Abstract:
:Resveratrol and quercetin are well-known polyphenolic compounds present in common foods, which have demonstrated enormous potential in the treatment of a wide variety of diseases. Owing to their exciting synergistic potential and combination delivery applications, we developed a simple and rapid RP-HPLC method based on isosbestic point detection. The separation was carried out on phenomenex Synergi 4μ Hydro-RP 80A column using methanol: acetonitrile (ACN): 0.1% phosphoric acid (60:10:30) as mobile phase. The method was able to quantify nanograms of analytes simultaneously on a single wavelength (269 nm), making it highly sensitive, rapid as well as economical. Additionally, forced degradation studies of resveratrol and quercetin were established and the method's applicability was evaluated on PLGA nanoparticles and human plasma. The analytes peaks were found to be well resolved in the presence of degradation products and excipients. The simplicity of the developed method potentializes its suitability for routine in vitro and in vivo analysis of resveratrol and quercetin.
journal_name
Food Chemjournal_title
Food chemistryauthors
Kumar S,Lather V,Pandita Ddoi
10.1016/j.foodchem.2015.11.078subject
Has Abstractpub_date
2016-04-15 00:00:00pages
959-64issue
Pt Aeissn
0308-8146issn
1873-7072pii
S0308-8146(15)30223-5journal_volume
197pub_type
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