Genomics of Cancer and a New Era for Cancer Prevention.

Abstract:

:A primary justification for dedicating substantial amounts of research funding to large-scale cancer genomics projects of both somatic and germline DNA is that the biological insights will lead to new treatment targets and strategies for cancer therapy. While it is too early to judge the success of these projects in terms of clinical breakthroughs, an alternative rationale is that new genomics techniques can be used to reduce the overall burden of cancer by prevention of new cases occurring and also by detecting them earlier. In particular, it is now becoming apparent that studying the genomic profile of tumors can help to identify new carcinogens and may subsequently result in implementing strategies that limit exposure. In parallel, it may be feasible to utilize genomic biomarkers to identify cancers at an earlier and more treatable stage using screening or other early detection approaches based on prediagnostic biospecimens. While the potential for these techniques is large, their successful outcome will depend on international collaboration and planning similar to that of recent sequencing initiatives.

journal_name

PLoS Genet

journal_title

PLoS genetics

authors

Brennan P,Wild CP

doi

10.1371/journal.pgen.1005522

subject

Has Abstract

pub_date

2015-11-05 00:00:00

pages

e1005522

issue

11

eissn

1553-7390

issn

1553-7404

pii

PGENETICS-D-15-01296

journal_volume

11

pub_type

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