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Dronabinol and lofexidine for cannabis use disorder: A randomized, double-blind, placebo-controlled trial.

Abstract：

BACKGROUND:Cannabis use disorder is associated with substantial morbidity and, after alcohol, is the most common drug bringing adolescents and adults into treatment. At present, there are no FDA-approved medications for cannabis use disorder. Combined pharmacologic interventions might be particularly useful in mitigating withdrawal symptoms and promoting abstinence. OBJECTIVE:The purpose of this study was to evaluate the safety and efficacy of dronabinol, a synthetic form of delta-9-tetrahydrocannabinol, a naturally occurring pharmacologically active component of marijuana, and lofexidine, an alpha-2 agonist, in treating cannabis dependence. METHODS:One hundred fifty six cannabis-dependent adults were enrolled and following a 1-week placebo lead-in phase 122 were randomized in a double-blind, placebo-controlled, 11-week trial. Participants were randomized to receive dronabinol 20mg three times a day and lofexidine 0.6 mg three times a day or placebo. Medications were maintained until the end of week eight, were then tapered over two weeks and patients were monitored off medications during the last study week. All participants received weekly motivational enhancement and relapse prevention therapy. Marijuana use was assessed using the timeline follow-back method. RESULTS:There was no significant difference between treatment groups in the proportion of participants who achieved 3 weeks of abstinence during the maintenance phase of the trial (27.9% for the medication group and 29.5% for the placebo group), although both groups showed a reduction over time. CONCLUSIONS:Based on this treatment study, the combined intervention did not show promise as a treatment for cannabis use disorder.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Levin FR,Mariani JJ,Pavlicova M,Brooks D,Glass A,Mahony A,Nunes EV,Bisaga A,Dakwar E,Carpenter KM,Sullivan MA,Choi JC

doi

10.1016/j.drugalcdep.2015.11.025

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

53-60

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(15)01778-0

journal_volume

159

pub_type

杂志文章,随机对照试验

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