Photokilling of bacteria by the natural dye curcumin.

Abstract:

:Curcumin is a yellow-orange compound derived from the root of Curcuma longa (Zingiberaceae family), that has been used as a medicine, spice and coloring agent. Curcumin has proved nontoxic in a number of cell culture and whole animal studies. Curcumin has, however, been reported to have bactericidal effects at very high concentrations. When illuminated, curcumin exerted potent phototoxic effects in micromolar amounts. Gram-negative bacteria displayed greater resistance to curcumin phototoxicity relative to Gram-positive bacteria. Oxygen was required for curcumin phototoxicity. Curcumin binding to cells was not required for photokilling; the reactive intermediate therefore must be relatively long-lived. The mechanism(s) of curcumin phototoxicity may involve hydrogen peroxide production. Singlet excited oxygen was not detected.

journal_name

Arch Microbiol

journal_title

Archives of microbiology

authors

Dahl TA,McGowan WM,Shand MA,Srinivasan VS

doi

10.1007/BF00414437

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

183-5

issue

2

eissn

0302-8933

issn

1432-072X

journal_volume

151

pub_type

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