Abstract：
FOCUSED QUESTION:What is the clinical influence of probiotics as an adjunctive therapy of scaling and root planing (SRP) when compared with SRP alone or in combination with placebo in the treatment of chronic periodontitis (CP). METHODS:Electronic databases were searched up to July 2015. Randomized controlled trials (RCTs) comparing SRP + probiotic versusSRP were included. PPD reduction and CAL gain were selected as primary outcome variables. RESULTS:Independent screening resulted in four eligible publications for the systematic review and three were included in the meta-analysis. Meta-analysis showed a statistically significant CAL gain (-0.42 mm, p = 0.002) and bleeding on probing (BOP) reduction (-14.66, p = 0.003) for SRP + probiotic treatment versusSRP at short-term. Only a tendency (p = 0.06) has been observed in terms of overall PPD reduction, whereas results were significant when stratified for moderate (-0.18, p = 0.001) and deep pockets (-0.67, p < 0.001). CONCLUSION:Within the limitations of this study, the findings of this meta-analysis seem to support the adjunctive use of L. reuteri to SRP in CP treatment at short-term, especially in deep pockets. Heterogeneity and limited available data may reduce the impact of these conclusions. Future long-term RCTs evaluating the clinical efficacy of adjunctive probiotics to SRP are needed.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Martin-Cabezas R,Davideau JL,Tenenbaum H,Huck Odoi
10.1111/jcpe.12545subject
Has Abstractpub_date
2016-06-01 00:00:00pages
520-30issue
6eissn
0303-6979issn
1600-051Xjournal_volume
43pub_type
杂志文章,meta分析,评审abstract：AIM:The objective of this literature review and subsequent case report is to discuss and illustrate the tunnel preparation procedure as a treatment alternative for furcation-involved molars. REVIEW OF THE LITERATURE:Furcation tunnel preparation, i.e., the creation of access for plaque control between periodontally dis...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
abstract：:In a previous experimental gingivitis study, it was shown that in children with Down's syndrome (DS), gingival inflammation started earlier, was more extensive and developed faster, than in normal healthy control children. In both groups, the start of the process was accompanied by an acute inflammatory response and a...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1988.tb01588.x
更新日期：1988-05-01 00:00:00
abstract：:The purpose of this cross-sectional epidemiological study was to determine the prevalence of pathologic tooth migration (PTM) among periodontal patients and to investigate the relationship and degree of association between PTM and the following factors: bone loss, tooth loss, gingival inflammation according to the gin...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1997.tb00217.x
更新日期：1997-07-01 00:00:00
abstract：AIM:The objective of this prospective study was to assess clinical and patient-centred outcomes of aesthetic crown lengthening surgery for the treatment of altered passive eruption. MATERIALS AND METHODS:Twenty-two patients were treated and followed up for 6 months. The evaluated clinical parameters included, among ot...
journal_title：Journal of clinical periodontology
pub_type：
doi：10.1111/jcpe.12482
更新日期：2015-12-01 00:00:00
abstract：:Individual sites with gain and loss of probing attachment were identified amongst 1688 proximal sites in non-molar teeth from 49 patients monitored for 24 months following oral hygiene instruction and root debridement. The distribution of sites with gain and loss of probing attachment was studied within each of the 49...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1987.tb01548.x
更新日期：1987-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate long-term (24 weeks) alveolar bone maturation following surgical application of recombinant human growth/differentiation factor-5 (rhGDF-5) in an injectable poly-lactide-co-glycolide-acid (PLGA) composite carrier using an established periodontal defect model. METHODS:Rou...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2012.01868.x
更新日期：2012-06-01 00:00:00
abstract：:13 patients with untreated adult periodontitis (AP) were compared to 8 subjects free of periodontal disease (H) with respect to plaque index (PlI), gingival index (GI), probing depth (PD) and differential counts of subgingival bacterial morphotypes from a pooled sample of 6 surfaces with the greatest probing depth. Se...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1986.tb00878.x
更新日期：1986-09-01 00:00:00
abstract：OBJECTIVES:The purpose of this article is to provide the necessary background and rationale for the accompanying studies, which are ultimately aimed at identifying genetic and environmental factors determining gingivitis susceptibility. MATERIALS AND METHODS:The literature on factors reported to modify the clinical ex...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-051x.2004.00477.x
更新日期：2004-04-01 00:00:00
abstract：:This study examines the incidence and severity of postoperative pain after gingivectomy using one non-eugenol-containing periodontal dressing, Coe-pak (n = 76) and 2 eugenol-containing periodontal dressings, Wondrpak (n = 64) and Nobetec (n = 86). All patients were subjected to gingivectomy using 1 type of local anaes...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-051x.1990.tb00028.x
更新日期：1990-07-01 00:00:00
abstract：OBJECTIVE:This paper reports a meta-analysis of studies that have investigated the effect of scaling and root planing on periodontal probing depth and attachment loss. MATERIAL AND METHODS:The criteria used for inclusion of studies were as follows: root planing and scaling alone was one of the primary treatment arms; ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,meta分析
doi：10.1034/j.1600-051x.2002.291102.x
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND/AIMS:There is little information about the occurrence and risk indicators for periodontal diseases in Latin America. The present study describes the prevalence, extent and severity of periodontal probing depth (PPD) and assesses the association between demographic, behavioural and environmental risk indicato...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2005.00637.x
更新日期：2005-02-01 00:00:00
abstract：:The polymorphonuclear neutrophil (PMN) appears to be an important cell in the protection of the host from pathogenic periodontal microorganisms and, despite some reports to the contrary, it is generally assumed that early-onset forms of periodontal disease (including both juvenile and rapidly progressing periodontitis...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1994.tb00300.x
更新日期：1994-03-01 00:00:00
abstract：OBJECTIVES:This retrospective study described the pattern of bone loss around teeth with endodontic posts in periodontitis patients, and compared it with contra-lateral teeth without posts. MATERIAL AND METHODS:From full-mouth radiographic surveys of 146 periodontitis patients (> or =35 years), 194 roots with endodont...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2009.01465.x
更新日期：2009-11-01 00:00:00
abstract：AIM:This study analysed the status of DNA methylation in the promoter region of the IL8 gene in oral mucosa cells from healthy, smoker and non-smoker subjects with chronic periodontitis and compared these findings among groups with mRNA levels. MATERIAL AND METHODS:Genomic DNA from epithelial oral cells of 41 healthy ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2009.01446.x
更新日期：2009-09-01 00:00:00
abstract：:116 subjects were recruited from a population of patients previously treated for adult periodontitis and maintained in periodontal health by means of periodic prophylaxes every 3-6 months. The subjects were divided into a control (C) and a test (T) group. A total of 33 patients in the T group and 47 in the C group com...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1989.tb01622.x
更新日期：1989-02-01 00:00:00
abstract：:The present study was performed to assess the effect of topical metronidazole therapy on ligature-induced periodontitis in beagle dogs. 6 beagle dogs with experimentally-induced periodontitis on the mandibular 2nd, 3rd and 4th premolars were treated with metronidazole 10% dental paste 2 x daily for 4 weeks in an open ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1992.tb02532.x
更新日期：1992-10-01 00:00:00
abstract：AIM:Comparison of regenerative therapy of infrabony defects with and without administration of postsurgical systemic doxycycline (DOXY). METHODS:In each of 61 patients one infrabony defect was treated with enamel matrix derivative (EMD), EMD plus filler or membrane at two centres. By random assignment patients receive...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2012.01861.x
更新日期：2012-05-01 00:00:00
abstract：:A case of juvenile periodontitis is described where biopsy material taken from a lower right incisor during periodontal surgery revealed plaque-derived bacteria present within the periodontal connective tissue. The gingival connective tissue contained an inflammatory infiltrate which exhibited a profound loss of colla...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1982.tb01225.x
更新日期：1982-01-01 00:00:00
abstract：AIM:This study evaluated possible effects of smoking and gingival inflammation on salivary antioxidants in gingivitis patients. METHODS:Twenty otherwise healthy gingivitis patients (10 self-reported smokers) and 20 periodontally and systemically healthy volunteer subjects were enrolled in the study. Whole saliva sampl...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2006.00892.x
更新日期：2006-03-01 00:00:00
abstract：AIM:The purpose of this retrospective case series study was to evaluate the usefulness and performance of a comprehensive approach to assigning periodontal prognosis by assessing the risk of tooth loss due to periodontal disease (TLPD) and estimate the survival time (ST) of periodontally compromised teeth (PCT). MATER...
journal_title：Journal of clinical periodontology
pub_type：
doi：10.1111/jcpe.12857
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Current interest in the assessment of probing attachment level measurements has been stimulated by recent introduction of novel periodontal probes as well as by the reclassification of periodontal diseases. Clinical attachment level (CAL) is currently the "gold standard" for diagnosing and monitoring periodo...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.0303-6979.2004.00464.x
更新日期：2004-03-01 00:00:00
abstract：AIMS:The aims of this study were to evaluate the effect of mechanical periodontal treatment with local application of minocycline (APT) on serum adiponectin as a marker of insulin resistance improvement in type 2 diabetes mellitus (T2DM) patients and to investigate if effect of APT on serum adiponectin level was sustai...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2008.01359.x
更新日期：2009-02-01 00:00:00
abstract：AIM:The aim of this study was to test whether or not soft tissue augmentation with a collagen matrix (VCMX) leads to a similar increase in ridge width around dental implants compared to the use of an autogenous subepithelial connective tissue graft (SCTG). MATERIALS AND METHODS:In 12 dogs, immediate dental implants we...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12635
更新日期：2017-02-01 00:00:00
abstract：:Application of standard statistical procedures to site-specific data in periodontal research is invalid unless site-to-site dependencies are accounted for. In this paper, we present the adjustments required for valid application of matched pair procedures, including the paired t-test and McNemar's chi 2 test for corre...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1991.tb00068.x
更新日期：1991-11-01 00:00:00
abstract：:An experimental study was designed to compare the claimed antibacterial effect of Betadine and Blend-a-med Fluid with the known plaque growth inhibiting effect of a 0.2% aqueous solution of chlorhexidine digluconate (Hibitane). Before the test perios for 5 days. During the following week they cleaned their teeth mecha...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1976.tb00038.x
更新日期：1976-11-01 00:00:00
abstract：BACKGROUND/AIMS:Periodontal infections with Actinobacillus actinomycetemcomitans seem to be refractory to conventional therapy. The aim of the present study was to test the in vitro susceptibilities of A. actinomycetemcomitans strains to a panel of seven orally administrable antibiotics. METHODS:A total of 60 isolates...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2002.290810.x
更新日期：2002-08-01 00:00:00
abstract：:The oral features of a patient with notable maxillary and mandibular gingival enlargement secondary to leukaemic infiltration in chronic lymphocyte leukaemia are presented. ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1994.tb01173.x
更新日期：1994-09-01 00:00:00
abstract：:The aim of the present study was to examine the dental status and smoking habits in randomized samples of 35-, 50-, 65-, and 75-year-old subjects (n = 1093), recruited for a cross-sectional epidemiological study in the County of Värmland, Sweden. The following clinical variables were recorded by 4 well-calibrated dent...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1998.tb02444.x
更新日期：1998-04-01 00:00:00
abstract：:Both transforming growth factor-beta (TGF-beta) and platelet-derived growth factor (PDGF) have been shown to affect cell proliferation in vitro. The hypothesis being tested was that the effects of the 2 cytokines would be modulated by the presence of serum in the medium. Gingival fibroblasts, obtained from periodontal...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1998.tb02363.x
更新日期：1998-01-01 00:00:00
abstract：AIM:To assess the effectiveness and clinical performance of early implant placement, 4-8 (Type 2) or 12-16 weeks (Type 3) after extraction, in single anterior sites. METHODS:Studies reporting on Type 2 and Type 3 implant placement were identified. Findings were summarized in evidence tables. Main outcome was implant s...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13092
更新日期：2019-06-01 00:00:00
