当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Etiology matters - Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy.

Etiology matters - Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy.

Abstract：

:This study tested the hypothesis that acquired epileptogenesis is accompanied by DNA methylation changes independent of etiology. We investigated DNA methylation and gene expression in the hippocampal CA3/dentate gyrus fields at 3 months following epileptogenic injury in three experimental models of epilepsy: focal amygdala stimulation, systemic pilocarpine injection, or lateral fluid-percussion induced traumatic brain injury (TBI) in rats. In the models studies, DNA methylation and gene expression profiles distinguished controls from injured animals. We observed consistent increased methylation in gene bodies and hypomethylation at non-genic regions. We did not find a common methylation signature in all three different models and few regions common to any two models. Our data provide evidence that genome-wide alteration of DNA methylation signatures is a general pathomechanism associated with epileptogenesis and epilepsy in experimental animal models, but the broad pathophysiological differences between models (i.e. pilocarpine, amygdala stimulation, and post-TBI) are reflected in distinct etiology-dependent DNA methylation patterns.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Dębski KJ,Pitkanen A,Puhakka N,Bot AM,Khurana I,Harikrishnan KN,Ziemann M,Kaspi A,El-Osta A,Lukasiuk K,Kobow K

doi

10.1038/srep25668

subject

Has Abstract

pub_date

2016-05-09 00:00:00

pages

25668

issn

2045-2322

pii

srep25668

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Design, transform and control of optical field in discrete optical system: an example.

    abstract：:A discrete optical system can broaden the spatial distribution of the input light through optical coupling in array waveguides, just like diffraction in continuous media. Here, we theoretically demonstrate several kinds of control methods of optical field propagation in a discrete optical system, which is composed of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05414-w

    authors： Deng H,Yuan Y,Yuan L

    更新日期：2017-07-12 00:00:00

  • Reference genes for quantitative real-time PCR analysis in symbiont Entomomyces delphacidicola of Nilaparvata lugens (Stål).

    abstract：:Nilaparvata lugens (Stål) (Hemiptera: Delphacidae) is a major rice pest that harbors an endosymbiont ascomycete fungus, Entomomyces delphacidicola str. NLU (also known as yeast-like symbiont, YLS). Driving by demand of novel population management tactics (e.g. RNAi), the importance of YLS has been studied and revealed...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42206

    authors： Wan PJ,Tang YH,Yuan SY,He JC,Wang WX,Lai FX,Fu Q

    更新日期：2017-02-13 00:00:00

  • Neural Network for Nanoscience Scanning Electron Microscope Image Recognition.

    abstract：:In this paper we applied transfer learning techniques for image recognition, automatic categorization, and labeling of nanoscience images obtained by scanning electron microscope (SEM). Roughly 20,000 SEM images were manually classified into 10 categories to form a labeled training set, which can be used as a referenc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13565-z

    authors： Modarres MH,Aversa R,Cozzini S,Ciancio R,Leto A,Brandino GP

    更新日期：2017-10-16 00:00:00

  • Rapid mixing of viscous liquids by electrical coiling.

    abstract：:The control for the processing of precursor liquids determines whether the properties and functions of the final material product can be engineered. An inherent challenge of processing viscous liquids arises from their large resistance to deform. Here, we report on the discovery of an electric approach that can signif...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19606

    authors： Kong T,Li J,Liu Z,Zhou Z,Ng PH,Wang L,Shum HC

    更新日期：2016-02-10 00:00:00

  • Additive manufacturing of laminar flow cells for single-molecule experiments.

    abstract：:A microfluidic laminar flow cell (LFC) forms an indispensable component in single-molecule experiments, enabling different substances to be delivered directly to the point under observation and thereby tightly controlling the biochemical environment immediately surrounding single molecules. Despite substantial progres...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53151-z

    authors： Ahmadi A,Till K,Hafting Y,Schüttpelz M,Bjørås M,Glette K,Tørresen J,Rowe AD,Dalhus B

    更新日期：2019-11-14 00:00:00

  • T-cell subset abnormalities predict progression along the Inflammatory Arthritis disease continuum: implications for management.

    abstract：:The presence of a disease continuum in inflammatory arthritis (IA) is a recognised concept, with distinct stages from at-risk stage (presence of anti citrullinated-peptide autoantibody) to diagnosis of rheumatoid arthritis (RA), including therapy-induced remission. Despite T-cell dysregulation being a key feature of R...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1038/s41598-020-60314-w

    authors： Ponchel F,Burska AN,Hunt L,Gul H,Rabin T,Parmar R,Buch MH,Conaghan PG,Emery P

    更新日期：2020-02-28 00:00:00

  • Transcriptomic profiles of Clostridium ljungdahlii during lithotrophic growth with syngas or H2 and CO2 compared to organotrophic growth with fructose.

    abstract：:Clostridium ljungdahlii derives energy by lithotrophic and organotrophic acetogenesis. C. ljungdahlii was grown organotrophically with fructose and also lithotrophically, either with syngas - a gas mixture containing hydrogen (H2), carbon dioxide (CO2), and carbon monoxide (CO), or with H2 and CO2. Gene expression was...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12712-w

    authors： Aklujkar M,Leang C,Shrestha PM,Shrestha M,Lovley DR

    更新日期：2017-10-13 00:00:00

  • Bamboo leaf flavone changed the community of cecum microbiota and improved the immune function in broilers.

    abstract：:It has been shown that bamboo leaf flavone (BLF) displays biological and pharmacological activities in mammals. However, the effects of BLF on broiler gut microbiota and related immune function have not been investigated. The aim of this study was to test our hypothesis that BLF can improve the health status of broile...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69010-1

    authors： Shu G,Kong F,Xu D,Yin L,He C,Lin J,Fu H,Wang K,Tian Y,Zhao X

    更新日期：2020-07-23 00:00:00

  • Thermomechanical Behavior of Molded Metallic Glass Nanowires.

    abstract：:Metallic glasses are disordered materials that offer the unique ability to perform thermoplastic forming operations at low thermal budget while preserving excellent mechanical properties such as high strength, large elastic strain limits, and wear resistance owing to the metallic nature of bonding and lack of internal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19530

    authors： Magagnosc DJ,Chen W,Kumar G,Schroers J,Gianola DS

    更新日期：2016-01-20 00:00:00

  • Author Correction: Localization and function of neurosecretory protein GM, a novel small secretory protein, in the chicken hypothalamus.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-24103-w

    authors： Shikano K,Bessho Y,Kato M,Iwakoshi-Ukena E,Taniuchi S,Furumitsu M,Tachibana T,Bentley GE,Kriegsfeld LJ,Ukena K

    更新日期：2018-04-13 00:00:00

  • The transcription factor Ets21C drives tumor growth by cooperating with AP-1.

    abstract：:Tumorigenesis is driven by genetic alterations that perturb the signaling networks regulating proliferation or cell death. In order to block tumor growth, one has to precisely know how these signaling pathways function and interplay. Here, we identified the transcription factor Ets21C as a pivotal regulator of tumor g...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34725

    authors： Toggweiler J,Willecke M,Basler K

    更新日期：2016-10-07 00:00:00

  • Zika Virus Associated Pathology and Antigen Presence in the Testicle in the Absence of Sexual Transmission During Subacute to Chronic Infection in a Mouse Model.

    abstract：:Zika virus (ZIKV) is an arboviral infection that has been shown to be sexually transmitted. The study outlined herein aims to determine if accessory sex glands and epididymal epithelial cells are sources of viral persistence in subacute and chronic ZIKV infection, and if infection of these organs is important in sexua...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44582-9

    authors： Clancy CS,Van Wettere AJ,Morrey JD,Julander JG

    更新日期：2019-06-06 00:00:00

  • Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin.

    abstract：:Vitiligo is characterized by death or functional defects of epidermal melanocytes through still controversial pathogenic process. Previously, we showed that mitochondria-driven pre-senescent phenotype diminishes the capability of vitiligo melanocytes to cope with stressful stimuli. In the current study, we investigate...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13961-5

    authors： Dell'Anna ML,Ottaviani M,Kovacs D,Mirabilii S,Brown DA,Cota C,Migliano E,Bastonini E,Bellei B,Cardinali G,Ricciardi MR,Tafuri A,Picardo M

    更新日期：2017-10-20 00:00:00

  • The mechanical principles behind the golden ratio distribution of veins in plant leaves.

    abstract：:Tree leaves are commonly composed of thin mesophyll, carrying out photosynthesis under sunlight, and thick veins. Although the role of leaf veins in water transportation has been known for a long time, their role in providing structural support and guaranteeing large sunlighted area was rarely studied and remains elus...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31763-1

    authors： Sun Z,Cui T,Zhu Y,Zhang W,Shi S,Tang S,Du Z,Liu C,Cui R,Chen H,Guo X

    更新日期：2018-09-14 00:00:00

  • Optimization of Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Detection of Glutamine-FMOC Ad-Hoc Derivative by Central Composite Design.

    abstract：:Glutamine (Gln) is converted to excitatory (glutamate, aspartate) and inhibitory (γ-amino butyric acid) amino acid neurotransmitters in brain, and is a source of energy during glucose deprivation. Current research utilized an Analytical Quality by Design approach to optimize levels and combinations of critical gas pre...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64099-w

    authors： Bheemanapally K,Ibrahim MMH,Briski KP

    更新日期：2020-04-28 00:00:00

  • Graphdiyne as a promising material for detecting amino acids.

    abstract：:The adsorption of glycine, glutamic acid, histidine and phenylalanine on single-layer graphdiyne/graphene is investigated by ab initio calculations. The results show that for each amino acid molecule, the adsorption energy on graphdiyne is larger than the adsorption energy on graphene and dispersion interactions predo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16720

    authors： Chen X,Gao P,Guo L,Zhang S

    更新日期：2015-11-16 00:00:00

  • Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate.

    abstract：:Heparan sulfate (HS) is a polysaccharide known to modulate many important biological processes, including Wnt signaling. However, the biochemical interaction between HS and Wnt molecules is not well characterized largely due to the lack of suitable methods. To determine the Wnt binding domain in HS, we used a Wnt sign...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26245

    authors： Gao W,Xu Y,Liu J,Ho M

    更新日期：2016-05-17 00:00:00

  • First in situ evidence of wakes in the far field behind offshore wind farms.

    abstract：:More than 12 GW of offshore wind turbines are currently in operation in European waters. To optimise the use of the marine areas, wind farms are typically clustered in units of several hundred turbines. Understanding wakes of wind farms, which is the region of momentum and energy deficit downwind, is important for opt...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20389-y

    authors： Platis A,Siedersleben SK,Bange J,Lampert A,Bärfuss K,Hankers R,Cañadillas B,Foreman R,Schulz-Stellenfleth J,Djath B,Neumann T,Emeis S

    更新日期：2018-02-01 00:00:00

  • Amblyopia, Strabismus and Refractive Errors in Congenital Ptosis: a systematic review and meta-analysis.

    abstract：:Congenital ptosis may be associated with abnormalities of visual development and function, including amblyopia, strabismus and refractive errors. However, the prevalence estimates of these abnormalities vary widely. We performed a systematic review and meta-analysis to estimate the prevalence of amblyopia, strabismus ...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-018-26671-3

    authors： Wang Y,Xu Y,Liu X,Lou L,Ye J

    更新日期：2018-05-29 00:00:00

  • In-situ restoration of one-stage partial nitritation-anammox process deteriorated by nitrate build-up via elevated substrate levels.

    abstract：:The one-stage partial nitritation and anammox process (PN/A) has been a promising microbial process to remove ammonia from wastewater especially with low carbon/nitrogen ratio. The main breakdown was the deterioration caused by overgrowth of nitrite oxidizing bacteria (NOB) resulting effluent nitrate build-up in the P...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37500

    authors： Wang X,Gao D

    更新日期：2016-11-24 00:00:00

  • Immune interconnectivity of anatomically distant tumors as a potential mediator of systemic responses to local therapy.

    abstract：:Complex interactions occur between tumor and host immune system at each site in the metastatic setting, the outcome of which can determine behavior ranging from dormancy to rapid growth. An additional layer of complexity arises from the understanding that cytotoxic T cells can traffic through the host circulatory syst...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27718-1

    authors： Walker R,Poleszczuk J,Pilon-Thomas S,Kim S,Anderson AARA,Czerniecki BJ,Harrison LB,Moros EG,Enderling H

    更新日期：2018-06-21 00:00:00

  • Manipulation of Optical Transmittance by Ordered-Oxygen-Vacancy in Epitaxial LaBaCo2O5.5+δ Thin Films.

    abstract：:Giant optical transmittance changes of over 300% in wide wavelength range from 500 nm to 2500 nm were observed in LaBaCo2O5.5+δ thin films annealed in air and ethanol ambient, respectively. The reduction process induces high density of ordered oxygen vacancies and the formation of LaBaCo2O5.5 (δ = 0) structure evidenc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37496

    authors： Cheng S,Lu J,Han D,Liu M,Lu X,Ma C,Zhang S,Chen C

    更新日期：2016-11-23 00:00:00

  • VirB8-like protein TraH is crucial for DNA transfer in Enterococcus faecalis.

    abstract：:Untreatable bacterial infections caused by a perpetual increase of antibiotic resistant strains represent a serious threat to human healthcare in the 21(st) century. Conjugative DNA transfer is the most important mechanism for antibiotic resistance and virulence gene dissemination among bacteria and is mediated by a p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24643

    authors： Fercher C,Probst I,Kohler V,Goessweiner-Mohr N,Arends K,Grohmann E,Zangger K,Meyer NH,Keller W

    更新日期：2016-04-22 00:00:00

  • Intermittent Lactobacilli-containing Vaginal Probiotic or Metronidazole Use to Prevent Bacterial Vaginosis Recurrence: A Pilot Study Incorporating Microscopy and Sequencing.

    abstract：:Bacterial vaginosis (BV) is associated with HIV acquisition and adverse pregnancy outcomes. Recurrence after metronidazole treatment is high. HIV-negative, non-pregnant Rwandan BV patients were randomized to four groups (n = 17/group) after seven-day oral metronidazole treatment: behavioral counseling only (control), ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60671-6

    authors： van de Wijgert JHHM,Verwijs MC,Agaba SK,Bronowski C,Mwambarangwe L,Uwineza M,Lievens E,Nivoliez A,Ravel J,Darby AC

    更新日期：2020-03-03 00:00:00

  • Few basepairing-independent motifs in the apical half of the avian HBV ε RNA stem-loop determine site-specific initiation of protein-priming.

    abstract：:Hepadnaviruses, including human hepatitis B virus (HBV), replicate their tiny DNA genomes by protein-primed reverse transcription of a pregenomic (pg) RNA. Replication initiation as well as pgRNA encapsidation depend on the interaction of the viral polymerase, P protein, with the ε RNA element, featuring a lower and a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07657-z

    authors： Gajer M,Dörnbrack K,Rösler C,Schmid B,Beck J,Nassal M

    更新日期：2017-08-02 00:00:00

  • Field-programmable beam reconfiguring based on digitally-controlled coding metasurface.

    abstract：:Digital phase shifters have been applied in traditional phased array antennas to realize beam steering. However, the phase shifter deals with the phase of the induced current; hence, it has to be in the path of each element of the antenna array, making the phased array antennas very expensive. Metamaterials and/or met...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20663

    authors： Wan X,Qi MQ,Chen TY,Cui TJ

    更新日期：2016-02-10 00:00:00

  • Revealing Tumor Habitats from Texture Heterogeneity Analysis for Classification of Lung Cancer Malignancy and Aggressiveness.

    abstract：:We propose an approach for characterizing structural heterogeneity of lung cancer nodules using Computed Tomography Texture Analysis (CTTA). Measures of heterogeneity were used to test the hypothesis that heterogeneity can be used as predictor of nodule malignancy and patient survival. To do this, we use the National ...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-019-38831-0

    authors： Cherezov D,Goldgof D,Hall L,Gillies R,Schabath M,Müller H,Depeursinge A

    更新日期：2019-03-14 00:00:00

  • Author Correction: Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-56287-0

    authors： Wang J,Sun P,Chen Y,Yao H,Wang S

    更新日期：2019-12-19 00:00:00

  • Refining the genetic structure and relationships of European cattle breeds through meta-analysis of worldwide genomic SNP data, focusing on Italian cattle.

    abstract：:The availability of genotyping assays has allowed the detailed evaluation of cattle genetic diversity worldwide. However, these comprehensive studies did not include some local European populations, including autochthonous Italian cattle. In this study, we assembled a large-scale, genome-wide dataset of single nucleot...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71375-2

    authors： Mastrangelo S,Tolone M,Ben Jemaa S,Sottile G,Di Gerlando R,Cortés O,Senczuk G,Portolano B,Pilla F,Ciani E

    更新日期：2020-09-03 00:00:00

  • Monitoring of biofouling communities in a Portuguese port using a combined morphological and metabarcoding approach.

    abstract：:Marine biofouling remains an unsolved problem with a serious economic impact on several marine associated industries and constitutes a major vector for the spread of non-indigenous species (NIS). The implementation of biofouling monitoring programs allows for better fouling management and also for the early identifica...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70307-4

    authors： Azevedo J,Antunes JT,Machado AM,Vasconcelos V,Leão PN,Froufe E

    更新日期：2020-08-10 00:00:00