Autologous Bone-Marrow Transplantation in Acute Lymphoblastic Leukaemia: 1980-89.

Abstract:

:The outcome of conventional therapy in adult acute lymphoblastic leukaemia (ALL) is disappointing. Allogeneic bone-marrow transplantation may give improved results but has only limited applicability because of the lack of a suitable donor in most patients. We have therefore investigated intensive chemotherapy and chemo/radiotherapy protocols with autologous bone-marrow rescue. 31 patients have been treated, 14 beyond first remission and 17 in first remission. The result of this therapy in both groups is poor with only 2 longterm survivors in each group. There is no reason to believe from this study that ablative therapy with autologous bone-marrow rescue will yield superior results to conventional therapy in adult ALL but further experience with TBI containing regimes is required.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Mcmillan AK,Gribben JG,Linch DC,Anderson C,Richards JD,Goldstone AH

doi

10.3109/10428199009042474

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

157-62

issue

3-4

eissn

1042-8194

issn

1029-2403

journal_volume

1

pub_type

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