Abstract:
:We propose a mechanism of action for the betL* mutation which is based on DNA topology. Removing a single thymine residue from the betL σ(A) promoter's -10 and -35 spacer results in a 'twist'-mediated activation of transcription which accounts for the osmotolerance phenotype observed for strains expressing betL*.
journal_name
Bioengineeredjournal_title
Bioengineeredauthors
Keane SM,Culligan EP,Hoffmann RF,Gahan CG,Hill C,Snelling WJ,Sleator RDdoi
10.1080/21655979.2016.1171438subject
Has Abstractpub_date
2016-04-02 00:00:00pages
116-9issue
2eissn
2165-5979issn
2165-5987journal_volume
7pub_type
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