Association between periodontitis and salivary 8-hydroxydeoxyguanosine among Korean rural adults.

Abstract:

OBJECTIVES:This study aimed to evaluate the association between salivary 8-hydroxydeoxyguanosine (8-OHdG) and periodontitis among community-dwelling Korean adults. METHODS:A total of 211 adults (80 men and 131 women) were cross-sectionally surveyed from the Sunchang Longevity Cohort. Periodontitis was defined as having at least 30% of teeth with proximal attachment loss ≥5 mm. The salivary 8-OHdG level was categorized into tertiles: low (<0.916 ng/ml), medium (0.916 to <2.675 ng/ml) and high (≥2.675 ng/ml). Sociodemographic, habitual and systemic health-related factors were controlled for. Logistic regression analysis was performed for the outcome of severe periodontitis. Analysis of covariance in general linear model was performed for the outcome of 8-OHdG. RESULTS:The high 8-OHdG level showed a significant association with periodontitis. The odds ratio (95% confidence interval) was 2.40 (1.05-5.51), and it was highlighted by adding the interaction term with drinking and smoking. The adjusted mean log-transformed value of 8-OHdG was significantly higher in the severe periodontitis group (1.40 ng/ml) than in the control group (1.02 ng/ml) (ancova, P = 0.028). CONCLUSIONS:8-OHdG was associated with periodontitis. Thus, salivary 8-OHdG could be a useful marker for periodontitis.

authors

Shin MS,Shin HS,Ahn YB,Kim HD

doi

10.1111/cdoe.12225

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

381-9

issue

4

eissn

0301-5661

issn

1600-0528

journal_volume

44

pub_type

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