Abstract:
:Further research is needed to investigate real-world acceptability of extended-release naltrexone for alcohol and opioid use disorders, and potential gender differences. This study examines treatment and clinical characteristics among men and women receiving extended-release naltrexone in a large, publicly funded substance use disorder treatment system (N = 465; 52% female). Patient demographics, treatment characteristics, and the number of extended-release naltrexone doses received were collected from administrative data and treatment program staff. Additionally, patients provided information on experiences with extended-release naltrexone in an open-ended format at 1, 2, and 3 weeks following their first injection. For a subsample of patients (N = 220), alcohol/opioid cravings and specific adverse effects were also assessed. Compared to men, women reported experiencing a higher rate and mean number of adverse effects. Overall, craving scores showed substantial reductions over time. However, among patients taking extended-release naltrexone for alcohol use, women showed a significantly greater reduction in craving scores compared to men. No gender differences were observed in the number of extended-release naltrexone doses received. Although women may have a greater need for additional support in managing early adverse effects, extended-release naltrexone as an adjunct to psychosocial treatment may be an acceptable and promising treatment approach for both men and women, and particularly for women prescribed extended-release naltrexone for alcohol use. This study contributes further information on patients' experiences during the early course of extended-release naltrexone treatment in real-world settings. Understanding these experiences may assist policy makers and treatment providers in addressing challenges of implementing this treatment into wider practice.
journal_name
J Addict Disjournal_title
Journal of addictive diseasesauthors
Herbeck DM,Jeter KE,Cousins SJ,Abdelmaksoud R,Crèvecoeur-MacPhail Ddoi
10.1080/10550887.2016.1189659subject
Has Abstractpub_date
2016-10-01 00:00:00pages
305-314issue
4eissn
1055-0887issn
1545-0848journal_volume
35pub_type
杂志文章abstract:BACKGROUND:Methadone has been effectively used in the treatment of opiate dependence. Adequate dose and blood level have correlated with success in treatment. A number of factors including the regular use of alcohol, medications, and urinary pH can influence blood level and thereby effectiveness. Fluvoxamine has been s...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v18n04_02
更新日期:1999-01-01 00:00:00
abstract::Objectives: We used treatment for alcohol withdrawal syndrome as an objective surrogate marker to investigate the relationship between alcohol-related health outcomes and home neighborhood alcohol outlet density and alcohol advertising density.Methods: Mixed effects logistic regression examined whether alcohol outlet ...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2020.1762029
更新日期:2020-07-01 00:00:00
abstract::Gestational smoking has been established as a risk to the fetus. However, many pregnant smokers are unable to quit due to the highly addictive nature of nicotine. Nicotine replacement therapy has failed in several studies in pregnant women. In a prospective matched, controlled observational study, of 22 pregnant smoke...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v24n02_02
更新日期:2005-01-01 00:00:00
abstract::The authors investigated whether patients receiving buprenorphine maintenance treatment (BMT) will have corrected QT (QTc) prolongation after taking buprenorphine for an extended period of time. They also compared QTc prolongation for patients in methadone maintenance treatment (MMT) versus BMT to determine which medi...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2013.824333
更新日期:2013-01-01 00:00:00
abstract::It is unknown whether infection with hepatitis C is a risk factor for pain among people who have used injection drugs. Multivariate regression was used to determine whether hepatitis C was associated with greater likelihood of reporting significant chronic pain and discomfort intolerance in a cohort of 97 injection dr...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2011.554775
更新日期:2011-04-01 00:00:00
abstract:INTRODUCTION:The prevalence and treatment outcome of smokeless tobacco (ST) use among hospitalized addiction patients is unclear. METHODS:Using initially a retrospective and then a prospective study design, data were collected about patients who described "other tobacco use." The data examined included demographics, m...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v21n02_03
更新日期:2002-01-01 00:00:00
abstract::We report the use of naltrexone for treatment of alcohol use disorder in patients with major psychiatric illness. We reviewed the records of 72 mentally ill outpatients treated with naltrexone for alcohol use disorders at a community mental health center. The psychiatric diagnoses included major depression (n = 37), s...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v19n03_05
更新日期:2000-01-01 00:00:00
abstract::The first drinking experience has been suggested as an important point in etiological processes associated with alcohol use and abuse. In this study, initial drinking experiences were assessed among populations of alcoholics, problem drinkers, and non-problem drinkers. Results showed that the alcoholics and problem dr...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v10n03_04
更新日期:1991-01-01 00:00:00
abstract::The altruism and/or solidarity of people who inject drugs helps protect sex and drug partners from HIV. Research has been hindered by lack of measures. We developed and administered scales to assess them to 300 people who inject drugs. Altruism and Solidarity Scales were both internally consistent. Each correlated sig...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2015.1059654
更新日期:2015-01-01 00:00:00
abstract::The purpose of this study was to determine the extent to which spiritual orientation was associated with adaptation to therapeutic community treatment. Spiritual orientation was assessed by the Spirituality Self-Rating Scale, a measure consistent with the conceptualization of spirituality typically reflected in Alcoho...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2010.489443
更新日期:2010-07-01 00:00:00
abstract::Background: Worldwide, substance use disorder is on the rise, especially amongst the young generation. Although cocaine-induced cardiovascular and cerebrovascular events are well documented, knowledge about the relationship of cocaine use and its effect on arterial perfusion in the lower limbs is scarce.Objective: Thi...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2020.1764160
更新日期:2020-07-01 00:00:00
abstract::Smoking-related illnesses are the leading causes of morbidity and mortality in Brazil. Despite a smoking prevalence of approximately 40%, there is limited national effort to reduce tobacco use in Brazil by means of public education and training of health care professionals to promote smoking education. In particular, ...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v18n01_03
更新日期:1999-01-01 00:00:00
abstract::Previous studies have noted the paradox of the dually-diagnosed (serious mental illness and substance abuse) in which the dually-diagnosed are judged to be both behaviorally more disorganized and simultaneously more socially competent. This study sought to further assess this paradox with a large sample size and a com...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v19n01_02
更新日期:2000-01-01 00:00:00
abstract::This study investigated whether adolescent's family type was associated with regular smoking or the use of illicit substances (cannabis or hard drugs) among underage adolescent psychiatric in-patients. The sample consisted of 471 adolescents aged 12-17 years admitted to psychiatric hospital between April 2001 and Marc...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550880802324853
更新日期:2008-01-01 00:00:00
abstract::This manuscript provides an overview of the current scientific literature on the impact of maternal drug use, specifically opioids and cocaine, during pregnancy on the acute and long-term outcomes of infants and toddlers from birth through age 3 years. Emphasis with regard to opioids is placed on heroin and opioid sub...
journal_title:Journal of addictive diseases
pub_type: 杂志文章,评审
doi:10.1080/10550881003684871
更新日期:2010-04-01 00:00:00
abstract::Previous studies have shown significant associations between OPRK1 and susceptibility to opioid dependence and the relationships between libido dysfunction and insomnia among opium addicts who underwent methadone maintenance treatment. The authors investigated the single locus and haplotype association of rs997917, rs...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2017.1361724
更新日期:2017-10-01 00:00:00
abstract::One difficulty for methadone maintenance treatment programs is the absence of a simple, analytical method useful for guiding adjustment of methadone dose. Currently, dose adjustment decisions are based upon: documentation of continuing opioid use by qualitative urine drug screens, patient complaints of dose not holdin...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v13n01_02
更新日期:1994-01-01 00:00:00
abstract::One line (strain) of mouse has been selectively bred in our laboratory for 15 generations to exhibit a very high sensitivity to levorphanol-induced analgesia on the hot plate assay (HAR or high antinociceptive response line). Concurrently, a second line (LAR or low antinociceptive response line) has been bred in the o...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v10n01_03
更新日期:1991-01-01 00:00:00
abstract::The study of personality is critical to enhance current knowledge of the psychological characteristics of alcohol dependence. Recent evidence shows that mindfulness-oriented meditation positively influences healthy individuals' character. Here, it was assessed whether 8-week mindfulness-oriented meditation promotes si...
journal_title:Journal of addictive diseases
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/10550887.2014.991657
更新日期:2015-01-01 00:00:00
abstract::Substance abuse treatment programs are an important platform for delivery of services for infectious diseases associated with drug and alcohol use. However, important components of infectious disease care are not universally provided. Clinician training often focuses on information about infectious diseases and less a...
journal_title:Journal of addictive diseases
pub_type: 杂志文章,多中心研究
doi:10.1080/10550880802544625
更新日期:2009-01-01 00:00:00
abstract::The non-medical use of prescription medications has been identified as a major public health problem among youth, although few longitudinal studies have examined non-medical use of prescription medications in the context of other drug use. Previous cross-sectional studies have shown gender and race differences in non-...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2016.1186413
更新日期:2016-10-01 00:00:00
abstract::To assess the utility of booster testing and to identify factors associated with a positive booster test, two-step tuberculin testing was performed in drug users recruited from methadone treatment. Participants also received a standardized interview on demographics and testing for HIV and CD4+ lymphocyte count. Of 619...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v26n02_09
更新日期:2007-01-01 00:00:00
abstract::Behavioral sensitization, the progressive and enduring enhancement of certain stimulant-induced behaviors following repetitive drug use, is mediated in part by dopaminergic pathways known to play a role in drug dependence. It has been theorized that sensitization underlies the development of drug craving and initiates...
journal_title:Journal of addictive diseases
pub_type: 杂志文章,评审
doi:10.1300/J069v20n03_03
更新日期:2001-01-01 00:00:00
abstract::In a one year study, 130 methadone maintained subjects with a six month history of good treatment performance were assigned randomly to an experimental condition of one monthly non-random urine screen, one monthly counseling session, one monthly doctor visit, two times per month methadone pick up, a quarterly true ran...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v12n04_05
更新日期:1993-01-01 00:00:00
abstract::A patient maintained on methadone for opioid-dependency developed recurrent syncope. Episodes occurred within hours after using cocaine, and were initially presumed secondary to seizure disorder. However, the patient subsequently suffered a cardiac arrest, and polymorphic ventricular tachycardia (torsade de pointes) w...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v24n01_05
更新日期:2005-01-01 00:00:00
abstract::Homeless men on parole are a hard-to-reach population with significant community reintegration challenges. This cross-sectional study describes sociodemographic, cognitive, psychosocial, and drug-related correlates of alcohol and methamphetamine use in 157 homeless male parolees (age range 18-60) enrolled in a substan...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2013.849973
更新日期:2013-01-01 00:00:00
abstract::We conducted this systematic review and meta-analysis study to better understand the factors (being drug use, drug type (methamphetamine vs others), sex partner, frequency of injection, homelessness and being HIV positive) associated with injecting-related risk behaviors (lending and/or borrowing already used syringes...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2020.1781346
更新日期:2020-10-01 00:00:00
abstract::The primary aim was to examine the effect of an eight day residential treatment for nicotine dependence on perceived stress, partner support, decisional balance, and self-efficacy for stopping smoking. Whether these variables predicted six months post treatment abstinence following residential treatment was also exami...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1300/J069v27n01_08
更新日期:2008-01-01 00:00:00
abstract::The smoking prevalence of medical faculty members has not been a subject of research as frequently as physicians and medical students. The objective of this study was to determine the status of tobacco use and some attitudes among medical faculty members of a Northern Cyprus university. The data were collected by a qu...
journal_title:Journal of addictive diseases
pub_type: 杂志文章
doi:10.1080/10550887.2020.1730129
更新日期:2020-04-01 00:00:00
abstract::The practice of health care professionals impaired by alcohol or other substance abuse is an often hidden, but continuing problem. Established by law in 1994, the Michigan Health Professional Recovery Program (MHPRP) provides a new approach to treating impaired health professionals. It is unique nationally, both in it...
journal_title:Journal of addictive diseases
pub_type: 杂志文章,评审
doi:10.1300/j069v20n04_09
更新日期:2001-01-01 00:00:00