当前位置： SCI文献检索 > Pulmonary Circulation期刊下所有文献 > The unique heart sound signature of children with pulmonary artery hypertension.

The unique heart sound signature of children with pulmonary artery hypertension.

Abstract：

:We hypothesized that vibrations created by the pulmonary circulation would create sound like the vocal cords during speech and that subjects with pulmonary artery hypertension (PAH) might have a unique sound signature. We recorded heart sounds at the cardiac apex and the second left intercostal space (2LICS), using a digital stethoscope, from 27 subjects (12 males) with a median age of 7 years (range: 3 months-19 years) undergoing simultaneous cardiac catheterization. Thirteen subjects had mean pulmonary artery pressure (mPAp) < 25 mmHg (range: 8-24 mmHg). Fourteen subjects had mPAp ≥ 25 mmHg (range: 25-97 mmHg). We extracted the relative power of the frequency band, the entropy, and the energy of the sinusoid formants from the heart sounds. We applied linear discriminant analysis with leave-one-out cross validation to differentiate children with and without PAH. The significance of the results was determined with a t test and a rank-sum test. The entropy of the first sinusoid formant contained within an optimized window length of 2 seconds of the heart sounds recorded at the 2LICS was significantly lower in subjects with mPAp ≥ 25 mmHg relative to subjects with mPAp < 25 mmHg, with a sensitivity of 93% and specificity of 92%. The reduced entropy of the first sinusoid formant of the heart sounds in children with PAH suggests the existence of an organized pattern. The analysis of this pattern revealed a unique sound signature, which could be applied to a noninvasive method to diagnose PAH.

journal_name

Pulm Circ

journal_title

Pulmonary circulation

authors

Elgendi M,Bobhate P,Jain S,Guo L,Kumar S,Rutledge J,Coe Y,Zemp R,Schuurmans D,Adatia I

doi

10.1086/683694

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

631-9

issue

4

eissn

2045-8932

issn

2045-8940

pii

PC2013237

journal_volume

5

pub_type

杂志文章

相关文献

Pulmonary Circulation文献大全
  • Effects of tetrahydrobiopterin oral treatment in hypoxia-induced pulmonary hypertension in rat.

    abstract：:Endothelial nitric oxide synthase (eNOS) plays a major role in maintaining pulmonary vascular homeostasis. Tetrahydrobiopterin (BH4), an essential cofactor that stabilizes the dimerization of eNOS and balances nitric oxide (NO) and superoxide production, may have therapeutic potential in pulmonary hypertension. In the...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1086/677361

    authors： Francis BN,Hale A,Channon KM,Wilkins MR,Zhao L

    更新日期：2014-09-01 00:00:00

  • Substrate stiffness-dependent exacerbation of endothelial permeability and inflammation: mechanisms and potential implications in ALI and PH (2017 Grover Conference Series).

    abstract：:The maintenance of endothelial barrier integrity is absolutely essential to prevent the vascular leak associated with pneumonia, pulmonary edema resulting from inhalation of toxins, acute elevation to high altitude, traumatic and septic lung injury, acute lung injury (ALI), and its life-threatening complication, acute...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894018773044

    authors： Karki P,Birukova AA

    更新日期：2018-04-01 00:00:00

  • Compensated right ventricular function of the onset of pulmonary hypertension in a rat model depends on chamber remodeling and contractile augmentation.

    abstract：:Right-ventricular function is a good indicator of pulmonary arterial hypertension (PAH) prognosis; however, how the right ventricle (RV) adapts to the pressure overload is not well understood. Here, we aimed at characterizing the time course of RV early remodeling and discriminate the contribution of ventricular geome...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894018800439

    authors： Vélez-Rendón D,Zhang X,Gerringer J,Valdez-Jasso D

    更新日期：2018-10-01 00:00:00

  • Rescue balloon pulmonary angioplasty in a rapidly deteriorating chronic thromboembolic pulmonary hypertension patient with liver failure and refractory infection.

    abstract：:Pulmonary endarterectomy (PEA) is the standard therapy for chronic thromboembolic pulmonary hypertension (CTEPH). Balloon pulmonary angioplasty (BPA) is an alternative therapy for such patients. Here we report the case of a 60-year-old woman who presented with severe CTEPH resulting in low cardiac output and liver fai...

    journal_title：Pulmonary circulation

    pub_type：

    doi：10.1086/675643

    authors： Tsuji A,Ogo T,Demachi J,Ono Y,Sanda Y,Morita Y,Fukuda T,Nakanishi N

    更新日期：2014-03-01 00:00:00

  • Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension.

    abstract：:Schistosomiasis-associated pulmonary arterial hypertension (PAH) is one of the most common causes of pulmonary hypertension worldwide. A potential contributing mechanism to the pathogenesis of this disease is a localized immune reaction to retained and persistent parasite-derived antigens. We sought to identify Schist...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.4103/2045-8932.93544

    authors： Graham BB,Chabon J,Bandeira A,Espinheira L,Butrous G,Tuder RM

    更新日期：2011-10-01 00:00:00

  • Advancing clinical trial design in pulmonary hypertension.

    abstract：:In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clin...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.4103/2045-8932.109933

    authors： Grieve AP,Chow SC,Curram J,Dawe S,Harnisch LO,Henig NR,Hung HM,Ivy DD,Kawut SM,Rahbar MH,Xiao S,Wilkins MR

    更新日期：2013-01-01 00:00:00

  • Transforming growth factor-β inhibition and endothelin receptor blockade in rats with monocrotaline-induced pulmonary hypertension.

    abstract：:Transforming growth factor-β (TGF-β) inhibition is an investigational therapy for pulmonary arterial hypertension with promising results in experimental studies. The present work compared this approach with endothelin-receptor blockade and evaluated the effects of combined administration. Pulmonary arterial hypertensi...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.4103/2045-8932.105034

    authors： Megalou AJ,Glava C,Vilaeti AD,Oikonomidis DL,Baltogiannis GG,Papalois A,Vlahos AP,Kolettis TM

    更新日期：2012-10-01 00:00:00

  • Medication adherence, hospitalization, and healthcare resource utilization and costs in patients with pulmonary arterial hypertension treated with endothelin receptor antagonists or phosphodiesterase type-5 inhibitors.

    abstract：:Adherence to therapy for pulmonary arterial hypertension is essential to optimize patient outcomes, but data on real-world adherence to different pulmonary arterial hypertension drug classes are limited. This retrospective database analysis evaluated relationships between adherence, hospitalization, and healthcare cos...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894019880086

    authors： Frantz RP,Hill JW,Lickert CA,Wade RL,Cole MR,Tsang Y,Drake W 3rd

    更新日期：2020-03-18 00:00:00

  • MicroRNA expression profile of pulmonary artery smooth muscle cells and the effect of let-7d in chronic thromboembolic pulmonary hypertension.

    abstract：:Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening condition characterized by single or recurrent pulmonary thromboemboli, which promote pulmonary vascular remodeling. MicroRNA (miRNA), is a small, noncoding RNA that is involved in multiple cell processes and functions and may partici...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1086/674310

    authors： Wang L,Guo LJ,Liu J,Wang W,Yuan JX,Zhao L,Wang J,Wang C

    更新日期：2013-09-01 00:00:00

  • Effects of exercise rehabilitation training on patients with pulmonary hypertension.

    abstract：:Pulmonary hypertension (PH) comprises a group of pathophysiological syndromes characterized by elevated pulmonary artery pressure and pulmonary vascular resistance, which lead to right ventricular overload, and even right heart failure. PH has a poor prognosis and severely leads to a decline in quality of life. Histor...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章,评审

    doi：10.1177/2045894020937129

    authors： Zhang X,Xu D

    更新日期：2020-07-07 00:00:00

  • Adverse physiologic effects of Western diet on right ventricular structure and function: role of lipid accumulation and metabolic therapy.

    abstract：:Little is known about the impact of metabolic syndrome (MS) on right ventricular (RV) structure and function. We hypothesized that mice fed a Western diet (WD) would develop RV lipid accumulation and impaired RV function, which would be ameliorated with metformin. Male C57/Bl6 mice were fed a WD or standard rodent die...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894018817741

    authors： Brittain EL,Talati M,Fortune N,Agrawal V,Meoli DF,West J,Hemnes AR

    更新日期：2019-01-01 00:00:00

  • Reducing rates of readmission and development of an outpatient management plan in pulmonary hypertension: lessons from congestive heart failure management.

    abstract：:Pulmonary hypertension currently has minimal guidelines for outpatient disease management. Congestive heart failure studies, however, have shown effectiveness of disease management plans in reducing all-cause mortality and all-cause and congestive heart failure-related hospital readmissions. Heart failure exacerbation...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894020968471

    authors： Dolan J,Mandras S,Mehta JP,Navas V,Tarver J,Chakinala M,Rahaghi F

    更新日期：2020-12-07 00:00:00

  • Current organization of specialist pulmonary hypertension clinics: results of an international survey.

    abstract：:Optimal pulmonary hypertension (PH) management relies on a timely, accurate diagnosis and follow-up in specialized clinics by multidisciplinary teams that have clearly defined responsibilities and protocols. Internationally agreed criteria for expert center staff are lacking, particularly with respect to nurses, who o...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894019855611

    authors： Doyle-Cox C,Nicholson G,Stewart T,Gin-Sing W

    更新日期：2019-04-01 00:00:00

  • Relationship of left ventricular outflow tract velocity time integral to treatment strategy in submassive and massive pulmonary embolism.

    abstract：:Pulmonary embolism is associated with high rates of mortality and morbidity. It is important to understand direct comparisons of current interventions to differentiate favorable outcomes and complications. The objective of this study was to compare ultrasound-accelerated thrombolysis versus systemic thrombolysis versu...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894020953724

    authors： Antoine D,Chuich T,Mylvaganam R,Malaisrie C,Freed B,Cuttica M,Schimmel D Jr

    更新日期：2020-09-28 00:00:00

  • Endothelial nitric oxide synthase genotype is associated with pulmonary hypertension severity in left heart failure patients.

    abstract：:The biological mechanisms behind the development of pulmonary hypertension in the setting of left heart failure (HF-PH), including combined pre- and post-capillary pulmonary hypertension (Cpc-PH), remains unclear. This study aimed to use candidate polymorphisms in nitric oxide synthase (NOS) genes to explore the role ...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894018773049

    authors： Duarte JD,Kansal M,Desai AA,Riden K,Arwood MJ,Yacob AA,Stamos TD,Cavallari LH,Zamanian RT,Shah SJ,Machado RF

    更新日期：2018-04-01 00:00:00

  • Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia.

    abstract：:Obesity is causally linked to a number of comorbidities, including cardiovascular disease, diabetes, renal dysfunction, and cancer. Obesity has also been linked to pulmonary disorders, including pulmonary arterial hypertension (PAH). It was long believed that obesity-related PAH was the result of hypoventilation and h...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1086/678510

    authors： Irwin DC,Garat CV,Crossno JT Jr,MacLean PS,Sullivan TM,Erickson PF,Jackman MR,Harral JW,Reusch JE,Klemm DJ

    更新日期：2014-12-01 00:00:00

  • Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury.

    abstract：:Radiotherapy as a primary treatment for thoracic malignancies induces deleterious effects, such as acute or subacute radiation-induced lung injury (RILI). Although the molecular etiology of RILI is controversial and likely multifactorial, a potentially important cellular target is the lung endothelial cytoskeleton tha...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1086/686491

    authors： Wang T,Mathew B,Wu X,Shimizu Y,Rizzo AN,Dudek SM,Weichselbaum RR,Jacobson JR,Hecker L,Garcia JG

    更新日期：2016-06-01 00:00:00

  • Deregulated angiogenesis in chronic lung diseases: a possible role for lung mesenchymal progenitor cells (2017 Grover Conference Series).

    abstract：:Chronic lung disease (CLD), including pulmonary fibrosis (PF) and chronic obstructive pulmonary disease (COPD), is the fourth leading cause of mortality worldwide. Both are debilitating pathologies that impede overall tissue function. A common co-morbidity in CLD is vasculopathy, characterized by deregulated angiogene...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045893217739807

    authors： Kropski JA,Richmond BW,Gaskill CF,Foronjy RF,Majka SM

    更新日期：2018-01-01 00:00:00

  • An observational study of inhaled-treprostinil respiratory-related safety in patients with pulmonary arterial hypertension.

    abstract：:Inhaled treprostinil (Tyvaso) has been shown to be a safe and effective addition to pulmonary arterial hypertension (PAH) oral therapies; however, the respiratory-related safety profile of inhaled treprostinil required further elucidation in the setting of routine clinical care. The objectives of this study were to ch...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1086/688059

    authors： Zamanian RT,Levine DJ,Bourge RC,De Souza SA,Rosenzweig EB,Alnuaimat H,Burger C,Mathai SC,Leedom N,DeAngelis K,Lim A,De Marco T

    更新日期：2016-09-01 00:00:00

  • Characterization of altered patterns of endothelial progenitor cells in sickle cell disease related pulmonary arterial hypertension.

    abstract：:Endothelial dysfunction plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH) in sickle cell disease (SCD). A variety of evidence suggests that circulating endothelial progenitor cells (EPCs) play an integral role in vascular repair. We hypothesized that SCD patients with PAH are deficie...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.4103/2045-8932.94834

    authors： Anjum F,Lazar J,Zein J,Jamaleddine G,Demetis S,Wadgaonkar R

    更新日期：2012-01-01 00:00:00

  • Dosing characteristics of oral treprostinil in real-world clinical practice.

    abstract：:Pharmacokinetic studies with oral treprostinil demonstrate that three times daily (TID) dosing reduces peak-to-trough plasma trepostinil fluctuations compared with twice daily (BID) dosing. TID dosing may allow for faster titration, higher total daily doses, and potentially improve the tolerability of oral trepostinil...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894018770654

    authors： Balasubramanian VP,Messick CR,Broderick M,Nelsen AC

    更新日期：2018-04-01 00:00:00

  • BMPR2 mutations and endothelial dysfunction in pulmonary arterial hypertension (2017 Grover Conference Series).

    abstract：:Despite the discovery more than 15 years ago that patients with hereditary pulmonary arterial hypertension (HPAH) inherit BMP type 2 receptor ( BMPR2) mutations, it is still unclear how these mutations cause disease. In part, this is attributable to the rarity of HPAH and difficulty obtaining tissue samples from patie...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894018765840

    authors： Frump A,Prewitt A,de Caestecker MP

    更新日期：2018-04-01 00:00:00

  • Determinants of right ventricular afterload (2013 Grover Conference series).

    abstract：:Right ventricular (RV) afterload consists of both resistive and capacitive (pulsatile) components. Total afterload can be measured directly with pulmonary artery input impedance spectra or estimated, either with lumped-parameter modeling or by pressure-volume analysis. However, the inverse, hyperbolic relationship bet...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章,评审

    doi：10.1086/676020

    authors： Tedford RJ

    更新日期：2014-06-01 00:00:00

  • BK channels in rat and human pulmonary smooth muscle cells are BKα-β1 functional complexes lacking the oxygen-sensitive stress axis regulated exon insert.

    abstract：:A loss of K+ efflux in pulmonary arterial smooth muscle cells (PASMCs) contributes to abnormal vasoconstriction and PASMC proliferation during pulmonary hypertension (PH). Activation of high-conductance Ca2+-activated (BK) channels represents a therapeutic strategy to restore K+ efflux to the affected PASMCs. However,...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1086/688838

    authors： Detweiler ND,Song L,McClenahan SJ,Versluis RJ,Kharade SV,Kurten RC,Rhee SW,Rusch NJ

    更新日期：2016-12-01 00:00:00

  • Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease.

    abstract：:The diagnosis of pulmonary vascular disease (PVD) is usually based on hemodynamic and/or clinical criteria. Noninvasive imaging of the heart and proximal vasculature can also provide useful information. An alternate approach to such criteria in the diagnosis of PVD is to image the vascular abnormalities in the lungs t...

    journal_title：Pulmonary circulation

    pub_type：

    doi：10.1086/685110

    authors： Dahhan T,Kaushik SS,He M,Mammarappallil JG,Tapson VF,McAdams HP,Sporn TA,Driehuys B,Rajagopal S

    更新日期：2016-03-01 00:00:00

  • Echocardiographic parameters of right ventricular function predict mortality in acute respiratory distress syndrome: a pilot study.

    abstract：:Right ventricular (RV) dysfunction in acute respiratory distress syndrome (ARDS) contributes to increased mortality. Our aim is to identify reproducible transthoracic echocardiography (TTE) parameters of RV dysfunction that can be used to predict outcomes in ARDS. We performed a retrospective single-center cohort pilo...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1086/685549

    authors： Shah TG,Wadia SK,Kovach J,Fogg L,Tandon R

    更新日期：2016-06-01 00:00:00

  • Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension.

    abstract：:Echocardiography, a non-invasive and cost-effective method for monitoring cardiac function, is commonly used for evaluation and pre-clinical diagnostics of pulmonary hypertension (PH). Previous echocardiographic studies in experimental models of PH are fragmentary in terms of the evaluation of right ventricle (RV) fun...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894019841987

    authors： Zhu Z,Godana D,Li A,Rodriguez B,Gu C,Tang H,Minshall RD,Huang W,Chen J

    更新日期：2019-04-01 00:00:00

  • Reactive oxygen species scavengers improve voltage-gated K(+) channel function in pulmonary arteries of newborn pigs with progressive hypoxia-induced pulmonary hypertension.

    abstract：:Abstract Changes in voltage-gated K(+) (Kv) channel function contribute to the pathogenesis of pulmonary hypertension. Yet the mechanisms underlying Kv channel impairments in the pulmonary circulation remain unclear. We tested the hypothesis that reactive oxygen species (ROSs) contribute to the Kv channel dysfunction ...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1086/674307

    authors： Fike CD,Aschner JL,Kaplowitz MR,Zhang Y,Madden JA

    更新日期：2013-09-01 00:00:00

  • Pulmonary tumor thrombotic microangiopathy: a systematic review.

    abstract：:Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal disease process in which pulmonary hypertension (PH) develops in the setting of malignancy. The purpose of this study is to present a detailed analysis of cases of PTTM reported in literature in the hopes of achieving more ante-mortem diagnoses. We conducted...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.1177/2045894019851000

    authors： Godbole RH,Saggar R,Kamangar N

    更新日期：2019-04-01 00:00:00

  • Right ventricular plasticity and functional imaging.

    abstract：:Right ventricular (RV) function is a strong independent predictor of outcome in a number of distinct cardiopulmonary diseases. The RV has a remarkable ability to sustain damage and recover function which may be related to unique anatomic, physiologic, and genetic factors that differentiate it from the left ventricle. ...

    journal_title：Pulmonary circulation

    pub_type： 杂志文章

    doi：10.4103/2045-8932.101407

    authors： Brittain EL,Hemnes AR,Keebler M,Lawson M,Byrd BF 3rd,Disalvo T

    更新日期：2012-07-01 00:00:00