Abstract:
:The response of olfactory receptor neurons to odor mixtures is not well understood. Here, using experimental constraints, we investigate the mathematical structure of the odor response space and its consequences. The analysis suggests that the odor response space is 3-dimensional, and predicts that the dose-response curve of an odor receptor can be obtained, in most cases, from three primary components with specific properties. This opens the way to an objective procedure to obtain specific olfactory receptor responses by manipulating mixtures in a mathematically predictable manner. This result is general and applies, independently of the number of odor components, to any olfactory sensory neuron type with a response curve that can be represented as a sigmoidal function of the odor concentration.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Marasco A,De Paris A,Migliore Mdoi
10.1038/srep24091subject
Has Abstractpub_date
2016-04-07 00:00:00pages
24091issn
2045-2322pii
srep24091journal_volume
6pub_type
杂志文章abstract::The SELEX (Systematic Evolution of Ligands by EXponential enrichment) method has been used successfully since 1990, but work is still required to obtain highly specific aptamers. Here, we present a novel approach called 'Competitive non-SELEX' (and termed as 'SELCOS' (Systematic Evolution of Ligands by COmpetitive Sel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43187-6
更新日期:2019-04-30 00:00:00
abstract::The recent rise of multidrug resistant microbial strains requires development of new and novel therapeutic alternatives. In this study, we present a novel antibacterial system that comprises of modified naturally abundant antimicrobial peptides in conjugation with silver nanoparticles. Further, we propose a simple rou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41005-7
更新日期:2019-03-14 00:00:00
abstract::Kyoto probe 1 (KP-1) rapidly distinguishes between human ES/iPS (hES/iPS) cells and their differentiated cells. Recently, we generated induced tissue-specific stem cells from pancreas (iTS-P cells) using reprogramming factors and tissue-specific selection. The iTS-P cells have self-renewal potential, and subcutaneousl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75016-6
更新日期:2020-10-22 00:00:00
abstract::A dual mode rare-earth based vanadate material (YVO4: Ho3+/Yb3+), prepared through ethylene glycol assisted hydrothermal method, demonstrating both downconversion and upconversion, along with systematic investigation of the luminescence spectroscopy within 12-300 K is presented herein. The energy transfer processes ha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36342
更新日期:2016-11-02 00:00:00
abstract::Cytological and molecular studies have revealed that inversion chromosomal polymorphism is widespread across taxa and that inversions are among the most common structural changes fixed between species. Two major mechanisms have been proposed for the origin of inversions considering that breaks occur at either repetiti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53582-8
更新日期:2019-11-18 00:00:00
abstract::Drug resistance is one of the leading causes of failed cancer therapy in the treatment of acute myeloid leukemia. Although the mechanisms of resistance are poorly understood, they may be related to the presence of leukemia stem cells (LSCs). Down-regulation of the miR-203 reportedly contributes to oncogenesis and chem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19995
更新日期:2016-02-05 00:00:00
abstract::In this paper, we analyze the synchronization problem of master-slave probabilistic Boolean networks (PBNs). The master Boolean network (BN) is a deterministic BN, while the slave BN is determined by a series of possible logical functions with certain probability at each discrete time point. In this paper, we firstly ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13437
更新日期:2015-08-28 00:00:00
abstract::Advanced glycation end-products (AGEs)-induced mesangial cell death is one of major causes of glomerulus dysfunction in diabetic nephropathy. Both endoplasmic reticulum (ER) stress and autophagy are adaptive responses in cells under environmental stress and participate in the renal diseases. The role of ER stress and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34167
更新日期:2016-09-26 00:00:00
abstract::This study uses retrospective forecasts made using an APEC Climate Center seasonal forecast model to investigate the cause of errors in predicting the amplitude of El Niño Southern Oscillation (ENSO)-driven sea surface temperature variability. When utilizing Bjerknes coupled stability (BJ) index analysis, enhanced err...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05221-3
更新日期:2017-07-20 00:00:00
abstract::The inactivation of pathogens in liquids has broad applications, ranging from water disinfection to food pasteurization. However, common cell inactivation methods (e.g., chlorination, ultraviolet radiation and thermal treatment) have significant drawbacks such as carcinogenic byproduct formation, energy intensiveness ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34027-0
更新日期:2018-10-25 00:00:00
abstract::High-pressure Raman spectroscopy and x-ray diffraction of Sb2S3 up to 53 GPa reveals two phase transitions at 5 GPa and 15 GPa. The first transition is evidenced by noticeable compressibility changes in distinct Raman-active modes, in the lattice parameter axial ratios, the unit cell volume, as well as in specific int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24246
更新日期:2016-04-06 00:00:00
abstract::Monocytes/macrophages have been found to be an important component of colitis. However, the key chemokine that initiates the CCR2+ monocytes migration from circulation to colitis tissue remains to be undiscovered. PC3-secreted microprotein (PSMP) is a novel chemokine whose receptor is CCR2. The physiological and patho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05255-7
更新日期:2017-07-11 00:00:00
abstract::Up to 90% of people with neurological deficits following whiplash injury report chronic symptoms. A recent unique study of neck-specific exercise showed positive results (post-intervention at 12 weeks), regarding arm pain and neurological deficits in people with chronic whiplash associated disorders (WAD). This 1-year...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-62722-4
更新日期:2020-04-21 00:00:00
abstract::Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 week...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27782
更新日期:2016-06-09 00:00:00
abstract::Phlebotomine sand flies are remarkable vectors of several etiologic agents (virus, bacterial, trypanosomatid Leishmania), posing a heavy health burden for human populations mainly located at developing countries. Their intestinal microbiota is involved in a wide range of biological and physiological processes, and cou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53769-z
更新日期:2019-11-28 00:00:00
abstract::Sacrospinous ligament fixation (SSLF) is one of the most utilized surgeries in the management of pelvic organ prolapse (POP). We conducted a large-series study of SSLF in a tertiary center by an experienced urogynecologic team. The 453 women with POP who underwent SSLF at National Taiwan University Hospital in the per...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61995-z
更新日期:2020-03-19 00:00:00
abstract::There are more than 2300 genes that are predominantly expressed in mouse testes. The role of hundreds of these genes has been studied in mouse spermatogenesis but still there are many genes whose function is unknown. Gene knockout (KO) strategy in mice is widely used for in vivo study of gene function. The present stu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23176-x
更新日期:2018-03-21 00:00:00
abstract::This is the first study to investigate the impact of a second fibula flap or a soft tissue flap combined with bridging plate for a repeated segmental mandibulectomy reconstruction on flap outcomes in head and neck cancer patients. A retrospective comparative analysis (2007-2016) of 61 patients who underwent a second s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44467-x
更新日期:2019-05-28 00:00:00
abstract::Maximal rate of heart rate (HR) increase (rHRI) as a measure of HR acceleration during the transition from rest to exercise, or during an increase in workload, tracks exercise performance. rHRI assessed at relative rather than absolute workloads may track performance better, and a field test would increase applicabili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71597-4
更新日期:2020-09-03 00:00:00
abstract::Coleoid cephalopods have an elaborate camera eye whereas nautiloids have primitive pinhole eye without lens and cornea. The Nautilus pinhole eye provides a unique example to explore the module of lens formation and its evolutionary mechanism. Here, we conducted an RNA-seq study of developing eyes of Nautilus and pygmy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01432
更新日期:2013-01-01 00:00:00
abstract::Repeated cycles of post-remission high-dose cytarabine (Ara-C) have been suggested to improve survival in core binding factor (CBF) acute myeloid leukaemia (AML). High-dose Ara-C used for induction regimens has also been reported to be associated with increased treatment-related mortality (TRM). Few data are available...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57414-y
更新日期:2020-01-20 00:00:00
abstract::Effective promotion of air filtration applications proposed for fibers requires their real nanoscale diameter, optimized pore structure, and high service strength; however, creating such filter medium has proved to be a tremendous challenge. This study first establishes a strategy to design and fabricate novel poly(m-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40550
更新日期:2017-01-11 00:00:00
abstract::A brain-computer interface (BCI) or brain-machine interface is a technology that enables the control of a computer and other external devices using signals from the brain. This technology has been tested in paralysed patients, such as those with cervical spinal cord injuries or amyotrophic lateral sclerosis, but it ha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20125-6
更新日期:2018-01-29 00:00:00
abstract::We have previously demonstrated that the Thymus algeriensis and Thymus fontanesii extracts have powerful anti-inflammatory, antipyretic, and analgesic effects against acute pain models. We profiled their chemical composition and found many phenolic acids, flavonoids, and phenolic diterpenes. In this work, we investiga...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77424-0
更新日期:2020-11-25 00:00:00
abstract::The airways of individuals with cystic fibrosis (CF) are abundantly colonised by Staphylococcus aureus and Pseudomonas aeruginosa. Co-infecting hypoxic regions of static mucus within CF airways, together with decreases in pulmonary function, mucus plugging and oxygen consumption by host neutrophils gives rise to regio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42952-x
更新日期:2019-05-01 00:00:00
abstract::In this report, we investigate the stabilization of saddle fixed points in coupled oscillators where individual oscillators exhibit the saddle fixed points. The coupled oscillators may have two structurally different types of suppressed states, namely amplitude death and oscillation death. The stabilization of saddle ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45909
更新日期:2017-04-05 00:00:00
abstract::The Great East Japan Earthquake on 11 March 2011, caused the release of radioactive materials from the Fukushima Daiichi Nuclear Power Plant (FDNPP), contaminating eastern Japan, particularly in part of Fukushima Prefecture. In 2012 and 2014, the radiocaesium concentration in brown rice did not exceed regulatory level...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20386
更新日期:2016-02-04 00:00:00
abstract::Stevia is a natural source of commercially important steviol glycosides (SGs), which share biosynthesis route with gibberellic acids (GAs) through plastidal MEP and cytosolic MVA pathways. Ontogeny-dependent deviation in SGs biosynthesis is one of the key factor for global cultivation of Stevia, has not been studied a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12025-y
更新日期:2017-09-19 00:00:00
abstract::Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quorum sensing system, and a poorly defined post-exponential growth phase...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14110-8
更新日期:2017-10-23 00:00:00
abstract::Whole-slide imaging of histologic sections captures tissue microenvironments and cytologic details in expansive high-resolution images. These images can be mined to extract quantitative features that describe tissues, yielding measurements for hundreds of millions of histologic objects. A central challenge in utilizin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15092-3
更新日期:2017-11-06 00:00:00