Abstract:
:Researchers have used mass spectrometry to conduct proteomic analyses of 77 genomically characterized breast tumors. Through this approach, they've uncovered functional consequences of somatic mutations. For instance, EGFR overexpression in basal-like breast cancer is potentially driven by the loss of two genes, SKP1 and CETN3, from the chromosome 5q deletion characteristic of this disease subtype.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
doi
10.1158/2159-8290.CD-NB2016-078subject
Has Abstractpub_date
2016-08-01 00:00:00pages
OF5issue
8eissn
2159-8274issn
2159-8290pii
2159-8290.CD-NB2016-078journal_volume
6pub_type
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