当前位置： SCI文献检索 > JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH期刊下所有文献 > Grafting of stomach tissue into the duodenum in F344 rats results in chimeric crypts and tumor development.

Grafting of stomach tissue into the duodenum in F344 rats results in chimeric crypts and tumor development.

Abstract：

:Gastric tissue was transplanted from the fundic and pyloric mucosa of 8-week old female F344 rats into the duodenum of males. Autopsy, 12 months after the operation, revealed grafts associated with persistent stones in the duodenum and/or calcification in the tissue. Pepsinogen positive chimeric glands with goblet cells also appeared in the grafts which gave rise to tumors in 18 out of 45 animals (40%). In conclusion, stomach grafts re-differentiate into intestine with goblet cells in the duodenum and this process predisposes to tumor development.

journal_name

J Exp Clin Cancer Res

journal_title

Journal of experimental & clinical cancer research : CR

authors

Watanabe H,Ando Y,Uesaka T,Ishimura Y,Shiraki K,Lu H,Ohara M,Shoji S,Katoh O

keywords:

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

207-10

issue

2

eissn

0392-9078

issn

1756-9966

journal_volume

19

pub_type

杂志文章

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