Abstract:
:Diarrhea-predominant irritable bowel syndrome (IBS-D) and functional diarrhea (FD) are highly prevalent, and the effectiveness of acupuncture for managing IBS-D and FD is still unknown.The aim of this study was to compare the effectiveness of electroacupuncture with loperamide.It was a prospective, randomized, parallel group controlled trial.A total of 448 participants were randomly assigned to He electroacupuncture group (n = 113), Shu-Mu electroacupuncture group (n = 111), He-Shu-Mu electroacupuncture group (n = 112), or loperamide group (n = 112). Participants in the 3 acupuncture groups received 16 sessions of electroacupuncture during a 4-week treatment phase, whereas participants in the loperamide group received oral loperamide 2 mg thrice daily. The primary outcome was the change from baseline in stool frequency at the end of the 4-weeks treatment. The secondary outcomes were the Bristol scale, the MOS 36-item short form health survey (SF-36), the weekly average number of days with normal defecations and the proportion of adverse events.Stool frequency was significantly reduced at the end of the 4-week treatment in the 4 groups (mean change from baseline, 5.35 times/week). No significant difference was found between the 3 electroacupuncture groups and the loperamide group in the primary outcome (He vs. loperamide group [mean difference 0.6, 95% CI, -1.2 to 2.4]; Shu-Mu vs. loperamide group [0.4, 95% CI, -1.4 to 2.3]; He-Shu-Mu vs. loperamide group [0.0, 95% CI, -1.8 to 1.8]). Both electroacupuncture and loperamide significantly improved the mean score of Bristol scale and increased the weekly average number of days with normal defecations and the mean scores of SF-36; they were equivalent in these outcomes. However, the participants in electroacupuncture groups did not report fewer adverse events than those in the loperamide group. Similar results were found in a subgroup analysis of separating patients with IBS-D and FD patients.Electroacupuncture is equivalent to loperamide for reducing stool frequency in IBS-D and FD patients. Further studies on cost effectiveness of acupuncture are warranted.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Zheng H,Li Y,Zhang W,Zeng F,Zhou SY,Zheng HB,Zhu WZ,Jing XH,Rong PJ,Tang CZ,Wang FC,Liu ZB,Wang SJ,Zhou MQ,Liu ZS,Zhu Bdoi
10.1097/MD.0000000000003884subject
Has Abstractpub_date
2016-06-01 00:00:00pages
e3884issue
24eissn
0025-7974issn
1536-5964pii
00005792-201606140-00040journal_volume
95pub_type
杂志文章,多中心研究,随机对照试验相关文献
MEDICINE文献大全abstract::To evaluate the application of multiple b values diffusion-weighted imaging based on biexponential signal decay model to predict the response to concurrent chemoradiotherapy in cervical cancer patients.This prospective study enrolled 28 patients (mean age: 50.89 ± 10.70 years) with cervical cancer confirmed by biopsy ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017943
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:This meta-analysis assessed the effectiveness of probiotics and synbiotics for acute diarrhea (AD) in children and investigated probiotic formulations, types of interventions, and country factors. METHODS:Randomized, double-blind, placebo-controlled trials evaluating the effects of probiotics or synbiotics o...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016618
更新日期:2019-09-01 00:00:00
abstract::The study proposed to evaluate the feasibility of predicting sphincter-sparing surgery (SSS) preoperatively in low-middle rectal cancer by using magnetic resonance (MR).The study included both retrospective and prospective design. In the retrospective design, the distance from lower edge of tumor to upper margin of th...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007418
更新日期:2017-07-01 00:00:00
abstract:RATIONALE:The occurrence of bleeding and hematoma from bone metastasis of hepatocellular carcinoma (HCC) is extremely rare. PATIENT CONCERNS:We present a case of scapular metastasis of HCC in a 69-year-old man who presented with acute bleeding and hematoma. DIAGNOSES:Chest computed tomography showed a large hematoma ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008736
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:High-grade prostate cancer (PCa) has a poor prognosis, and up to 15% of patients worldwide experience lymph node invasion (LNI). To further improve the prediction lymph node invasion in prostate cancer, we adopted risk scores of the genes expression based on the nomogram in guidelines. METHODS:We analyzed c...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016534
更新日期:2019-07-01 00:00:00
abstract:RATIONALE:Multiple primary central nervous system lymphoma (MPCNSL) is a rare disease with differential diagnosis and treatment. As the underlying pathogenesis is not yet clarified, the early-stage clinical manifestations are occult and atypical. Also, the imaging manifestations are not specific, which is challenging f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016841
更新日期:2019-08-01 00:00:00
abstract::Serums were collected from people to assess whether polio immunity level was high enough to satisfy the polio vaccine immunization switch in Chongqing.People in 7 age groups (<1 year, 1-2 years, 3-4 years, 5-6 years, 7-14 years, 15-19 years, ≧20 years) were randomly selected in 3 areas by different geographical featur...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021298
更新日期:2020-07-31 00:00:00
abstract:RATIONALE:Despite the approval of antiangiogenic therapy for high grade glioma (HGG) patients, survival benefits are still limited. New treatment plans have always been developed to improve the survival. PATIENT CONCERNS:A 26-year-old woman was admitted to our hospital for distending pain of head and eye. DIAGNOSES:R...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010859
更新日期:2018-06-01 00:00:00
abstract::The objective of this retrospective study was to evaluate the efficacy of high-energy focused extracorporeal shock wave therapy (HF-ESWT) on painful bone marrow edema syndrome (BMES) of the hip and shorten the natural course of disease.Thirty-four consecutive patients with BMES of the hip were treated with HF-ESWT in ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019747
更新日期:2020-04-01 00:00:00
abstract::Ramadan is the holy month for Muslims whereby they fast from predawn to after sunset and is observed by all healthy Muslim adults as well as a large population of type 2 diabetic Muslims.To determine the comparative effectiveness of various strategies that have been used for type 2 diabetic Muslim who fast during Rama...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000002457
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Early diagnosis of acute kidney injury (AKI) remains a challenge. Recently, [TIMP-2]·[IGFBP7], which is a combination of urine tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor (IGF) binding protein 7 (IGFBP7), has been identified as a potential biomarker of AKI. We performed ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000007484
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:To compare the effect of selective laser trabeculoplasty (SLT) and travoprost on 24-hour IOP fluctuations in primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG). METHODS:Sixty eyes were included. Sixteen and 14 eyes of POAG patients were randomized to receive 360° SLT or 0.004% travoprost, ...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000006047
更新日期:2017-02-01 00:00:00
abstract::To observe optical coherence tomography angiography (OCTA) images during follow-up of choroidal neovascularization (CNV) caused by pathological myopia (PM) or idiopathy and discuss OCTA's clinical applicationsPatients with CNV caused by PM or idiopathic CNV (ICNV) were recruited prospectively from the Department of Op...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003264
更新日期:2016-04-01 00:00:00
abstract::As a noninvasive treatment technique, ultrasound-guided high-intensity focused ultrasound (HIFU) has been considered as a routine treatment for uterine fibroids and adenomyosis in China. Contrast-enhanced ultrasound (CEUS) has been proposed as another option to assess the treatment efficacy during HIFU treatment. The ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000729
更新日期:2015-04-01 00:00:00
abstract::This study aimed to assess the associations of human leukocyte antigen (HLA)-DR and interleukin (IL)-18 gene polymorphisms with hepatitis B virus (HBV).Clinical data were retrospectively reviewed between December 2006 and December 2015 at Xiangyang Central Hospital. HBV patients were assigned to the high and low viral...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011249
更新日期:2018-07-01 00:00:00
abstract::The clinical symptoms of pylephlebitis caused by acute appendicitis are varied and atypical, which leads to delayed diagnosis and poor outcomes. Here, we report a case of intestinal necrosis caused by thrombophlebitis of the portomesenteric veins as a complication of acute appendicitis after appendectomy. The patient ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001033
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Postoperative nausea and vomiting (PONV) is a main complication of surgery, and by now, drugs cannot prevent it completely. Some meta-analyses have proved acupuncture therapy can prevent PONV. However, it is still controversial whether noninvasive acupuncture therapies are comparable with invasive ones. This...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021544
更新日期:2020-07-31 00:00:00
abstract::Blood pressure (BP) control is the most established practice for preventing the progression and complications of chronic kidney disease (CKD). We examined the influence of BP patterns on target organ damage in hypertensive patients with CKD by using long-term follow-up data of the APrODiTe-2 study.We collected 5 years...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000019209
更新日期:2020-02-01 00:00:00
abstract::There is an increased enthusiasm in treating osteolytic metastatic acetabulum via injecting polymethyl-methacrylate (PMMA) as a bone filler to provide pain relief and potential structural support. The aim of this respective study is to determine the function and quality of life improvement after cement acetabuloplasty...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017029
更新日期:2019-09-01 00:00:00
abstract::The aim of this study was to investigate whether histogram analysis in diffusion-weighted (DW) magnetic resonance imaging (MRI) can help differentiate pancreatic adenocarcinomas from neuroendocrine tumors.Sixty-four patients with histologically confirmed 53 pancreatic adenocarcinomas or 19 neuroendocrine tumors underw...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002574
更新日期:2016-01-01 00:00:00
abstract:RATIONALE:Communicating bronchopulmonary foregut malformation (CBPFM) is a rare congenital malformation involving both the digestive and respiratory systems. To our best knowledge, most cases of CBPFM reported in the literature were in infancy or adulthood and CBPFM in infantile is even rarer with a high case-fatality ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006307
更新日期:2017-03-01 00:00:00
abstract::Several studies have investigated the incidence of and risk factors for acute exacerbation (AE) in patients with interstitial lung disease (ILD) after lung resection surgery. However, the incidence and risk factors for AE-ILD after non-pulmonary surgery are not known. The aim of this study was to investigate the incid...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014296
更新日期:2019-02-01 00:00:00
abstract::The objective to assess the association between gastrectomy and the risk of pulmonary tuberculosis among patients without gastric cancer in Taiwan.There were 762 subjects with newly performing gastrectomy as the gastrectomy group since 2000 to 2012, and 2963 randomly selected subjects without gastrectomy as the non-ga...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011388
更新日期:2018-07-01 00:00:00
abstract:RATIONALE:Bariatric surgery is the recommended treatment for morbid obesity because of its rapid and sustained body weight loss effect. Nutrient deficiency-related neurological complications after bariatric surgery are often disabling. Thus, early recognition of these complications is important. Neurological complicati...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014808
更新日期:2019-03-01 00:00:00
abstract:RATIONALE:Pulmonary embolism (PE) is a relatively common disease; however, myasthenia gravis leading to PE has been rarely reported in the literature. We report a case of PE in a patient with myasthenia gravis and discuss the possible mechanism underlying the development of PE. We hypothesize that inflammatory mediator...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013578
更新日期:2018-12-01 00:00:00
abstract::[This corrects the article DOI: 10.1097/MD.0000000000002223.]. ...
journal_title:Medicine
pub_type: 已发布勘误
doi:10.1097/MD.0000000000007997
更新日期:2017-09-01 00:00:00
abstract::Hydration with sodium bicarbonate is one of the strategies to prevent contrast-induced acute kidney injury (CI-AKI). The purpose of this study was to determine how strong is the evidence for sodium bicarbonate to prevent CI-AKI after coronary angiography (CAG) and/or percutaneous coronary intervention (PCI).We conduct...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000002715
更新日期:2016-02-01 00:00:00
abstract::Despite the wide recognition of the inverse association between socioeconomic position (SEP) and suicidal behaviors, its underlying process and potential mediators are little known. This study investigated the pathway from SEP to suicide attempts with attention to potential mediators.From the Korean Health and Nutriti...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009331
更新日期:2017-12-01 00:00:00
abstract::Dyslipidemia is one of the most important factors for coronary artery disease (CAD). The atherogenic index of plasma (AIP), a new comprehensive lipid index, might be a strong marker for predicting the risk of CAD.A hospital-based case-control study including 2936 CAD patients and 2451 controls was conducted in a Chine...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008058
更新日期:2017-09-01 00:00:00
abstract::We conducted the current study to search for subclinical atherosclerosis in patients with rheumatoid arthritis (RA) without clinically evident atherosclerosis or its complications who had been treated for a long duration, and to assess whether demographic or clinical factors affect the development of atherosclerotic d...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/01.md.0000101572.76273.60
更新日期:2003-11-01 00:00:00