Fibroblast growth factor receptor signaling as therapeutic targets in gastric cancer.

abstract：AIM:To test the hypothesis that enhancement of the activity of heme oxygenase can interfere with processes of fibrogenesis associated with recurrent liver injury, we investigated the therapeutic potential of over-expression of heme oxygense-1 in a CCl(4)-induced micronodular cirrhosis model. METHODS:Recombinant adeno-...

journal_title：World journal of gastroenterology

authors： Tsui TY,Lau CK,Ma J,Glockzin G,Obed A,Schlitt HJ,Fan ST

更新日期：2006-04-07 00:00:00

abstract：AIM:To assess the association between smoking and alcohol consumption and extrahepatic cholangiocarcinoma (ECC) through a meta-analysis of clinical observational studies. METHODS:A literature search was conducted using Embase and MEDLINE databases from inception to 31 May 2013 without language limitations, and by manu...

journal_title：World journal of gastroenterology

authors： Ye XH,Huai JP,Ding J,Chen YP,Sun XC

更新日期：2013-12-14 00:00:00

abstract：AIM:To evaluate the functional aspect of esophageal motility in healthy subjects and in patients who were referred for esophageal function testing using multichannel intraluminal impedance-esophageal manometry (MII-EM), and to assess the clinical utility of MII-EM. METHODS:From September 2003 to January 2004, we perfo...

journal_title：World journal of gastroenterology

authors： Cho YK,Choi MG,Park JM,Oh JH,Paik CN,Lee JW,Lee IS,Kim SW,Chung IS

更新日期：2006-10-21 00:00:00

abstract：:Weight loss supplements often contain powerful pharmacoactive ingredients with the potential to cause harm. Trials used to determine product safety and effectiveness, meanwhile, tend to be small, of short duration, and frequently lack financial conflict of interest disclosures. These factors could conspire to place co...

journal_title：World journal of gastroenterology

authors： Lobb A

更新日期：2010-10-14 00:00:00

abstract：AIM:To select the peptide mimicking the neutralization epitope of hepatitis E virus which bound to non-type-specific and conformational monoclonal antibodies (mAbs) 8C11 and 8H3 fromed 7-peptide phage display library, and expressed the peptide recombinant with HBcAg in E.coli, and to observe whether the recombinant HBc...

journal_title：World journal of gastroenterology

authors： Gu Y,Zhang J,Wang YB,Li SW,Yang HJ,Luo WX,Xia NS

更新日期：2004-06-01 00:00:00

abstract：:Because of the low prevalence of non-ampullary duodenal epithelial tumors (NADETs), standardized clinical management of sporadic superficial NADETs, including diagnosis, treatment, and follow-up, has not yet been established. Retrospective studies have revealed certain endoscopic findings suggestive of malignancy. Duo...

journal_title：World journal of gastroenterology

authors： Kakushima N,Kanemoto H,Tanaka M,Takizawa K,Ono H

更新日期：2014-09-21 00:00:00

abstract：AIM:To compare ghrelin levels in plasma and gastric mucosa before and after Helicobacter pylori (H. pylori) treatment in children with H. pylori-associated functional dyspepsia. METHODS:Children with H. pylori-associated functional dyspepsia were enrolled in this study. H. pylori infection was confirmed by positive ba...

journal_title：World journal of gastroenterology

authors： Deng ZH,Chu B,Xu YZ,Zhang B,Jiang LR

更新日期：2012-09-28 00:00:00

abstract：:Despite advancements in medical therapy of Crohn's disease (CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for sur...

journal_title：World journal of gastroenterology

authors： Toh JW,Stewart P,Rickard MJ,Leong R,Wang N,Young CJ

更新日期：2016-10-28 00:00:00

abstract：AIM:To observe the expression of cyclooxygenase-2 (COX-2) and to investigate the association between COX-2 expression and infection with cytotoxic-associated gene A (cagA) positive strain Helicobacter pylori (Hp) in human gastric cancer, and subsequently to provide fresh ideas for the early prevention of gastric cancer...

journal_title：World journal of gastroenterology

authors： Guo XL,Wang LE,Du SY,Fan CL,Li L,Wang P,Yuan Y

更新日期：2003-02-01 00:00:00

abstract：AIM:To investigate the efficacy of neoadjuvant chemoradiotherapy (NACRT) for resectability of locally advanced gastric cancer (LAGC). METHODS:Between November 2007 and January 2014, 29 patients with LAGC (clinically T3 with distal esophagus invasion/T4 or bulky regional node metastasis) that were treated with NACRT fo...

journal_title：World journal of gastroenterology

authors： Kim MS,Lim JS,Hyung WJ,Lee YC,Rha SY,Keum KC,Koom WS

更新日期：2015-03-07 00:00:00

abstract：:Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colit...

journal_title：World journal of gastroenterology

authors： Rapozo DC,Bernardazzi C,de Souza HS

更新日期：2017-03-28 00:00:00

abstract：AIM:To investigate the predictive factors of self-expandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS:A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clini...

journal_title：World journal of gastroenterology

authors： Kim SH,Chun HJ,Yoo IK,Lee JM,Nam SJ,Choi HS,Kim ES,Keum B,Seo YS,Jeen YT,Lee HS,Um SH,Kim CD

更新日期：2015-08-14 00:00:00

abstract：AIM:To evaluate the clinical relevance of each cofactor on clinical presentation of chronic hepatitis B. METHODS:Out of 1366 hepatitis B surface antigen (HBsAg) positive subjects consecutively observed in 79 Italian hospitals, 53 (4.3%) showed as the only cofactor hepatitis D virus (HDV) infection [hepatitis B virus (...

journal_title：World journal of gastroenterology

authors： Sagnelli E,Stroffolini T,Mele A,Imparato M,Sagnelli C,Coppola N,Almasio PL

更新日期：2012-04-14 00:00:00

abstract：BACKGROUND:Identifying predictors of therapeutic response is the cornerstone of personalized medicine. AIM:To identify predictors of long-term mucosal healing (MH) in patients with Crohn's disease (CD) treated with tumor necrosis factor α (TNF-α) inhibitors. METHODS:Prospective single center study. Consecutive patien...

journal_title：World journal of gastroenterology

authors： Alfaro I,Masamunt MC,Planell N,López-García A,Castro J,Gallego M,Barastegui R,Giner A,Vara A,Salas A,Ricart E,Panés J,Ordás I

更新日期：2019-04-14 00:00:00

abstract：:The term "hemangioma" refers to the common tumor of infancy that exhibits rapid postnatal growth and slow regression during childhood. It may cause confusion with venous malformations that are often incorrectly called "cavernous hemangioma". Venous malformations comprise abnormally formed channels that are lined by qu...

journal_title：World journal of gastroenterology

authors： Fernandez-Pineda I

更新日期：2009-11-07 00:00:00

abstract：AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ: 10 mg or 20 mg od, 20 mg bid, or 10 mg qid for 14 d. All patients completed a f...

journal_title：World journal of gastroenterology

authors： Sugimoto M,Nishino M,Kodaira C,Yamade M,Uotani T,Ikuma M,Umemura K,Furuta T

更新日期：2011-04-14 00:00:00

abstract：AIM:To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes. METHODS:This study was a retrospective case comparison study using prospectively collected data. The study covered the period from Apr...

journal_title：World journal of gastroenterology

authors： Cheung TT,Ng KK,Chok KS,Chan SC,Poon RT,Lo CM,Fan ST

更新日期：2010-06-28 00:00:00

abstract：:While therapeutic strategies able to change the natural history of the disease are developing, it is of major importance to have available predictive factors for aggressive disease to try and target these therapeutic strategies. Clinical predictors have probably been the most broadly studied. In both Crohn's disease (...

journal_title：World journal of gastroenterology

authors： Louis E,Belaiche J,Reenaers C

更新日期：2010-06-07 00:00:00

abstract：AIM:To provide hepatic protection through administration of doxorubicin before stop-flow chemotherapy (SFC) and to investigate the expression of heat shock protein 72 (HSP72) and role of nuclear factor kappa B (NF-kappaB) in this effect. METHODS:The hepatic preconditioning of doxorubicin was established in a porcine m...

journal_title：World journal of gastroenterology

authors： Lu H,Zhu ZG,Yao XX,Zhao R,Yan C,Zhang Y,Liu BY,Yin HR,Lin YZ

更新日期：2005-04-14 00:00:00

abstract：AIM:To investigate the ability of histamine to modulate tryptase release from human colon mast cells and the potential mechanisms. METHODS:Enzymatically dispersed cells from human colons were challenged with histamine, anti-IgE or calcium ionophore A23187 (CI), and the cell supernatants after challenge were collected....

journal_title：World journal of gastroenterology

authors： He SH,Xie H

更新日期：2004-02-01 00:00:00

abstract：:Laparoscopic cholecystectomy (LC) does not require advanced techniques, and its performance has therefore rapidly spread worldwide. However, the rate of biliary injuries has not decreased. The concept of the critical view of safety (CVS) was first documented two decades ago. Unexpected injuries are principally due to ...

journal_title：World journal of gastroenterology

authors： Hori T,Oike F,Furuyama H,Machimoto T,Kadokawa Y,Hata T,Kato S,Yasukawa D,Aisu Y,Sasaki M,Kimura Y,Takamatsu Y,Naito M,Nakauchi M,Tanaka T,Gunji D,Nakamura K,Sato K,Mizuno M,Iida T,Yagi S,Uemoto S,Yoshimura T

更新日期：2016-12-21 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common primary cancers in the world. Surgery is the gold standard for treatment of patients with HCC. Recurrence and metastasis are the major obstacles to further improve the prognosis of HCC. Most recurrences are intrahepatic. However, 30% of the recurrences are extra...

journal_title：World journal of gastroenterology

authors： Sun L,Guan YS,Pan WM,Chen GB,Luo ZM,Wu H

更新日期：2007-10-28 00:00:00

abstract：AIM:To examine the extent of use of specific therapies in clinical practice, and their relationship to therapies validated in clinical trials. METHODS:The US National Cancer Institutes' Patterns of Care study was used to examine therapies and survival of patients diagnosed in 2001 with histologically-confirmed gastroe...

journal_title：World journal of gastroenterology

authors： Cronin-Fenton DP,Mooney MM,Clegg LX,Harlan LC

更新日期：2008-05-28 00:00:00

abstract：AIM:To detect microsatellite instability (MSI) in patients with hereditary nonpolyposis colorectal cancer or ordinary hereditary colorectal cancer and to provide criteria for screening the kindreds with hereditary nonpolyposis colorectal cancer at molecular level. METHODS:MSI was detected in the specimens from 20 case...

journal_title：World journal of gastroenterology

authors： Liu WZ,Jin F,Zhang ZH,Wang SB

更新日期：2006-08-07 00:00:00

abstract：:A 21-year-old woman with complaints of hematochezia was diagnosed as having Cowden's disease (CD), an autosomal dominant condition characterized by multiple hamartomas, since facial papules and gingival papillomas were identified. On endoscopy, multiple hyperplastic polyps were seen in the rectum and left-side colon. ...

journal_title：World journal of gastroenterology

authors： Isomoto H,Furusu H,Ohnita K,Takehara Y,Wen CY,Kohno S

更新日期：2005-03-14 00:00:00

abstract：AIM:To evaluate the possible influences of HCV infection and relative antiviral treatment on seminal parameters and reproductive hormonal serum levels. METHODS:Ten male patients with HCV-related chronic hepatitis and 16 healthy male volunteers were studied. In all subjects seminal parameters (nemaspermic concentration...

journal_title：World journal of gastroenterology

authors： Durazzo M,Premoli A,Di Bisceglie C,Bertagna A,Faga E,Biroli G,Manieri C,Bo S,Pagano G

更新日期：2006-05-21 00:00:00

abstract：AIM:To investigate the expression frequency of endocan in colorectal cancer and analyze the relationship between endocan expression and clinical parameters and to study the role of endocan in colorectal carcinogenesis. METHODS:Expression of endocan in 72 tumor tissue samples of colorectal cancer as well as in 27 norma...

journal_title：World journal of gastroenterology

authors： Zuo L,Zhang SM,Hu RL,Zhu HQ,Zhou Q,Gui SY,Wu Q,Wang Y

更新日期：2008-07-28 00:00:00

abstract：BACKGROUND:Liver resection is an effective treatment for benign and malignant liver tumors. However, a method for preoperative evaluation of hepatic reserve has not yet been established. Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and d...

journal_title：World journal of gastroenterology

authors： Ishii M,Itano O,Shinoda M,Kitago M,Abe Y,Hibi T,Yagi H,Takeuchi A,Tsujikawa H,Abe T,Kitagawa Y

更新日期：2020-02-21 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of death in cancer and has a 5-year survival of < 5%. Only about 15% of the patients present with a resectable PDAC with potential to undergo "curative" surgery. After surgery, local and systemic recurrence, is though very common. The median survival ...

journal_title：World journal of gastroenterology

authors： Ansari D,Gustafsson A,Andersson R

更新日期：2015-03-21 00:00:00

abstract：AIM:To compare the outcomes of concomitant cholangiocarcinoma (C-CCA) and subsequent cholangiocarcinoma (S-CCA) associated with hepatolithiasis. METHODS:From December 1987 to December 2007, 276 patients underwent hepatic resection for hepatolithiasis in Changhua Christian Hospital. Sixty-five patients were excluded du...

journal_title：World journal of gastroenterology

authors： Lin CC,Lin PY,Chen YL

更新日期：2013-01-21 00:00:00