Part mutual information for quantifying direct associations in networks.

abstract：:Monovalent antibodies (Fab) directed to two classes of transformation-sensitive cell surface components, ganglioside and galactoprotein a (Gap a), inhibit the process of oncogenic viral transformation of cells. Mouse 3T3 cells infected with murine sarcoma virus were not transformed in terms of morphology change and en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lingwood CA,Ng A,Hakomori S

更新日期：1978-12-01 00:00:00

abstract：:Vascular endothelial cells (ECs) sense and respond to hemodynamic shear stress, which is critical for circulatory homeostasis and the pathophysiology of vascular diseases. The mechanisms of shear stress mechanotransduction, however, remain elusive. We previously demonstrated a direct role of mitochondria in the purine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto K,Nogimori Y,Imamura H,Ando J

更新日期：2020-12-29 00:00:00

abstract：:Voltage-dependent anion channels (VDACs) are pore-forming proteins (porins) that form the major pathway for movement of adenine nucleotides through the outer mitochondrial membrane. Electrophysiological studies indicate that VDAC-like channel activity is also prevalent in the cell membranes of many mammalian cells. Ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buettner R,Papoutsoglou G,Scemes E,Spray DC,Dermietzel R

更新日期：2000-03-28 00:00:00

abstract：:Filtration through the kidney eliminates toxins, manages electrolyte balance, and controls water homeostasis. Reabsorption of water from the luminal fluid of the nephron occurs through aquaporin-2 (AQP2) water pores in principal cells that line the kidney-collecting duct. This vital process is impeded by formation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whiting JL,Ogier L,Forbush KA,Bucko P,Gopalan J,Seternes OM,Langeberg LK,Scott JD

更新日期：2016-07-26 00:00:00

abstract：:Using an antiserum raised against a synthetic C-terminal peptide of porcine pancreastatin, we detected pancreastatin-like immunoreactivity (PLI) in human pancreatic islets, adrenal medulla, and endocrine tumors. From a carcinoid liver metastasis, human PLI was extracted and purified by HPLC. Two C-terminally amidated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt WE,Siegel EG,Kratzin H,Creutzfeldt W

更新日期：1988-11-01 00:00:00

abstract：:Cathepsin B (CTSB) is overexpressed in tumors of the lung, prostate, colon, breast, and stomach. However, evidence of primary genomic alterations in the CTSB gene during tumor initiation or progression has been lacking. We have found a novel amplicon at 8p22-23 that results in CTSB overexpression in esophageal adenoca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes SJ,Glover TW,Zhu XX,Kuick R,Thoraval D,Orringer MB,Beer DG,Hanash S

更新日期：1998-10-13 00:00:00

abstract：:Using short-term cultures of hamster embryo cells, we have examined the effects of the free-radical scavenger superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) and the enzyme catalase (hydrogen-peroxide:hydrogenperoxide oxidoreductase, EC 1.11.1.6) on x-ray- and bleomycin-induced transformation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borek C,Troll W

更新日期：1983-03-01 00:00:00

abstract：:Dense granules of platelets contain a high content of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A). We have previously demonstrated an antithrombotic effect of this compound in a live rabbit model. In the present study we find that certain synthetic Ap4A analogues are superior to Ap4A in inhibiting ADP-induced aggr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamecnik PC,Kim B,Gao MJ,Taylor G,Blackburn GM

更新日期：1992-03-15 00:00:00

abstract：:The usual way to compute Hartree-Fock type functions for molecules is by an expansion of the one-electron functions (molecular orbitals) in a linear combination of analytical functions (LCAO-MO-SCF, linear combination of atomic orbitals-Molecular Orbital-Self Consistent field). The expansion coefficients are obtained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clementi E

更新日期：1972-10-01 00:00:00

abstract：:Morphine produces analgesia at opiate receptors expressed in nociceptive circuits. mu, delta, and kappa opiate receptor subtypes are expressed in circuits that can modulate nociception and receive inputs from endogenous opioid neuropeptide ligands. The roles played by each receptor subtype in nociceptive processing in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sora I,Takahashi N,Funada M,Ujike H,Revay RS,Donovan DM,Miner LL,Uhl GR

更新日期：1997-02-18 00:00:00

abstract：:Goblet cell metaplasia and mucus hypersecretion are observed in many pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. However, the regulation of goblet cell differentiation remains unclear. Here, we identify a regulator of this process in an N-ethyl-N-nitrosourea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim HT,Yin W,Nakamichi Y,Panza P,Grohmann B,Buettner C,Guenther S,Ruppert C,Kobayashi Y,Guenther A,Stainier DYR

更新日期：2019-12-17 00:00:00

abstract：:This paper reports the results of a large-scale field experiment designed to test the hypothesis that group membership can increase participation and prosocial lending for an online crowdlending community, Kiva. The experiment uses variations on a simple email manipulation to encourage Kiva members to join a lending t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ai W,Chen R,Chen Y,Mei Q,Phillips W

更新日期：2016-12-27 00:00:00

abstract：:Synthetic genes for human insulin A and B chains were cloned separately in plasmid pBR322. The cloned synthetic genes were then fused to an Escherichia coli beta-galactosidase gene to provide efficient transcription and translation and a stable precursor protein. The insulin peptides were cleaved from beta-galactosida...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goeddel DV,Kleid DG,Bolivar F,Heyneker HL,Yansura DG,Crea R,Hirose T,Kraszewski A,Itakura K,Riggs AD

更新日期：1979-01-01 00:00:00

abstract：:Sleep is recognized as a physiological state associated with learning, with studies showing that knowledge acquisition improves with naps. Little work has examined sleep-dependent learning in people with developmental disorders, for whom sleep quality is often impaired. We examined the effect of natural, in-home naps ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spanò G,Gómez RL,Demara BI,Alt M,Cowen SL,Edgin JO

更新日期：2018-11-13 00:00:00

abstract：:Excited electronic states created by UV excitation of the diribonucleoside monophosphates ApA, ApG, ApC, ApU, and CpG were studied by the femtosecond transient-absorption technique. Bleach recovery signals recorded at 252 nm show that long-lived excited states are formed in all five dinucleosides. The lifetimes of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takaya T,Su C,de La Harpe K,Crespo-Hernández CE,Kohler B

更新日期：2008-07-29 00:00:00

abstract：:The his4 region of yeast contains the information necessary for the catalysis of three steps in the histidine biosynthetic pathway. The three activities specified by this region remain physically associated during gel filtration and ultracentrifugation and after extensive purification. Nonsense mutations in the "opera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaffer B,Rytka J,Fink GR

更新日期：1969-08-01 00:00:00

abstract：:Ultraviolet irradiation of the [3H]colchicine-tubulin complex leads to direct photolabeling of tubulin with low but practicable efficiency. The bulk (70% to greater than 90%) of the labeling occurs on beta-tubulin and appears early after irradiation, whereas alpha-tubulin is labeled later. The labeling ratio of beta-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolff J,Knipling L,Cahnmann HJ,Palumbo G

更新日期：1991-04-01 00:00:00

abstract：:Some monoclonal antibodies (mAbs) against interleukin (IL) 1 alpha have been found to activate antigen-presenting cells (APC, human peripheral blood monocytes and B lymphocytes), so that unstimulated T lymphocytes cultured with them are induced to proliferate and secrete IL-2. Control mAbs of the same isotypes and mAb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eugui EM,Almquist SJ

更新日期：1990-02-01 00:00:00

abstract：:A detailed phenomenology of low energy excitations is a crucial starting point for microscopic understanding of complex materials, such as the cuprate high-temperature superconductors. Because of its unique momentum-space discrimination, angle-resolved photoemission spectroscopy (ARPES) is ideally suited for this task...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vishik IM,Hashimoto M,He RH,Lee WS,Schmitt F,Lu D,Moore RG,Zhang C,Meevasana W,Sasagawa T,Uchida S,Fujita K,Ishida S,Ishikado M,Yoshida Y,Eisaki H,Hussain Z,Devereaux TP,Shen ZX

更新日期：2012-11-06 00:00:00

abstract：:Tau is a highly soluble protein, yet it aggregates abnormally in Alzheimer's disease. Here, we address the question of proteolytic processing of tau and the nucleation of aggregates by tau fragments. We show in neuronal cell models that fragments of the repeat domain of tau containing mutations of FTDP17 (frontotempor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang YP,Biernat J,Pickhardt M,Mandelkow E,Mandelkow EM

更新日期：2007-06-12 00:00:00

abstract：:Chromosome 14 allelic loss is common in nasopharyngeal carcinoma (NPC) and may reflect essential tumor suppressor gene loss in tumorigenesis. An intact chromosome 14 was transferred to an NPC cell line using a microcell-mediated chromosome transfer approach. Microcell hybrids (MCHs) containing intact exogenously trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung AK,Lung HL,Ko JM,Cheng Y,Stanbridge EJ,Zabarovsky ER,Nicholls JM,Chua D,Tsao SW,Guan XY,Lung ML

更新日期：2009-08-25 00:00:00

abstract：:Bacteriophage Mu replicates as a transposable element, exploiting host enzymes to promote initiation of DNA synthesis. The phage-encoded transposase MuA, assembled into an oligomeric transpososome, promotes transfer of Mu ends to target DNA, creating a fork at each end, and then remains tightly bound to both forks. In...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakai H,Doseeva V,Jones JM

更新日期：2001-07-17 00:00:00

abstract：:Despite the proclamation of Lowenstam and Weiner that crustaceans are the "champions of mineral mobilization and deposition of the animal kingdom," relatively few proteins from the two main calcification sites in these animals, i.e., the exoskeleton and the transient calcium storage organs, have been identified, seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shechter A,Glazer L,Cheled S,Mor E,Weil S,Berman A,Bentov S,Aflalo ED,Khalaila I,Sagi A

更新日期：2008-05-20 00:00:00

abstract：:Docosahexaenoic acid (DCHA), a major polyunsaturated acid component of fish lipid, is not a substrate for prostaglandin synthetase from ram seminal vesicles but is a strong competitive inhibitor (Ki, 0.36 microM) of the conversion by this enzyme of arachidonate (Km, 5.9 microM) to prostaglandins. In contrast, DCHA exh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corey EJ,Shih C,Cashman JR

更新日期：1983-06-01 00:00:00

abstract：:Gene amplification may be visualized within a chromosome as a homogeneously stained region (HSR) and HSRs have rarely been reported in human tumor cells with identification of the amplified gene. A parental line and seven clones derived from KB cells resistant to methotrexate (MTX) contain dihydrofolate reductase (DHF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolman SR,Craven ML,Grill SP,Domin BA,Cheng YC

更新日期：1983-02-01 00:00:00

abstract：:Infants born prematurely risk significant life-long cognitive disability, representing a major pediatric health crisis. The neuropathology of this cohort is accurately modeled in mice subjected to sublethal postnatal hypoxia. Massively parallel transcriptome analysis using cDNA microchips (9,262 genes), combined with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curristin SM,Cao A,Stewart WB,Zhang H,Madri JA,Morrow JS,Ment LR

更新日期：2002-11-26 00:00:00

abstract：:Surface proteins of mouse thymus and spleen cells were radioiodinated with lactoperoxidase. After solubilization, the labeled proteins were precipitated by antibodies directed against mouse immunoglobulin chains; the precipitates were analyzed by radioautography after Na dodecyl sulfate-gel electrophoresis. Radioactiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lisowska-Bernstein B,Rinuy A,Vassalli P

更新日期：1973-10-01 00:00:00

abstract：:Inflammation is a hallmark of many diseases, such as atherosclerosis, chronic obstructive pulmonary disease, arthritis, infectious diseases, and cancer. Although steroids and cyclooxygenase inhibitors are effective antiinflammatory therapeutical agents, they may cause serious side effects. Therefore, developing unique...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeon KI,Xu X,Aizawa T,Lim JH,Jono H,Kwon DS,Abe J,Berk BC,Li JD,Yan C

更新日期：2010-05-25 00:00:00

abstract：:The massive forests of central Amazonia are often considered relatively resilient against climatic variation, but this view is challenged by the wildfires invoked by recent droughts. The impact of such fires that spread from pervasive sources of ignition may reveal where forests are less likely to persist in a drier f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores BM,Holmgren M,Xu C,van Nes EH,Jakovac CC,Mesquita RCG,Scheffer M

更新日期：2017-04-25 00:00:00

abstract：:Meiosis-specific homologs of RecA protein have been identified in Saccharomyces cerevisiae and higher eukaryotes including mammals, but their enzymatic activities have not been described. We have purified the human protein HsDmc1 produced in Escherichia coli from a cloned copy of the cDNA. The recombinant enzyme had D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Golub EI,Gupta R,Radding CM

更新日期：1997-10-14 00:00:00