Immunogenicity, effectiveness and safety of combined hepatitis A and B vaccine: a systematic literature review.

Abstract:

BACKGROUND:Hepatitis A and B are two of the most common vaccine-preventable diseases and vaccination for Hepatitis A virus (HAV) and hepatitis B virus (HBV) is recommended for those at risk of contracting HAV and/or HBV through their occupation, travel or lifestyle. OBJECTIVE:To describe the vaccine efficacy, immunogenicity, effectiveness and safety of the combined vaccine against hepatitis A and hepatitis B. METHODS:A systematic review of the literature published between 1990 and 2015. RESULTS:Anti-HAV seropositivity rates ranged from 96.2% to 100% and anti-HBs seroprotection rates from 82% to 100%. Antibodies persisted up to 15 years and geometric mean concentration (GMC) remained above the seropositivity cut-off value for both. Anti-HAV and anti-HBs immune responses were lower in less immunocompetent individuals one month after completion of the immunization schedule. The safety profiles of Twinrix(TM) and monovalent hepatitis A and B vaccines were similar. CONCLUSION:The vaccine offers satisfactory long-term immunogenicity rates, expected duration of protection and safety profile similar to the monovalent hepatitis A or B vaccines.

journal_name

Expert Rev Vaccines

authors

Bakker M,Bunge EM,Marano C,de Ridder M,De Moerlooze L

doi

10.1586/14760584.2016.1150182

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

829-51

issue

7

eissn

1476-0584

issn

1744-8395

journal_volume

15

pub_type

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