Abstract:
:Investigations on the NAB2-STAT6 fusion gene in solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) have increased since its discovery in 2013. Although several SFTs reported without NAB2-STAT6 fusion gene analysis, we reviewed 546 SFTs/HPCs with NAB2-STAT6 fusion gene analysis in this study and investigated differences between the gene variants. In total, 452 cases tested positive for the NAB2-STAT6 fusion gene, with more than 40 variants being detected. The most frequent of these were NAB2 exon 6-STAT6 exon 16/17/18 and NAB2 exon 4-STAT6 exon 2/3, with the former occurring most frequently in SFTs in meninges, soft tissues, and head and neck; the latter predominated in SFTs in the pleura and lung. There was no difference between the histology of SFTs and fusion gene variants. A follow-up analysis of SFTs showed that 51 of 202 cases had a recurrence, with 18 of 53 meningeal SFTs having a local recurrence and/or metastasis within 0-19 years. In meninges and soft tissue, SFTs with the NAB2 exon 6-STAT6 exon 16/17/18 tended to recur more frequently than SFTs with the NAB2 exon 4-STAT6 exon 2/3. Clinicopathological data, including yearly follow-ups, are required for meningeal SFTs/HPCs to define the correlation of variants of NAB2-STAT6 fusion gene.
journal_name
Brain Tumor Patholjournal_title
Brain tumor pathologyauthors
Nakada S,Minato H,Nojima Tdoi
10.1007/s10014-016-0264-6subject
Has Abstractpub_date
2016-07-01 00:00:00pages
169-74issue
3eissn
1433-7398issn
1861-387Xpii
10.1007/s10014-016-0264-6journal_volume
33pub_type
杂志文章abstract::The objective of this study is to clarify clinical significance of the H3F3A K27M mutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwe...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-020-00369-9
更新日期:2020-07-01 00:00:00
abstract::The present retrospective data analysis was performed to determine whether intraoperative pathological diagnosis (IOD) using frozen section (FS) could clearly distinguish high-grade glioma from WHO grade II gliomas. IOD was retrospectively compared to the pathological diagnosis using permanent paraffin sections (PS) o...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-014-0177-1
更新日期:2014-07-01 00:00:00
abstract::There is now compelling evidence that gliomas harbor a small population of cells, termed glioma-initiating cells (GICs), characterized by their ability to undergo self-renewal and initiate tumorigenesis. The development of therapeutic strategies targeted toward GIC signaling may improve the treatment of malignant glio...
journal_title:Brain tumor pathology
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doi:10.1007/s10014-010-0011-3
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abstract::Dysembryoplastic neuroepithelial tumor (DNT) is a relatively new nosologic entity. First described in 1988, it is now included in the "neuronal and mixed neuronal-glial tumours" category in the revised 2000 World Health Organization (WHO) Classification of Tumours of the Nervous System. The collective experience of mo...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478934
更新日期:2002-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478880
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abstract::A 53-year-old woman was found to have a tumor in the pineal region. Histologically, Homer-Wright rosettes were sporadically distributed in a diffuse proliferation of round tumor cells that were immunoreactive for synaptophysin and chromogranin. A few perivascular pseudorosettes were also present, and the perivascular ...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478945
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-008-0243-7
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-010-0004-2
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02483446
更新日期:2003-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-015-0238-0
更新日期:2016-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-015-0239-z
更新日期:2016-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-011-0071-z
更新日期:2012-04-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-011-0074-9
更新日期:2012-04-01 00:00:00
abstract::Chordomas and chondrosarcomas are two major malignant bone neoplasms located at the skull base. These tumors are rarely metastatic, but can be locally invasive and resistant to conventional chemotherapies and radiotherapies. Accordingly, therapeutic approaches for the treatment of these tumors can be difficult. Additi...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-017-0283-y
更新日期:2017-04-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02478921
更新日期:2001-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-015-0217-5
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-010-0264-x
更新日期:2010-04-01 00:00:00
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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doi:10.1007/s10014-007-0225-1
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-007-0219-z
更新日期:2007-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-017-0280-1
更新日期:2017-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-018-0312-5
更新日期:2018-04-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-016-0252-x
更新日期:2016-07-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02484284
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
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