Abstract:
:Sexual dimorphisms are recognized in cardiovascular conditions such as hypertension, stroke, thrombosis and vasculitis. B-type natriuretic peptide (BNP) is a guanylyl cyclase A (GC-A) agonist. The anti-hypertensive, vasodilatory, anti-fibrotic, and anti-hypertrophic properties of BNP are well established in male animal models. Although circulating BNP levels are higher in women, when compared to age-matched men, the cardiovascular protective propensity of BNP in females is poorly understood. We assessed the cardiovascular consequences of BNP deletion in genetically null (Nppb-/-) female rat lines. Throughout the study, blood pressure (BP) remained uninfluenced by genotype, and cardiorenal consequences of BNP knock out remained minor. Unexpectedly, approximately 60% of Nppb-/- females developed mesenteric polyarteritis-nodosa (PAN)-like vasculitis in their life span, some as early as 4 months of age. Mesenteric lesions involved intense arterial remodeling, progressive inflammation, occluded lumens, and less frequently intestinal necrosis and multiple visceral arterial aneurysms. Cumulative pathologies resulted in a significant decline in survival of the Nppb-/- female. This study highlights BNP's vasoprotective propensity, bringing to light a possible sex specific difference in the cardiovascular protection provided by BNP. Defects in the BNP/GC-A/cGMP pathway may play a role in arteriopathies in women, while GC-A agonists may provide effective therapy for arteritis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Holditch SJ,Schreiber CA,Burnett JC,Ikeda Ydoi
10.1038/srep25623subject
Has Abstractpub_date
2016-05-10 00:00:00pages
25623issn
2045-2322pii
srep25623journal_volume
6pub_type
杂志文章abstract::Surgery and anesthesia induce inflammatory changes in the central nervous system, which ultimately lead to neuronal damage concomitant with an increase in the level of neurodegeneration markers. Despite some experimental data showing prolonged activation of the immune system post-surgery, no study has determined the e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42351-2
更新日期:2019-05-09 00:00:00
abstract::Orbital angular momentum (OAM) multiplexing technique has recently emerged and generated widespread interests since the OAM was discovered as a property of electromagnetic wave and acoustic wave. It was widely acknowledged that OAM multiplexing can achieve very high effective degrees of freedom (EDOF) and improve the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61329-z
更新日期:2020-03-23 00:00:00
abstract::Metal-organic frameworks (MOFs) formed from metals and organic ligands, are crystalline materials that are degradable in aqueous medium, and capable of releasing Ca and Sr ions. In this manuscript, the ability of MOFs to degrade and release osteogenic Ca and Sr ions was investigated. MOFs were generated by choosing os...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49536-9
更新日期:2019-09-10 00:00:00
abstract::1-Aminocyclopropane-1-carboxylic acid (ACC) is a precursor molecule of ethylene whose concentration is elevated in the plant subjected to biotic and abiotic stress. Several soil microorganisms are reported to produce ACC deaminase (ACCd) which degrades ACC thereby reducing stress ethylene in host plants. This study is...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35565-3
更新日期:2018-11-30 00:00:00
abstract::With about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte nucleus. How viral cccDNA gene expression is regulated by its chromatin structure; more importa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25901
更新日期:2016-05-13 00:00:00
abstract::Nuclear receptor corepressor 1 (NCOR1) is a transcriptional regulator bridging repressive chromatin modifying enzymes with transcription factors. NCOR1 regulates many biological processes, however its role in T cells is not known. Here we show that Cd4-Cre-mediated deletion of NCOR1 (NCOR1 cKOCd4) resulted in a reduct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15918-0
更新日期:2017-11-21 00:00:00
abstract::Incident myocardial infarction (MI) is a leading cause of adult mortality in the United States. However, because MI has a relatively low incidence in the young population, little information exists on the disease in younger adults. Because the retina has the unique quality that its vasculature is readily and noninvasi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24083-x
更新日期:2018-04-04 00:00:00
abstract::Any processing delay between the two eyes can result in illusory 3D percepts for moving objects because of either changes in the pure disparities over time for disparity sensors or by changes to sensors that encode motion/disparity conjointly. This is demonstrated by viewing a fronto-parallel pendulum through a neutra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06151-w
更新日期:2017-07-17 00:00:00
abstract::Dissecting the complex molecular interplay between the host plant and invading virus improves our understanding of the mechanisms underlying viral pathogenesis. In this study, immunoprecipitation together with the mass spectrometry analysis revealed that the heat shock protein 70 (Hsp70) family homolog, Hsc70-2, was c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22778-9
更新日期:2018-03-14 00:00:00
abstract::Laser radiation pressure is a basis of numerous applications in science and technology such as atom cooling, particle manipulation, material processing, etc. This light force for the case of scalar beams is proportional to the intensity-weighted wavevector known as optical current. The ability to design the optical cu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35341
更新日期:2016-10-13 00:00:00
abstract::Plasmodiophora brassicae causes clubroot disease in cruciferous. In this report, lipid droplets were observed in the resting spores of P. brassicae. 295 lipid droplet-associated proteins were identified and categorized into nine groups. Transcriptome analysis of these proteins during three different zoosporic stages r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36965
更新日期:2016-11-22 00:00:00
abstract::Oxidative stress and mitochondrial dysfunction have been associated with metabolic and age-related diseases. Thus, the prevention of mitochondrial oxidative damage is nowadays a recognized pharmacological strategy to delay disease progression. Epidemiological studies suggested an association between the consumption of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07272-y
更新日期:2017-07-28 00:00:00
abstract::Psychological and behavioural interventions may be effective in reducing menopause-related symptoms. This randomized controlled trial aimed to evaluate the effectiveness of Mindfulness-based Stress Reduction (MBSR) in reducing menopause-related symptoms by comparing with an active control group, the menopause educatio...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/s41598-018-24945-4
更新日期:2018-04-26 00:00:00
abstract::DDX3, a subunit of CK1ε, phosphorylates Dvl2 to promote β-catenin activation. Overexpression of the Dvl2 protein results in potent activation of β-catenin/TCF signaling in colorectal cancer. Therefore, we hypothesized that DDX3 might promote tumor invasion via the CK1ε/Dvl2 axis due to β-catenin/TCF activation. Wester...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21483
更新日期:2016-02-19 00:00:00
abstract::Nanoliposomal formulation of C6-ceramide, a proapoptotic sphingolipid metabolite, presents an effective way to treat malignant tumor. Here, we provide evidence that acute treatment (30 min) of melanoma and breast cancer cells with nanoliposomal C6-ceramide (NaL-C6) may suppress cell migration without inducing cell dea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09275
更新日期:2015-03-20 00:00:00
abstract::IgE, forming an immune complex with small proteins, can enhance the specific antibody and CD4(+) T cell responses in vivo. The effects require the presence of CD23 (Fcε-receptor II)(+) B cells, which capture IgE-complexed antigens (Ag) in the circulation and transport them to splenic B cell follicles. In addition, als...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28290
更新日期:2016-06-16 00:00:00
abstract::As a follow-up on the data presented for seals, we herein report and discuss outcomes resulting from a retrospective evaluation of harbour porpoise stranding and necropsy data from Schleswig-Holstein, Germany (n = 4463) to enable an objective evaluation of potential ecological effects of grey seal predation on porpois...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73258-y
更新日期:2020-10-01 00:00:00
abstract::PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28890
更新日期:2016-07-04 00:00:00
abstract::Mounting evidence indicated that human mesenchymal stem cells (hMSCs) are responsive not only to biochemical but also to physical cues, such as substrate topography and stiffness. To simulate the dynamic structures of extracellular environments of the marrow in vivo, we designed a novel surrogate substrate for marrow ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24264
更新日期:2016-04-15 00:00:00
abstract::The effect on post-operative outcomes after coronary artery bypass graft (CABG) surgery is not clear. Among 17,812 patients who underwent CABG during October 1,2006-September 28,2012 in any Department of US Veterans Affairs (VA) hospital, we identified 5,968 with available preoperative urine albumin-creatinine ratio (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16458
更新日期:2015-11-09 00:00:00
abstract::Perpendicularly magnetized tunnel junctions (p-MTJs) that contain synthetic antiferromagnetic (SAF) frames show promise as reliable building blocks to meet the demands of perpendicular magnetic anisotropy (PMA)-based spintronic devices. In particular, Co/Pd multilayer-based SAFs have been widely employed due to their ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21324
更新日期:2016-02-18 00:00:00
abstract::The ability to form mineral structures under biological control is widespread among animals. In several species, specific proteins have been shown to be involved in biomineralization, but it is uncertain how they influence the shape of the growing biomineral and the resulting skeleton. Calcareous sponges are the only ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45658
更新日期:2017-04-13 00:00:00
abstract::Intuitively, deriving meaning from an abstract image is a uniquely human, idiosyncratic experience. Here we show that, despite having no universally recognised lexical association, abstract images spontaneously elicit specific concepts conveyed by words, with a consistency akin to that of concrete images. We presented...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25441-5
更新日期:2018-05-08 00:00:00
abstract::Open algal cultivation platforms often suffer crop losses to herbivorous grazers that have potential to devastate biomass production within a few days. While a number of studies suggest synthetic chemicals as control agents for voracious algal grazers, environmental and safety concerns associated with the use of these...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23535-8
更新日期:2018-03-29 00:00:00
abstract::Internet technologies have demonstrated their value for the early detection and prediction of epidemics. In diverse cases, electronic surveillance systems can be created by obtaining and analyzing on-line data, complementing other existing monitoring resources. This paper reports the feasibility of building such a sys...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61686-9
更新日期:2020-03-16 00:00:00
abstract::Flavivirus-mediated inflammation causes neuronal death, but whether the infected neurons can evoke an innate immune response to elicit their own protection, is unknown. In an earlier study we have shown that neuronal RIG-I, play a significant role in inducing production and release of molecules that are related to inf...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00347
更新日期:2012-01-01 00:00:00
abstract::To understand the role of commensal gut bacteria on the progression of cognitive decline in Alzheimer's disease via the microbiota-gut-brain axis, we isolated anti-inflammatory Bifidobacterium longum (NK46) from human gut microbiota, which potently inhibited gut microbiota endotoxin production and suppressed NF-κB act...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48342-7
更新日期:2019-08-14 00:00:00
abstract::Tobacco smoking is the major cause of many chronic diseases, especially lung cancer. Knowledge about population-wide tobacco use and exposure is essential to characterise its burden on public health and evaluate policy efficacy. Obtaining such knowledge remains challenging with current methods (e.g., surveys, biomonit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31324-6
更新日期:2018-09-05 00:00:00
abstract::AKT is an important signal transduction protein that plays a crucial role in cancer development. Therefore, we evaluated associations between single nucleotide polymorphisms (SNPs) in the AKT promoter region and gastric cancer (GCa) risk in a case-control study of 1,110 GCa patients and 1,114 matched cancer-free contr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20008
更新日期:2016-01-28 00:00:00
abstract::We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong's "Children of 1997" birth cohort, adjusted associations of prematurity and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56086-7
更新日期:2020-01-15 00:00:00