Abstract:
BACKGROUND:This study aimed to investigate the development of opioid tolerance in patients receiving long-term methadone maintenance treatment (MMT). METHODS:A region-wide cross-sectional study was performed focusing on dosage and duration of treatment. Differences between racemic methadone and levomethadone were examined. All 20 psychiatric hospitals and all 110 outpatient clinics in Berlin licensed to offer MMT were approached in order to reach patients under MMT fulfilling the DSM IV criteria of opiate dependence. In the study, 720 patients treated with racemic methadone or levomethadone gave information on the dosage of treatment. Out of these, 679 patients indicated the duration of MMT. RESULTS:Treatment with racemic methadone was reported for 370 patients (54.5%), with levomethadone for 309 patients (45.5%). Mean duration of MMT was 7.5 years. We found a significant correlation between dosage and duration of treatment, both in a conjoint analysis for the two substances racemic methadone and levomethadone and for each substance separately. These effects remained significant when only patients receiving MMT for 1 year or longer were considered, indicating proceeding tolerance development in long-term treatment. When correlations were compared between racemic methadone and levomethadone, no significant difference was found. CONCLUSIONS:Our data show a tolerance development under long-term treatment with both racemic methadone and levomethadone. Tolerance development did not differ significantly between the two substances.
journal_name
Harm Reduct Jjournal_title
Harm reduction journalauthors
Gutwinski S,Schoofs N,Stuke H,Riemer TG,Wiers CE,Bermpohl Fdoi
10.1186/s12954-016-0095-0subject
Has Abstractpub_date
2016-02-16 00:00:00pages
7issn
1477-7517pii
10.1186/s12954-016-0095-0journal_volume
13pub_type
杂志文章abstract:BACKGROUND:We have recently published some work on CEA levels in hookah (also called narghile, shisha elsewhere) and cigarette smokers. Hookah smokers had higher levels of CEA than non-smokers although mean levels were low compared to cigarette smokers. However some of them were also users of other tobacco products (ci...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-5-19
更新日期:2008-05-24 00:00:00
abstract:BACKGROUND AND RATIONALE:The HIV epidemic in Vietnam has from its start been concentrated among injecting drug users. Vietnam instituted the 2006 HIV/AIDS Law which includes comprehensive harm reduction measures, but these are unevenly accepted and inadequately implemented. Ward police are a major determinant of risk f...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-9-27
更新日期:2012-07-09 00:00:00
abstract:BACKGROUND:During the 1990s, the New York Police Department (NYPD) greatly expanded arrests for smoking marijuana in public view (MPV). By 2000, MPV accounted for 15% of all arrests. The NYPD's supporters report this arrest activity is just part of quality-of-life (QOL) policing, which seeks to promote order in public ...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-3-22
更新日期:2006-08-04 00:00:00
abstract:BACKGROUND:There are few studies of mortality amongst people who inject drugs (PWID) in Australia. In this study, we estimate mortality in a cohort of PWID in Melbourne and examine predictors of mortality including health service use, demographic characteristics, drug use and personal wellbeing. FINDINGS:We linked ide...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-015-0089-3
更新日期:2015-12-09 00:00:00
abstract:BACKGROUND:Due to the high prevalence of mental disorders among people with opioid use disorder, the objective of this study was to determine the association between concurrent mental disorders, mortality, morbidity, and continuous treatment retention for patients in opioid agonist treatment in Ontario, Canada. METHOD...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-020-00396-x
更新日期:2020-07-23 00:00:00
abstract:BACKGROUND:Health services globally are struggling to manage the impact of COVID-19. The existing global disease burden related to opioid use is significant. Particularly challenging groups include older drug users who are more vulnerable to the effects of COVID-19. Increasing access to safe and effective opioid agonis...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-020-00394-z
更新日期:2020-07-17 00:00:00
abstract:BACKGROUND:Gambling has quickly emerged as an important global public health issue. With new technologies used to develop high intensity gambling products and promotions aimed at driving consumption, public health organisations and researchers, community groups, and politicians have argued for a range of regulatory and...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-017-0173-y
更新日期:2017-07-25 00:00:00
abstract:BACKGROUND:Patients with opioid use disorder (OUD) frequently present to the emergency department for acute treatment of overdose and withdrawal. CASE PRESENTATION:A 29-year-old male presented to the emergency room after intravenous heroin use followed by accidental ingestion of naltrexone. He was treated with bupreno...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-020-00417-9
更新日期:2020-10-07 00:00:00
abstract::Harm reduction is a controversial model for treating drug users, with little formal research available on its operation and effectiveness. In order to advance the field, we first conducted participatory research of harm reduction with 120 clients using nominal-group technique to develop culturally relevant outcomes to...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-1-7
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Condom provision is one of the most effective harm reduction interventions to control sexually transmitted infections (STIs) including HIV/AIDS and viral hepatitis in prisons. Yet, very few countries around the world provide prisoners with condoms. The present study aimed to elucidate principles of effective...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-021-00462-y
更新日期:2021-01-28 00:00:00
abstract::Substance-using women who exchange sex for money, drugs or shelter as a means of basic subsistence (ie. survival sex) have remained largely at the periphery of HIV and harm reduction policies and services across Canadian cities. This is notwithstanding global evidence of the multiple harms faced by this population, in...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-4-20
更新日期:2007-12-08 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) is one of the major public health problems both in developed and developing countries. Prison represents a high-risk environment for prisoners, in that it is characterized by high-risk behaviors such as injecting drug use (IDU), tattooing, unprotected sexual intercourses, or sharing s...
journal_title:Harm reduction journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12954-018-0231-0
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:Recovery from substance use disorder (SUD) is often considered at odds with harm reduction strategies. More recently, harm reduction has been categorized as both a pathway to recovery and a series of services to reduce the harmful consequences of substance use. Peer recovery support services (PRSS) are effec...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-018-0258-2
更新日期:2018-10-22 00:00:00
abstract::BACKGROUND: Harm reduction is a relatively new and controversial model for treating drug users, with little formal research on its operation and effectiveness. In order to advance the study of harm reduction programs and our understanding of how drug users define their progress, qualitative research was conducted to d...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-1-8
更新日期:2004-08-26 00:00:00
abstract:UNLABELLED:This qualitative study of travel-related risk behaviours of Slovene injection drug users was based on interviews with individuals enrolled in drug addiction treatment programmes run by three regional centres for prevention and treatment of drug addiction. The primary objective of the study was to analyse beh...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-8-8
更新日期:2011-04-17 00:00:00
abstract:OBJECTIVES:The COVID-19 pandemic led to the closure of the IDEA syringe services program medical student-run free clinic in Miami, Florida. In an effort to continue to serve the community of people who inject drugs and practice compassionate and non-judgmental care, the students transitioned the clinic to a model of Te...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-020-00438-4
更新日期:2020-11-17 00:00:00
abstract:BACKGROUND:Patients with substance use disorders grow older thanks to effective treatments. Together with a high prevalence of comorbidities, psychological problems, and low social support, these patients are at high risk for medication non-adherence. Established treatment facilities face challenges to accommodate thes...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-017-0182-x
更新日期:2017-08-16 00:00:00
abstract:INTRODUCTION:The aim of this study is to identify the profiles of young people who use drugs (YPUD) and their exposure to HIV risks in the 3 main cities of Vietnam, Haiphong, Hanoi, and Ho Chi Minh City (HCMC), in order to design a community-based intervention to prevent HIV. METHODS:A survey using respondent-driven s...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-020-00357-4
更新日期:2020-02-24 00:00:00
abstract:BACKGROUND:Methadone maintenance treatment is the most widely prescribed treatment for opiate dependence with proven benefits for patients. In naïve users or in case of recreational misuse, methadone can be a source of potentially lethal intoxications, resulting in fatal overdoses. A few cases of infantile intoxication...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-11-20
更新日期:2014-07-02 00:00:00
abstract:BACKGROUND:The growing HIV epidemic in Eastern Europe and Central Asia has been driven by high rates of injection drug use. The Republic of Georgia has among the highest injection drug use rates globally, with a prevalence of 2.24%. The reach of evidence-based HIV prevention interventions like needle and syringe progra...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-019-0292-8
更新日期:2019-03-21 00:00:00
abstract:AIMS:To identify geographic "hotspots" for potential transmission of HIV and HCV and for drug overdose among persons who use heroin and cocaine in New York City and to examine historical continuities in problem drug use hotspots in the city. METHODS:A total of 2714 study participants were recruited among persons enter...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-019-0326-2
更新日期:2019-09-02 00:00:00
abstract::The findings of our research show that while police play multiple roles in the fight against drug-related crime, they often perceived their tasks - especially preventing and controlling drug use on the one hand, and supporting harm reduction on the other - as contradictory, and this creates tensions in their work and ...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-9-25
更新日期:2012-07-09 00:00:00
abstract:BACKGROUND:We utilized multiple recruitment approaches to recruit IDUs in a longitudinal cohort study to examine HIV incidence and behavior change pre- and post-introduction of comprehensive HIV prevention services. METHODS:IDUs were recruited through peer referral, targeted outreach by outreach workers (ORWs) and as ...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-10-16
更新日期:2013-09-25 00:00:00
abstract:BACKGROUND:To examine the predictors of continued drug- and sex-related HIV-risk behaviors among drug users in methadone maintenance therapy (MMT) programs in China. METHODS:We followed a sample of 5,035 drug users enrolled for the first time in MMT programs at baseline, 6 months, and 12 months utilizing a longitudina...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-10-23
更新日期:2013-10-10 00:00:00
abstract::Whilst unsupervised injectable methadone and diamorphine treatment has been part of the British treatment system for decades, the numbers receiving injectable opioid treatment (IOT) has been steadily diminishing in recent years. In contrast, there has been a recent expansion of supervised injectable diamorphine progra...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-3-28
更新日期:2006-09-27 00:00:00
abstract:BACKGROUND:People who smoke crack cocaine experience a wide variety of health-related issues. However, public health programming designed for this population is limited, particularly in comparison with programming for people who inject drugs. Canadian best practice recommendations encourage needle and syringe programs ...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-017-0144-3
更新日期:2017-05-12 00:00:00
abstract::Alcohol and other drug misuse are significant but neglected public health issues in conflict-affected populations. In this article, we review the literature on the challenges and strategies for implementing substance misuse treatment and prevention services in conflict and post-conflict settings in low- and middle-inc...
journal_title:Harm reduction journal
pub_type: 杂志文章,评审
doi:10.1186/s12954-018-0267-1
更新日期:2018-11-28 00:00:00
abstract:BACKGROUND:The hepatitis C virus (HCV) is a major cause of drug-related morbidity and mortality, with incidence data implicating a wide range of HCV transmission risk practices. The Blood-Borne Virus Transmission Risk Assessment Questionnaire (BBV-TRAQ) is a content valid instrument that comprehensively assesses HCV ri...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/1477-7517-5-12
更新日期:2008-04-23 00:00:00
abstract:BACKGROUND:Injection drug use is on the rise in the USA, and skin and soft tissue infections (SSTI) are a common complication, resulting in significant morbidity and mortality. Due to structural barriers to care-seeking, many people who inject drugs avoid formal care and resort to self-care techniques, but little is kn...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-019-0345-z
更新日期:2019-12-12 00:00:00
abstract:BACKGROUND:Stigma and discrimination may adversely affect the benefits of methadone maintenance treatment (MMT) for drug users, especially in disadvantaged settings. This study assessed stigma and discrimination against MMT patients in the mountainous and rural areas in Vietnam and explored their associated factors to ...
journal_title:Harm reduction journal
pub_type: 杂志文章
doi:10.1186/s12954-016-0127-9
更新日期:2017-01-06 00:00:00