The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, including subtle and less-well-recognised changes.

Abstract:

:Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal adenocarcinoma (PDAC). The constellation of histopathological changes secondary to chemoradiation is diverse and has been well documented, particularly in other gastrointestinal organs such as the oesophagus and colorectum. However, the histological changes specific to the pancreas have not been fully characterised and described. This review aims to provide a detailed catalogue of histological features associated with NCRT-treated PDAC and highlight any subtle, less-recognised changes.

journal_name

J Clin Pathol

authors

Kalimuthu SN,Serra S,Dhani N,Chetty R

doi

10.1136/jclinpath-2016-203604

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

463-71

issue

6

eissn

0021-9746

issn

1472-4146

pii

jclinpath-2016-203604

journal_volume

69

pub_type

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