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Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices.

Abstract：

:The sensitivity of localized surface plasmon resonance (LSPR) of metal nanostructures to adsorbates lends itself to a powerful class of label-free biosensors. Optical properties of plasmonic nanostructures are dependent on the geometrical features and the local dielectric environment. The exponential decay of the sensitivity from the surface of the plasmonic nanotransducer calls for the careful consideration in its design with particular attention to the size of the recognition and analyte layers. In this study, we demonstrate that short peptides as biorecognition elements (BRE) compared to larger antibodies as target capture agents offer several advantages. Using a bioplasmonic paper device (BPD), we demonstrate the selective and sensitive detection of the cardiac biomarker troponin I (cTnI). The smaller sized peptide provides higher sensitivity and a lower detection limit using a BPD. Furthermore, the excellent shelf-life and thermal stability of peptide-based LSPR sensors, which precludes the need for special storage conditions, makes it ideal for use in resource-limited settings.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Tadepalli S,Kuang Z,Jiang Q,Liu KK,Fisher MA,Morrissey JJ,Kharasch ED,Slocik JM,Naik RR,Singamaneni S

doi

10.1038/srep16206

subject

Has Abstract

pub_date

2015-11-10 00:00:00

pages

16206

issn

2045-2322

pii

srep16206

journal_volume

5

pub_type

杂志文章

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