Angiogenic mechanisms of human dental pulp and their relationship with substance P expression in response to occlusal trauma.

Abstract:

:Angiogenesis is the formation of new blood vessels based on a pre-existing vasculature. It comprises two processes, sprouting of endothelial cells and the division of vessels due to abnormal growth of the microvasculature. It has been demonstrated that substance P (SP) can induce angiogenesis either by modulating endothelial cell growth (direct mechanism) or by attracting cells with angiogenic potential to the injury site (indirect mechanism). Therefore, the purpose of this article is to review the angiogenic mechanisms that regulate mineralized tissue formation in human dental pulp tissue and their relationship with SP expression as a defence response to stimuli such as the masticatory function and occlusal trauma. Articles included in this review were searched in PubMed, Scopus and ISI Web of Science databases, combining the following keywords: human dentine pulp, angiogenesis, angiogenic growth factors, neuropeptides, substance P, neurogenic inflammation, dentine matrix, dentinogenesis, occlusal trauma and dental occlusion. It is concluded that human dental pulp tissue responds to occlusal trauma and masticatory function with a neurogenic inflammatory phenomenon in which SP plays an important role in the direct and indirect mechanisms of angiogenesis by the action evoked via NK1 receptors at different cells, such as fibroblasts, endothelial and inflammatory cells, leading to new blood vessel formation which are needed to stimulate mineralized tissue formation as a defence mechanism.

journal_name

Int Endod J

authors

Caviedes-Bucheli J,Gomez-Sosa JF,Azuero-Holguin MM,Ormeño-Gomez M,Pinto-Pascual V,Munoz HR

doi

10.1111/iej.12627

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

339-351

issue

4

eissn

0143-2885

issn

1365-2591

journal_volume

50

pub_type

杂志文章,评审
  • Evaluation of the mechanical behaviour of PathFile and ProGlider pathfinding nickel-titanium rotary instruments.

    abstract:AIM:To assess and compare the resistance to cyclic fatigue, torsional stress, bending and buckling of ProGlider (PG; Dentsply Maillefer, Ballaigues, Switzerland) instruments with PathFile (PF; Dentsply Maillefer) pathfinding nickel-titanium rotary instruments. METHODOLOGY:Size 16, .02 taper PG and PF instruments were ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12386

    authors: Elnaghy AM,Elsaka SE

    更新日期:2015-09-01 00:00:00

  • Shaping ability of the M4 handpiece and Safety Hedstrom files in simulated root canals.

    abstract::The aim of this study was to assess the shaping ability of the M4 reciprocating handpiece and Safety Hedstrom files in simulated canals. A total of 40 simulated canals of various angles and positions of curvature were prepared with an M4 handpiece using Safety Hedstrom files oriented with the ground, flattened surface...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.1997.tb01094.x

    authors: Lloyd A,Jaunberzins A,Dhopatkar A,Bryant S,Dummer PM

    更新日期:1997-01-01 00:00:00

  • Microbial community in persistent apical periodontitis: a 16S rRNA gene clone library analysis.

    abstract:AIM:To characterize the microbial composition of persistent periapical lesions of root filled teeth using a molecular genetics approach. METHODOLOGY:Apical lesion samples were collected from 12 patients (23-80 years old) who visited the Kyushu University Hospital for apicectomy with persistent periapical lesions assoc...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12361

    authors: Zakaria MN,Takeshita T,Shibata Y,Maeda H,Wada N,Akamine A,Yamashita Y

    更新日期:2015-08-01 00:00:00

  • Resistance to fracture of roots filled with three different techniques.

    abstract:AIM:To compare the fracture resistance of roots filled with different materials. METHODOLOGY:Thirty-four freshly extracted human maxillary central incisor teeth with similar dimension were selected. Crowns were sectioned at the cemento-enamel junction, and the length of the roots were adjusted to 13 mm. Following the ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2006.01177.x

    authors: Sagsen B,Er O,Kahraman Y,Akdogan G

    更新日期:2007-01-01 00:00:00

  • Reliability of different electronic apex locators to detect root perforations in vitro.

    abstract::The aim of this study was to evaluate the accuracy of the electronic apex locator Root ZX compared to the Sono Explorer Mark II Junior and Apit III in detecting root perforations. Extracted human teeth (n = 30) were perforated artificially in the middle third of the root and embedded in a box containing alginate. Dete...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.1997.00107.x

    authors: Kaufman AY,Fuss Z,Keila S,Waxenberg S

    更新日期:1997-11-01 00:00:00

  • Scanning electron microscope appearances of Lightspeed instruments used clinically: a pilot study.

    abstract::The cutting heads of the first 18 instruments in six sets of clinically used Lightspeed instruments (sizes 20-65) were examined in a scanning electron microscope (SEM). Three sets had been used by full-time faculty and discarded as follows: instrument sizes 20-32.5 after 18 treated root canals; instrument sizes 35-47....

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:

    authors: Marending M,Lutz F,Barbakow F

    更新日期:1998-01-01 00:00:00

  • Anatomical danger zone reconsidered: a micro-CT study on dentine thickness in mandibular molars.

    abstract:AIM:To investigate the smallest dentine thickness in mesial canals of mandibular molars along the cervical and middle thirds of the root by means of a micro-computed tomographic (micro-CT) technology and digital image analysis. METHODOLOGY:Fifty mesial roots of mandibular molars having two independent canals (mesiobuc...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.13141

    authors: De-Deus G,Rodrigues EA,Belladonna FG,Simões-Carvalho M,Cavalcante DM,Oliveira DS,Souza EM,Giorgi KA,Versiani MA,Lopes RT,Silva EJNL,Paciornik S

    更新日期:2019-10-01 00:00:00

  • Impact of motion artefacts and motion-artefact correction on diagnostic accuracy of apical periodontitis in CBCT images: an ex vivo study in human cadavers.

    abstract:AIM:To assess the impact of motion artefacts and motion-artefact correction on diagnostic accuracy of apical periodontitis (AP) in CBCT images. METHODOLOGY:Based on clinical and radiographic inspection of 40 formalin-fixated human jaw specimens, 77 roots in 45 teeth (molars and premolars), with various disease and tre...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.13326

    authors: Spin-Neto R,Kruse C,Hermann L,Kirkevang LL,Wenzel A

    更新日期:2020-09-01 00:00:00

  • The effect of medicaments used in endodontic regeneration on root fracture and microhardness of radicular dentine.

    abstract:AIM:To investigate the effect of medicaments used in endodontic regeneration on root fracture resistance and microhardness of radicular dentine. METHODOLOGY:The root canals of mandibular premolars (n = 180) were instrumented and randomized into three treatment groups and an untreated control group. Each treatment grou...

    journal_title:International endodontic journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/iej.12046

    authors: Yassen GH,Vail MM,Chu TG,Platt JA

    更新日期:2013-07-01 00:00:00

  • Bacterial leakage versus dye leakage in obturated root canals.

    abstract:AIM:The aim of this study was to compare in vitro bacterial and dye leakage tests, commonly used to determine the seal of root canal fillings. METHODOLOGY:Ninety-six single-rooted teeth had their crowns removed at the cemento-enamel junction and their roots instrumented to ISO size 60 within 1 mm of the apex. Three gr...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.1999.00235.x

    authors: Barthel CR,Moshonov J,Shuping G,Orstavik D

    更新日期:1999-09-01 00:00:00

  • Bovine teeth can reliably substitute human dentine in an intra-tooth push-out bond strength model?

    abstract:AIM:To investigate the reliability of using bovine teeth as an alternative to human teeth in an intra-tooth push-out model by comparing the bond strength of three root canal sealers in both tooth substrates. METHODOLOGY:From human and bovine incisors (12 per group), one 1-mm disc was obtained from each root. On each d...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.13085

    authors: Silva EJNL,Carvalho NK,Prado MC,Senna PM,Souza EM,De-Deus G

    更新日期:2019-07-01 00:00:00

  • Effects of ultrasonic removal of fractured files from the middle third of root canals on dentinal cracks: a micro-computed tomography study.

    abstract:AIM:To evaluate the frequency of dentinal microcracks after ultrasonic removal of fractured files from the middle third of root canals using micro-computed tomography (micro-CT). METHODOLOGY:Eighteen bilaterally matched pairs of human mandibular incisors extracted for periodontal reasons were included. The matched pai...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12909

    authors: Fu M,Huang X,He W,Hou B

    更新日期:2018-09-01 00:00:00

  • A comparative analysis of periapical health based on historic and current data.

    abstract:AIM:To compare periapical health using samples from prehistoric and historic periods until the present day, and to emphasize the major risk indicators for apical periodontitis (AP). METHODOLOGY:A comparative survey to assess periapical health was performed on five samples (525 individuals) drawn from different periods...

    journal_title:International endodontic journal

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1365-2591.2005.00905.x

    authors: Chazel JC,Tramini P,Valcarcel J,Pélissier B

    更新日期:2005-05-01 00:00:00

  • Bonding self-adhesive resin cements to glass fibre posts: to silanate or not silanate?

    abstract:AIM:To evaluate the bond strength of self-adhesive resin cements (SARCs) to glass fibre posts with or without a silane coupling agent. METHODOLOGY:The SARCs tested were: Maxcem Elite (MXE; Kerr), RelyX Unicem clicker (UNI; 3M ESPE), seT capsule (SET; SDI), and SmartCem 2 (SC2; Dentsply Caulk). The conventional cement ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2011.01883.x

    authors: Oliveira AS,Ramalho ES,Ogliari FA,Moraes RR

    更新日期:2011-08-01 00:00:00

  • Mineral trioxide aggregate suppresses pro-inflammatory cytokine expression via the calcineurin/nuclear factor of activated T cells/early growth response 2 pathway in lipopolysaccharide-stimulated macrophages.

    abstract:AIM:To elucidate mechanisms by which mineral trioxide aggregate (MTA) suppresses pro-inflammatory cytokine mRNA expression in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. METHODOLOGY:Mineral trioxide aggregate extracts were prepared by immersing set ProRoot MTA in culture medium. RAW264.7 cells were cultu...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.13386

    authors: Kuramoto M,Kawashima N,Tazawa K,Nara K,Fujii M,Noda S,Hashimoto K,Nozaki K,Okiji T

    更新日期:2020-12-01 00:00:00

  • Effect of reciprocating file motion on microcrack formation in root canals: an SEM study.

    abstract:AIM:To compare dentinal microcrack formation whilst using Ni-Ti hand K-files, ProTaper hand and rotary files and the WaveOne reciprocating file. METHODOLOGY:One hundred and fifty mandibular first molars were selected. Thirty teeth were left unprepared and served as controls, and the remaining 120 teeth were divided in...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12197

    authors: Ashwinkumar V,Krithikadatta J,Surendran S,Velmurugan N

    更新日期:2014-07-01 00:00:00

  • Impact of needle insertion depth on the removal of hard-tissue debris.

    abstract:AIM:To evaluate the effect of depth of insertion of an irrigation needle tip on the removal of hard-tissue debris using micro-computed tomographic (micro-CT) imaging. METHODOLOGY:Twenty isthmus-containing mesial roots of mandibular molars were anatomically matched based on similar morphological dimensions using micro-...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12648

    authors: Perez R,Neves AA,Belladonna FG,Silva EJNL,Souza EM,Fidel S,Versiani MA,Lima I,Carvalho C,De-Deus G

    更新日期:2017-06-01 00:00:00

  • Influence of the exposure of MTA with and without calcium chloride to phosphate-buffered saline on the push-out bond strength to dentine.

    abstract:AIM:To analyse the influence of exposure of mineral trioxide aggregate (MTA) with and without calcium chloride (CaCl2 ) to phosphate-buffered saline (PBS) on the push-out bond strength, over different experimental periods. METHODOLOGY:One hundred and twenty dentine discs with standardized cavities were filled with MTA...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12168

    authors: de Almeida J,Felippe MC,Bortoluzzi EA,Teixeira CS,Felippe WT

    更新日期:2014-05-01 00:00:00

  • Endodontic-periodontal management of two rooted maxillary lateral incisor associated with complex radicular lingual groove by using spiral computed tomography as a diagnostic aid: a case report.

    abstract:AIM:To present the successful endodontic and periodontal management of a two rooted maxillary lateral incisor tooth with a complex radicular lingual groove and severe periodontal destruction using spiral computed tomography as a diagnostic aid. SUMMARY:A 30-year-old male patient presented with a chief complaint of mob...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2011.01868.x

    authors: Gandhi A,Kathuria A,Gandhi T

    更新日期:2011-06-01 00:00:00

  • An in vitro investigation into the effects of retained coronal dentine on the strength of a tooth restored with a cemented post and partial core restoration.

    abstract:AIM:This study aimed to examine the fracture resistance of teeth restored with cast post and partial cores supported by different heights of coronal tooth structure. METHODOLOGY:Four specimen groups were prepared. Group A was the control and consisted of 10 single-rooted teeth restored with post and cores cemented in ...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2002.00596.x

    authors: Al-Wahadni A,Gutteridge DL

    更新日期:2002-11-01 00:00:00

  • Comparative in-vitro evaluation of three chelator pastes.

    abstract:AIM:To compare the effect of three paste chelating agents on the root dentine of extracted teeth: Calcinase-Slide (lege artis, Dettenhausen, Germany), Glyde-File (DeTrey/Dentsply, Konstanz, Germany), RC-Prep (Premier, Norristown, USA). METHODOLOGY:Ten slices of root dentine were covered with one of the chelating agent...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2002.00543.x

    authors: Hülsmann M,Heckendorff M,Schäfers F

    更新日期:2002-08-01 00:00:00

  • Evaluation of the effect of EDTA, EDTAC and citric acid on the microhardness of root dentine.

    abstract:AIM:To evaluate the effect of citric acid, ethylenediaminetetraacetic acid (EDTA) and ethylenediaminetetraacetic acid plus Cetavlon (EDTAC) solutions on the microhardness of human root canal dentine. METHODOLOGY:Sixteen maxillary human canines were sectioned transversely at the cemento-enamel junction and the crowns w...

    journal_title:International endodontic journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2591.2006.01094.x

    authors: De-Deus G,Paciornik S,Mauricio MH

    更新日期:2006-05-01 00:00:00

  • Toll-like receptor 2 expression in refractory periapical lesions.

    abstract:AIM:To investigate the expression of TLR2 in refractory periapical lesions. METHODOLOGY:Refractory periapical lesion biopsies were histopathologically and clinically categorized into asymptomatic periapical granuloma (n=10), symptomatic periapical granuloma (n=10) or periapical cyst (n=10) and prepared for immunohisto...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/j.1365-2591.2011.01893.x

    authors: Desai SV,Love RM,Rich AM,Seymour GJ

    更新日期:2011-10-01 00:00:00

  • A method of adapting gutta-percha master cones for obturation of open apex cases using heat.

    abstract::CLINICAL TECHNIQUE: It is generally accepted that the success of root-canal treatment is mainly dependent on the proper cleaning, shaping and hermetic obturation of root canals. Obturation of the root canal is of importance as 60% of endodontic failures are attributable to incomplete obliteration of the root-canal sys...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.1999.00180.x

    authors: Kerezoudis NP,Valavanis D,Prountzos F

    更新日期:1999-01-01 00:00:00

  • The removal of the smear layer using the Quantec system. A study using the scanning electron microscope.

    abstract:AIM:The aim of this study was to determine the ability of the Quantec Series 2000 rotary nickel-titanium endodontic system to remove dentinal debris and smear layer produced during canal preparation. METHODOLOGY:A first group (control) of 12 curved root canals was prepared using conventional manual instruments and the...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.1999.00231.x

    authors: Bertrand MF,Pizzardini P,Muller M,Médioni E,Rocca JP

    更新日期:1999-05-01 00:00:00

  • The induction of reparative dentine by enamel proteins.

    abstract:AIM:This study was designed to examine whether enamel matrix derivative (EMD) could induce reparative dentine formation without eliciting adverse side-effects in pulpotomized teeth in the miniature swine. METHODOLOGY:Pulpotomy was performed in 36 mandibular incisor teeth from 11 adult miniature swine. Following the su...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2002.00556.x

    authors: Nakamura Y,Hammarström L,Matsumoto K,Lyngstadaas SP

    更新日期:2002-05-01 00:00:00

  • Prodromal herpes zoster--a diagnostic challenge in endodontics.

    abstract::This case report highlights the diagnostic challenge that herpes zoster represents if pain develops in the prodromal stage. A 58-year-old male presented with pain in the left maxilla. The symptoms had lasted for 7 months. The first premolar had been extracted soon after the onset, and the second premolar root filled s...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1046/j.1365-2591.2002.00605.x

    authors: Fristad I,Bårdsen A,Knudsen GC,Molven O

    更新日期:2002-12-01 00:00:00

  • Biocompatibility of root filling pastes used in primary teeth.

    abstract:AIM:To evaluate the biocompatibility of two pastes designed to fill the root canals of primary teeth. METHODOLOGY:A study group of 54 mice received subcutaneous tissue implants of polyethylene tubes containing CTZ or calcium hydroxide paste or, as a negative control, empty tubes. Biocompatibility was evaluated on days...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12328

    authors: Lima CC,Conde Júnior AM,Rizzo MS,Moura RD,Moura MS,Lima MD,Moura LF

    更新日期:2015-05-01 00:00:00

  • Effect of oral premedication on the anaesthetic efficacy of inferior alveolar nerve block in patients with irreversible pulpitis - A systematic review and network meta-analysis of randomized controlled trials.

    abstract::This systematic review (SR; PROSPERO database: CRD42017075160) and network meta-analysis (NMA) identified the most effective oral premedication for anaesthetic success of inferior alveolar nerve blocks (IANB) in cases of irreversible pulpitis. Medline and Ebscohost databases were searched up until 10/2017. Randomized ...

    journal_title:International endodontic journal

    pub_type: 杂志文章,meta分析

    doi:10.1111/iej.12912

    authors: Pulikkotil SJ,Nagendrababu V,Veettil SK,Jinatongthai P,Setzer FC

    更新日期:2018-09-01 00:00:00

  • Comparative analysis of general dental practitioners' fees and scheduled fees for root canal treatment and coronal restorations in the adult population of Sweden: a 5-year follow-up of data from the Swedish Dental Register.

    abstract:AIM:To investigate the fees charged by Swedish dentists for root fillings, coronal restorations and further dental interventions during a follow-up period of 5-6 years. METHODOLOGY:A total of 248 299 root fillings were linked with the tooth, the patient and the provider and entered into the Swedish Social Insurance Ag...

    journal_title:International endodontic journal

    pub_type: 杂志文章

    doi:10.1111/iej.12817

    authors: Wigsten E,Kvist T,Dawson VS,Isberg PE,EndoReCo.,Fransson H

    更新日期:2018-02-01 00:00:00