Systematic, Evidence-Based Review of Exercise, Physical Activity, and Physical Fitness Effects on Cognition in Persons with Multiple Sclerosis.

Abstract:

:Cognitive dysfunction is highly prevalent, disabling, and poorly-managed in persons with multiple sclerosis (MS). Recent evidence suggests that exercise might have beneficial effects on cognition in this population. The current systematic, evidence-based review examined the existing literature on exercise, physical activity, and physical fitness effects on cognition in MS to accurately describe the current status of the field, offer recommendations for clinicians, and identify study-specific and participant-specific characteristics for providing future direction for ongoing MS research. We performed an open-dated search of Medline, PsychInfo, and CINAHL in December 2015. The search strategy involved using the terms 'exercise' OR 'physical activity' OR 'physical fitness' OR 'aerobic' OR 'resistance' OR 'balance' OR 'walking' OR 'yoga' OR 'training' OR 'rehabilitation' AND 'multiple sclerosis'. Articles were eliminated from the systematic review if it was a review article, theoretical paper, or textbook chapter; did not involve persons with MS; involved only persons with pediatric-onset MS; did not involve neuropsychological outcomes; did not include empirical data to evaluate outcomes; involved pharmacological interventions; or was not available in English. The selected articles were first classified as examining exercise, physical activity, or physical fitness, and were then randomly assigned to 2 independent reviewers who rated each article for level of evidence based on American Academy of Neurology criteria. Reviewers further completed a table to characterize important elements of each study (i.e., intervention characteristics), the cognitive domain(s) that were targeted, participant-specific characteristics, outcome measures, and study results. The present review resulted in 26 studies on the effects of exercise, physical activity, and physical fitness on cognition in persons with MS. This included 1 Class I study, 3 Class II studies, 8 Class III studies, and 14 Class IV studies. Of the 26 total studies, 6 were randomized controlled trials. Overall, there is conflicting evidence for the effects of exercise on cognition in MS, and overall positive, but not definitive evidence for the effects of physical activity and physical fitness, respectively, on cognition in this population. Collectively, there is insufficient well-designed research to definitively conclude that exercise, physical activity, and physical fitness are effective for improving cognition in MS. This is based, in part, on methodological issues of Class I and II studies, such as inclusion of cognition as a secondary outcome (35 % of reviewed studies), poorly-developed exercise interventions, and paucity of research that included cognitively-impaired MS samples. However, promising evidence from Class III and Class IV studies may be useful for informing the development of better intervention research.

journal_name

Neuropsychol Rev

journal_title

Neuropsychology review

authors

Sandroff BM,Motl RW,Scudder MR,DeLuca J

doi

10.1007/s11065-016-9324-2

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

271-294

issue

3

eissn

1040-7308

issn

1573-6660

pii

10.1007/s11065-016-9324-2

journal_volume

26

pub_type

杂志文章,评审
  • The Neural Substrate of Reward Anticipation in Health: A Meta-Analysis of fMRI Findings in the Monetary Incentive Delay Task.

    abstract::The monetary incentive delay task breaks down reward processing into discrete stages for fMRI analysis. Here we look at anticipation of monetary gain and loss contrasted with neutral anticipation. We meta-analysed data from 15 original whole-brain group maps (n = 346) and report extensive areas of relative activation ...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,meta分析

    doi:10.1007/s11065-018-9385-5

    authors: Wilson RP,Colizzi M,Bossong MG,Allen P,Kempton M,MTAC.,Bhattacharyya S

    更新日期:2018-12-01 00:00:00

  • Poststroke depression: prevalence, course, and associated factors.

    abstract::Despite the considerable amount of research that has been undertaken on poststroke depression, a review of the literature demonstrates that there are many inconclusive findings in the area. In particular, the causes and course of the disorder remain to be firmly established. While studies of prevalence differ with res...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/BF01874894

    authors: Hosking SG,Marsh NV,Friedman PJ

    更新日期:1996-09-01 00:00:00

  • Executive Function and Theory of Mind in Children with ADHD: a Systematic Review.

    abstract::In developmental research, the relationship between Executive Function (EF) and Theory of Mind (ToM) has been extensively assessed, and EF has been considered a condition for ToM. However, few researchers have studied the relationship between EF and ToM in clinical populations, especially that of Attention Deficit Hyp...

    journal_title:Neuropsychology review

    pub_type: 杂志文章

    doi:10.1007/s11065-018-9381-9

    authors: Pineda-Alhucema W,Aristizabal E,Escudero-Cabarcas J,Acosta-López JE,Vélez JI

    更新日期:2018-09-01 00:00:00

  • Towards a Better Understanding of Cognitive Deficits in Absence Epilepsy: a Systematic Review and Meta-Analysis.

    abstract::Cognition in absence epilepsy (AE) is generally considered undisturbed. However, reports on cognitive deficits in AE in recent years have suggested otherwise. This review systematically assesses current literature on cognitive performance in children with AE. A systematic literature search was performed in Pubmed, Emb...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,meta分析

    doi:10.1007/s11065-019-09419-2

    authors: Fonseca Wald ELA,Hendriksen JGM,Drenthen GS,Kuijk SMJV,Aldenkamp AP,Vles JSH,Vermeulen RJ,Debeij-van Hall MHJA,Klinkenberg S

    更新日期:2019-12-01 00:00:00

  • Facial emotion recognition in autism spectrum disorders: a review of behavioral and neuroimaging studies.

    abstract::Behavioral studies of facial emotion recognition (FER) in autism spectrum disorders (ASD) have yielded mixed results. Here we address demographic and experiment-related factors that may account for these inconsistent findings. We also discuss the possibility that compensatory mechanisms might enable some individuals w...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-010-9138-6

    authors: Harms MB,Martin A,Wallace GL

    更新日期:2010-09-01 00:00:00

  • The association between delirium and cognitive decline: a review of the empirical literature.

    abstract::Delirium is a common neurobehavioral syndrome that occurs across health care settings which is associated with adverse outcomes, including death. There are limited data on long-term cognitive outcomes following delirium. This report reviews the literature regarding relationships between delirium and cognitive impairme...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1023/b:nerv.0000028080.39602.17

    authors: Jackson JC,Gordon SM,Hart RP,Hopkins RO,Ely EW

    更新日期:2004-06-01 00:00:00

  • Methodological considerations in the neuropsychological study of central nervous system underarousal with a specific emphasis on coma.

    abstract::Several obstacles exist that impede the scientific study of pathological underarousal (stupor and coma). For instance, there is a lack of a clear, rational, standardized taxonomy with which to describe the phenomenon. Moreover, there is considerable confusion of the construct of arousal with other neurobehavioral cons...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1023/a:1021670203013

    authors: Stanczak DE

    更新日期:1998-12-01 00:00:00

  • A Systematic Review of the Positive Valence System in Autism Spectrum Disorder.

    abstract::This review synthesized current literature of behavioral and cognitive studies targeting reward processing in autism spectrum disorder (ASD). The National Institute of Mental Health's Research Domain Criteria (RDoC) Positive Valence System (PVS) domain was used as an overarching framework. The objectives were to deter...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-020-09459-z

    authors: Tschida JE,Yerys BE

    更新日期:2020-11-11 00:00:00

  • Memory for music in Alzheimer's disease: unforgettable?

    abstract::The notion that memory for music can be preserved in patients with Alzheimer's Disease (AD) has been raised by a number of case studies. In this paper, we review the current research examining musical memory in patients with AD. In keeping with models of memory described in the non-musical domain, we propose that vari...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-009-9085-2

    authors: Baird A,Samson S

    更新日期:2009-03-01 00:00:00

  • A Meta-Analysis of Neuropsychological Effort Test Performance in Psychotic Disorders.

    abstract::Psychotic disorders are characterized by a generalized neurocognitive deficit (i.e., performance 1.5 SD below controls across neuropsychological domains with no specific profile of differential deficits). A motivational account of the generalized neurocognitive deficit has been proposed, which attributes poor neuropsy...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-020-09448-2

    authors: Ruiz I,Raugh IM,Bartolomeo LA,Strauss GP

    更新日期:2020-09-01 00:00:00

  • Systematic review: are overweight and obese individuals impaired on behavioural tasks of executive functioning?

    abstract::This review was aimed at systematically investigating the evidence suggesting that obese individuals demonstrate impaired performance on behavioural tasks examining executive functioning abilities. A systematic review of literature was carried out by searching five separate databases (PsycINFO, MEDLINE, EMBASE, CINAHL...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-013-9224-7

    authors: Fitzpatrick S,Gilbert S,Serpell L

    更新日期:2013-06-01 00:00:00

  • Multiple chemical sensitivity: a review of the theoretical and research literature.

    abstract::Multiple chemical sensitivity (MCS) is a term used to describe a disorder characterized by a vast array of somatic, cognitive, and affective symptoms, the cause of which is attributed to exposure to extremely low levels of a variety of chemicals. Upon examination of the patient with a diagnosis of MCS, objective physi...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1023/a:1026460726965

    authors: Labarge XS,McCaffrey RJ

    更新日期:2000-12-01 00:00:00

  • Alzheimer's disease as a disconnection syndrome?

    abstract::This paper reviews the growing amount of evidence supporting the hypothesis that Alzheimer's disease includes a disconnection syndrome. This evidence came mainly from neuropathological, electrophysiological, and neuroimaging studies. Moreover, a few recent neuropsychological studies have also explored the effects of a...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1023/a:1023832305702

    authors: Delbeuck X,Van der Linden M,Collette F

    更新日期:2003-06-01 00:00:00

  • Olfaction in persons with Alzheimer's disease.

    abstract::The need for low cost, noninvasive procedures for aiding in the diagnosis and understanding of Alzheimer's Disease (AD) has led to theories and procedures examining the role of olfactory disorders because of the finding that the brains of AD patients invariably exhibit neuropathology in the hippocampus and entorhinal ...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1023/a:1025627106073

    authors: Thompson MD,Knee K,Golden CJ

    更新日期:1998-03-01 00:00:00

  • Self-report measures to identify post traumatic stress disorder and/or mild traumatic brain injury and associated symptoms in military veterans of Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF).

    abstract::Individuals serving in Iraq and Afghanistan sustain injuries associated with physical and psychological trauma. Among such injuries, mild traumatic brain injury (mTBI) and post traumatic stress disorder (PTSD) are common. Self-report measures are frequently used to identify mTBI and/or PTSD and symptoms associated wit...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-012-9191-4

    authors: Betthauser LM,Bahraini N,Krengel MH,Brenner LA

    更新日期:2012-03-01 00:00:00

  • The Early Presentation of Dementia in People with Down Syndrome: a Systematic Review of Longitudinal Studies.

    abstract::Adults with Down syndrome (DS) are at a very high risk of developing early onset Alzheimer's disease (AD) due to trisomy of chromosome 21. AD is preceded by a prolonged prodromal "pre-clinical" phase presenting with clinical features that do not fulfil the diagnostic criteria for AD. It is important to clinically char...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-017-9341-9

    authors: Lautarescu BA,Holland AJ,Zaman SH

    更新日期:2017-03-01 00:00:00

  • Evaluating single-subject treatment research: lessons learned from the aphasia literature.

    abstract::The mandate for evidence-based practice has prompted careful consideration of the weight of the scientific evidence regarding the therapeutic value of various clinical treatments. In the field of aphasia, a large number of single-subject research studies have been conducted, providing clinical outcome data that are po...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-006-9013-7

    authors: Beeson PM,Robey RR

    更新日期:2006-12-01 00:00:00

  • Neuropsychological aspects of facial asymmetry during emotional expression: a review of the normal adult literature.

    abstract::This review focuses on facial asymmetries during emotional expression. Facial asymmetry is defined as the expression intensity or muscular involvement on one side of the face ("hemiface") relative to the other side and has been used as a behavioral index of hemispheric specialization for facial emotional expression. T...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,meta分析

    doi:10.1007/BF02876972

    authors: Borod JC,Haywood CS,Koff E

    更新日期:1997-03-01 00:00:00

  • Genetics and brain morphology.

    abstract::A wealth of empirical evidence is accumulating on the genetic mediation of brain structure phenotypes. This comes from twin studies that assess heritability and genetic covariance between traits, candidate gene associations, and genome-wide association studies (GWAS) that can identify specific genetic variants. Here w...

    journal_title:Neuropsychology review

    pub_type: 杂志文章

    doi:10.1007/s11065-015-9281-1

    authors: Strike LT,Couvy-Duchesne B,Hansell NK,Cuellar-Partida G,Medland SE,Wright MJ

    更新日期:2015-03-01 00:00:00

  • Distinct Activity Patterns of the Human Bed Nucleus of the Stria Terminalis and Amygdala during Fear Learning.

    abstract::The amygdala and, more recently, also the bed nucleus of the stria terminalis, have been widely implicated in fear and anxiety. Much of our current knowledge is derived from animal studies and suggests an intricate convergence and divergence in functions related to defensive responding. In a recent paper, Klumpers and...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-018-9383-7

    authors: Luyck K,Goode TD,Lee Masson H,Luyten L

    更新日期:2019-06-01 00:00:00

  • Neuropsychological issues in the assessment of refugees and victims of mass violence.

    abstract::Brain injury, stressor severity, depression, premorbid vulnerabilities, and PTSD are frequently intertwined in trauma populations. This interaction is further complicated when the neuropsychologist evaluates refugees from other cultures. In addition, the observed psychiatric symptoms reported in refugees and victims o...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1023/a:1016650623996

    authors: Weinstein CS,Fucetola R,Mollica R

    更新日期:2001-09-01 00:00:00

  • Apraxia and Alzheimer's disease: review and perspectives.

    abstract::Apraxia is one of the cognitive deficits that characterizes Alzheimer's disease. Despite its prevalence and relevance to diagnosing Alzheimer's disease, this topic has received little attention and is without comprehensive review. The review herein is aimed to fill this gap by first presenting an overview of the impai...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-013-9235-4

    authors: Lesourd M,Le Gall D,Baumard J,Croisile B,Jarry C,Osiurak F

    更新日期:2013-09-01 00:00:00

  • Prosaccade and Antisaccade Paradigms in Persons with Alzheimer's Disease: A Meta-Analytic Review.

    abstract::Persons with Mild Cognitive Impairment (MCI) are at high Alzheimer's Disease (AD) risk but the development of sensitive measures to assess subtle cognitive decline in this population poses a major challenge for clinicians and researchers. Eye movement monitoring is a non-invasive, sensitive way to assess subtle cognit...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11065-017-9362-4

    authors: Kahana Levy N,Lavidor M,Vakil E

    更新日期:2018-03-01 00:00:00

  • Neuropsychological sequelae of PTSD and TBI following war deployment among OEF/OIF veterans.

    abstract::Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are highly prevalent among Veterans of the conflicts in Iraq and Afghanistan. These conditions are associated with common and unique neuropsychological and neuroanatomical changes. This review synthesizes neuropsychological and neuroimaging st...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-012-9190-5

    authors: Dolan S,Martindale S,Robinson J,Kimbrel NA,Meyer EC,Kruse MI,Morissette SB,Young KA,Gulliver SB

    更新日期:2012-03-01 00:00:00

  • Assessment of intelligence in the preschool period.

    abstract::Intelligence testing has a long and revered history in psychological measurement in childhood. Yet, the years between infancy and early childhood have been understudied with respect to emergent intellectual and cognitive functioning. Factor analytic models of intelligence that have demonstrated applicability when test...

    journal_title:Neuropsychology review

    pub_type: 杂志文章

    doi:10.1007/s11065-012-9215-0

    authors: Baron IS,Leonberger KA

    更新日期:2012-12-01 00:00:00

  • Luria's neuropsychological evaluation in the nordic countries.

    abstract::The publication of Luria's Neuropsychological Investigation (LNI) by Christensen in 1975 introduced Luria's evaluation procedures to worldwide neuropsychology. The LNI demonstrated the benefit of a thorough qualitative analysis of an individual patient's functioning as well as the usefulness of a comprehensive theory ...

    journal_title:Neuropsychology review

    pub_type: 历史文章,杂志文章,评审

    doi:10.1023/a:1025655707095

    authors: Christensen AL,Caetano C

    更新日期:1999-06-01 00:00:00

  • Four neuropsychologists.

    abstract::The achievements of Henry Hécaen, Oliver Zangwill, Hans-Lukas Teuber, and Norman Geschwind are reviewed. Each made an enormously significant contribution to the form and content of the field of neuropsychology as we know it today. ...

    journal_title:Neuropsychology review

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/BF01875020

    authors: Benton A

    更新日期:1994-03-01 00:00:00

  • The Role of the Amygdala and the Ventromedial Prefrontal Cortex in Emotional Regulation: Implications for Post-traumatic Stress Disorder.

    abstract::The importance of the amygdala as a salience detector and in emotional learning is now well accepted. The mechanisms that regulate and inhibit the amygdala, however, are less well understood. This review provides evidence from imaging and lesion studies to support the role of the ventromedial prefrontal cortex (vmPFC)...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-019-09398-4

    authors: Andrewes DG,Jenkins LM

    更新日期:2019-06-01 00:00:00

  • Aging, training, and the brain: a review and future directions.

    abstract::As the population ages, the need for effective methods to maintain or even improve older adults' cognitive performance becomes increasingly pressing. Here we provide a brief review of the major intervention approaches that have been the focus of past research with healthy older adults (strategy training, multi-modal i...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-009-9119-9

    authors: Lustig C,Shah P,Seidler R,Reuter-Lorenz PA

    更新日期:2009-12-01 00:00:00

  • Turning it upside down: areas of preserved cognitive function in schizophrenia.

    abstract::Patients with schizophrenia demonstrate marked impairments on most clinical neuropsychological tests. These findings suggest that patients suffer from a generalized form of cognitive impairment, with little evidence of spared performance documented in several large meta-analytic reviews of the clinical literature. In ...

    journal_title:Neuropsychology review

    pub_type: 杂志文章,评审

    doi:10.1007/s11065-009-9098-x

    authors: Gold JM,Hahn B,Strauss GP,Waltz JA

    更新日期:2009-09-01 00:00:00