Abstract:
BACKGROUND:Traumatic brain injury (TBI) is an acquired brain injury that occurs when there is sudden trauma that leads to brain damage. This acute complex event can happen when the head is violently or suddenly struck or an object pierces the skull or brain. The current principal treatment of TBI includes various pharmaceutical agents, hyperbaric oxygen, and hypothermia. There is evidence that secondary injury from a TBI is specifically related to oxidative stress. However, the clinical management of TBI often does not include antioxidants to reduce oxidative stress and prevent secondary injury. AIMS:The purpose of this article is to examine current literature regarding the use of antioxidant therapies in treating TBI. This review evaluates the evidence of antioxidant therapy as an adjunctive treatment used to reduce the underlying mechanisms involved in secondary TBI injury. METHODS:A systematic review of the literature published between January 2005 and September 2015 was conducted. Five databases were searched including CINAHL, PubMed, the Cochrane Library, PsycINFO, and Web of Science. FINDINGS:Critical evaluation of the six studies that met inclusion criteria suggests that antioxidant therapies such as amino acids, vitamins C and E, progesterone, N-acetylcysteine, and enzogenol may be safe and effective adjunctive therapies in adult patients with TBI. Although certain limitations were found, the overall trend of using antioxidant therapies to improve the clinical outcomes of TBI was positive. LINKING EVIDENCE TO ACTION:By incorporating antioxidant therapies into practice, clinicians can help attenuate the oxidative posttraumatic brain damage and optimize patients' recovery.
journal_name
Worldviews Evid Based Nursjournal_title
Worldviews on evidence-based nursingauthors
Shen Q,Hiebert JB,Hartwell J,Thimmesch AR,Pierce JDdoi
10.1111/wvn.12167subject
Has Abstractpub_date
2016-10-01 00:00:00pages
380-389issue
5eissn
1545-102Xissn
1741-6787journal_volume
13pub_type
杂志文章,评审abstract:BACKGROUND:Globalization of health care demands nursing education programs that equip students with evidence-based patient safety competences in the global context. Nursing students' entrance into clinical placements requires professional readiness. Thus, evidence-based learning activities about patient safety must be ...
journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/wvn.12088
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Pressure ulcers are associated with substantial health burden, but could be preventable. Hospital-acquired pressure ulcers (HAPUs) prevention has become a priority for all healthcare settings, as it is considered a sign of quality of care providing. Intensive care unit (ICU) patients are at higher risk for H...
journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章,评审
doi:10.1111/wvn.12177
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Heart failure (HF) is considered a condition in which a portion of hospital admissions are preventable if timely and appropriate outpatient care management occurs. Facility readmission rates for HF are reportable and subject to penalty. Both military and civilian healthcare systems have fiscal responsibility...
journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/wvn.12336
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The purpose of the study was to ascertain the place of knowledge and evidence in the context of Australian general practice nursing. General practice nursing is a rapidly developing area of specialized nursing in Australia. The provision of primary care services in Australia rests largely with medical genera...
journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/j.1741-6787.2009.00163.x
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Ventilator-associated pneumonia (VAP) is an ongoing challenge for critical care nurses as they use current evidence-based strategies to decrease its incidence and prevalence. Mechanical intubation negates effective cough reflexes and impedes mucociliary clearance of secretions, causing leakage and microaspir...
journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章,评审
doi:10.1111/j.1741-6787.2008.00140.x
更新日期:2008-01-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章,随机对照试验
doi:10.1111/wvn.12097
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Evidence-based guidelines assist clinicians in practice, but how the guidelines are implemented is less established. AIM:To describe the nurses' implementation of activities recommended in evidence-based guidelines for falls prevention and care of older people with cognitive impairment. METHODS:Structured ...
journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/wvn.12376
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Metacognitive training (MCT) was developed in 2007 and widely used to modify the delusions for patient with schizophrenia. However, its effectiveness remains unclear. AIMS:To investigate the overall effectiveness of MCT for delusion in schizophrenia patients from 2007 to 2016, and to investigate the variabl...
journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章,meta分析,评审
doi:10.1111/wvn.12282
更新日期:2018-04-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2008-01-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/j.1741-6787.2012.00243.x
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/wvn.12143
更新日期:2016-06-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/wvn.12289
更新日期:2018-06-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/wvn.12360
更新日期:2019-06-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/wvn.12323
更新日期:2018-10-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/wvn.12057
更新日期:2014-12-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/j.1741-6787.2006.00051.x
更新日期:2006-01-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/wvn.12453
更新日期:2020-08-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章,meta分析
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更新日期:2019-12-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
doi:10.1111/wvn.12158
更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章,评审
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更新日期:2011-06-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章,评审
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journal_title:Worldviews on evidence-based nursing
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00