Multiplex amplicon sequencing for microbe identification in community-based culture collections.

abstract：:The foregut endoderm gives rise to several organs including liver, pancreas, lung and thyroid with important roles in human physiology. Understanding which genes and signalling pathways regulate their development is crucial for understanding developmental disorders as well as diseases in adulthood. We exploited unique...

journal_title：Scientific reports

authors： Trubiroha A,Gillotay P,Giusti N,Gacquer D,Libert F,Lefort A,Haerlingen B,De Deken X,Opitz R,Costagliola S

更新日期：2018-04-04 00:00:00

abstract：:The natural alkaloid berberine has several pharmacological properties and recently received attention as a potential anticancer agent. In this work, we investigated the molecular mechanisms underlying the anti-tumor effect of berberine on glioblastoma U343 and pancreatic carcinoma MIA PaCa-2 cells. Human dermal fibrob...

journal_title：Scientific reports

authors： Agnarelli A,Natali M,Garcia-Gil M,Pesi R,Tozzi MG,Ippolito C,Bernardini N,Vignali R,Batistoni R,Bianucci AM,Marracci S

更新日期：2018-07-13 00:00:00

abstract：:Amyloid precursor protein (APP) and its cleavage product amyloid β (Aβ) have been thoroughly studied in Alzheimer's disease. However, APP also appears to be important for neuronal development. Differentiation of induced pluripotent stem cells (iPSCs) towards cortical neurons enables in vitro mechanistic studies on hum...

journal_title：Scientific reports

authors： Bergström P,Agholme L,Nazir FH,Satir TM,Toombs J,Wellington H,Strandberg J,Bontell TO,Kvartsberg H,Holmström M,Boreström C,Simonsson S,Kunath T,Lindahl A,Blennow K,Hanse E,Portelius E,Wray S,Zetterberg H

更新日期：2016-07-07 00:00:00

abstract：:Transcatheter aortic valve implantation (TAVI) still presents complications: paravalvular leakage (PVL) and onset of conduction abnormalities leading to permanent pacemaker implantation. Our aim was testing a validated patient-specific computational framework for prediction of TAVI outcomes and possible complications....

journal_title：Scientific reports

authors： Bosi GM,Capelli C,Cheang MH,Delahunty N,Mullen M,Taylor AM,Schievano S

更新日期：2020-06-18 00:00:00

abstract：:This study was aimed to assess the relationship of intraocular forward scattering, corneal backward scattering, and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) in eyes with granular corneal dystrophy (GCD). We retrospectively examined forty two eyes of 42 consecutive patients w...

journal_title：Scientific reports

authors： Kamiya K,Kobashi H,Igarashi A,Shoji N,Shimizu K

更新日期：2016-04-18 00:00:00

abstract：:Quantum coherence and quantum correlations are important quantum resources for quantum computation and quantum information. In this paper, using entropy-based measures, we investigate the relationships between quantum correlated coherence, which is the coherence between subsystems, and two main kinds of quantum correl...

journal_title：Scientific reports

authors： Wang XL,Yue QL,Yu CH,Gao F,Qin SJ

更新日期：2017-09-21 00:00:00

abstract：:Because of ubiquity of thioesters, thioesterases play a critical role in metabolism, membrane biosynthesis, signal transduction, and gene regulation. In many bacteria, YbgC is such an enzyme, whose coding gene mostly resides in the tol-pal cluster. Although all other proteins encoded in the tol-pal cluster are clearly...

journal_title：Scientific reports

authors： Gao T,Meng Q,Gao H

更新日期：2017-06-21 00:00:00

abstract：:Type 2 Diabetes (T2D) is increasing but the effectiveness of large-scale diabetes screening programmes is debated. We assessed associations between coverage of a national cardiovascular and diabetes risk assessment programme in England (NHS Health Check) and detection and management of incident cases of non-diabetic h...

journal_title：Scientific reports

authors： Palladino R,Vamos EP,Chang KC,Khunti K,Majeed A,Millett C

更新日期：2020-01-27 00:00:00

abstract：:In this work, we report our study of protein expression in rat peri-infarct tissue, 48 h after the induction of permanent focal cerebral ischemia. Two proteomic approaches, gel electrophoresis with mass spectrometry and combined fractional diagonal chromatography (COFRADIC), were performed using tissue samples from th...

journal_title：Scientific reports

authors： Brea D,Agulla J,Staes A,Gevaert K,Campos F,Sobrino T,Blanco M,Dávalos A,Castillo J,Ramos-Cabrer P

更新日期：2015-07-08 00:00:00

abstract：:High abundance and widespread distribution of the archaeal phylum Bathyarchaeota in marine environment have been recognized recently, but knowledge about Bathyarchaeota in terrestrial settings and their correlation with environmental parameters is fairly limited. Here we reported the abundance of Bathyarchaeota member...

journal_title：Scientific reports

authors： Xiang X,Wang R,Wang H,Gong L,Man B,Xu Y

更新日期：2017-03-21 00:00:00

abstract：:The strange three-dimensional flight behaviour of slowly spinning soccer balls is one of the most interesting and unknown phenomenon associated with the trajectories of sports balls. Many spectators have experienced numerous exciting and emotional instances while observing the curious flight behaviour of these balls. ...

journal_title：Scientific reports

authors： Mizota T,Kurogi K,Ohya Y,Okajima A,Naruo T,Kawamura Y

更新日期：2013-01-01 00:00:00

abstract：:Encapsulation is essential to protect the air-sensitive components of organic light-emitting diodes (OLEDs) such as active layers and cathode electrodes. In this study, hybrid zirconium inorganic/organic nanolaminates were fabricated using remote plasma enhanced atomic layer deposition (PEALD) and molecular layer depo...

journal_title：Scientific reports

authors： Chen Z,Wang H,Wang X,Chen P,Liu Y,Zhao H,Zhao Y,Duan Y

更新日期：2017-01-06 00:00:00

abstract：:Rheumatoid Arthritis (RA) causes chronic inflammation of joints. The cytokines TNFα and IFNγ are central players in RA, however their source has not been fully elucidated. Natural Killer (NK) cells are best known for their role in elimination of viral-infected and transformed cells, and they secrete pro-inflammatory c...

journal_title：Scientific reports

authors： Yamin R,Berhani O,Peleg H,Aamar S,Stein N,Gamliel M,Hindi I,Scheiman-Elazary A,Gur C

更新日期：2019-02-04 00:00:00

abstract：:The synthesis of artificial cell is a route for searching the origin of protocell. Here, we create a novel cell model of graphene capsules with selective ion channels, indicating that graphene might be an embryo of protocell membrane. Firstly, we found that the highly oxidized graphene and phospholipid-graphene oxide ...

journal_title：Scientific reports

authors： Li Z,Wang C,Tian L,Bai J,Yao H,Zhao Y,Zhang X,Cao S,Qi W,Wang S,Shi K,Xu Y,Mingliang Z,Liu B,Qiu H,Liu J,Wu W,Wang X,Wenzhen A

更新日期：2015-05-19 00:00:00

abstract：:The neuronal accumulation of phosphorylated tau plays a critical role in the pathogenesis of Alzheimer's disease (AD). Here, we examined the effect of fisetin, a flavonol, on tau levels. Treatment of cortical cells or primary neurons with fisetin resulted in significant decreases in the levels of phosphorylated tau. I...

journal_title：Scientific reports

authors： Kim S,Choi KJ,Cho SJ,Yun SM,Jeon JP,Koh YH,Song J,Johnson GV,Jo C

更新日期：2016-04-26 00:00:00

abstract：:Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with significant morbidity and costs. Anti-microbial polycationic dendrimers G3KL and G3R...

journal_title：Scientific reports

authors： Abdel-Sayed P,Kaeppeli A,Siriwardena T,Darbre T,Perron K,Jafari P,Reymond JL,Pioletti DP,Applegate LA

更新日期：2016-02-25 00:00:00

abstract：:Current robots can manipulate only surface-attached cells seriously limiting the fields of their application for single cell handling. We developed a computer vision-based robot applying a motorized microscope and micropipette to recognize and gently isolate intact individual cells for subsequent analysis, e.g., DNA/R...

journal_title：Scientific reports

authors： Ungai-Salánki R,Gerecsei T,Fürjes P,Orgovan N,Sándor N,Holczer E,Horvath R,Szabó B

更新日期：2016-02-09 00:00:00

abstract：:Recently, slow earthquakes (slow EQ) have received much attention relative to understanding the mechanisms underlying large earthquakes and to detecting their precursors. Low-frequency earthquakes (LFE) are a specific type of slow EQ. In the present paper, we reveal the relevance of LFEs to the 11 March 2011 Great Toh...

journal_title：Scientific reports

authors： Tokuda T,Shimada H

更新日期：2019-06-27 00:00:00

abstract：:With countless biological details emerging from cancer experiments, there is a growing need for minimal mathematical models which simultaneously advance our understanding of single tumors and metastasis, provide patient-personalized predictions, whilst avoiding excessive hard-to-measure input parameters which complica...

journal_title：Scientific reports

authors： Choe SC,Zhao G,Zhao Z,Rosenblatt JD,Cho HM,Shin SU,Johnson NF

更新日期：2011-01-01 00:00:00

abstract：:In arthropods, retinoid X receptor (RXR) is a highly conserved nuclear hormone receptor. By forming a heterodimeric complex with the ecdysone receptor (EcR), RXR is known to be vital importance for various physiological processes. However, in comparison to EcR, the RXR signaling pathway and its roles in crustacean rep...

journal_title：Scientific reports

authors： Gong J,Huang C,Shu L,Bao C,Huang H,Ye H,Zeng C,Li S

更新日期：2016-03-24 00:00:00

abstract：:Malaria transmission-blocking vaccines (TBVs) target the development of Plasmodium parasites within the mosquito, with the aim of preventing malaria transmission from one infected individual to another. Different vaccine platforms, mainly protein-in-adjuvant formulations delivering the leading candidate antigens, have...

journal_title：Scientific reports

authors： Kapulu MC,Da DF,Miura K,Li Y,Blagborough AM,Churcher TS,Nikolaeva D,Williams AR,Goodman AL,Sangare I,Turner AV,Cottingham MG,Nicosia A,Straschil U,Tsuboi T,Gilbert SC,Long CA,Sinden RE,Draper SJ,Hill AV,Cohuet A,

更新日期：2015-06-11 00:00:00

abstract：:Hypertension is a public health issue in Iran. The study aimed to estimate the prevalence, awareness, treatment, and control of hypertension, and to explore their determinants among 10,040 Kurdish adults from Ravansar Non-Communicable Disease (RaNCD) cohort study in Iran. Univariate, and multivariate analyses were use...

journal_title：Scientific reports

authors： Rajati F,Hamzeh B,Pasdar Y,Safari R,Moradinazar M,Shakiba E,Bazargan-Hejazi S,Karim H,Najafi F

更新日期：2019-08-27 00:00:00

abstract：:Small oligomers formed early along human islet amyloid polypeptide (hIAPP) aggregation is responsible for the cell death in Type II diabetes. The epigallocatechin gallate (EGCG), a green tea extract, was found to inhibit hIAPP fibrillation. However, the inhibition mechanism and the conformational distribution of the s...

journal_title：Scientific reports

authors： Mo Y,Lei J,Sun Y,Zhang Q,Wei G

更新日期：2016-09-13 00:00:00

abstract：:One of the main characteristics of cancer tissues is poor development of neovascularization that results in a limited blood circulation. Because of this phenomenon, it is harder for cancer tissues to diffuse their elevated heat into other parts of the body. The scientific principle of radiofrequency hyperthermia relie...

journal_title：Scientific reports

authors： Chung HJ,Lee HK,Kwon KB,Kim HJ,Hong ST

更新日期：2018-09-10 00:00:00

abstract：:The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver microenvironment and its peripheral blood counterpart in ...

journal_title：Scientific reports

authors： Rios DA,Valva P,Casciato PC,Frias S,Soledad Caldirola M,Gaillard MI,Bezrodnik L,Bandi J,Galdame O,Ameigeiras B,Krasniansky D,Brodersen C,Mullen E,Matteo EN,Preciado MV

更新日期：2017-10-16 00:00:00

abstract：:We herein present a novel and sustainable technology for mercury recycling, with the maximum observed uptake capacity. Facile synthesis of the most efficient (~1.9 gg-1) nano-trap, made of montmorillonite-Fe-iron oxides, was performed to instantaneously remove mercury(II) ions from water. Elemental Hg was recovered fr...

journal_title：Scientific reports

authors： Ganguly M,Dib S,Ariya PA

更新日期：2018-11-02 00:00:00

abstract：:Developing an effective universal influenza vaccine against influenza virus with highly conserved antigenic epitopes could induce a broad-spectrum immune response to prevent infection. The soluble protein M1 that can induce the M1 specific immune response was first confirmed in our previous study. In this study, we ch...

journal_title：Scientific reports

authors： Liu F,Wang X,Zheng M,Xiong F,Liu X,Zhou L,Tan W,Chen Z

更新日期：2020-03-05 00:00:00

abstract：:In spite of many compounds identified as antifibrotic in preclinical studies, pulmonary fibrosis remains a life-threatening condition for which highly effective treatment is still lacking. Towards improving the success-rate of bench-to-bedside translation, we investigated in vivo µCT-derived biomarkers to repeatedly q...

journal_title：Scientific reports

authors： Dekoster K,Decaesteker T,Berghen N,Van den Broucke S,Jonckheere AC,Wouters J,Krouglov A,Lories R,De Langhe E,Hoet P,Verbeken E,Vanoirbeek J,Vande Velde G

更新日期：2020-09-30 00:00:00

abstract：:Accurate placement of a coordinate system on the radius is important to quantitatively report 3D surgical planning parameters or joint kinematics using 4D imaging techniques. In clinical practice, the scanned length of the radial shaft varies among scanning protocols and scientific studies. The error in positioning a ...

journal_title：Scientific reports

authors： de Roo MGA,Dobbe JGG,Peymani A,van der Made AD,Strackee SD,Streekstra GJ

更新日期：2020-05-15 00:00:00

abstract：:Conventional concentrators with inhomogeneous coating materials that fully enclose the destined region pose great challenges for fabrication. In this paper, we propose to design an EM concentrator with homogeneous materials. Distinguished from conventional ones, the elaborately designed EM concentrator features a conc...

journal_title：Scientific reports

authors： Madni HA,Hussain K,Jiang WX,Liu S,Aziz A,Iqbal S,Mahboob A,Cui TJ

更新日期：2018-06-25 00:00:00