Discovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae.

abstract：:Long term multiple systemic antibiotics form the cornerstone in the treatment of bone and joint tuberculosis, often combined with local surgical eradication. Implanted carriers for local drug delivery have recently been introduced to overcome some of the limitations associated with conventional treatment strategies. I...

journal_title：Scientific reports

authors： Qayoom I,Verma R,Murugan PA,Raina DB,Teotia AK,Matheshwaran S,Nair NN,Tägil M,Lidgren L,Kumar A

更新日期：2020-08-24 00:00:00

abstract：:We demonstrate that the microstructural and mechanical properties of bacterial biofilms can be created through colloidal self-assembly of cells and polymers, and thereby link the complex material properties of biofilms to well understood colloidal and polymeric behaviors. This finding is applied to soften and disassem...

journal_title：Scientific reports

authors： Stewart EJ,Ganesan M,Younger JG,Solomon MJ

更新日期：2015-08-14 00:00:00

abstract：:For treatment individualisation of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with primary radiochemotherapy, we explored the capabilities of different deep learning approaches for predicting loco-regional tumour control (LRC) from treatment-planning computed tomography images...

journal_title：Scientific reports

authors： Starke S,Leger S,Zwanenburg A,Leger K,Lohaus F,Linge A,Schreiber A,Kalinauskaite G,Tinhofer I,Guberina N,Guberina M,Balermpas P,von der Grün J,Ganswindt U,Belka C,Peeken JC,Combs SE,Boeke S,Zips D,Richter C,Troost

更新日期：2020-09-24 00:00:00

abstract：:Gram-negative bacteria belonging to the genus Klebsiella are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as Escheric...

journal_title：Scientific reports

authors： Denkovskienė E,Paškevičius Š,Misiūnas A,Stočkūnaitė B,Starkevič U,Vitkauskienė A,Hahn-Löbmann S,Schulz S,Giritch A,Gleba Y,Ražanskienė A

更新日期：2019-10-28 00:00:00

abstract：:Cell sorting via flow cytometry is a powerful tool to select subpopulations of cells in many biological fields. Selection of fertilisation-prone sperm is a critical step to ensure a stable and high fertilisation rate in in vitro fertilisation (IVF). However, a combination of conventional cell sorting and IVF system ha...

journal_title：Scientific reports

authors： Nakao S,Takeo T,Watanabe H,Kondoh G,Nakagata N

更新日期：2020-06-01 00:00:00

abstract：:We aimed to discover novel associations between leptin and circulating proteins which could link leptin to the development of cardiovascular disease in patients with type 2 diabetes (T2DM). In a discovery phase, we investigated associations between 88 plasma proteins, assessed with a proximity extension assay, and pla...

journal_title：Scientific reports

authors： Vavruch C,Nowak C,Feldreich T,Östgren CJ,Sundström J,Söderberg S,Lind L,Nyström F,Ärnlöv J

更新日期：2020-08-04 00:00:00

abstract：:Despite advances in stem cell research, cell transplantation therapy for liver failure is impeded by a shortage of human primary hepatocytes (HPH), along with current differentiation protocol limitations. Several studies have examined the concept of co-culture of human induced pluripotent cells (hiPSCs) with various t...

journal_title：Scientific reports

authors： Pettinato G,Lehoux S,Ramanathan R,Salem MM,He LX,Muse O,Flaumenhaft R,Thompson MT,Rouse EA,Cummings RD,Wen X,Fisher RA

更新日期：2019-06-20 00:00:00

abstract：:Parasites may severely impact the fitness and life-history of their hosts. After infection, surviving individuals may suppress the growth of the parasite, or completely clear the infection and develop immunity. Consequently, parasite prevalence is predicted to decline with age. Among elderly individuals, immunosenesce...

journal_title：Scientific reports

authors： Hammers M,Komdeur J,Kingma SA,Hutchings K,Fairfield EA,Gilroy DL,Richardson DS

更新日期：2016-07-19 00:00:00

abstract：:Lytic bacteriophages are valuable therapeutic agents against bacterial infections. There is continual effort to obtain new phages to increase the effectivity of phage preparations against emerging phage-resistant strains. Here we described the genomic diversity of spontaneous host-range mutants of kayvirus 812. Five m...

journal_title：Scientific reports

authors： Botka T,Pantůček R,Mašlaňová I,Benešík M,Petráš P,Růžičková V,Havlíčková P,Varga M,Žemličková H,Koláčková I,Florianová M,Jakubů V,Karpíšková R,Doškař J

更新日期：2019-04-02 00:00:00

abstract：:In this study, a simple technique was developed for the electrochemical detection of anionic analytes in weakly supported media. This was conducted by the use of electrochemical paper-based analytical devices (ePADs). A sensing platform was modified with nereistoxin and used to determine nitrite as a case study. The e...

journal_title：Scientific reports

authors： Khoshroo A,Fattahi A

更新日期：2020-09-03 00:00:00

abstract：:Potential of microalgal cultivation as an alternative approach to the treatment of anaerobic digestion (AD) effluents was examined using two representative Chlorella species, Chlorella vulgaris (CV) and Chlorella protothecoides (CP). Both species effectively removed NH4+-N from the AD effluents from four digesters tre...

journal_title：Scientific reports

authors： Yu H,Kim J,Lee C

更新日期：2019-04-16 00:00:00

abstract：:The stratum corneum plays a crucial role in epidermal barrier function. Various changes occur in granular cells at the uppermost stratum granulosum during cornification. To understand the temporal details of this process, we visualized the cell shape and organelles of cornifying keratinocytes in a living human epiderm...

journal_title：Scientific reports

authors： Ipponjima S,Umino Y,Nagayama M,Denda M

更新日期：2020-03-26 00:00:00

abstract：:Attaching Unique Molecular Identifiers (UMI) to RNA molecules in the first step of sequencing library preparation establishes a distinct identity for each input molecule. This makes it possible to eliminate the effects of PCR amplification bias, which is particularly important where many PCR cycles are required, for e...

journal_title：Scientific reports

authors： Sena JA,Galotto G,Devitt NP,Connick MC,Jacobi JL,Umale PE,Vidali L,Bell CJ

更新日期：2018-09-03 00:00:00

abstract：:A gas of magnons in magnetic films differs from all other known systems demonstrating Bose-Einstein condensation (BEC), since it possesses two energetically degenerate lowest-energy quantum states with non-zero wave vectors ±k(BEC). Therefore, BEC in this system results in a spontaneously formed two-component Bose-Ein...

journal_title：Scientific reports

authors： Nowik-Boltyk P,Dzyapko O,Demidov VE,Berloff NG,Demokritov SO

更新日期：2012-01-01 00:00:00

abstract：:Peatland ecosystem services include drinking water provision, flood mitigation, habitat provision and carbon sequestration. Dissolved organic carbon (DOC) removal is a key treatment process for the supply of potable water downstream from peat-dominated catchments. A transition from peat-forming Sphagnum moss to vascul...

journal_title：Scientific reports

authors： Ritson JP,Bell M,Brazier RE,Grand-Clement E,Graham NJ,Freeman C,Smith D,Templeton MR,Clark JM

更新日期：2016-11-18 00:00:00

abstract：:Humans, like all organisms, are subject to fundamental biophysical laws. Van Valen predicted that, because of zero-sum dynamics, all populations of all species in a given environment flux the same amount of energy on average. Damuth's 'energetic equivalence rule' supported Van Valen´s conjecture by showing a tradeoff ...

journal_title：Scientific reports

authors： Burger JR,Weinberger VP,Marquet PA

更新日期：2017-03-02 00:00:00

abstract：:Waves of any kinds, including sound waves and light waves, can interfere constructively or destructively when they are overlapped, allowing for myriad applications. However, unlike continuous waves of a single frequency, interference of photoacoustic pulses is often overlooked because of their broadband characteristic...

journal_title：Scientific reports

authors： Lee T,Li Q,Guo LJ

更新日期：2016-02-12 00:00:00

abstract：:Flux balance analysis is the only modelling approach that is capable of producing genome-wide predictions of gene essentiality that may aid to unveil metabolic liabilities in cancer. Nevertheless, a systemic validation of gene essentiality predictions by flux balance analysis is currently missing. Here, we critically ...

journal_title：Scientific reports

authors： Gatto F,Miess H,Schulze A,Nielsen J

更新日期：2015-06-04 00:00:00

abstract：:It is unknown whether YOD (young onset diabetes) and LOD (late onset diabetes) require similar insulin doses for intensive insulin therapy with a metformin add-on to achieve glycemic control. We analyzed data from our two previously performed randomized, controlled open-label trials. Patients were randomized to receiv...

journal_title：Scientific reports

authors： Li FF,Liu BL,Yin GP,Zhang DF,Zhai XF,Chen MY,Su XF,Wu JD,Ye L,Ma JH

更新日期：2017-11-27 00:00:00

abstract：:Traditional radiomics models mainly rely on explicitly-designed handcrafted features from medical images. This paper aimed to investigate if deep features extracted via transfer learning can generate radiomics signatures for prediction of overall survival (OS) in patients with Glioblastoma Multiforme (GBM). This study...

journal_title：Scientific reports

authors： Lao J,Chen Y,Li ZC,Li Q,Zhang J,Liu J,Zhai G

更新日期：2017-09-04 00:00:00

abstract：:Numerous essential metal elements (EMEs) are necessary to maintain the proper function of human body. In this case-control study, we investigated the associations of 11 EMEs [Calcium (Ca), potassium (K), magnesium (Mg), sodium (Na), manganese (Mn), selenium (Se), cobalt (Co), Molybdenum (Mo), copper (Cu), zinc (Zn), a...

journal_title：Scientific reports

authors： Ma J,Yan L,Guo T,Yang S,Liu Y,Xie Q,Ni D,Wang J

更新日期：2020-07-03 00:00:00

abstract：:Large bowel preparation may cause a substantial change in the gut microbiota and metabolites. Here, we included a bowel prep group and a no-procedure control group and evaluated the effects of bowel prep on the stability of the gut microbiome and metabolome as well as on recovery. Gut microbiota and metabolome composi...

journal_title：Scientific reports

authors： Nagata N,Tohya M,Fukuda S,Suda W,Nishijima S,Takeuchi F,Ohsugi M,Tsujimoto T,Nakamura T,Shimomura A,Yanagisawa N,Hisada Y,Watanabe K,Imbe K,Akiyama J,Mizokami M,Miyoshi-Akiyama T,Uemura N,Hattori M

更新日期：2019-03-11 00:00:00

abstract：:Despite strengthened antimicrobial therapy, biofilm infections of Acinetobacter baumannii are associated with poor prognosis and limited therapeutic options. Assessing antibiotics on planktonic bacteria can result in failure against biofilm infections. Currently, antibiotics to treat biofilm infections are administere...

journal_title：Scientific reports

authors： Wannigama DL,Hurst C,Pearson L,Saethang T,Singkham-In U,Luk-In S,Storer RJ,Chatsuwan T

更新日期：2019-04-19 00:00:00

abstract：:Solar conversion to fuels or to electricity in semiconductors using far red-to-near infrared (NIR) light, which accounts for about 40% of solar energy, is highly significant. One main challenge is the development of novel strategies for activity promotion and new basic mechanisms for NIR response. Mother Nature has ev...

journal_title：Scientific reports

authors： Yan R,Chen M,Zhou H,Liu T,Tang X,Zhang K,Zhu H,Ye J,Zhang D,Fan T

更新日期：2016-01-28 00:00:00

abstract：:Primary IgA nephropathy (IgAN) diagnosis is based on IgA-dominant glomerular deposits and histological scoring is done on formalin-fixed paraffin embedded tissue (FFPE) sections using the Oxford classification. Our aim was to use this underexploited resource to extract RNA and identify genes that characterize active (...

journal_title：Scientific reports

authors： Cox SN,Chiurlia S,Divella C,Rossini M,Serino G,Bonomini M,Sirolli V,Aiello FB,Zaza G,Squarzoni I,Gangemi C,Stangou M,Papagianni A,Haas M,Schena FP

更新日期：2020-09-16 00:00:00

abstract：:Internal solitary waves (ISWs) in the NE South China Sea (SCS) are tidally generated at the Luzon Strait. Their propagation, evolution, and dissipation processes involve numerous issues still poorly understood. Here, a novel method of seismic oceanography capable of capturing oceanic finescale structures is used to st...

journal_title：Scientific reports

authors： Tang Q,Wang C,Wang D,Pawlowicz R

更新日期：2014-06-20 00:00:00

abstract：:Mayaro virus (MAYV) is endemic in South American countries where it is responsible for sporadic outbreaks of acute febrile illness. The hallmark of MAYV infection is a highly debilitating and chronic arthralgia. Although MAYV emergence is a potential threat, there are no specific therapies or licensed vaccine. In this...

journal_title：Scientific reports

authors： Mota MTO,Costa VV,Sugimoto MA,Guimarães GF,Queiroz-Junior CM,Moreira TP,de Sousa CD,Santos FM,Queiroz VF,Passos I,Hubner J,Souza DG,Weaver SC,Teixeira MM,Nogueira ML

更新日期：2020-03-24 00:00:00

abstract：:Sexual spores are important for the dispersal and population dynamics of fungi. They show remarkable morphological diversity, but the underlying forces driving spore evolution are poorly known. We investigated whether trophic status and substrate associations are associated with morphology in 787 macrofungal genera. W...

journal_title：Scientific reports

authors： Calhim S,Halme P,Petersen JH,Læssøe T,Bässler C,Heilmann-Clausen J

更新日期：2018-03-29 00:00:00

abstract：:Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid protein of Alzheimer's disease. However, little is known about the association between fibrinogen a...

journal_title：Scientific reports

authors： Page MJ,Thomson GJA,Nunes JM,Engelbrecht AM,Nell TA,de Villiers WJS,de Beer MC,Engelbrecht L,Kell DB,Pretorius E

更新日期：2019-02-28 00:00:00

abstract：:Macrophages play an important role in the inflammatory process that contributes to the development of abdominal aortic aneurysm (AAA). Studies of human and mouse AAA tissue reveal expanded populations of macrophages producing an abundance of pro-inflammatory cytokines, including TNF-α, IL-12p40 and high level of metal...

journal_title：Scientific reports

authors： Yan H,Hu Y,Akk A,Ye K,Bacon J,Pham CTN

更新日期：2019-07-18 00:00:00