[Immunomodulation as innovative therapy for head and neck tumors : Current developments].

Abstract:

:Head and neck squamous cell carcinoma (HNSCC) is characterized by its intense immune suppression and its elaborate immune escape mechanisms. Due to the fact that survival rates remain low, the role of immunotherapy has become more important and the focus of current clinical studies has shifted toward antibody-based immune checkpoint modulation. Application of immunotherapy in curative settings or for prevention of recurrent disease would be desirable.

journal_name

HNO

journal_title

HNO

authors

Schuler PJ,Doescher JC,Laban S,Hoffmann TK

doi

10.1007/s00106-016-0131-0

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

470-8

issue

7

eissn

0017-6192

issn

1433-0458

pii

10.1007/s00106-016-0131-0

journal_volume

64

pub_type

杂志文章,评审

相关文献

HNO文献大全
  • [The transverse rectus abdominis muscle (TRAM) flap. A "second defensive line" in microvascular reconstructions of defects in the head and neck area].

    abstract:BACKGROUND:The microvascular anastomosed transverse rectus abdominis muscle (TRAM) island flap has been successfully used in plastic surgery for more than 10 years. In reconstructive head and neck surgery, however, it is not yet established. METHOD:We analysed the preparation and anatomical variation in TRAM flaps in ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-005-1286-2

    authors: Schipper J,Klenzner T,Arapakis I,Maier W,Horch R

    更新日期:2006-01-01 00:00:00

  • [Insect venom allergies : Update 2016 for otorhinolaryngologists].

    abstract::Due to the increasing incidence of hymenoptera venom allergies and the potentially life-threatening reactions, it is important for otolaryngologists working in allergology to have an understanding of modern diagnostic and treatment standards for this allergic disease. Molecular diagnosis with recombinant single allerg...

    journal_title:HNO

    pub_type: 杂志文章,评审

    doi:10.1007/s00106-016-0274-z

    authors: Klimek L,Dippold N,Sperl A

    更新日期:2016-12-01 00:00:00

  • [Counselling versus a self-help manual for tinnitus outpatients: a comparison of effectiveness].

    abstract:BACKGROUND:Counselling is a basic psychological intervention for chronic tinnitus the effectiveness of which has not yet been evaluated. SCIENTIFIC QUESTION:The therapeutic effect of counselling was compared to that of a self-help manual. Outcome was analysed for tinnitus disability, tendency to become chronic, and ac...

    journal_title:HNO

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00106-005-1350-y

    authors: Konzag TA,Rübler D,Bloching M,Bandemer-Greulich U,Fikentscher E,Frommer J

    更新日期:2006-08-01 00:00:00

  • [Value of acoustic speech analysis for prognostic assessment of stuttering in children. Partial results of a prospective longitudinal study].

    abstract:UNLABELLED:PRESENT STATE OF KNOWLEDGE: There are currently no known acoustic parameters by which stuttering children can be appraised which will predict their subsequent speech fluency. AIM:To explain the significance of factors which perpetuate stuttering by using computer-based speech analysis of fluent speech for a...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s001060050748

    authors: Brosch S,Häge A,Johannsen HS

    更新日期:2001-04-01 00:00:00

  • [Auditory processing and perception disorders (APPD): summary and updated overview].

    abstract::The APD guideline of 2009 was supplemented by the statements listed here. The addition is based on current knowledge and findings. Otherwise, the Guideline 2009 remains valid. Here, a summary of the updated APD guideline is given, thus proving an overview of the definition of APD, diagnosis, differential diagnosis and...

    journal_title:HNO

    pub_type: 杂志文章,评审

    doi:10.1007/s00106-015-0002-0

    authors: Nickisch A,Gross M,Schönweiler R,Berger R,Wiesner T,Am Zehnhoff Dinnesen A,Ptok M

    更新日期:2015-06-01 00:00:00

  • [Recurrent epistaxis of unknown origin. A rare differential diagnosis and its treatment].

    abstract::We present the case report on a 66-year-old male patient who appeared in our clinic with recurrent epistaxis. Anterior rhinoscopy during acute bleeding yielded no information on the origin of hemorrhage. On renewed epistaxis, angiography was performed on which an arteriovenous malformation in the sphenoid sinus could ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-011-2328-6

    authors: Schuldt T,Dommerich S

    更新日期:2012-03-01 00:00:00

  • [Voice change and laryngeal obstruction caused by a median thyroglossal duct cyst].

    abstract::Thyroglossal duct cysts are common primary neck tumors, resulting from remnants of the ductus thyroglossus. They can occur at any point along the migratory path of the thyroid gland anlage until the 2nd or 3rd decade of life. The usual symptoms leading to the diagnosis are painless midline neck masses orfistulas. Desp...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s001060050707

    authors: Lübben B,Alberty J,Lang-Roth R,Stoll W,Seifert E

    更新日期:2001-01-01 00:00:00

  • [Treatment of post-traumatic cerebrospinal fluid rhinorrhea with lumbar drainage (author's transl)].

    abstract::Three patients with CSF-rhinorrhea following frontobasal skull and brain injury were treated with lumbar CSF drainage. Rhinorrhea was successfully stopped in one patient few hours after onset of the drainage while a pneumatocephalus developed in each of the remaining patients during the first post-trauma week. We beli...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Schmitt HE,de Preux J,Spoerri O

    更新日期:1980-04-01 00:00:00

  • [Role of the tumor marker TAG-72 in head and neck neoplasms].

    abstract::The serum glycoprotein TAG-72 level was determined in 34 patients with chronic laryngitis or ENT malignancy. This marker is in widespread use in cases of gynaecological and gastrointestinal malignancy. TAG-72 levels did not differ significantly either from the levels of healthy subjects or in the post-operative follow...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Altissimi G,von Garrel C

    更新日期:1990-10-01 00:00:00

  • [Adult multilocular rhabdomyoma as etiology of a space-occupying lesion in the area of the neck].

    abstract::Real rhabdomyomas belong to the rarest tumors in the human body. The origin of these benign neoplasms is in the cardiac or skeletal muscle, in the beginning, there are no significant symptoms and the tumor grows very slowly. Extracardiac rhabdomyomas seldom occur and are mostly located in the head and neck region. A m...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s001060170081

    authors: Welzel C,Gajda M,Jamali Y,Schrom T,Berghaus A,Holzhausen HJ

    更新日期:2001-07-01 00:00:00

  • [Tinnitus and psychological comorbidities].

    abstract::Comorbidity is the presence of one or more disorders in addition to the main disorder. Comorbidities negatively influence the development of the main disease. For patients with tinnitus a comorbidity is an additional component complicating the habituation of ear noise and patients with decompensated tinnitus often hav...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-009-2050-9

    authors: Zirke N,Goebel G,Mazurek B

    更新日期:2010-07-01 00:00:00

  • [Clinical efficiency and the influence of human factors on ear, nose, and throat navigation systems].

    abstract:BACKGROUND:The aim of this study was to evaluate the Navibase navigation system for ear, nose, and throat (ENT) surgery. A new methodology for evaluating surgical and human factors is developed. PATIENTS AND METHODS:The evaluation is based on 102 ENT surgical applications, including 89 cases of functional endoscopic s...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-006-1401-z

    authors: Strauss G,Koulechov K,Röttger S,Bahner J,Trantakis C,Hofer M,Korb W,Burgert O,Meixensberger J,Manzey D,Dietz A,Lüth T

    更新日期:2006-12-01 00:00:00

  • [Megadolichobasilar artery as the etiology of sensorineural deafness in differential sudden deafness diagnosis].

    abstract::The megadolichobasilar artery is a rare vascular anomaly that can cause a variety of clinical symptoms but is usually asymptomatic. Not much attention has been given as yet to a possible sensorineural hearing loss caused by a megadolichobasilar anomaly. Vascular compression of the vestibulocochlear nerve must be assum...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s001060050411

    authors: Otterstedde CR,Tischendorf M,Reisser C

    更新日期:1999-05-01 00:00:00

  • [Balloon dilation of the Eustachian tube in pediatric chronic obstructive Eustachian tube dysfunction patients].

    abstract:OBJECTIVE:Balloon dilation of the Eustachian tube has recently been introduced as a novel and minimally invasive method for treating chronic obstructive Eustachian tube dysfunction. For the first time worldwide, we assessed the role of this technique in a large cohort of children with Eustachian tube dysfunction that d...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-015-0050-5

    authors: Maier S,Tisch M,Maier H

    更新日期:2015-10-01 00:00:00

  • [Computer-based auditory training for hearing rehabilitation of adult cochlear implant users].

    abstract:BACKGROUND:Digitalization has become a part of everyday life and digital applications offer an opportunity to promote health. In Germany, hearing rehabilitation after cochlear implantation (CI) typically takes place in specialized audiology centers. However, a variety of new auditory training programs have been develop...

    journal_title:HNO

    pub_type: 杂志文章,评审

    doi:10.1007/s00106-020-00898-x

    authors: Völter C,Schirmer C,Stöckmann C,Dazert S

    更新日期:2020-11-01 00:00:00

  • [Effectiveness of partial and complete instrumental masking in chronic tinnitus. Studies with reference to retraining therapy].

    abstract::Jastreboff und Hazell [9] developed a neurophysiological approach to tinnitus perception, including the important role of the central nervous system in the maintenance and intrusiveness of tinnitus. They introduced tinnitus-retraining therapy, consisting of four different strategies: (1) directive and person-centered ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s001060050143

    authors: von Wedel H,von Wedel UC,Streppel M,Walger M

    更新日期:1997-09-01 00:00:00

  • [Inoperable nasoseptal defects: closure with custom-made silastic prostheses].

    abstract:INTRODUCTION:The therapy of choice in nasoseptal defects is reconstruction with vital respiratory mucosa; in particular, three-layer repair using the bridge-flap technique according to Schultz-Coulon is the most promising. Cases exceeding operative limitations can be treated with silastic buttons. Our aim was to overco...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-009-2072-3

    authors: Neumann A,Schneider M,Tholen C,Minovi A

    更新日期:2010-04-01 00:00:00

  • [Somatosensoric tinnitus].

    abstract::Tinnitus can be caused or triggered by functional disorders of the cervical spine, temporomandibular joint or any other musculoskeletal structure of the neck or head. This special form of tinnitus is called somatosensory tinnitus and represents a discrete subgroup among the different kinds of tinnitus. Distinctive for...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-014-2971-9

    authors: Biesinger E,Groth A,Höing R,Hölzl M

    更新日期:2015-04-01 00:00:00

  • [The diagnostic use of computed tomography in the management of mediastinal abscess (author's transl)].

    abstract::Computed tomography (CT) is of outstanding importance in the current diagnosis of mediastinal pathology. We have recently treated a patient who underwent laryngectomy and then experienced a septic temperature pattern during the postoperative period which was suspect of mediastinal abscess. A mediastinal CT was obtaine...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Wey W,Hasse J,Herwig W,Vock P

    更新日期:1980-01-01 00:00:00

  • [Vertigo and fluctuating hearing-loss. Differential diagnosis: Ménière's disease, migraine, and psychogenic vertigo].

    abstract::We present the case of a female patient suffering from recurrent vertigo and low-frequency hearing loss who was admitted for inpatient treatment with the diagnosis of Ménière's disease. After evaluation of all diagnostic examinations, including psychosomatic evaluation, a diagnosis of vestibular migraine with accompan...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-011-2312-1

    authors: Schaaf H,Hesse G

    更新日期:2011-11-01 00:00:00

  • [Comparison of the vitamin A blood serum level in patients with head-neck cancer and healthy persons].

    abstract::Serum vitamin A levels of 104 patients with head and neck cancer were analysed and compared with those of 74 normal subjects (standard values 1.1-3.7 micromol/l). Lower values of vitamin A (0.91 +/- 0.33-1.37 +/- 0.99) were found 2.4 times oftener in patients with stage III and IV disease. We were unable to determine ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Murr G,Kostelić F,Donkić-Pavicić I,Grdinić B,Subić N

    更新日期:1988-09-01 00:00:00

  • [Proliferation behavior of cholesteatoma].

    abstract::Two types of growth can be observed clinically in cholesteatoma: an aggressive and a less aggressive type. In this study monoclonal antibodies to Ki-67 proliferation antigen, epidermal growth-related factor (EGFR) and collagen type IV were used to examine cholesteatoma specimens from 36 patients undergoing tympanomast...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Hoppe F

    更新日期:1995-12-01 00:00:00

  • [How best to present the radiological picture of the temporal bone today?].

    abstract::The detailed evaluation of anatomy and pathology of the temporal bone requires imaging modalities that are superior to plain x-ray films. Conventional polytomography has today largely been replaced by high-resolution CT. High-resolution CT provides excellent demonstration of the delicate bony structures and provides s...

    journal_title:HNO

    pub_type: 杂志文章,评审

    doi:

    authors: Haas JP,Kahle G

    更新日期:1988-03-01 00:00:00

  • [Refractory behaviour of the electrically stimulated auditory nerve].

    abstract:INTRODUCTION:Electrically evoked compound action potentials (TECAP) of the auditory nerve can be recorded in cochlear implants. TECAP thresholds are used to predict threshold levels for speech processor maps. The auditory nerve's refractory properties can influence these levels. METHODS:Recovery functions were investi...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-007-1660-3

    authors: Morsnowski A,Charasse B,Collet L,Killian M,Müller-Deile J

    更新日期:2008-02-01 00:00:00

  • [Diving ranula. A rare disease picture].

    abstract::The case of a 24-year-old woman with a plunging ranula is reported. Primarily, the patient noticed extensive swelling of the neck, which had developed 3 months previously. The polycystic, firmly attached tumor and the sublingual and submandibular glands of the right side of the neck were surgically removed. Pathologic...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s001060050132

    authors: Vorpahl H,Schauss F

    更新日期:1997-07-01 00:00:00

  • [Chronic recurrent parotitis].

    abstract::Chronic recurrent parotitis is a non-obstructive disease with episodes of mostly painful swelling of the gland. It is categorized into a juvenile and an adult form, even without clear information on its actual origin. As to the etiology of the juvenile form, genetic factors and duct malformations as well as bacterial ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-009-2079-9

    authors: Zenk J,Koch M,Klintworth N,Iro H

    更新日期:2010-03-01 00:00:00

  • [Active language development in children with severe hearing loss and deafness in relation to technical auditory management].

    abstract::The extent of vocabulary depends on the success of rehabilitation in hearing, language and speech. In hearing impaired and deaf children, it is important to select the optimum technical device-hearing aid or cochlear implant. This study was performed on 30 children with hearing aids or cochlear implants using the Test...

    journal_title:HNO

    pub_type: 杂志文章

    doi:10.1007/s00106-003-0849-3

    authors: Witt G,Landgraf S,Pau HW

    更新日期:2003-10-01 00:00:00

  • [Intracochlear drug delivery in combination with cochlear implants : Current aspects].

    abstract::Local drug application to the inner ear offers a number of advantages over systemic delivery. Local drug therapy currently encompasses extracochlear administration (intratympanic injection); intracochlear administration, particularly for gene and stem cell therapy; as well as various combinations with auditory neurose...

    journal_title:HNO

    pub_type: 杂志文章,评审

    doi:10.1007/s00106-016-0257-0

    authors: Plontke SK,Götze G,Rahne T,Liebau A

    更新日期:2016-11-01 00:00:00

  • [Artificial nutrition with nasogastric catheters. Experiences with a new administration system].

    abstract::Enteral nutrition via a nasogastric tube is widely used but is inconvenient for patients: the nostril and skin of the nose become irritated and ulcerated, and the tube causes pain and psychological trauma. We have developed a new system which combines the security and ease of nasogastric tube feeding with comfort for ...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Milewski C

    更新日期:1991-07-01 00:00:00

  • [New and changed guidelines in the TNM system of head and neck tumors].

    abstract::Starting on the 1st of January 1987, the 4th edition of the UICC classification of the TNM-system is to be applied. Only slight changes have been made in the rules for the larynx and the skin, whereas the classification of the nodal status has undergone a more profound change. New rules have been established for the c...

    journal_title:HNO

    pub_type: 杂志文章

    doi:

    authors: Schwab W,Clasen B,Steinhoff HJ

    更新日期:1987-03-01 00:00:00