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Salt intake and plasma renin activity in the freshwater turtle.

Abstract：

:In mammals, a well-documented inverse relationship exists between oral salt intake and plasma renin activity (PRA). We carried out this study to determine if a similar relationship exists in the freshwater turtle Pseudemys scripta. Three groups of turtles (N = 8 for each group) were fed different amounts of salt dissolved in distilled water (2 cc/kg). The high salt group received 580 mg (10 mEq) NaCl/kg twice per week, the medium salt group received 290 mg (5 mEq) NaCl/kg twice per week, and the low salt (control) group received 2 cc/kg distilled water twice per week with no salt. The animals were weighed weekly and blood was collected by cardiac puncture after 3 and 6 weeks of salt loading and again 3 weeks after termination of the salt loading. PRA and plasma electrolytes (PNa, PK, PCl) were determined. The low salt (control) group showed no changes in any of the measured variables throughout the 9-week study. At 3 weeks the following mean values were obtained for the control group: PNa, 119.5 +/- 7.2 mEq/liter; PK, 5.0 +/- 1.0 mEq/liter; PCl, 74.1 +/- 2.6 mEq/liter; PRA, 1.0 +/- 0.2 ng/ml/hr. In the medium salt group, no significant changes were seen until 3 weeks after termination of the salt loading when PNa and PRA were elevated to 137.9 +/- 3.6 mEq/liter and 1.9 +/- 0.2 ng/ml/hr, respectively (P less than 0.05 compared to control). In the high salt group, PNa (136.5 +/- 6.5 mEq/liter) was elevated after 3 weeks of salt loading. At 6 weeks, PNa (136.8 +/- 4.9 mEq/liter) remained elevated in the high salt group and PCl (86.3 +/- 1.3 mEq/liter) and PRA (1.7 +/- 0.2 ng/ml/hr) also increased significantly (P less than 0.05 compared to control in each case). Three weeks after termination of salt loading, PNa (136.8 +/- 3.3 mEq/liter). PCl (88.0 +/- 1.6 mEq/liter), and PRA (1.9 +/- 0.2 ng/ml/hr) remained elevated (P less than 0.05 in each case) in the high salt group while PK dropped to 3.5 +/- 1.6 mEq/liter (P less than 0.05). The results show that after 6 weeks of salt loading sufficient to raise PNa in the turtle, PRA was significantly elevated.

journal_name

Gen Comp Endocrinol

journal_title

General and comparative endocrinology

authors

Stephens GA,Hauben D

doi

10.1016/0016-6480(89)90138-x

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

421-6

issue

eissn

0016-6480

issn

1095-6840

pii

0016-6480(89)90138-X

journal_volume

pub_type

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Salt intake and plasma renin activity in the freshwater turtle.