Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid.

Abstract:

BACKGROUND:Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). METHODS:In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10(-8) and removed SNPs where the direction of the effect was different between the two datasets. RESULTS:We identified 12 SNPs associated with increased prolactin levels in both biological fluids. CONCLUSIONS:Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.

journal_name

BMC Genomics

journal_title

BMC genomics

authors

Staley LA,Ebbert MT,Parker S,Bailey M,Alzheimer’s Disease Neuroimaging Initiative.,Ridge PG,Goate AM,Kauwe JS

doi

10.1186/s12864-016-2785-0

subject

Has Abstract

pub_date

2016-06-29 00:00:00

pages

436

issn

1471-2164

pii

10.1186/s12864-016-2785-0

journal_volume

17 Suppl 3

pub_type

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