Abstract:
:Selective autophagy entails cooperation between target recognition and assembly of the autophagic apparatus. Target recognition is conducted by receptors that often recognize tags, such as ubiquitin and galectins, although examples of selective autophagy independent of these tags are emerging. It is less known how receptors cooperate with the upstream autophagic regulators, beyond the well-characterized association of receptors with Atg8 or its homologs, such as LC3B (encoded by MAP1LC3B), on autophagic membranes. The molecular details of the emerging role in autophagy of the family of proteins called TRIMs shed light on the coordination between cargo recognition and the assembly and activation of the principal autophagy regulators. In their autophagy roles, TRIMs act both as receptors and as platforms ('receptor regulators') for the assembly of the core autophagy regulators, such as ULK1 and Beclin 1 in their activated state. As autophagic receptors, TRIMs can directly recognize endogenous or exogenous targets, obviating a need for intermediary autophagic tags, such as ubiquitin and galectins. The receptor and regulatory features embodied within the same entity allow TRIMs to govern cargo degradation in a highly exact process termed 'precision autophagy'.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Kimura T,Mandell M,Deretic Vdoi
10.1242/jcs.163758subject
Has Abstractpub_date
2016-03-01 00:00:00pages
881-91issue
5eissn
0021-9533issn
1477-9137pii
jcs.163758journal_volume
129pub_type
杂志文章,评审abstract::The formation and maturation of membrane carriers that transport cargo from the ER to the Golgi complex involves the sequential action of the coat protein complexes COPII and COPI. Recruitment of COPI to nascent carriers requires activation of ADP-ribosylation factors by a BrefeldinA-sensitive guanine nucleotide excha...
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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更新日期:2011-10-15 00:00:00
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journal_title:Journal of cell science
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doi:
更新日期:1995-02-01 00:00:00
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journal_title:Journal of cell science
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更新日期:2010-07-01 00:00:00
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doi:
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更新日期:2006-09-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章,评审
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更新日期:2008-03-15 00:00:00
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journal_title:Journal of cell science
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doi:
更新日期:2000-08-01 00:00:00
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pub_type: 杂志文章,评审
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