Abstract:
:The potential for developing molecules of interest in preclinical preeclampsia from candidate genes that were discovered on gene expression microarray analysis has been challenged by limited access to additional first trimester trophoblast and decidual tissues. The question of whether these candidates encode secreted proteins that may be detected in maternal circulation early in pregnancy has been investigated using various proteomic methods. Pilot studies utilizing mass spectrometry based proteomic assays, along with enzyme linked immunosorbent assays (ELISAs), and Western immunoblotting in first trimester samples are reported. The novel targeted mass spectrometry methods led to robust multiple reaction monitoring assays. Despite detection of several candidates in early gestation, challenges persist. Future antibody-based studies may lead to a novel multiplex protein panel for screening or detection to prevent or mitigate preeclampsia.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Founds S,Zeng X,Lykins D,Roberts JMdoi
10.3390/ijms161126023subject
Has Abstractpub_date
2015-11-13 00:00:00pages
27208-27issue
11issn
1422-0067pii
ijms161126023journal_volume
16pub_type
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