Randomized, double-blind, placebo-controlled study of methylphenidate for the treatment of depression in SSRI-treated cancer patients receiving palliative care.

Abstract:

OBJECTIVE:To determine the effectiveness of methylphenidate for depression treatment in patients with advanced cancer. DESIGN:An 18-day randomized, double-blind, placebo-controlled clinical trial of methylphenidate for treatment of depression in selective serotonin reuptake inhibitor-treated patients with advanced cancer in hospice or receiving palliative care. The primary outcome was depression remission, defined as a ≥50% reduction in score on the Montgomery-Asberg Depression Rating Scale. RESULTS:Among 47 enrolled participants, 34 were randomized. At study day 18, 85% of the methylphenidate and 60% of the placebo group were in depression remission (P = .22). Mean time to depression remission was 10.3 days [standard error (SE) 1.8] in the methylphenidate and 8.1 (SE 1.3) in the placebo group (P = .48). The mean baseline score for the Hospital Anxiety and Depression Scale (HADS) was 10.4 in each group and decreased by 3.6 (SE 1.1) in the methylphenidate and 2.3 (SE 1.2) in the placebo group (P = .51) by day 18. Once in remission, 1 methylphenidate and 5 placebo participants relapsed to depression (P = .18). There was no difference in mortality between the groups during the trial. Trial results were limited by small sample size attributed to difficulties in recruiting terminally ill patients. CONCLUSIONS:This trial failed to demonstrate that methylphenidate treatment in selective serotonin reuptake inhibitor-treated patients had a significant effect on depression remission in patients with advanced cancer. This study underscores the difficulties in conducting trials for symptom management in patients with shortened life expectancy.

journal_name

Psychooncology

journal_title

Psycho-oncology

authors

Sullivan DR,Mongoue-Tchokote S,Mori M,Goy E,Ganzini L

doi

10.1002/pon.4220

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1763-1769

issue

11

eissn

1057-9249

issn

1099-1611

journal_volume

26

pub_type

杂志文章,随机对照试验
  • Romantic relationships of emerging adult survivors of childhood cancer.

    abstract:OBJECTIVE:To assess whether childhood cancer survivors experience difficulties in their romantic relationships during emerging adulthood (18-25 years) and to identify who may be at risk for long-term social sequelae. METHODS:Emerging adult survivors of childhood cancer (n=60) and controls without a history of chronic ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1471

    authors: Thompson AL,Marsland AL,Marshal MP,Tersak JM

    更新日期:2009-07-01 00:00:00

  • The impact of follicular (FL) and other indolent non-Hodgkin's lymphomas (NHL) on work productivity-a preliminary analysis.

    abstract:INTRODUCTION:Although much is known about the efficacy, toxicity, and direct costs of treatment for follicular lymphoma (FL), there is no data assessing the impact of this diagnosis on the work productivity of affected individuals. METHODS:We conducted a cross-sectional survey study of consecutive patients attending a...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1404

    authors: Cheung MC,Imrie KR,Friedlich J,Buckstein R,Lathia N,Mittmann N

    更新日期:2009-05-01 00:00:00

  • Nurses' recognition of the mental state of cancer patients and their own stress management - a study of Japanese cancer-care nurses.

    abstract:OBJECTIVE:The primary aim of this study was to describe Japanese oncology nurses' self-reported ability to assess and care for cancer patients' mental health. A secondary aim was to describe nurses' self-reported stress levels and need for stress management related to caring for oncology patients. METHODS:This cross-s...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3191

    authors: Kaneko M,Ryu S,Nishida H,Tamasato K,Shimodaira Y,Nishimura K,Kume M

    更新日期:2013-07-01 00:00:00

  • Does felt age reflect health-related quality of life in cancer patients?

    abstract::Subjective age is related to health and to life satisfaction. The present study on post-surgical cancer patients addressed two questions: (1) Do people differ in their health-related quality of life (HRQOL) depending on their felt age? (2) Is change in felt age associated with change in HRQOL? Data were collected at o...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1011

    authors: Boehmer S

    更新日期:2006-08-01 00:00:00

  • A qualitative study of women's experiences of familial ovarian cancer screening.

    abstract:OBJECTIVE:One risk management strategy that women at increased familial risk of ovarian cancer may use is screening. Until recently, this has been available as part of the UK Familial Ovarian Cancer Screening Study (UKFOCSS), using ultrasound scans of the ovaries and tumour marker blood tests. The present study aimed t...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3324

    authors: Lifford KJ,Clements A,Fraser L,Lancastle D,Brain K,PsyFOCS Management Group.

    更新日期:2013-11-01 00:00:00

  • Effects of dignity therapy on dignity, psychological well-being, and quality of life among palliative care cancer patients: A systematic review and meta-analysis.

    abstract:OBJECTIVES:The review aims to identify available evidence related to the effects of dignity therapy on dignity, psychological well-being, and quality of life (QoL) among patients with cancer under palliative care. METHODS:Thirteen electronic databases were searched for published articles in English or Chinese from inc...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,meta分析

    doi:10.1002/pon.5162

    authors: Xiao J,Chow KM,Liu Y,Chan CWH

    更新日期:2019-09-01 00:00:00

  • Economic survivorship stress is associated with poor health-related quality of life among distressed survivors of hematopoietic stem cell transplantation.

    abstract:BACKGROUND:Hematopoietic stem cell transplantation is a demanding cancer treatment associated with enduring physical and psychological complications. Survivors' well-being may be further compromised by exposure to chronic stressors common to this population, including difficulties arising from costly medical care, chan...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3091

    authors: Hamilton JG,Wu LM,Austin JE,Valdimarsdottir H,Basmajian K,Vu A,Rowley SD,Isola L,Redd WH,Rini C

    更新日期:2013-04-01 00:00:00

  • The shared experience of adolescent and young adult cancer patients and their caregivers.

    abstract:OBJECTIVE:We examined the interdependent, dyadic, mental health of adolescent and young adult (AYA) cancer patients and their caregivers. Our aims were as follows: (1) to investigate the degree to which patients' and caregivers' subjective perceptions of illness severity are congruent with objective severity (i.e., med...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3785

    authors: Juth V,Silver RC,Sender L

    更新日期:2015-12-01 00:00:00

  • Psychological distress and use of psychosocial support in familial adenomatous polyposis.

    abstract:OBJECTIVE:Familial adenomatous polyposis (FAP) is characterized by multiple adenomas in the colorectum with a high risk to develop colorectal cancer. It is unclear whether individuals at risk of FAP experience distress due to this potentially life-threatening disease. This nationwide study assessed: (1) the prevalence ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1570

    authors: Douma KF,Aaronson NK,Vasen HF,Gerritsma MA,Gundy CM,Janssen EP,Vriends AH,Cats A,Verhoef S,Bleiker EM

    更新日期:2010-03-01 00:00:00

  • Sexual issues among cervical cancer survivors: how can we help women seek help?

    abstract:OBJECTIVE:Many women treated for cervical cancer (CC) report sexual complaints and sexual distress. It is important to assess these women's and their partners' sexual healthcare needs. This study aims to (a) investigate the prevalence of psychosexual healthcare needs and help-seeking behaviour among CC survivors, (b) i...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/pon.3663

    authors: Vermeer WM,Bakker RM,Kenter GG,de Kroon CD,Stiggelbout AM,ter Kuile MM

    更新日期:2015-04-01 00:00:00

  • Relationships among perceived diagnostic disclosure, health locus of control, and levels of hope in Taiwanese cancer patients.

    abstract:OBJECTIVES:To explore relationships among perceived diagnostic disclosure, health locus of control, and levels of hope in Taiwanese cancer patients. RESEARCH DESIGN:A cross-sectional, descriptive correlational design was used in this study. One hundred and twenty-four (N=124) patients were recruited. The Background In...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.854

    authors: Lin CC,Tsay HF

    更新日期:2005-05-01 00:00:00

  • Assessing the psychological predictors of benefit finding in patients with head and neck cancer.

    abstract:BACKGROUND:Some individuals are able to gain psychological benefits from illness and adversity, such as a greater sense of purpose and closer relationships, termed 'benefit finding' (BF). The main aim of this study was to explore the extent to which BF is reported in patients with head and neck cancer (HNC). Secondary ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.2065

    authors: Llewellyn CD,Horney DJ,McGurk M,Weinman J,Herold J,Altman K,Smith HE

    更新日期:2013-01-01 00:00:00

  • Quality of life in patients surviving at least 12 months following high dose chemotherapy with autologous bone marrow support.

    abstract:BACKGROUND:Over the past decade, high dose chemotherapy with autologous bone marrow (HDC-ABMT) support has been used increasingly in the treatment of patients with breast cancer. In evaluating the results of HDC-ABMT in patients with breast cancer, an assessment of quality of life can add to the traditional endpoints (...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-1611(199903/04)8:2<167::AID-PON

    authors: Winer EP,Lindley C,Hardee M,Sawyer WT,Brunatti C,Borstelmann NA,Peters W

    更新日期:1999-03-01 00:00:00

  • Improving reporting of meta-ethnography: The eMERGe reporting guidance.

    abstract:AIMS:The aim of this study was to provide guidance to improve the completeness and clarity of meta-ethnography reporting. BACKGROUND:Evidence-based policy and practice require robust evidence syntheses which can further understanding of people's experiences and associated social processes. Meta-ethnography is a rigoro...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4915

    authors: France EF,Cunningham M,Ring N,Uny I,Duncan EAS,Jepson RG,Maxwell M,Roberts RJ,Turley RL,Booth A,Britten N,Flemming K,Gallagher I,Garside R,Hannes K,Lewin S,Noblit GW,Pope C,Thomas J,Vanstone M,Higginbottom GMA,N

    更新日期:2019-03-01 00:00:00

  • Psychotropic drug metabolism in the cancer patient: clinical aspects of management of potential drug interactions.

    abstract::An overview of drug metabolism, with particular focus on the cytochrome p450 system, is provided in this review. To date, there has been a growing body of literature concerning the cytochrome p450 enzyme, drug-drug interactions and the role of psychotropic medications when co-administered with medications prescribed i...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1099-1611(199807/08)7:4<307::AID-PON

    authors: Kalash GR

    更新日期:1998-07-01 00:00:00

  • Distress screening in allogeneic hematopoietic stem cell (HSCT) caregivers and patients.

    abstract:UNLABELLED:Family caregivers of allogeneic hematopoietic stem cell transplant (HSCT) patients are at risk for experiencing significant psychological distress yet screening caregivers has not been well studied. OBJECTIVE:This analysis explored the psychometric characteristics of the Distress Thermometer (DT) by examini...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1906

    authors: Bevans M,Wehrlen L,Prachenko O,Soeken K,Zabora J,Wallen GR

    更新日期:2011-06-01 00:00:00

  • The psychosocial experience of women treated for breast cancer by high-dose chemotherapy supported by autologous stem cell transplant: a qualitative analysis of support groups.

    abstract::Autologous bone marrow transplantation (AuBMT) is probably among the most aggressive of physical treatments endured by cancer patients. High-risk breast cancer patients who choose this therapy face prolonged, agonizing and life-threatening interventions that are no less arduous than confronting the malignant disease i...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1611(200001/02)9:1<57::aid-pon4

    authors: Feigin R,Greenberg A,Ras H,Hardan Y,Rizel S,Ben Efraim T,Stemmer SM

    更新日期:2000-01-01 00:00:00

  • Sensory and affective dimensions of advanced cancer pain.

    abstract::The present study was designed to explore the extent to which advanced cancer pain is explicable in terms of both physical pain intensity and affect. Most notably, it expanded on previous findings by more clearly elucidating the relationship between several discrete emotional states and the total experience of cancer ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.551

    authors: Sela RA,Bruera E,Conner-spady B,Cumming C,Walker C

    更新日期:2002-01-01 00:00:00

  • Bereaved mothers' and fathers' prolonged grief and psychological health 1 to 5 years after loss-A nationwide study.

    abstract:OBJECTIVE:To assess differences in prolonged grief, depression, posttraumatic stress, and sleep disturbances in bereaved parents across years since loss (1-5 years) and by gender and to assess potential interactive effects of time since loss and gender on bereavement outcomes. METHODS:This study examined symptom level...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.5112

    authors: Pohlkamp L,Kreicbergs U,Sveen J

    更新日期:2019-07-01 00:00:00

  • Use of antidepressants in women after prophylactic bilateral oophorectomy: A Danish national cohort study.

    abstract:OBJECTIVE:To investigate the association between prophylactic bilateral oophorectomy and use of antidepressants in women with a family history of cancer. METHODS:Nationwide population-based cohort study using Danish National Registries including women oophorectomized due to a family history of cancer (n = 2,002) and a...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.5290

    authors: Abildgaard J,Ahlström MG,Nielsen DL,Daugaard G,Lindegaard B,Obel N,Lidegaard Ø

    更新日期:2020-04-01 00:00:00

  • Breaking bad news to cancer patients: survey and analysis.

    abstract:PURPOSE:To find out how patients perceived the disclosure of news about their cancer as regards the physician counselling and how they perceived the flow of information between hospital-based and family physicians. METHODS:272 cancer patients were polled with a 16-item questionnaire. RESULTS:252 cancer patients, 92.6...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1383

    authors: Spiegel W,Zidek T,Maier M,Vutuc C,Isak K,Karlic H,Micksche M

    更新日期:2009-02-01 00:00:00

  • Prevalence and correlates of current smoking among medical oncology outpatients.

    abstract:BACKGROUND:Continued smoking following a cancer diagnosis has adverse impacts on cancer treatment and puts individuals at risk of secondary cancers. Data on the prevalence and correlates of smoking among cancer patients are critical for successfully targeting smoking cessation interventions. AIMS:To explore among a sa...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3893

    authors: Regan T,Carey M,Bryant J,Waller A,Mansfield E,Sitas F,Tracey E

    更新日期:2015-10-01 00:00:00

  • Head and neck cancer and dysphagia; caring for carers.

    abstract:OBJECTIVES:A diagnosis of head and neck cancer (HNC) is a profound event for patients and family members who play a crucial role in their care. Eating and drinking difficulties affect patients' quality of life (QOL), but the impact on the carers' QOL has not been explored. This preliminary mixed method study reports on...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3226

    authors: Patterson JM,Rapley T,Carding PN,Wilson JA,McColl E

    更新日期:2013-08-01 00:00:00

  • Posttraumatic growth, social support, and social constraint in hematopoietic stem cell transplant survivors.

    abstract:OBJECTIVE:The relation between posttraumatic growth (PTG) and aspects of the social context, such as social support and social constraint, continues to be unclear in cancer survivors. Social cognitive processing theory is a useful framework for examining the effect of the social context on PTG. In theory, support inter...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.2073

    authors: Nenova M,DuHamel K,Zemon V,Rini C,Redd WH

    更新日期:2013-01-01 00:00:00

  • Patterns and covariates of benefit finding in young Black breast cancer survivors: A longitudinal, observational study.

    abstract:OBJECTIVE:To examine the patterns and covariates of benefit finding over time among young Black breast cancer (BC) survivors. METHODS:Black women (N = 305) with invasive BC diagnosed ≤50 years were recruited an average of 1.9 years post-BC diagnosis. Participants completed self-report questionnaires of benefit finding...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.5398

    authors: Conley CC,Small BJ,Christie J,Hoogland AI,Augusto BM,Garcia JD,Pal T,Vadaparampil ST

    更新日期:2020-07-01 00:00:00

  • Healthcare professionals' views on discussing fertility preservation with young cancer patients: a mixed method systematic review of the literature.

    abstract:OBJECTIVE:In spite of efforts to guarantee patients are adequately informed about their risk of fertility loss and offered treatment for fertility preservation (FP), previous studies have reported that this topic is not routinely discussed with patients, especially with younger patient populations. A mixed method syste...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,评审

    doi:10.1002/pon.4092

    authors: Vindrola-Padros C,Dyer KE,Cyrus J,Lubker IM

    更新日期:2017-01-01 00:00:00

  • Advance care planning for cancer patients: a systematic review of perceptions and experiences of patients, families, and healthcare providers.

    abstract:BACKGROUND:Patients with advanced cancer may benefit from end of life (EOL) planning, but there is evidence that their willingness and desire to engage in advance care planning (ACP) varies. The reasons for this remain poorly understood. Previous reviews on ACP most commonly report outcome measures related to medical i...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,评审

    doi:10.1002/pon.3926

    authors: Johnson S,Butow P,Kerridge I,Tattersall M

    更新日期:2016-04-01 00:00:00

  • The effects of anxiety on the receipt of treatments for esophageal cancer.

    abstract:OBJECTIVE:This study aimed to evaluate the association between anxiety and receipt of treatments for esophageal cancer. METHODS:We used a population-based cohort to obtain information of patients with esophageal cancer. Baseline diagnoses of depression or anxiety were identified. Competing risk analyses were used to e...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4903

    authors: Wang TY,Chen VC,Yang YH,Chen CY,Lee CP,Wu SI

    更新日期:2019-01-01 00:00:00

  • Determinants of the burden and positivity of family caregivers of terminally ill cancer patients in Korea.

    abstract:OBJECTIVE:Caregivers may experience positive or negative feelings about their role. The study investigated the determinants of the burden and positivity of family caregivers of Korean terminal cancer patients. METHODS:A multicenter cross-sectional survey was conducted with 139 family caregivers. Determinants of caregi...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1893

    authors: Park CH,Shin DW,Choi JY,Kang J,Baek YJ,Mo HN,Lee MS,Park SJ,Park SM,Park S

    更新日期:2012-03-01 00:00:00

  • Perceived diagnostic delay and cancer-related distress: a cross-sectional study of patients with colorectal cancer.

    abstract:OBJECTIVE:This study aimed to examine the effect of perceived diagnostic delay on cancer-related distress and determine whether fear of cancer-recurrence and quality of life mediate this relationship. METHODS:Cross-sectional study in which 311 colorectal cancer (CRC) survivors in Scotland completed a survey, which inc...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4093

    authors: Miles A,McClements PL,Steele RJ,Redeker C,Sevdalis N,Wardle J

    更新日期:2017-01-01 00:00:00