Identifying early-warning signals of critical transitions with strong noise by dynamical network markers.


:Identifying early-warning signals of a critical transition for a complex system is difficult, especially when the target system is constantly perturbed by big noise, which makes the traditional methods fail due to the strong fluctuations of the observed data. In this work, we show that the critical transition is not traditional state-transition but probability distribution-transition when the noise is not sufficiently small, which, however, is a ubiquitous case in real systems. We present a model-free computational method to detect the warning signals before such transitions. The key idea behind is a strategy: "making big noise smaller" by a distribution-embedding scheme, which transforms the data from the observed state-variables with big noise to their distribution-variables with small noise, and thus makes the traditional criteria effective because of the significantly reduced fluctuations. Specifically, increasing the dimension of the observed data by moment expansion that changes the system from state-dynamics to probability distribution-dynamics, we derive new data in a higher-dimensional space but with much smaller noise. Then, we develop a criterion based on the dynamical network marker (DNM) to signal the impending critical transition using the transformed higher-dimensional data. We also demonstrate the effectiveness of our method in biological, ecological and financial systems.


Sci Rep


Scientific reports


Liu R,Chen P,Aihara K,Chen L




Has Abstract


2015-12-09 00:00:00










  • Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats.

    abstract::We have previously demonstrated that the Thymus algeriensis and Thymus fontanesii extracts have powerful anti-inflammatory, antipyretic, and analgesic effects against acute pain models. We profiled their chemical composition and found many phenolic acids, flavonoids, and phenolic diterpenes. In this work, we investiga...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Rezq S,Alsemeh AE,D'Elia L,El-Shazly AM,Monti DM,Sobeh M,Mahmoud MF

    更新日期:2020-11-25 00:00:00

  • The 5'UTR in human adenoviruses: leader diversity in late gene expression.

    abstract::Human adenoviruses (HAdVs) shut down host cellular cap-dependent mRNA translation while initiating the translation of viral late mRNAs in a cap-independent manner. HAdV 5' untranslated regions (5'UTRs) are crucial for cap-independent initiation, and influence mRNA localization and stability. However, HAdV translationa...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ramke M,Lee JY,Dyer DW,Seto D,Rajaiya J,Chodosh J

    更新日期:2017-04-04 00:00:00

  • Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

    abstract::Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been identified in humans and mice on the basis of their extensive portfoli...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wu Y,Chang YM,Stell AJ,Priestnall SL,Sharma E,Goulart MR,Gribben J,Xia D,Garden OA

    更新日期:2019-09-17 00:00:00

  • Acfs: accurate circRNA identification and quantification from RNA-Seq data.

    abstract::Circular RNAs (circRNAs) are a group of single-stranded RNAs in closed circular form. They are splicing-generated, widely expressed in various tissues and have functional implications in development and diseases. To facilitate genome-wide characterization of circRNAs using RNA-Seq data, we present a freely available s...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: You X,Conrad TO

    更新日期:2016-12-08 00:00:00

  • Influence of impact speed on water droplet erosion of TiAl compared with Ti6Al4V.

    abstract::Water Droplet Erosion (WDE) as a material degradation phenomenon has been a concern in power generation industries for decades. Steam turbine blades and the compressor blades of gas turbines that use water injection usually suffer from WDE. The present work focuses on studying erosion resistance of TiAl as a potential...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Mahdipoor MS,Kirols HS,Kevorkov D,Jedrzejowski P,Medraj M

    更新日期:2015-09-22 00:00:00

  • Fast and reliable advanced two-step pore-size analysis of biomimetic 3D extracellular matrix scaffolds.

    abstract::The tissue microenvironment is a major contributor to cellular functions, such as cell adhesion, migration and invasion. A critical physical parameter for determining the effect of the microenvironment on cellular functions is the average pore-size of filamentous scaffolds, such as 3D collagen fiber matrices, which ar...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Fischer T,Hayn A,Mierke CT

    更新日期:2019-06-07 00:00:00

  • A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage.

    abstract::Obesity causes low-grade inflammation that is involved in male infertility. Interleukin 1 beta (IL1β) plays an important role in this process. A high-fat diet (HFD) is the most common cause of obesity. However, the effect of a HFD on IL1β and its consequence in reproduction remain unclear. We established a HFD model i...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhang J,Li K,Yuan M,Zhang J,Huang G,Ao J,Tan H,Li Y,Gong D,Li J,Kang L,An N,Li F,Lin P,Huang L

    更新日期:2017-04-03 00:00:00

  • Genetic Predisposition to Sporadic Congenital Hearing Loss in a Pediatric Population.

    abstract::Discriminating between inherited and non-inherited sporadic hearing loss is challenging. Here, we attempted to delineate genetic inheritance in simplex cases of severe-to-profound congenital hearing loss in Korean children. Variations in SLC26A4 and GJB2 in 28 children with bilateral severe-to-profound non-syndromic h...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jung J,Lee JS,Cho KJ,Yu S,Yoon JH,Yung Gee H,Choi JY

    更新日期:2017-04-06 00:00:00

  • Numerical analysis of thermal conductive hybrid nanofluid flow over the surface of a wavy spinning disk.

    abstract::A three dimensional (3D) numerical solution of unsteady, Ag-MgO hybrid nanoliquid flow with heat and mass transmission caused by upward/downward moving of wavy spinning disk has been scrutinized. The magnetic field has been also considered. The hybrid nanoliquid has been synthesized in the presence of Ag-MgO nanoparti...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ahmadian A,Bilal M,Khan MA,Asjad MI

    更新日期:2020-11-02 00:00:00

  • Complex societies and the growth of the law.

    abstract::While many informal factors influence how people interact, modern societies rely upon law as a primary mechanism to formally control human behaviour. How legal rules impact societal development depends on the interplay between two types of actors: the people who create the rules and the people to which the rules poten...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Katz DM,Coupette C,Beckedorf J,Hartung D

    更新日期:2020-10-30 00:00:00

  • Variation of soil organic carbon and physical properties in relation to land uses in the Yellow River Delta, China.

    abstract::Soil physical properties and soil organic carbon (SOC) are considered as important factors of soil quality. Arable land, grassland, and forest land coexist in the saline-alkali reclamation area of the Yellow River Delta (YRD), China. Such different land uses strongly influence the services of ecosystem to induce soil ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jiao S,Li J,Li Y,Xu Z,Kong B,Li Y,Shen Y

    更新日期:2020-11-23 00:00:00

  • Expression and replication of virus-like circular DNA in human cells.

    abstract::The consumption of bovine milk and meat is considered a risk factor for colon- and breast cancer formation, and milk consumption has also been implicated in an increased risk for developing Multiple Sclerosis (MS). A number of highly related virus-like DNAs have been recently isolated from bovine milk and sera and fro...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Eilebrecht S,Hotz-Wagenblatt A,Sarachaga V,Burk A,Falida K,Chakraborty D,Nikitina E,Tessmer C,Whitley C,Sauerland C,Gunst K,Grewe I,Bund T

    更新日期:2018-02-12 00:00:00

  • HLA genotypes and cold medicine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis.

    abstract::Serious cutaneous adverse drug reactions [i.e., SJS/TEN with severe ocular complications (SOC)] associated with cold medicine (CM) were reported in several studies. To assess the risks of CM-induced SJS/TEN with SOC, systematic review and meta-analysis were employed. Studies investigating associations between HLA geno...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析


    authors: Tangamornsuksan W,Chanprasert S,Nadee P,Rungruang S,Meesilsat N,Ueta M,Lohitnavy M

    更新日期:2020-06-29 00:00:00

  • Huntington's disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer's disease.

    abstract::There is widespread transcriptional dysregulation in Huntington's disease (HD) brain, but analysis is inevitably limited by advanced disease and postmortem changes. However, mutant HTT is ubiquitously expressed and acts systemically, meaning blood, which is readily available and contains cells that are dysfunctional i...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Hensman Moss DJ,Flower MD,Lo KK,Miller JR,van Ommen GB,'t Hoen PA,Stone TC,Guinee A,Langbehn DR,Jones L,Plagnol V,van Roon-Mom WM,Holmans P,Tabrizi SJ

    更新日期:2017-03-21 00:00:00

  • Genome-wide analyses of long noncoding RNA expression profiles in lung adenocarcinoma.

    abstract::LncRNAs have emerged as a novel class of critical regulators of cancer. We aimed to construct a landscape of lncRNAs and their potential target genes in lung adenocarcinoma. Genome-wide expression of lncRNAs and mRNAs was determined using microarray. qRT-PCR was performed to validate the expression of the selected lnc...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Peng Z,Wang J,Shan B,Yuan F,Li B,Dong Y,Peng W,Shi W,Cheng Y,Gao Y,Zhang C,Duan C

    更新日期:2017-11-10 00:00:00

  • Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling.

    abstract::HIF-1α, an essential transcription factor under hypoxic condition, is indispensable for chondrocytes during skeletal development but its expression and roles in articular chondrocytes are yet to be revealed. We examined HIF-1α protein expression and the hypoxic condition during mouse osteoarthritis (OA) development us...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Okada K,Mori D,Makii Y,Nakamoto H,Murahashi Y,Yano F,Chang SH,Taniguchi Y,Kobayashi H,Semba H,Takeda N,Piao W,Hanaoka K,Nagano T,Tanaka S,Saito T

    更新日期:2020-03-25 00:00:00

  • Highly efficient and autocatalytic H2₂ dissociation for CO₂ reduction into formic acid with zinc.

    abstract::Artificial photosynthesis, specifically H2O dissociation for CO2 reduction with solar energy, is regarded as one of the most promising methods for sustainable energy and utilisation of environmental resources. However, a highly efficient conversion still remains extremely challenging. The hydrogenation of CO2 is regar...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jin F,Zeng X,Liu J,Jin Y,Wang L,Zhong H,Yao G,Huo Z

    更新日期:2014-03-28 00:00:00

  • The catalytic activity and secretion of zebrafish RNases are essential for their in vivo function in motor neurons and vasculature.

    abstract::Angiogenin (hANG), a member of the Ribonuclease A superfamily has angiogenic, neurotrophic and neuroprotective activities. Mutations in hANG have been found in patients with Amyotrophic lateral sclerosis (ALS). The zebrafish (Danio rerio) rnasel-1, 2 and 3 are orthologues of hANG and of these only Rnasel-1 and Rnasel-...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ferguson R,Holloway DE,Chandrasekhar A,Acharya KR,Subramanian V

    更新日期:2019-02-01 00:00:00

  • Use-dependent potentiation of voltage-gated calcium channels rescues neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A.

    abstract::Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse BoNT-induced blockade of neuromuscular transmission. While aminopyridines have ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Beske PH,Hoffman KM,Machamer JB,Eisen MR,McNutt PM

    更新日期:2017-11-20 00:00:00

  • The effect of thermal treatment on ac/dc conductivity and current fluctuations of PVDF/NMP/[EMIM][TFSI] solid polymer electrolyte.

    abstract::The experimental study deals with the investigation of the effect of diverse crystallinity of imidazolium ionic-liquid-based SPE on conductivity and current fluctuations. The experimental study was carried out on samples consisting of [EMIM][TFSI] as ionic liquid, PVDF as a polymer matrix and NMP as a solvent. After t...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Sedlak P,Gajdos A,Macku R,Majzner J,Holcman V,Sedlakova V,Kubersky P

    更新日期:2020-12-03 00:00:00

  • A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations.

    abstract::The impact of statin therapy on plasma asymmetric dimethylarginine (ADMA) levels has not been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of statins on circulating ADMA levels. We searched selected databases (up to August 2014) to identify randomized controlled trials (RCTs) t...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析,评审


    authors: Serban C,Sahebkar A,Ursoniu S,Mikhailidis DP,Rizzo M,Lip GY,Kees Hovingh G,Kastelein JJ,Kalinowski L,Rysz J,Banach M

    更新日期:2015-05-13 00:00:00

  • Fecal Bacterial Communities in treated HIV infected individuals on two antiretroviral regimens.

    abstract::Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We conducted a cross-se...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Pinto-Cardoso S,Lozupone C,Briceño O,Alva-Hernández S,Téllez N,Adriana A,Murakami-Ogasawara A,Reyes-Terán G

    更新日期:2017-03-06 00:00:00

  • Cell-free measurements of brightness of fluorescently labeled antibodies.

    abstract::Validation of imaging contrast agents, such as fluorescently labeled imaging antibodies, has been recognized as a critical challenge in clinical and preclinical studies. As the number of applications for imaging antibodies grows, these materials are increasingly being subjected to careful scrutiny. Antibody fluorescen...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhou H,Tourkakis G,Shi D,Kim DM,Zhang H,Du T,Eades WC,Berezin MY

    更新日期:2017-02-02 00:00:00

  • Noise suppression beyond the thermal limit with nanotransistor biosensors.

    abstract::Transistor biosensors are mass-fabrication-compatible devices of interest for point of care diagnosis as well as molecular interaction studies. While the actual transistor gates in processors reach the sub-10 nm range for optimum integration and power consumption, studies on design rules for the signal-to-noise ratio ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kutovyi Y,Madrid I,Zadorozhnyi I,Boichuk N,Kim SH,Fujii T,Jalabert L,Offenhaeusser A,Vitusevich S,Clément N

    更新日期:2020-07-29 00:00:00

  • Responses of crop yield growth to global temperature and socioeconomic changes.

    abstract::Although biophysical yield responses to local warming have been studied, we know little about how crop yield growth-a function of climate and technology-responds to global temperature and socioeconomic changes. Here, we present the yield growth of major crops under warming conditions from preindustrial levels as simul...

    journal_title:Scientific reports

    pub_type: 历史文章,杂志文章


    authors: Iizumi T,Furuya J,Shen Z,Kim W,Okada M,Fujimori S,Hasegawa T,Nishimori M

    更新日期:2017-08-10 00:00:00

  • Identification of brain antigens recognized by autoantibodies in experimental autoimmune encephalomyelitis-induced animals treated with etomoxir or interferon-β.

    abstract::Multiple sclerosis (MS) is a neurodegenerative autoimmune disease, where chronic inflammation plays an essential role in its pathology. A feature of MS is the production of autoantibodies stimulated by an altered-peptide-ligand response and epitope spreading, resulting in loss of tolerance for self-proteins. The invol...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Mørkholt AS,Kastaniegaard K,Trabjerg MS,Gopalasingam G,Niganze W,Larsen A,Stensballe A,Nielsen S,Nieland JD

    更新日期:2018-05-04 00:00:00

  • Optofluidic UV-Vis spectrophotometer for online monitoring of photocatalytic reactions.

    abstract::On-chip integration of optical detection units into the microfluidic systems for online monitoring is highly desirable for many applications and is also well in line with the spirit of optofluidics technology-fusion of optics and microfluidics for advanced functionalities. This paper reports the construction of a UV-V...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang N,Tan F,Zhao Y,Tsoi CC,Fan X,Yu W,Zhang X

    更新日期:2016-06-29 00:00:00

  • Elucidation of microstructural changes in leaves during senescence using spectral domain optical coherence tomography.

    abstract::Leaf senescence provides a unique window to explore the age-dependent programmed degradation at organ label in plants. Here, spectral domain optical coherence tomography (SD-OCT) has been used to study in vivo senescing leaf microstructural changes in the deciduous plant Acer serrulatum Hayata. Hayata leaves show autu...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Anna T,Chakraborty S,Cheng CY,Srivastava V,Chiou A,Kuo WC

    更新日期:2019-02-04 00:00:00

  • Speeding up bioproduction of selenium nanoparticles by using Vibrio natriegens as microbial factory.

    abstract::Selenium and selenium nanoparticles (SeNPs) are extensively used in biomedicine, electronics and some other industrial applications. The bioproduction of SeNPs is gaining interest as a green method to manufacture these biotechnologically relevant products. Several microorganisms have been used for the production of Se...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Fernández-Llamosas H,Castro L,Blázquez ML,Díaz E,Carmona M

    更新日期:2017-11-22 00:00:00

  • Targeting miR-155 to Treat Experimental Scleroderma.

    abstract::Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here, we found that expression of miR-155 was up regulated in lesional skin tissue from patients with either systemic or localized scleroderma, and correlated with f...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yan Q,Chen J,Li W,Bao C,Fu Q

    更新日期:2016-02-01 00:00:00