Significance of Pharmacogenetics and Pharmacogenomics Research in Current Medical Practice.

Abstract:

:Human genome sequencing highlights the involvement of genetic variation towards differential risk of human diseases, presence of different phenotypes, and response to pharmacological elements. This brings the field of personalized medicine to forefront in the era of modern health care. Numerous recent approaches have shown that how variation in the genome at single nucleotide level can be used in pharmacological research. The two broad aspects that deal with pharmacological research are pharmacogenetics and pharmacogenomics. This review encompasses how these variations have created the basis of pharmacogenetics and pharmacogenomics research and important milestones accomplished in these two fields in different diseases. It further discusses at length their importance in disease diagnosis, response of drugs, and various treatment modalities on the basis of genetic determinants.

journal_name

Curr Drug Metab

journal_title

Current drug metabolism

authors

Prakash S,Agrawal S

doi

10.2174/1389200217666160804150959

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

862-876

issue

9

eissn

1389-2002

issn

1875-5453

pii

CDM-EPUB-77552

journal_volume

17

pub_type

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