Abstract：
:Background Patients admitted to intensive care unit (ICU) present with severe and life-threatening illnesses. Most of them suffer from various comorbidities. They usually receive complex pharmacotherapy with large number of medicines which increase the risk of drug-drug interactions (DDIs). Objective The present report aimed to investigate prevalence and levels of potential DDIs (pDDIs) in medical ICU. Methods Medications profiles of 416 patients were checked for pDDIs using Micromedex Drug-Reax(®). Prevalence, levels of severity and levels of documentation were reported. Results Of total 416 patients, 310 were exposed to pDDIs (overall prevalence = 74.5 %). Likewise, a prevalence rate of 13.9 % was recorded for contraindicated pDDIs, 52.2 % for major pDDI and 58.4 % for moderate pDDI. This study reported 740 interacting drug pairs that were presented in total 1686 pDDIs. Of 1686 pDDIs, 4.3 % were of contraindicated severity, 33.8 % of major severity and 49.6 % of moderate severity, whereas 45.5 % were of fair scientific evidence and 41.4 % of good scientific evidence. Conclusion In this study, pDDIs were found highly prevalent in ICU patients at a rate of 74.5 %. Most of the pDDIs had moderate severity; however, substantial number of interactions (38.1 %) had major and contraindicated severity.
journal_name
Int J Clin Pharmjournal_title
International journal of clinical pharmacyauthors
Ismail M,Khan F,Noor S,Haider I,Haq IU,Ali Z,Shah Z,Hassam Mdoi
10.1007/s11096-016-0340-3subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1052-6issue
5eissn
2210-7703issn
2210-7711pii
10.1007/s11096-016-0340-3journal_volume
38pub_type
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更新日期：2020-02-01 00:00:00
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更新日期：2016-12-01 00:00:00
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journal_title：International journal of clinical pharmacy
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更新日期：2015-10-01 00:00:00
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journal_title：International journal of clinical pharmacy
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更新日期：2012-06-01 00:00:00
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journal_title：International journal of clinical pharmacy
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更新日期：2017-12-01 00:00:00
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章
doi：10.1007/s11096-016-0378-2
更新日期：2016-12-01 00:00:00
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章
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更新日期：2020-10-09 00:00:00
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journal_title：International journal of clinical pharmacy
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
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更新日期：2019-12-01 00:00:00
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章,多中心研究
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更新日期：2017-02-01 00:00:00
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章,评审
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更新日期：2017-12-01 00:00:00
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章
doi：10.1007/s11096-011-9586-y
更新日期：2012-02-01 00:00:00
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章
doi：10.1007/s11096-016-0292-7
更新日期：2016-08-01 00:00:00
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章
doi：10.1007/s11096-020-01008-1
更新日期：2020-04-01 00:00:00
