Abstract:
BACKGROUND:Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). METHODS:In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10(-8) and removed SNPs where the direction of the effect was different between the two datasets. RESULTS:We identified 12 SNPs associated with increased prolactin levels in both biological fluids. CONCLUSIONS:Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.
journal_name
BMC Genomicsjournal_title
BMC genomicsauthors
Staley LA,Ebbert MT,Parker S,Bailey M,Alzheimer’s Disease Neuroimaging Initiative.,Ridge PG,Goate AM,Kauwe JSdoi
10.1186/s12864-016-2785-0subject
Has Abstractpub_date
2016-06-29 00:00:00pages
436issn
1471-2164pii
10.1186/s12864-016-2785-0journal_volume
17 Suppl 3pub_type
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