Abstract:
:Internalizing pathology is related to alterations in amygdala resting state functional connectivity, potentially implicating altered emotional reactivity and/or emotion regulation in the etiological pathway. Importantly, there is accumulating evidence that stress exposure and genetic vulnerability impact amygdala structure/function and risk for internalizing pathology. The present study examined whether early life stress and genetic profile scores (10 single nucleotide polymorphisms within 4 hypothalamic-pituitary-adrenal axis genes: CRHR1, NR3C2, NR3C1, and FKBP5) predicted individual differences in amygdala functional connectivity in school-age children (9- to 14-year-olds; N = 120). Whole-brain regression analyses indicated that increasing genetic "risk" predicted alterations in amygdala connectivity to the caudate and postcentral gyrus. Experience of more stressful and traumatic life events predicted weakened amygdala-anterior cingulate cortex connectivity. Genetic "risk" and stress exposure interacted to predict weakened connectivity between the amygdala and the inferior and middle frontal gyri, caudate, and parahippocampal gyrus in those children with the greatest genetic and environmental risk load. Furthermore, amygdala connectivity longitudinally predicted anxiety symptoms and emotion regulation skills at a later follow-up. Amygdala connectivity mediated effects of life stress on anxiety and of genetic variants on emotion regulation. The current results suggest that considering the unique and interacting effects of biological vulnerability and environmental risk factors may be key to understanding the development of altered amygdala functional connectivity, a potential factor in the risk trajectory for internalizing pathology.
journal_name
J Abnorm Psycholjournal_title
Journal of abnormal psychologyauthors
Pagliaccio D,Luby JL,Bogdan R,Agrawal A,Gaffrey MS,Belden AC,Botteron KN,Harms MP,Barch DMdoi
10.1037/abn0000094subject
Has Abstractpub_date
2015-11-01 00:00:00pages
817-33issue
4eissn
0021-843Xissn
1939-1846pii
2015-52362-005journal_volume
124pub_type
杂志文章abstract::Antisocial behavior (AB) in adolescence predicts problematic outcomes in adulthood. However, researchers have noted marked heterogeneity within the broad group of youth engaging in these destructive behaviors and have attempted to identify those with distinct etiologies and different trajectories of symptoms. In the p...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/abn0000029
更新日期:2015-05-01 00:00:00
abstract::In a previous article, we demonstrated in a large twin study that disordered gambling (DG), as defined by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV), ran in families, that about half of the variation in liability for DG was due to familial factors, and that all of this was explained by...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0022879
更新日期:2011-08-01 00:00:00
abstract::Implicit self-associations are theorized to be rigidly and excessively negative in affective disorders like depression. Such information processing patterns may be useful as an approach to parsing heterogeneous etiologies, substrates, and treatment outcomes within the broad syndrome of depression. However, there is a ...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/abn0000651
更新日期:2021-02-01 00:00:00
abstract::The main purpose of the present study was to examine implicit and explicit self-esteem (SE) in patients with persecutory delusions. In samples of paranoid patients, depressed patients, and healthy controls, implicit SE was assessed using the experimental go/no-go association task, whereas explicit SE was measured usin...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0022856
更新日期:2011-08-01 00:00:00
abstract::The current study examined vulnerability to depression during the transition from early to middle adolescence from the perspective of the response styles theory. During an initial assessment, 382 adolescents (ages 11-15 years) completed self-report measures assessing rumination and depressive symptoms as well as a sem...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0022796
更新日期:2011-05-01 00:00:00
abstract::In the present study, we sought to examine information seeking among individuals with social anxiety disorder (SAD, n = 31) and nonanxious controls (n = 32) during an impression-formation task. Participants were given an initial description of a protagonist that included polarized information on the social rank dimens...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0029555
更新日期:2013-02-01 00:00:00
abstract::The serotonin transporter promoter region polymorphism (5-HTTLPR) is associated with neural response to negative images in brain regions involved in the experience of emotion. However, the behavioral implications of this sensitivity have been studied far less extensively. The current study used eye-tracking methodolog...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0022125
更新日期:2011-02-01 00:00:00
abstract::A stressor vulnerability model of stress-induced drinking was tested in a stratified random sample of 1,316 Black and White adult drinkers. Stressors were highly predictive of both alcohol use and drinking problems among men who relied on avoidant forms of emotion coping or held strong positive expectancies for alcoho...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.101.1.139
更新日期:1992-02-01 00:00:00
abstract::Drunk driving, a major contributor to alcohol-related mortality, has been linked to a variety of other alcohol-related (e.g., Alcohol Dependence, early age at first drink) and non-alcohol-related externalizing behaviors. In a sample of 517 same-sex twin pairs from the National Longitudinal Study of Adolescent Health, ...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0034426
更新日期:2013-11-01 00:00:00
abstract::Little longitudinal research has examined progression to more severe bipolar disorders in individuals with "soft" bipolar spectrum conditions. We examine rates and predictors of progression to bipolar I and II diagnoses in a nonpatient sample of college-age participants (n = 201) with high General Behavior Inventory s...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0023973
更新日期:2012-02-01 00:00:00
abstract::In 2 experiments we investigated the effects of withdrawal and stress on the affective correlates of urges to smoke. In both, habitual cigarette smokers were divided into continuing and withdrawing smoker groups. In the 1st study, 44 adults reported current mood, urge, and expectations over a 24-hr period. In the 2nd,...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.101.4.617
更新日期:1992-11-01 00:00:00
abstract::This study assessed the structural relations between borderline personality disorder (BPD) features and purported etiological correlates. Approximately 5,000 18-year-old nonclinical young adults were screened for BPD features, and 2 cohorts of participants (total N = 421; approximately one half of whom endorsed signif...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.110.3.471
更新日期:2001-08-01 00:00:00
abstract::The authors evaluated whether self-reported trait anhedonia in schizophrenia reflects faulty memory, such that patients are capable of experiencing pleasure while engaged in enjoyable activities but underestimate their pleasure in recalling these experiences. Thirty schizophrenia patients and 31 nonpatient control par...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/0021-843X.115.3.496
更新日期:2006-08-01 00:00:00
abstract::Diminished responding to hearing one's own name is one of the earliest and strongest predictors of autism spectrum disorder (ASD). Here, we studied, for the first time, the neural correlates of hearing one's own name in ASD. Based on existing research, we hypothesized enhancement of late parietal positive activity spe...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/abn0000329
更新日期:2018-01-01 00:00:00
abstract::Individuals with autism spectrum disorder (ASD) often display enhanced attention to detail and exhibit restricted behavior. However, due to a lack of comprehensive eye-movement modeling techniques, it is currently unknown whether these behavioral effects are also evident during scene viewing (i.e., detailed visual ins...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/abn0000145
更新日期:2016-04-01 00:00:00
abstract::Schizophrenic (n = 21), bipolar (n = 18), and normal control subjects (n = 21) were compared on a word recognition measure of semantic priming. The task involved the presentation of related, neutral, and unrelated word pairs; the second word (target word) in each pair was presented in a degraded form. Facilitation was...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.99.3.215
更新日期:1990-08-01 00:00:00
abstract::Categorical and dimensional models for classifying personality disorders were evaluated by comparing the structure of personality pathology in a clinical sample (n = 158) with the structure in a general population sample (n = 274). Subjects completed 100 personality scales. Separate factor analyses revealed similar st...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.101.3.432
更新日期:1992-08-01 00:00:00
abstract::Self-reported emotional experience does not differ between patients with schizophrenia and healthy individuals, suggesting that the anhedonia in schizophrenia instead reflects decoupling of affect from motivated behavior. In 2 behavioral conditions, participants with schizophrenia and healthy participants were able to...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/0021-843X.116.2.268
更新日期:2007-05-01 00:00:00
abstract::We examined the course of PTSD symptoms in a cohort of U.S. Marines (N = 867) recruited for the Marine Resiliency Study (MRS) from a single infantry battalion that deployed as a unit for 7 months to Afghanistan during the peak of conflict there. Data were collected via structured interviews and self-report questionnai...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/abn0000020
更新日期:2015-02-01 00:00:00
abstract::There is considerable concern about the adjustment of children of depressed mothers. Earlier we studied the specificity of these difficulties to maternal depression. Child adjustment difficulties were evident in 7- to 13-year-old children of both depressed and nondepressed psychiatric patient mothers but not in the ch...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.100.4.473
更新日期:1991-11-01 00:00:00
abstract::In a four-wave, cohort-longitudinal design with a community sample of 515 children and adolescents (grades 2 through 9), this study examined the longitudinal structure of and prospective interrelations between maladaptive cognitions and depressive symptoms. Multigroup structural equation modeling generated four major ...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0024685
更新日期:2011-08-01 00:00:00
abstract::Schizophrenia is associated with deficits in P50 suppression to the second stimulus in a pair, a process often conceptualized as a preattentive index of sensory gating. This study assessed the malleability of the deficit by determining whether early attentional control can influence P50 gating across different phases ...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0018265
更新日期:2010-02-01 00:00:00
abstract::The role of bodily shame as a mediator between sexual or physical abuse and depression was investigated in a community sample of 101 women who had been followed for 8 years. In general, childhood and adult abuse were related to the occurrence of depression in the study period but when both were considered together, on...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.104.2.277
更新日期:1995-05-01 00:00:00
abstract::The high comorbidity of depression and anxiety is well established empirically but not well understood conceptually, in terms of either psychological or biological mechanisms. A neuropsychological model of regional brain activity in emotion provides contrasting hypotheses for depression and anxiety, with depression as...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::Social anhedonia (SA), the diminished pleasure from social relationships, is a prominent characteristic of the vulnerability and manifestation of schizophrenia disorder. However, SA can develop for multiple reasons and little is known about its neural basis; these 2 issues hinder the utility and sensitivity of SA as a...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0035223
更新日期:2014-02-01 00:00:00
abstract::This study tests the hypothesis that psychopathy-prone adolescents show reduced anticipatory skin conductance responding. Electrodermal activity was recorded while participants anticipated and responded to a 105 dB signaled or unsignaled white-noise burst. Using an extreme groups design, the authors used Child Psychop...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/0021-843X.114.2.187
更新日期:2005-05-01 00:00:00
abstract::Despite consistent documentation of associations between childhood negative emotionality and externalizing psychopathology, few genetically informative studies have investigated the etiology of that association. The goal of the current study was to delineate the etiology of the covariation of negative emotionality and...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0019342
更新日期:2010-05-01 00:00:00
abstract::We find Brewin's (2016) critiques of the narratives, power, and coherence measures in Rubin et al. (2016) without merit; his suggestions for a "revised formulation" (p. 1015) of coherence are contradicted by data readily available in the target article but ignored. We place Brewin's commentary in a historical context ...
journal_title:Journal of abnormal psychology
pub_type: 评论,杂志文章
doi:10.1037/abn0000211
更新日期:2016-10-01 00:00:00
abstract::An item-cuing directed forgetting task was used to investigate whether women reporting repressed (n = 13) or recovered (n = 13) memories of childhood sexual abuse (CSA) exhibit an avoidant encoding style (and resultant impaired memory) for trauma cues relative to women reporting no CSA experience (n = 15). All partici...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037//0021-843x.110.1.151
更新日期:2001-02-01 00:00:00
abstract::Research suggests that spatial navigation relies on the same neural network as episodic memory, episodic future thinking, and theory of mind (ToM). Such findings have stimulated theories (e.g., the scene construction and self-projection hypotheses) concerning possible common underlying cognitive capacities. Consistent...
journal_title:Journal of abnormal psychology
pub_type: 杂志文章
doi:10.1037/a0034819
更新日期:2013-11-01 00:00:00