Foldamer-mediated manipulation of a pre-amyloid toxin.

abstract：:Polaritons are widely investigated quasiparticles with fundamental and technological significance due to their unique properties. They have been studied most extensively in semiconductors when photons interact with various elementary excitations. However, other strongly coupled excitations demonstrate similar dynamics...

journal_title：Nature communications

authors： Berk C,Jaris M,Yang W,Dhuey S,Cabrini S,Schmidt H

更新日期：2019-06-14 00:00:00

abstract：:Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ult...

journal_title：Nature communications

authors： Snaidero N,Schifferer M,Mezydlo A,Zalc B,Kerschensteiner M,Misgeld T

更新日期：2020-09-29 00:00:00

abstract：:The use of hyperpolarized agents in magnetic resonance, such as (13)C-labelled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarization technique is the inherently short spin-relaxation times, typically <60 ...

journal_title：Nature communications

authors： Rej E,Gaebel T,Boele T,Waddington DE,Reilly DJ

更新日期：2015-10-09 00:00:00

abstract：:Forests are of major importance to human society, contributing several crucial ecosystem services. Biodiversity is suggested to positively influence multiple services but evidence from natural systems at scales relevant to management is scarce. Here, across a scale of 400,000 km(2), we report that tree species richnes...

journal_title：Nature communications

authors： Gamfeldt L,Snäll T,Bagchi R,Jonsson M,Gustafsson L,Kjellander P,Ruiz-Jaen MC,Fröberg M,Stendahl J,Philipson CD,Mikusiński G,Andersson E,Westerlund B,Andrén H,Moberg F,Moen J,Bengtsson J

更新日期：2013-01-01 00:00:00

abstract：:Split spawning in coral populations occurs when gamete maturation and mass spawning are split over two consecutive months. While split spawning has been observed at many reefs, little is known about the frequency and significance of these events. Here we show that split spawning occurred frequently and predictably ove...

journal_title：Nature communications

authors： Foster T,Heyward AJ,Gilmour JP

更新日期：2018-02-19 00:00:00

abstract：:The ability to quickly spread a liquid across a surface and form a film is fundamental for a diverse range of technological processes, including printing, painting and spraying. Here we show that liquid dielectrophoresis or electrowetting can produce wetting on normally non-wetting surfaces, without needing modificati...

journal_title：Nature communications

authors： McHale G,Brown CV,Sampara N

更新日期：2013-01-01 00:00:00

abstract：:Planar neural networks and interfaces serve as versatile in vitro models of central nervous system physiology, but adaptations of related methods to three dimensions (3D) have met with limited success. Here, we demonstrate for the first time volumetric functional imaging in a bioengineered neural tissue growing in a t...

journal_title：Nature communications

authors： Dana H,Marom A,Paluch S,Dvorkin R,Brosh I,Shoham S

更新日期：2014-06-05 00:00:00

abstract：:Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53's invasive/migratory gain-of-function by incre...

journal_title：Nature communications

authors： Novo D,Heath N,Mitchell L,Caligiuri G,MacFarlane A,Reijmer D,Charlton L,Knight J,Calka M,McGhee E,Dornier E,Sumpton D,Mason S,Echard A,Klinkert K,Secklehner J,Kruiswijk F,Vousden K,Macpherson IR,Blyth K,Bailey P,

更新日期：2018-11-29 00:00:00

abstract：:Enantioenriched 1,4-dienes are versatile building blocks in asymmetric synthesis, therefore their efficient synthesis directly from chemical feedstock is highly sought after. Here, we show an enantioselective cross-hydroalkenylation of cyclic 1,3-diene and hetero-substituted terminal olefin by using a chiral [NHC-Ni(a...

journal_title：Nature communications

authors： Chen Y,Dang L,Ho CY

更新日期：2020-05-08 00:00:00

abstract：:Mesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing rel...

journal_title：Nature communications

authors： Condon MD,Platt NJ,Zhang YF,Roberts BM,Clements MA,Vietti-Michelina S,Tseu MY,Brimblecombe KR,Threlfell S,Mann EO,Cragg SJ

更新日期：2019-09-19 00:00:00

abstract：:The growth of large-domain single crystalline graphene with the controllable number of layers is of central importance for large-scale integration of graphene devices. Here we report a new pathway to greatly reduce the graphene nucleation density from ~10(6) to 4 nuclei cm(-2), enabling the growth of giant single crys...

journal_title：Nature communications

authors： Zhou H,Yu WJ,Liu L,Cheng R,Chen Y,Huang X,Liu Y,Wang Y,Huang Y,Duan X

更新日期：2013-01-01 00:00:00

abstract：:Surface and subsurface are commonly considered as separate entities because of the difference in the bonding environment and are often investigated separately due to the experimental challenges in differentiating the surface and subsurface effects. Using in-situ atomic-scale transmission electron microscopy to resolve...

journal_title：Nature communications

authors： Sun X,Zhu W,Wu D,Li C,Wang J,Zhu Y,Chen X,Boscoboinik JA,Sharma R,Zhou G

更新日期：2020-01-16 00:00:00

abstract：:Although chemically very simple, Fe2O3 is known to undergo a series of enigmatic structural, electronic and magnetic transformations at high pressures and high temperatures. So far, these transformations have neither been correctly described nor understood because of the lack of structural data. Here we report a syste...

journal_title：Nature communications

authors： Bykova E,Dubrovinsky L,Dubrovinskaia N,Bykov M,McCammon C,Ovsyannikov SV,Liermann HP,Kupenko I,Chumakov AI,Rüffer R,Hanfland M,Prakapenka V

更新日期：2016-02-11 00:00:00

abstract：:Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-α-induced killing while simultaneously blocking TNF-α growth-promoting activities. SMCs also regulate several immunomodulatory properties within immune cells. We report that SMCs synergize with innat...

journal_title：Nature communications

authors： Beug ST,Beauregard CE,Healy C,Sanda T,St-Jean M,Chabot J,Walker DE,Mohan A,Earl N,Lun X,Senger DL,Robbins SM,Staeheli P,Forsyth PA,Alain T,LaCasse EC,Korneluk RG

更新日期：2017-02-15 00:00:00

abstract：:Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcri...

journal_title：Nature communications

authors： Aramillo Irizar P,Schäuble S,Esser D,Groth M,Frahm C,Priebe S,Baumgart M,Hartmann N,Marthandan S,Menzel U,Müller J,Schmidt S,Ast V,Caliebe A,König R,Krawczak M,Ristow M,Schuster S,Cellerino A,Diekmann S,Englert C

更新日期：2018-01-30 00:00:00

abstract：:The main advantage of organic transistors with dual gates/bases is that the threshold voltages can be set as a function of the applied second gate/base bias, which is crucial for the application in logic gates and integrated circuits. However, incorporating a dual gate/base structure into an ultra-short channel vertic...

journal_title：Nature communications

authors： Guo E,Wu Z,Darbandy G,Xing S,Wang SJ,Tahn A,Göbel M,Kloes A,Leo K,Kleemann H

更新日期：2020-09-18 00:00:00

abstract：:Complex polyketides are typically associated with microbial metabolism. Here, we report that animals also make complex, microbe-like polyketides. We show there is a widespread branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan animals use to synthesize complex products. The...

journal_title：Nature communications

authors： Torres JP,Lin Z,Winter JM,Krug PJ,Schmidt EW

更新日期：2020-06-08 00:00:00

abstract：:Because of the potential impact on agriculture and other key human activities, efforts have been dedicated to the local control of precipitation. The most common approach consists of dispersing small particles of dry ice, silver iodide, or other salts in the atmosphere. Here we show, using field experiments conducted ...

journal_title：Nature communications

authors： Henin S,Petit Y,Rohwetter P,Stelmaszczyk K,Hao ZQ,Nakaema WM,Vogel A,Pohl T,Schneider F,Kasparian J,Weber K,Wöste L,Wolf JP

更新日期：2011-08-30 00:00:00

abstract：:Ultra-small, magic-sized metal nanoclusters represent an important new class of materials with properties between molecules and particles. However, their small size challenges the conventional methods for structure characterization. Here we present the structure of ultra-stable Au144(SR)60 magic-sized nanoclusters obt...

journal_title：Nature communications

authors： Jensen KM,Juhas P,Tofanelli MA,Heinecke CL,Vaughan G,Ackerson CJ,Billinge SJ

更新日期：2016-06-14 00:00:00

abstract：:Circadian rhythms are a nearly universal feature of living organisms and affect almost every biological process. Our innate preference for mornings or evenings is determined by the phase of our circadian rhythms. We conduct a genome-wide association analysis of self-reported morningness, followed by analyses of biolog...

journal_title：Nature communications

authors： Hu Y,Shmygelska A,Tran D,Eriksson N,Tung JY,Hinds DA

更新日期：2016-02-02 00:00:00

abstract：:Assembly of infectious influenza A viruses (IAV) is a complex process involving transport from the nucleus to the plasma membrane. Rab11A-containing recycling endosomes have been identified as a platform for intracellular transport of viral RNA (vRNA). Here, using high spatiotemporal resolution light-sheet microscopy ...

journal_title：Nature communications

authors： Bhagwat AR,Le Sage V,Nturibi E,Kulej K,Jones J,Guo M,Tae Kim E,Garcia BA,Weitzman MD,Shroff H,Lakdawala SS

更新日期：2020-01-07 00:00:00

abstract：:Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced levels of BRCA1, but not of other DNA repair factors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mi...

journal_title：Nature communications

authors： Suberbielle E,Djukic B,Evans M,Kim DH,Taneja P,Wang X,Finucane M,Knox J,Ho K,Devidze N,Masliah E,Mucke L

更新日期：2015-11-30 00:00:00

abstract：:Here we benchmark device-to-device variation in field-effect transistors (FETs) based on monolayer MoS2 and WS2 films grown using metal-organic chemical vapor deposition process. Our study involves 230 MoS2 FETs and 160 WS2 FETs with channel lengths ranging from 5 μm down to 100 nm. We use statistical measures to eval...

journal_title：Nature communications

authors： Sebastian A,Pendurthi R,Choudhury TH,Redwing JM,Das S

更新日期：2021-01-29 00:00:00

abstract：:Ultralow threshold nanolasers have been sought after as power efficient light sources in photonic integrated circuits. Here a single-cell nanobeam laser with a nanoisland quantum well is proposed and demonstrated. Continuous operation at 1.5 μm is achieved at room temperature with an ultralow lasing threshold of 210 n...

journal_title：Nature communications

authors： Jang H,Karnadi I,Pramudita P,Song JH,Kim KS,Lee YH

更新日期：2015-09-22 00:00:00

abstract：:Diversity-oriented synthesis (DOS) can provide a collection of diverse and complex drug-like small molecules, which is critical in the development of new chemical probes for biological research of undruggable targets. However, the design and synthesis of small-molecule libraries with improved biological relevance as w...

journal_title：Nature communications

authors： Kim J,Jung J,Koo J,Cho W,Lee WS,Kim C,Park W,Park SB

更新日期：2016-10-24 00:00:00

abstract：:Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2-7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer seeds revealing a preference for guanine in positions 1 and 2 and a high overall G or C content in the seed of the most toxic siRNAs for four ...

journal_title：Nature communications

authors： Gao QQ,Putzbach WE,Murmann AE,Chen S,Sarshad AA,Peter JM,Bartom ET,Hafner M,Peter ME

更新日期：2018-10-29 00:00:00

abstract：:Single chip integrated spectrometers are critical to bring chemical and biological sensing, spectroscopy, and spectral imaging into robust, compact and cost-effective devices. Existing on-chip spectrometer approaches fail to realize both high resolution and broad band. Here we demonstrate a microring resonator-assiste...

journal_title：Nature communications

authors： Zheng SN,Zou J,Cai H,Song JF,Chin LK,Liu PY,Lin ZP,Kwong DL,Liu AQ

更新日期：2019-05-28 00:00:00

abstract：:Ferroelectrics based on proton tautomerism are promising in low-field and above-room-temperature operations. Here seven organic ferroelectric crystals are examined to search for efficient switching of strong spontaneous polarization on proton tautomerism. Solution-grown crystals exhibit strong pinning of ferroelectric...

journal_title：Nature communications

authors： Horiuchi S,Kobayashi K,Kumai R,Ishibashi S

更新日期：2017-02-16 00:00:00

abstract：:Inorganic perovskites such as CsPbX3 (X=Cl, Br, I) have attracted attention due to their excellent thermal stability and high photoluminescence quantum efficiency. However, the electroluminescence quantum efficiency of their light-emitting diodes was <1%. We posited that this low efficiency was a result of high leakag...

journal_title：Nature communications

authors： Zhang L,Yang X,Jiang Q,Wang P,Yin Z,Zhang X,Tan H,Yang YM,Wei M,Sutherland BR,Sargent EH,You J

更新日期：2017-06-07 00:00:00

abstract：:Choroidal neovascularization (CNV) is a major cause of visual impairment in patients suffering from wet age-related macular degeneration (AMD), particularly when refractory to intraocular anti-VEGF injections. Here we report that treatment with the oral mineralocorticoid receptor (MR) antagonist spironolactone reduces...

journal_title：Nature communications

authors： Zhao M,Mantel I,Gelize E,Li X,Xie X,Arboleda A,Seminel M,Levy-Boukris R,Dernigoghossian M,Prunotto A,Andrieu-Soler C,Rivolta C,Canonica J,Naud MC,Lechner S,Farman N,Bravo-Osuna I,Herrero-Vanrell R,Jaisser F,Behar-Co

更新日期：2019-01-21 00:00:00