Grafting of stomach tissue into the duodenum in F344 rats results in chimeric crypts and tumor development.

Abstract:

:Gastric tissue was transplanted from the fundic and pyloric mucosa of 8-week old female F344 rats into the duodenum of males. Autopsy, 12 months after the operation, revealed grafts associated with persistent stones in the duodenum and/or calcification in the tissue. Pepsinogen positive chimeric glands with goblet cells also appeared in the grafts which gave rise to tumors in 18 out of 45 animals (40%). In conclusion, stomach grafts re-differentiate into intestine with goblet cells in the duodenum and this process predisposes to tumor development.

journal_name

J Exp Clin Cancer Res

authors

Watanabe H,Ando Y,Uesaka T,Ishimura Y,Shiraki K,Lu H,Ohara M,Shoji S,Katoh O

keywords:

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

207-10

issue

2

eissn

0392-9078

issn

1756-9966

journal_volume

19

pub_type

杂志文章
  • Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells.

    abstract:BACKGROUND:Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward oxaliplatin due to yet-unknown underlying mechanisms. We recently established that oxaliplatin also e...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-018-0837-9

    authors: Chen HY,Islam A,Yuan TM,Chen SW,Liu PF,Chueh PJ

    更新日期:2018-07-20 00:00:00

  • CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma.

    abstract:BACKGROUND:Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene family involved in multiple malignancies. CMTM4 is a member of this family and is located at chromosome 16q22.1, a locus that harbours a number of tumour suppressor genes. It has been defined as a regulator of ce...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-015-0236-4

    authors: Li T,Cheng Y,Wang P,Wang W,Hu F,Mo X,Lv H,Xu T,Han W

    更新日期:2015-10-16 00:00:00

  • Single nucleotide polymorphisms in the mitochondrial displacement loop and outcome of esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described for different types of cancers and might be associated with cancer risk and disease outcome. We used a population-based series of esophageal squamous cell carcinoma (ESCC) ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-29-155

    authors: Zhang R,Wang R,Zhang F,Wu C,Fan H,Li Y,Wang C,Guo Z

    更新日期:2010-11-26 00:00:00

  • circPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma.

    abstract:BACKGROUND:Growing evidences indicate that circular RNAs (circRNAs) play an important role in the regulation of biological behavior of tumor. We aim to explore the role of circRNA in glioma and elucidate how circRNA acts. METHODS:Real-time PCR was used to examine the expression of circPTN in glioma tissues and normal ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1376-8

    authors: Chen J,Chen T,Zhu Y,Li Y,Zhang Y,Wang Y,Li X,Xie X,Wang J,Huang M,Sun X,Ke Y

    更新日期:2019-09-11 00:00:00

  • Efficacy and safety of ipilimumab in elderly patients with pretreated advanced melanoma treated at Italian centres through the expanded access programme.

    abstract:BACKGROUND:Elderly patients with metastatic melanoma have different disease characteristics and a poorer prognosis than younger patients. Data from clinical trials and expanded access programmes (EAPs) suggest ipilimumab confers a consistent survival benefit and has a similar safety profile across different age groups ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1186/1756-9966-33-30

    authors: Chiarion Sileni V,Pigozzo J,Ascierto PA,Grimaldi AM,Maio M,Di Guardo L,Marchetti P,de Rosa F,Nuzzo C,Testori A,Cocorocchio E,Bernengo MG,Guida M,Marconcini R,Merelli B,Parmiani G,Rinaldi G,Aglietta M,Grosso M,Queiro

    更新日期:2014-04-04 00:00:00

  • AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?

    abstract:BACKGROUND:Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have bee...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-30-40

    authors: Solivetti FM,Elia F,Latini A,Cota C,Cordiali-Fei P,Di Carlo A

    更新日期:2011-04-13 00:00:00

  • Direct inhibition of ACTN4 by ellagic acid limits breast cancer metastasis via regulation of β-catenin stabilization in cancer stem cells.

    abstract:BACKGROUND:Pharmacology-based target identification has become a novel strategy leading to the discovery of novel pathological biomarkers. Ellagic acid (EA), a dietary polyphenol compound, exhibits potent anticancer activities; however, the underlying mechanisms remain unclear. The current study sought to determine the...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-017-0635-9

    authors: Wang N,Wang Q,Tang H,Zhang F,Zheng Y,Wang S,Zhang J,Wang Z,Xie X

    更新日期:2017-12-02 00:00:00

  • SNPs in DNA repair or oxidative stress genes and late subcutaneous fibrosis in patients following single shot partial breast irradiation.

    abstract:BACKGROUND:The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-oxidative activities. The paper aims to identify marker genes able to predict an increased risk of l...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 临床试验,杂志文章

    doi:10.1186/1756-9966-31-7

    authors: Falvo E,Strigari L,Citro G,Giordano C,Boboc G,Fabretti F,Bruzzaniti V,Bellesi L,Muti P,Blandino G,Pinnarò P

    更新日期:2012-01-24 00:00:00

  • Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is third leading cause of cancer-related death globally. Evidence suggest that long non-coding RNAs (lncRNAs) have emerged as key regulators of tumorigenesis and metastasis in HCC. In this study, we investigated the functional significance of SNHG12 and explored whether SNHG12 ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0486-9

    authors: Lan T,Ma W,Hong Z,Wu L,Chen X,Yuan Y

    更新日期:2017-01-10 00:00:00

  • Toxicity and morbility after isolated lower limb perfusion in 242 chemo-hyperthermal treatments for cutaneous melanoma: the experience of the Tuscan Reference Centre.

    abstract:BACKGROUND:The aim of this retrospective study was to assess the results concerning the regional and systemic toxicity and complications in 242 chemo-hyperthermal treatments (HILPs) for lower limb melanoma. PATIENTS AND METHODS:60 HILPs (G-A) were performed with mild HT plus L-PAM (10 mg/lt) +/- D-actimomycin; 74 HILP...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-27-67

    authors: Pace M,Gattai R,Matteini M,Mascitelli EM,Bechi P

    更新日期:2008-11-12 00:00:00

  • Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia.

    abstract:BACKGROUND:Expression of the Sp1 transcription factor is induced by hypoxia, and the ADAM17 promoter contains predicted Sp1 binding sites. ADAM17 contributes to hypoxic-induce invasiveness of glioma. In this study, we investigated whether Sp1 transcription factor induces ADAM17 and/or contributes to tumor cell invasive...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-28-129

    authors: Szalad A,Katakowski M,Zheng X,Jiang F,Chopp M

    更新日期:2009-09-22 00:00:00

  • Neck dissection for surgical treatment of lymphnode metastasis in papillary thyroid carcinoma.

    abstract::In papillary thyroid carcinoma lymphnode metastases at presentation do not seem to adversely affect survival, but do increase the risk of loco-regional tumor recurrence. The value of systematic versus selective lymphadenectomy is far less standardized, whereas the role of postoperative radioiodine in preventing either...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 临床试验,杂志文章

    doi:

    authors: Ducci M,Appetecchia M,Marzetti M

    更新日期:1997-09-01 00:00:00

  • MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia.

    abstract:BACKGROUND:Acute myeloid leukemia (AML) is initiated and maintained by a unique, small subset of leukemia stem cells (LSCs). LSCs are characterized by unrestricted self-renewal and contribute to the malignancy of leukemia. Aberrant protein fucosylation is associated with AML progression. However, it is still less under...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1179-y

    authors: Liu B,Ma H,Liu Q,Xiao Y,Pan S,Zhou H,Jia L

    更新日期:2019-05-16 00:00:00

  • Influence of time interval between surgery and radiotherapy on tumor regrowth.

    abstract:UNLABELLED:In order to evaluate the influence of time intervals between tumor cell injection and radiotherapy on tumor control and regrowth after surgery, we performed two kinds of experiments on C3D2F1 mice bearing a mammary carcinoma inoculated in the foot or leg. 1st experiment: tumor in foot. END POINT:Tumor Contr...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Cividalli A,Creton G,Ceciarelli F,Strigari L,Tirindelli Danesi D,Benassi M

    更新日期:2005-03-01 00:00:00

  • Inhibition of ATRA-induced myeloid differentiation in acute promyelocytic leukemia by a new protein tyrosine phosphatase inhibitor, 3,4-dephostatin.

    abstract::We previously reported that the expression and the activity of SHP-1, a non-transmembrane protein tyrosine phosphatase (PTPase) increased during myeloid differentiation of an acute promyelocytic leukemia cell line (HT93) induced by all-trans retinoic acid (ATRA). To examine whether inhibition of SHP-1 activity attenua...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Uesugi Y,Fuse I,Toba K,Kishi K,Hashimoto S,Furukawa T,Narita M,Takahashi M,Aizawa Y

    更新日期:2000-09-01 00:00:00

  • Human plasma antioxidant capacity during radiotherapy for lung cancer: a clinical study.

    abstract::Even though it is well established that oxygen-free radicals are the main mechanism responsible for the cytotoxicity produced during radiotherapy, the role of the human antioxidant defense system in clinical radiation oncology is still to be clarified. Changes in the human plasma total peroxyl radical trapping capacit...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 临床试验,杂志文章

    doi:

    authors: Erhola M,Nieminen MM,Ojala A,Metsä-Ketelä T,Kellokumpu-Lehtinen P,Alho H

    更新日期:1998-09-01 00:00:00

  • Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification.

    abstract:BACKGROUND:This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) rangi...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-017-0613-2

    authors: Ercolani C,Marchiò C,Di Benedetto A,Fabi A,Perracchio L,Vici P,Sperati F,Buglioni S,Arena V,Pescarmona E,Sapino A,Terrenato I,Mottolese M

    更新日期:2017-10-13 00:00:00

  • Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer.

    abstract:BACKGROUND:Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is catalyzed by 15-lipoxygenase (15-LOX), and it has recently been reported to exhibit anti-cancer effects....

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-017-0655-5

    authors: Zong L,Chen K,Jiang Z,Chen X,Sun L,Ma J,Zhou C,Xu Q,Duan W,Han L,Lei J,Li X,Ma Q,Wang Z

    更新日期:2017-12-11 00:00:00

  • Viruses in human oral cancers.

    abstract::The role of viruses in the etiology of human oral cancer is critically reviewed. Available evidences show a positive correlation for human oral cancer with human papilloma virus (HPV), herpes simplex virus (HSV) and human herpes virus type-6 (HHV-6), having strongest association with HPV. These viruses may act alone o...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,评审

    doi:

    authors: Vasudevan DM,Vijayakumar T

    更新日期:1998-03-01 00:00:00

  • Correction to: Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s13046-020-01663-2

    authors: Sheng W,Shi X,Lin Y,Tang J,Jia C,Cao R,Sun J,Wang G,Zhou L,Dong M

    更新日期:2020-08-24 00:00:00

  • Enhancement of cisplatin sensitivity in Lewis Lung carcinoma by liposome-mediated delivery of a survivin mutant.

    abstract:BACKGROUND:A high concentration of cisplatin (CDDP) induces apoptosis in many tumor cell lines. CDDP has been administered by infusion to avoid severe toxicity. Recently, it has been reported that changes in survivin expression or function may lead to tumor sensitization to chemical and physical agents. The aim of this...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-29-46

    authors: Yu DD,Wang CT,Shi HS,Li ZY,Pan L,Yuan QZ,Leng F,Wen Y,Chen X,Wei YQ

    更新日期:2010-05-12 00:00:00

  • High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods.

    abstract:BACKGROUND:Next generation sequencing (NGS) is being increasingly applied for assisting cancer molecular diagnosis. However, it is still needed to validate NGS accuracy on detection of DNA alternations based on a large number of clinical samples, especially for DNA rearrangements and copy number variations (CNVs). This...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-017-0591-4

    authors: Su D,Zhang D,Chen K,Lu J,Wu J,Cao X,Ying L,Jin Q,Ye Y,Xie Z,Xiong L,Mao W,Li F

    更新日期:2017-09-07 00:00:00

  • miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma.

    abstract:BACKGROUND:Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) play crucial roles regulating CD133+ and EpCAM+ CSCs in HCC, although it is unclear whether miRNAs regulate CD90+ CSCs in HCC. METHODS:The miRNA profiles of CD90+ and CD90- HCC c...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0452-6

    authors: Zhang X,Jiang P,Shuai L,Chen K,Li Z,Zhang Y,Jiang Y,Li X

    更新日期:2016-11-11 00:00:00

  • Inhibition of Aurora B by CCT137690 sensitizes colorectal cells to radiotherapy.

    abstract::Colorectal cancer is the third most commonly diagnosed cancer worldwide. Although surgery remains the best treatment for this disease, adjuvant chemotherapy and radiotherapy are also very important in clinical practice. However, the notorious refractory lack of responses to radiochemotherapy greatly limits the applica...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-33-13

    authors: Wu X,Liu W,Cao Q,Chen C,Chen Z,Xu Z,Li W,Liu F,Yao X

    更新日期:2014-01-29 00:00:00

  • Effect of bacterial metabolism in the intestine on colorectal tumors induced by 1,2-dimethylhydrazine in transgenic mice harboring human prototype c-Ha-ras genes.

    abstract::The number of colorectal tumors per mouse induced by 1,2-dimethylhydrazine in transgenic (Tg) mice carrying human c-Ha-ras genes was significantly reduced by ingestion of apple pectin (AP) or a culture condensate of Bifidobacterium longum(MB) compared with a control diet and non-Tg mice. However, there were no differe...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Ohno K,Narushima S,Takeuchi S,Itoh K,Itoh T,Hioki K,Nomura T

    更新日期:2001-03-01 00:00:00

  • Combined effect of arsenic trioxide and sulindac sulfide in A549 human lung cancer cells in vitro.

    abstract::Arsenic trioxide has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukemia (APL) as well as solid tumors. Arsenic can act through a considerable number of different pathways including mitochondrial respiration and tubulin formation, affecting growth, blood flow, diffe...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Jiang TT,Brown SL,Kim JH

    更新日期:2004-06-01 00:00:00

  • Activity and toxicity of oxaliplatin and bolus fluorouracil plus leucovorin in pretreated colorectal cancer patients: a phase II study.

    abstract::The aim of the current study was to evaluate the activity and toxicity of a combination of oxaliplatin with bolus fluorouracil and leucovorin in colorectal cancer (CRC) patients pretreated for advanced disease with various schedules including continuous fluorouracil infusion. Thirty consecutive patients with pretreate...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 临床试验,杂志文章

    doi:

    authors: Ferraresi V,Giampaolo MA,Gabriele A,Mansueto G,Buccilli A,Giannarelli D,Ciccarese M,Gamucci T

    更新日期:2005-06-01 00:00:00

  • m6A modification in RNA: biogenesis, functions and roles in gliomas.

    abstract::The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the development of m6A RNA seq...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,评审

    doi:10.1186/s13046-020-01706-8

    authors: Zhang Y,Geng X,Li Q,Xu J,Tan Y,Xiao M,Song J,Liu F,Fang C,Wang H

    更新日期:2020-09-17 00:00:00

  • Impact of tumor stage, operative down-staging, tumor grade and radioresponsitivity of the tumor on survival in supratentorial astrocytomas.

    abstract::This retrospective study analyzed specifically the predicting factors for radioresponse and survival in 74 supratentorial astrocytoma patients. As a result of this study, cytoreduction in terms of ODs to T1 or T0 stage level or pre-RT T1 tumor stage along with radioresponse has a positive impact on long-term survival....

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Erkurt E,Tunali C,Erkişi M,Boyer B,Burgurt R

    更新日期:1998-12-01 00:00:00

  • A pseudogene-signature in glioma predicts survival.

    abstract::Pseudogene was recognized as a potential tumor suppressor or oncogene in varies of diseases, however its roles in glioma have not been investigated. Our study was to identify the pseudogene-signature that predicted glioma survival. Using a pseudogene-mining approach, we performed pseudogene expression profiling in 183...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-015-0137-6

    authors: Gao KM,Chen XC,Zhang JX,Wang Y,Yan W,You YP

    更新日期:2015-03-04 00:00:00