Developing Potential Candidates of Preclinical Preeclampsia.

Abstract:

:The potential for developing molecules of interest in preclinical preeclampsia from candidate genes that were discovered on gene expression microarray analysis has been challenged by limited access to additional first trimester trophoblast and decidual tissues. The question of whether these candidates encode secreted proteins that may be detected in maternal circulation early in pregnancy has been investigated using various proteomic methods. Pilot studies utilizing mass spectrometry based proteomic assays, along with enzyme linked immunosorbent assays (ELISAs), and Western immunoblotting in first trimester samples are reported. The novel targeted mass spectrometry methods led to robust multiple reaction monitoring assays. Despite detection of several candidates in early gestation, challenges persist. Future antibody-based studies may lead to a novel multiplex protein panel for screening or detection to prevent or mitigate preeclampsia.

journal_name

Int J Mol Sci

authors

Founds S,Zeng X,Lykins D,Roberts JM

doi

10.3390/ijms161126023

subject

Has Abstract

pub_date

2015-11-13 00:00:00

pages

27208-27

issue

11

issn

1422-0067

pii

ijms161126023

journal_volume

16

pub_type

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