Abstract：
:Omega-3 nutraceuticals are extensively used as health supplements worldwide. Various administration forms for delivery of omega-3 are available. However, the niche omega-3 tablets have so far remained unexplored. In this work tablets containing 25-40% (w/w) omega-3 oil as triglycerides or ethyl esters were prepared utilizing a direct compaction grade powder with β-cyclodextrin as encapsulating agent. It was found that powders with up to 35% (w/w) triglyceride oil and 30% (w/w) ethyl ester oil, respectively, can be directly compressed into tablets of excellent quality. Physical properties of omega-3 containing powders and tablets are described. The powder X-ray diffractograms of the powders and crushed tablets show evidence of the formation of new crystalline phases not present in β-cyclodextrin. In addition, (1)H NMR data suggest that the ethyl esters form inclusion complexes with β-cyclodextrin. Compaction of other, commercially available, omega-3 powders was performed as a comparison and deemed unsuccessful.
journal_name
Food Chemjournal_title
Food chemistryauthors
Vestland TL,Jacobsen Ø,Sande SA,Myrset AH,Klaveness Jdoi
10.1016/j.foodchem.2015.10.142subject
Has Abstractpub_date
2016-04-15 00:00:00pages
496-502issue
Pt Aeissn
0308-8146issn
1873-7072pii
S0308-8146(15)30141-2journal_volume
197pub_type
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