders. Although systolic heart failure is a well-known risk factor for postcontrast acute kidney injury (PC-AKI), few studies have evaluated the association between diastolic dysfunction and PC-AKI. Therefore, the a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017994
更新日期:2019-11-01 00:00:00
abstract:RATIONALE:Hepatoid adenocarcinoma (HAC) of the fallopian tubes is a rare malignant tumor in the female reproductive system. PATIENT CONCERNS:An 81-year-old Chinese woman presented with an elevated serum alpha-fetoprotein (AFP) level. DIAGNOSIS:Positron emission tomography-computed tomography (PET-CT) scan revealed a ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014534
更新日期:2019-03-01 00:00:00
abstract::To evaluate the rationality of drug use to treat community-acquired pneumonia (CAP) in children of a Chinese hospital using a set of developed indicators.We performed a retrospective cross-sectional study in West China Second University Hospital. Hospitalized children (0-18 years old) diagnosed with CAP from October 2...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013224
更新日期:2018-11-01 00:00:00
abstract:RATIONALE:Sclerosing osteomyelitis of Garré is a rare condition that occurs most commonly in tubular bones and the mandible. Its nontypical symptoms, low morbidity, and insidious process make its diagnosis difficult at an early stage. In this article, we reported a case of chronic sclerosing osteomyelitis which occurre...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008692
更新日期:2017-11-01 00:00:00
abstract::Pigmentary mosaicism of the (hypomelanosis of) Ito type is an umbrella term, which includes phenotypes characterized by mosaic hypopigmentation in the form of streaks, whorls, patchy, or more bizarre skin configurations (running along the lines of Blaschko): these cutaneous patterns can manifest as an isolated skin di...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002705
更新日期:2016-03-01 00:00:00
abstract:RATIONALE:Epithelioid trophoblastic tumor (ETT) is a very rare form of gestational trophoblastic disease (GTD) which arises from neoplastic proliferation of intermediate trophoblasts. Metastatic ETT of the lung is extremely rare in postmenopausal women. PATIENT CONCERNS:Here we describe a 50-year-old woman with a meta...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010306
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Ischemic stroke often leads to lifelong disability or death in stroke patients. It is one of the most common causes of death and disability worldwide, so it is a global health problem. The objective of this protocol is to provide the methods for using overview and network meta-analysis to identify the more e...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000015384
更新日期:2019-04-01 00:00:00
abstract:RATIONALE:Primary repair of acute ligament injury is possible due to the proximity of the ends. In the case of chronic injury, however, primary repair is difficult because the ends of ruptured ligament will have receded, and tendon graft, transfer, or reconstruction is needed. Satisfactory clinical results have been re...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022506
更新日期:2020-10-02 00:00:00
abstract::We aimed to obtain overall and regional estimates of hypertension prevalence, and to examine the pattern of this disease condition across different socio-demographic characteristics in low-and middle-income countries. We searched electronic databases from inception to August 2015. We included population-based studies ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000001959
更新日期:2015-12-01 00:00:00
abstract::Fine needle aspiration (FNA) is the procedure of choice for evaluating thyroid nodules. It is indicated for nodules >2 cm, even in cases of very low suspicion of malignancy. FNA has associated risks and expenses. In this study, we developed an image analysis model using a deep learning algorithm and evaluated if the a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015133
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION:Papillary meningioma is an extremely rare malignant lesion with high degree of invasiveness, high recurrence rate, and perivascular pseudopapillary structure. The incidence of cystic degeneration in papillary meningiomas is relatively low, and cystic papillary meningiomas growing in the ventricle are even ...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000021514
更新日期:2020-07-31 00:00:00
abstract:RATIONALE:Primary biliary cholangitis (PBC) is a liver autoimmune disease. If this disease is associated with other liver injury factors, both misdiagnosis and missed diagnosis will easily occur. Therefore, detailed disease history collection and related laboratory examination should be performed on patients with liver...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012395
更新日期:2018-09-01 00:00:00
abstract:RATIONALE:Retrograde drilling is a well accepted procedure for osteochondral lesion of the talus and subchondral cyst with intact overlying cartilage. It has good results in most reports. Compared to anterograde drilling, retrograde drilling can protect the integrity of the articular cartilage. The purpose of this stud...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005418
更新日期:2016-12-01 00:00:00
abstract::Emergent resistance to antibiotics among Streptococcus pneumoniae isolates is a severe problem worldwide. Antibiotic resistance profiles for S pneumoniae isolates identified from pediatric patients in mainland China remains to be established.The clinical features, antimicrobial resistance, and multidrug resistance pat...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000015942
更新日期:2019-06-01 00:00:00
abstract:RATIONALE:Pegaspargase has been used in the treatment of acute lymphoblastic leukemia with promising results. However, it has also been associated with several potentially serious complications, including thrombosis. Pegaspargase-induced cerebral venous thrombosis and bone marrow necrosis are very rare. PATIENT CONCER...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000008715
更新日期:2017-11-01 00:00:00
abstract::The aim of this paper was to define an unexplained non-classified polyneuropathy condition as a new neurological disease. This new diagnosis of occupation related polyneuropathy has been named as "WORKING HAND SYNDROME (WHS)."This study collected and compared clinic and electrophysiological analyze data from healthy c...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007235
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Since the COVID-19 outbreak in 2020, more than 20 million people worldwide have been diagnosed with COVID-19, and all health care workers are looking for ways to improve the cure rate of the disease. As an important method of rehabilitation therapy, exercise therapy has been proved to improve the level of hu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023762
更新日期:2020-12-18 00:00:00
abstract:RATIONALE:Extracorporeal membrane oxygenation (ECMO) is a well-known technique to provide cardio-pulmonary support. Although continuous renal replacement therapy (CRRT) is frequently indicated, the need for faster fluid removal as the primary indication for ECMO is uncommon. Experiences on concomitant applications of E...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014194
更新日期:2019-01-01 00:00:00
abstract::Noninvasive computed tomography angiography (CTA) is widely used in acute ischemic stroke, even for diagnosing various internal carotid artery (ICA) occlusion sites, which often need cerebral digital subtraction angiography (DSA) confirmation. We evaluated whether clinical outcomes vary depending on the DSA-based occl...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005722
更新日期:2017-02-01 00:00:00
abstract:INTRODUCTION:Treating blood stasis is effective in treating obesity and metabolic diseases in traditional Korean medicine. The aim of this prospective observational study is to determine the effectiveness of the diagnosis index for metabolic diseases with blood stasis by analyzing clinical data and blood samples. METH...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000021140
更新日期:2020-07-02 00:00:00
abstract::Despite widespread pneumococcal vaccination of children and adults, invasive pneumococcal disease (IPD) remains prominent. Using our database of all Streptococcus pneumoniae infections at the Veterans Affairs Medical Center, Houston, Texas, since 2000, we reviewed cases of IPD, defined as the isolation of pneumococci ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0b013e3181f2b824
更新日期:2010-09-01 00:00:00
abstract::The effects of residual cannabis use on emotional expression recognition and the P3 event-related potential in participants who scored highly for subclinical depression were investigated. Comparisons were made between participants who were classified as depressed or nondepressed cannabis users, depressed non-cannabis ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006385
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION:Smoking is well-known to increase cancer risk, particularly risk of lung cancer, and negatively affects efficacy of cancer treatment. However, recent evidence suggests that among cancer patients, paradoxically, smokers respond to treatment better than non-smokers. We propose to conduct a focused review and...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022104
更新日期:2020-09-18 00:00:00
abstract:BACKGROUND:The blood-brain barrier is impaired in patients with stroke. The release of protein markers such as Sirtuin1 (SIRTl) into circulation may be useful to assess the prognosis of patients with cerebrovascular disease. In this study, we investigated the predictive value of SIRT1 levels in acute ischemic stroke (A...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012959
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Reversible splenial lesion syndrome (RESLES) is a newly recognized syndrome, and a reversible progress associated with transiently reduced diffusion lesion in the splenium of the corpus callosum (SCC) is the typical pathological finding. The routine clinical symptoms include mildly altered states of consciou...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005258
更新日期:2016-11-01 00:00:00
abstract::In 2006, a previous study at our institution reported high perioperative and anesthesia-related mortality rates of 21.97 and 1.12 per 10,000 anesthetics, respectively. Since then, changes in surgical practices may have decreased these rates. However, the actual perioperative and anesthesia-related mortality rates in B...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002208
更新日期:2016-01-01 00:00:00