Primary non-Hodgkin lymphoma of the breast. Is it possible to avoid mastectomy?

Abstract:

:Primary lymphoma of the breast is a rare disease that has been estimated to represent from 0.05% to 0.53% of all malignant breast tumors and approximately 2.2% of all extranodal lymphomas. The aim of this study is to review all cases of primary lymphoma of the breast at the Institute of Oncology and Radiology of Serbia from 1984 to 1996 in order to determine the incidence, patterns of clinical presentation, radiological features, histopathology, mode of therapy and outcome of the disease. The criteria for inclusion in this retrospective study corresponded to a revision of the original criteria suggested by Wiseman and Liao. The clinical histories of ten patients with breast lymphomas were reviewed. Clinical follow-up was obtained through a review of the patients hospital chart or by direct contact with the patients. Ten cases of primary lymphoma of the breast have been identified during the 12-yr period, presenting 0.05% of all patients with malignant breast disease. All patients were female, median age at diagnosis 58 years (range 49-69), all presented with breast lumps (3 right, 7 left) of median size 5 cm (range 3.5-8 cm). Mammography and breast echography were unable to bring a suspicion of lymphoma. Histologically, 6 cases were diffuse large cell, 3 of which with features consistent with immunoblastic lymphoma; 2 were diffuse mixed cells and 2 had small lymphocytic morphology. In 4 out of 5 patients, in the clinical stage corresponding to the "operable breast cancer" category, the ex tempore histological analysis could not differentiate lymphoma from cancer, so that all of them had mastectomy with axillary dissection. Those corresponding to the "locally advanced breast cancer" category, escaped mastectomy and a classical biopsy was performed, anticipating eventual neoadjuvant procedures. Thus, four patients underwent radical mastectomy, 1 wide local excision and 5 diagnostic biopsies. Further treatment included chemotherapy for 8 patients. The projected probability of a 10-years survival was 0,60. The rarity of this disease, and uneven treatment modalities make prognosis of breast lymphoma difficult. It seems that cooperation between the surgeon and the pathologist is necessary in order to reach the correct diagnosis during ex tempore analysis. With the limitations of available diagnostic procedures, it appears that most patients with breast lymphoma, in the stage corresponding to the "operable breast cancer" category, will unnecessarily undergo mastectomy and axillary dissection as primary treatment approach.

journal_name

J Exp Clin Cancer Res

authors

Babovic N,Jelic S,Jovanovic V

keywords:

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

149-54

issue

2

eissn

0392-9078

issn

1756-9966

journal_volume

19

pub_type

杂志文章
  • Fusion between homologous cells, modified epigenetic environment and possible cell cancerization.

    abstract::For a long time now we have been putting forwards the hypothesis that, when two cells belonging to different tissues of the same organism fuse, the nucleous/nuclei of the resulting "fused" cell could lay into a cytoplasm possibly containing factors influencing the activation or deactivation of genes able to interfere ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Sebastiani M,Soldati V

    更新日期:2002-06-01 00:00:00

  • Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway.

    abstract:BACKGROUND:The cisplatin-resistance is still a main course for chemotherapy failure of lung cancer patients. Cisplatin-resistant cancer cells own higher malignance and exhibited increased metastatic ability, but the mechanism is not clear. In this study, we investigated the effects of Ataxia Telangiectasia Mutated (ATM...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1161-8

    authors: Shen M,Xu Z,Xu W,Jiang K,Zhang F,Ding Q,Xu Z,Chen Y

    更新日期:2019-04-08 00:00:00

  • Activity and toxicity of oxaliplatin and bolus fluorouracil plus leucovorin in pretreated colorectal cancer patients: a phase II study.

    abstract::The aim of the current study was to evaluate the activity and toxicity of a combination of oxaliplatin with bolus fluorouracil and leucovorin in colorectal cancer (CRC) patients pretreated for advanced disease with various schedules including continuous fluorouracil infusion. Thirty consecutive patients with pretreate...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 临床试验,杂志文章

    doi:

    authors: Ferraresi V,Giampaolo MA,Gabriele A,Mansueto G,Buccilli A,Giannarelli D,Ciccarese M,Gamucci T

    更新日期:2005-06-01 00:00:00

  • RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.

    abstract:BACKGROUND:Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig-I had broader roles in antibacterial immunity and cancer protection. However, the potential roles a...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0471-3

    authors: Zhu H,Xu WY,Hu Z,Zhang H,Shen Y,Lu S,Wei C,Wang ZG

    更新日期:2017-01-05 00:00:00

  • Hepatitis B virus whole-X and X protein play distinct roles in HBV-related hepatocellular carcinoma progression.

    abstract:BACKGROUND:The role of HBV X protein (HBx) in the development of hepatocellular carcinoma (HCC) has been well studied. However, little is known about the molecular functions of HBV whole-X protein (HBwx), a protein fused with HBx and upstream 56 amino acid, in HCC. In current study, the molecular functions of HBwx in H...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0366-3

    authors: Zhang Y,Liu H,Yi R,Yan T,He Y,Zhao Y,Liu J

    更新日期:2016-06-03 00:00:00

  • Radiofrequency thermal ablation (RFA) of liver tumors: percutaneous and open surgical approaches.

    abstract::Radiofrequency Thermal Ablation (RFA) of liver tumors is done by percutaneous, laparoscopic and open surgical approach. Selection criteria for percutaneous or open surgical ablation of 65 hepatic lesions are here evaluated in 45 patients treated in a two-years period. Twenty-five patients were males and 20 females, ag...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Crucitti A,Danza FM,Antinori A,Vincenzo A,Pirulli PG,Bock E,Magistrelli P

    更新日期:2003-12-01 00:00:00

  • UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1.

    abstract:BACKGROUND:Ubiquitin-like protein 4A (UBL4A) plays a significant role in protein metabolism and the maintenance of cellular homeostasis. In cancer, UBL4A represses tumorigenesis and is involved in various signaling pathways. Pancreatic ductal adenocarcinoma (PDAC) is still a major cause of cancer-related death and the ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1278-9

    authors: Chen H,Li L,Hu J,Zhao Z,Ji L,Cheng C,Zhang G,Zhang T,Li Y,Chen H,Pan S,Sun B

    更新日期:2019-07-09 00:00:00

  • Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.

    abstract:BACKGROUND:Microtubule Targeting Agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are widely used in the treatment of various cancers. As with most chemotherapeutic agents, adverse effects and drug resistance are commonly associated with the clinical use of these agents. Methyl 2-(5-fluoro-2-hydroxyph...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0332-0

    authors: Hasanpourghadi M,Karthikeyan C,Pandurangan AK,Looi CY,Trivedi P,Kobayashi K,Tanaka K,Wong WF,Mustafa MR

    更新日期:2016-03-31 00:00:00

  • circPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma.

    abstract:BACKGROUND:Growing evidences indicate that circular RNAs (circRNAs) play an important role in the regulation of biological behavior of tumor. We aim to explore the role of circRNA in glioma and elucidate how circRNA acts. METHODS:Real-time PCR was used to examine the expression of circPTN in glioma tissues and normal ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1376-8

    authors: Chen J,Chen T,Zhu Y,Li Y,Zhang Y,Wang Y,Li X,Xie X,Wang J,Huang M,Sun X,Ke Y

    更新日期:2019-09-11 00:00:00

  • Medical decision making for melanoma of the glans penis.

    abstract::This case report describes a rare presentation of penile melanoma in which 3 successive primaries arose and were operated from an area of melanosis on the glans penis and prepuce. One of the major factors accounting for the poor prognosis of this patient was the long delay in presentation. This was largely due to the ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Testori A,Mazzarol G,Viale G,De Cobelli O,Lotti M,Rocco F,Andreoni B

    更新日期:1999-06-01 00:00:00

  • Usefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia.

    abstract::Patients with ulcerative colitis (UC) have a higher incidence of colorectal cancer. UC-associated colorectal cancer is thought to develop in patients with preexisting UC-associated dysplasia. It is crucial to diagnose UC-associated dysplasia and early stage of cancer in patients with long-standing UC for the purpose o...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Fujii S,Fujimori T,Chiba T

    更新日期:2003-03-01 00:00:00

  • Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma.

    abstract:BACKGROUND:MYB-related protein B (B-MYB/MYBL2), a member of the myeloblastosis family of transcription factors, has been reported for its role in the genesis and progression of tumors. Forkhead box M1 (FoxM1), another transcriptional factor, is considered to be an independent predictor of poor survival in many solid ca...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 临床试验,杂志文章

    doi:10.1186/s13046-017-0573-6

    authors: Zhang X,Lv QL,Huang YT,Zhang LH,Zhou HH

    更新日期:2017-08-07 00:00:00

  • Anti-CD40-induced inflammatory E-cadherin+ dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma.

    abstract:BACKGROUND:Agonistic CD40 antibodies have been demonstrated to activate antigen-presenting cells (APCs) and enhance antitumour T cell responses, thereby providing a new therapeutic option in cancer immunotherapy. In agonistic CD40 antibody-mediated inflammatory responses, a novel subset of E-cadherin + dendritic cells ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-015-0126-9

    authors: Zhang Y,Hu X,Hu Y,Teng K,Zhang K,Zheng Y,Hong X,Yu K,Wang Y,Liu L

    更新日期:2015-02-05 00:00:00

  • Influencing factors and clinical significance of the metastatic lymph nodes ratio in gastric adenocarcinoma.

    abstract:BACKGROUND:To investigate influencing factors of the metastatic lymph nodes ratio (MLR) and whether it is related to survival in patients with gastric adenocarcinoma. METHODS:We retrospectively evaluated the clinical features of 121 patients with gastric adenocarcinoma enrolled in our hospital between 2000 and 2007. T...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-28-55

    authors: Yu JW,Wu JG,Zheng LH,Zhang B,Ni XC,Li XQ,Jiang BJ

    更新日期:2009-04-26 00:00:00

  • MiR-302a/b/c/d cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein(P-gp) by targeting MAP/ERK kinase kinase 1 (MEKK1).

    abstract:BACKGROUND:The importance of individual microRNAs (miRNAs) in tumor has been established in different cancers. However, their association with tumor chemoresistance has not been fully understood. Previously, we found two novel MDR-associated microRNAs (miRNAs). In this report, we investigated the combined effects of mi...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0300-8

    authors: Zhao L,Wang Y,Jiang L,He M,Bai X,Yu L,Wei M

    更新日期:2016-02-03 00:00:00

  • LncRNA SLCO4A1-AS1 facilitates growth and metastasis of colorectal cancer through β-catenin-dependent Wnt pathway.

    abstract:BACKGROUND:Emerging evidence has shown long noncoding RNAs (lncRNAs) exert important roles in colorectal cancer (CRC) tumorigenesis. However, most lncRNAs involved in this process remain undefined and the underlying molecular mechanisms mediated by lncRNAs are largely unknown. METHODS:An unbiased screening was used to...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-018-0896-y

    authors: Yu J,Han Z,Sun Z,Wang Y,Zheng M,Song C

    更新日期:2018-09-10 00:00:00

  • Antisense oligonucleotide targeting Livin induces apoptosis of human bladder cancer cell via a mechanism involving caspase 3.

    abstract:BACKGROUND AND AIM:in recent years, Livin, a new member of IAPs family, is found to be a key molecule in cancers. Researchers consider Livin may become a new target for tumor therapy; however, the role of it in bladder cancer is still unclear. The purpose of this article is to investigate Antisense Oligonucleotide (ASO...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-29-63

    authors: Liu C,Wu X,Luo C,Hu Z,Yin Z,He Y,Du H,Zhang W,Jiang Q,Lin Y

    更新日期:2010-06-03 00:00:00

  • Linc-ROR promotes esophageal squamous cell carcinoma progression through the derepression of SOX9.

    abstract:BACKGROUND:Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) and sex-determining region Y-box 9 (SOX9), and the...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-017-0658-2

    authors: Wang L,Yu X,Zhang Z,Pang L,Xu J,Jiang J,Liang W,Chai Y,Hou J,Li F

    更新日期:2017-12-13 00:00:00

  • p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine.

    abstract:BACKGROUND:Berberine (BBR), a component from traditional Chinese medicine, has been shown to possess anti-tumor activity against a wide spectrum of cancer cells including human lung cancer, but the detailed mechanism underlining this has not been well elucidated. METHODS:In this study, the effect of berberine on cell ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-33-36

    authors: Zheng F,Tang Q,Wu J,Zhao S,Liang Z,Li L,Wu W,Hann S

    更新日期:2014-04-26 00:00:00

  • Third generation EGFR inhibitor osimertinib combined with pemetrexed or cisplatin exerts long-lasting anti-tumor effect in EGFR-mutated pre-clinical models of NSCLC.

    abstract:BACKGROUND:The third generation Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) osimertinib has been initially approved for T790M positive Non-Small Cell Lung Cancer (NSCLC) and more recently for first-line treatment of EGFR-mutant T790M negative NSCLC patients. Similarly to previous generation ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1240-x

    authors: La Monica S,Minari R,Cretella D,Flammini L,Fumarola C,Bonelli M,Cavazzoni A,Digiacomo G,Galetti M,Madeddu D,Falco A,Lagrasta CA,Squadrilli A,Barocelli E,Romanel A,Quaini F,Petronini PG,Tiseo M,Alfieri R

    更新日期:2019-05-28 00:00:00

  • Expression of the chemokine receptor CXCR4 in human hepatocellular carcinoma and its role in portal vein tumor thrombus.

    abstract:BACKGROUND:This study was conducted to investigate the expression of CXCR4 in portal vein tumor thrombus (PVTT) tissue and its possible role in the invasiveness of tumor thrombus cells. METHODS:We detected differential expression of CXCR4 between PVTT and hepatocellular carcinoma (HCC) by an immunohistochemical assay....

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-29-156

    authors: Li N,Guo W,Shi J,Xue J,Hu H,Xie D,Wu M,Cheng S

    更新日期:2010-11-27 00:00:00

  • Anti-tumour effects of all-trans retinoid acid on serous ovarian cancer.

    abstract:BACKGROUND:Annexin A2 is increased in serous ovarian cancer and plays an essential role in ovarian cancer invasion and metastasis. In combination with S100A10, annexin A2 plays an important role in the plasminogen activator system regulating plasmin production. The aim of this study was to investigate the potential uti...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-018-1017-7

    authors: Lokman NA,Ho R,Gunasegaran K,Bonner WM,Oehler MK,Ricciardelli C

    更新日期:2019-01-08 00:00:00

  • Treatment of MDS patients with recombinant human erythropoietin and the role of GSTs.

    abstract::Glutathione S-transferases (GSTs) are a group of enzymes involved in the detoxification process of carcinogens and other substances. The genes encoding isoenzymes M1 and T1 have "null" alleles, which are polymorphic in humans. Our purpose was to examine whether the GSTM1 and GSTT1 homozygous null genotypes have an imp...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Tsabouri SE,Georgiou I,Katsaraki A,Bourantas KL

    更新日期:2004-09-01 00:00:00

  • Molecular markers associated with outcome and metastasis in human pancreatic cancer.

    abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins to be revealed, genes or pathways that specifically drive tumour progression or metastasis are not ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-31-68

    authors: Van den Broeck A,Vankelecom H,Van Eijsden R,Govaere O,Topal B

    更新日期:2012-08-27 00:00:00

  • LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer.

    abstract:BACKGROUND:Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology and treatment of cancer, regulation of oncogene by chromatin modifiers at post-transcriptional level is critical and remains unclear. We have investigated the role of GINS4 in NSCLC. METHODS:The expres...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1276-y

    authors: Yang R,Liu N,Chen L,Jiang Y,Shi Y,Mao C,Liu Y,Wang M,Lai W,Tang H,Gao M,Xiao D,Wang X,Yu F,Cao Y,Yan Q,Liu S,Tao Y

    更新日期:2019-06-28 00:00:00

  • Cell cycle proteins in laryngeal cancer: role in proliferation and prognosis.

    abstract::A study of laryngeal carcinomas was performed in order to analyze (a) the expression of p53/p21, cyclin D1/cyclin E, p21/p27 (b) the relation of normal and abnormal protein expression, with the proliferation status, as determined by the expression of Ki67 and PCNA and (c) the correlation of our findings with prognosis...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Peschos D,Stefanou D,Vougiouklakis T,Assimakopoulos DA,Agnantis NJ

    更新日期:2005-09-01 00:00:00

  • Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation.

    abstract:BACKGROUND:The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and tumor progression remain...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-018-0701-y

    authors: Li X,Zhang Z,Zhang Y,Cao Y,Wei H,Wu Z

    更新日期:2018-02-26 00:00:00

  • Role of retinoic receptors in lung carcinogenesis.

    abstract::Several in vitro and in vivo studies have examined the positive and negative effects of retinoids (vitamin A analogs) in premalignant and malignant lesions. Retinoids have been used as chemopreventive and anticancer agents because of their pleiotropic regulator function in cell differentiation, growth, proliferation a...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,评审

    doi:10.1186/1756-9966-27-18

    authors: Bogos K,Renyi-Vamos F,Kovacs G,Tovari J,Dome B

    更新日期:2008-07-14 00:00:00

  • Basigin-mediated redistribution of CD98 promotes cell spreading and tumorigenicity in hepatocellular carcinoma.

    abstract:BACKGROUND:Dysregulated endocytosis of membrane proteins contributes significantly to several hallmarks of cancer. Basigin can enhance cancer progression, but its precise mechanism remains unclear. CD98 promotes cell spreading and tumorigenicity by triggering integrin clustering and enhancing cell adhesion to the extra...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-015-0226-6

    authors: Wu B,Wang Y,Yang XM,Xu BQ,Feng F,Wang B,Liang Q,Li Y,Zhou Y,Jiang JL,Chen ZN

    更新日期:2015-10-06 00:00:00

  • A possible role of VEGF in osteolytic bone metastasis of hepatocellular carcinoma.

    abstract::The incidence of bone metastasis was around 13% in 404 patients with hepatocellular carcinoma (HCC) who underwent treatment at the National Kyushu Cancer Center between 1988-97, which is a high value among various cancers. This is, in part, due to the prolonged survival time of HCC patients in recent years. Serum vasc...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Iguchi H,Yokota M,Fukutomi M,Uchimura K,Yonemasu H,Hachitanda Y,Nakao Y,Tanaka Y,Sumii T,Funakoshi A

    更新日期:2002-09-01 00:00:00