Direct printing of patterned three-dimensional ultrafine fibrous scaffolds by stable jet electrospinning for cellular ingrowth.

abstract：:Four-dimensional (4D) bioprinting, encompassing a wide range of disciplines including bioengineering, materials science, chemistry, and computer sciences, is emerging as the next-generation biofabrication technology. By utilizing stimuli-responsive materials and advanced three-dimensional (3D) bioprinting strategies, ...

journal_title：Biofabrication

authors： Li YC,Zhang YS,Akpek A,Shin SR,Khademhosseini A

更新日期：2016-12-02 00:00:00

abstract：:Three-dimensional bioprinting of biomaterials shows great potential for producing cell-encapsulated scaffolds to repair nerves after injury or disease. For this, preparation of biomaterials and bioprinting itself are critical to create scaffolds with both biological and mechanical properties appropriate for nerve rege...

journal_title：Biofabrication

authors： Ning L,Sun H,Lelong T,Guilloteau R,Zhu N,Schreyer DJ,Chen X

更新日期：2018-06-29 00:00:00

abstract：:Degeneration of the intervertebral disc (IVD) represents a significant musculoskeletal disease burden. Tissue engineering has proposed several strategies comprising the use of biodegradable materials to prepare scaffolds that can present mechanical properties similar to those of native IVD tissues. However, this might...

journal_title：Biofabrication

authors： van Uden S,Silva-Correia J,Correlo VM,Oliveira JM,Reis RL

更新日期：2015-01-21 00:00:00

abstract：:In this paper we explore the printability of reversible networks formed by catechol functionalized PEG solutions and metal cations (Al3+, Fe3+ or V3+). The printability and shape fidelity were dependent on the ink composition (metal ion type, pH, PEG molecular weight) and printing parameters (extrusion pressure and pr...

journal_title：Biofabrication

authors： Włodarczyk-Biegun MK,Paez JI,Villiou M,Feng J,Del Campo A

更新日期：2020-04-29 00:00:00

abstract：:We report on the fabrication of silicon-reinforced carbon (C:Si) structures by combinatorial pulsed laser deposition to search for the best design for a new generation of multi-functional coated implants. The synthesized films were characterized from the morphological, structural, compositional, mechanical and microbi...

journal_title：Biofabrication

authors： Mihailescu IN,Bociaga D,Popescu-Pelin G,Stan GE,Duta L,Socol G,Chifiriuc MC,Bleotu C,Lazar V,Husanu MA,Zgura I,Miculescu F,Negut I,Hapenciuc C

更新日期：2017-06-01 00:00:00

abstract：:Here we developed a composite scaffold of pearl/poly(lactic-co-glycolic acid) (pearl/PLGA) utilizing the low-temperature deposition manufacturing (LDM). LDM makes it possible to fabricate scaffolds with designed microstructure and macrostructure, while keeping the bioactivity of biomaterials by working at a low temper...

journal_title：Biofabrication

authors： Xu M,Li Y,Suo H,Yan Y,Liu L,Wang Q,Ge Y,Xu Y

更新日期：2010-06-01 00:00:00

abstract：:The tumour microenvironment is heterogeneous and consists of multiple cell types, variable extracellular matrix (ECM) composition, and contains cell-defined gradients of small molecules, oxygen, nutrients and waste. Emerging in vitro cell culture systems that attempt to replicate these features often fail to incorpora...

journal_title：Biofabrication

authors： Rodenhizer D,Cojocari D,Wouters BG,McGuigan AP

更新日期：2016-10-18 00:00:00

abstract：:An engineered three-dimensional scaffold with hierarchical porosity and multiple niche microenvironments is produced using a combined multi-nozzle deposition-freeze casting technique. In this paper we present a process to fabricate a scaffold with improved interconnectivity and hierarchical porosity. The scaffold is p...

journal_title：Biofabrication

authors： Snyder JE,Hunger PM,Wang C,Hamid Q,Wegst UG,Sun W

更新日期：2014-03-01 00:00:00

abstract：:Three-dimensional (3D) tissue models are invaluable tools that can closely reflect the in vivo physiological environment. However, they are usually difficult to develop, have a low throughput and are often costly; limiting their utility to most laboratories. The recent availability of inexpensive additive manufacturin...

journal_title：Biofabrication

authors： Flood P,Alvarez L,Reynaud EG

更新日期：2016-10-11 00:00:00

abstract：:Tissue engineering needs innovative solutions to better fit the requirements of a minimally invasive approach, providing at the same time instructive cues to cells. The use of shape memory polyurethane has been investigated by producing 4D scaffolds via additive manufacturing technology. Scaffolds with two different p...

journal_title：Biofabrication

authors： Hendrikson WJ,Rouwkema J,Clementi F,van Blitterswijk CA,Farè S,Moroni L

更新日期：2017-08-02 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) can be differentiated at high efficiency into cells of a targeting type but the resulting cell population has to be of high purity for clinical therapies to avoid teratomas. Herein, we report a microfluidic device with integrated and surface functionalised fishnet-like str...

journal_title：Biofabrication

authors： Li X,Yu L,Li J,Minami I,Nakajima M,Noda Y,Kotera H,Liu L,Chen Y

更新日期：2016-09-08 00:00:00

abstract：:Cell mechanical microenvironment (CMM) significantly affects cell behaviors such as spreading, migration, proliferation and differentiation. However, most studies on cell response to mechanical stimulation are based on two-dimensional (2D) planar substrates, which cannot mimic native three-dimensional (3D) CMM. Accumu...

journal_title：Biofabrication

authors： Huang G,Wang L,Wang S,Han Y,Wu J,Zhang Q,Xu F,Lu TJ

更新日期：2012-12-01 00:00:00

abstract：:This paper presents a novel continuous tool-path planning methodology for hollowed scaffold fabrication in tissue engineering. A new functionally gradient porous architecture is proposed with a continuous material deposition planning scheme. A controllable variational pore size and hence the porosity have been achieve...

journal_title：Biofabrication

authors： Khoda AK,Ozbolat IT,Koc B

更新日期：2011-09-01 00:00:00

abstract：:Calcium alginate hydrogels are widely used as biocompatible materials in a substantial number of biomedical applications. This paper reports on a hybrid 3D printing and electrodeposition approach for forming 3D calcium alginate hydrogels in a controllable manner. Firstly, a specific 3D hydrogel printing system is deve...

journal_title：Biofabrication

authors： Shang W,Liu Y,Wan W,Hu C,Liu Z,Wong CT,Fukuda T,Shen Y

更新日期：2017-06-07 00:00:00

abstract：:A recently emerged approach for tissue engineering is to biofabricate tissues using cellular spheroids as building blocks. Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), can be cultured to generate large numbers of cells and can presumably...

journal_title：Biofabrication

authors： Lin H,Li Q,Lei Y

更新日期：2017-04-24 00:00:00

abstract：:We report a method for preparing cell-laden hydrogel tubes. This method uses a coaxial double-orifice spinneret, simpler than triple-orifice spinnerets which have been used for preparing similar constructs. The intended application was to create a template for preparing filament-like structures composed of two heterog...

journal_title：Biofabrication

authors： Sakai S,Liu Y,Mah EJ,Taya M

更新日期：2013-03-01 00:00:00

abstract：:Engineering surfaces with functional polymers is a crucial issue in the field of micro/nanofabrication and cell-material interface studies. For many applications of surface patterning, it does not need cells to attach on the whole surface. Herein, we introduce a novel polymer fabrication protocol of off-stoichiometry ...

journal_title：Biofabrication

authors： Liu W,Li Y,Ding X

更新日期：2017-04-24 00:00:00

abstract：:In conventional primary cultures, cardiac cells prepared from a newborn rat undergo spontaneous formation of cell clusters after several days. These cell clusters may be non-homogeneously distributed on a flat surface and show irregular beating which can be recorded by calcium ion imaging. In order to improve the cell...

journal_title：Biofabrication

authors： Wang L,Liu L,Magome N,Agladze K,Chen Y

更新日期：2013-09-01 00:00:00

abstract：:Electrospun fibers of natural polymers are desirable for biomedical applications such as tissue engineering. Crosslinking of electrospun fibers of natural polymers is needed to prevent dissolution in water and to enhance mechanical strength. In this study, an in situ UV-crosslinking method was developed for crosslinki...

journal_title：Biofabrication

authors： Lin WH,Tsai WB

更新日期：2013-09-01 00:00:00

abstract：:Omentum-based matrices fabricated by decellularization have the potential to serve as autologous scaffolds for tissue engineering. Transplantation of such scaffolds prepared from the patient's own biomaterial may reduce the immunogenic response after transplantation. Recently we reported on the potential of the decell...

journal_title：Biofabrication

authors： Soffer-Tsur N,Shevach M,Shapira A,Peer D,Dvir T

更新日期：2014-09-01 00:00:00

abstract：:In recent years, novel biofabrication technologies have enabled the rapid manufacture of hydrogel-cell suspensions into tissue-imitating constructs. The development of novel materials for biofabrication still remains a challenge due to a gap between contradicting requirements such as three-dimensional printability and...

journal_title：Biofabrication

authors： Köpf M,Campos DF,Blaeser A,Sen KS,Fischer H

更新日期：2016-05-20 00:00:00

abstract：:Recent research has been focusing on the generation of living personalized osteochondral constructs for joint repair. Native articular cartilage has a zonal structure, which is not reflected in current constructs and which may be a cause of the frequent failure of these repair attempts. Therefore, we investigated the ...

journal_title：Biofabrication

authors： Mancini IAD,Schmidt S,Brommer H,Pouran B,Schäfer S,Tessmar J,Mensinga A,van Rijen MHP,Groll J,Blunk T,Levato R,Malda J,van Weeren PR

更新日期：2020-07-01 00:00:00

abstract：:Advances in three-dimensional cell cultures offer new opportunities in biomedical research and drug development. However, there are still challenges to overcome, including the lack of reliability, repeatability and complexity of tissues obtained by these techniques. In this study, we describe a new bioprinting system ...

journal_title：Biofabrication

authors： da Conceicao Ribeiro R,Pal D,Ferreira AM,Gentile P,Benning M,Dalgarno K

更新日期：2018-12-27 00:00:00

abstract：:The high attrition rate of neuro-pharmaceuticals as they proceed to market necessitates the development of clinically-relevant in vitro neural microphysiological systems that can be utilized during the preclinical screening phase to assess the safety and efficacy of potential compounds. Historically, proposed models h...

journal_title：Biofabrication

authors： Bowser DA,Moore MJ

更新日期：2019-10-21 00:00:00

abstract：:In clinical islet transplantation, allogeneic islets of Langerhans are transplanted into the portal vein of patients with type 1 diabetes, enabling the restoration of normoglycemia. After intra-hepatic transplantation several factors are involved in the decay in islet mass and function mainly caused by an immediate bl...

journal_title：Biofabrication

authors： Marchioli G,van Gurp L,van Krieken PP,Stamatialis D,Engelse M,van Blitterswijk CA,Karperien MB,de Koning E,Alblas J,Moroni L,van Apeldoorn AA

更新日期：2015-05-28 00:00:00

abstract：:Critical understanding of the complex metastatic cascade of prostate cancer is necessary for the development of a therapeutic interventions for treating metastatic prostate cancer. Increasing evidence supports the synergistic role of biochemical and biophysical cues in cancer progression at metastases. The biochemical...

journal_title：Biofabrication

authors： Jasuja H,Kar S,Katti DR,Katti K

更新日期：2021-01-08 00:00:00

abstract：:The precise positioning and arrangement of cell spheroids and organoids are critical to reconstructing complex tissue architecture for tissue engineering and regenerative medicine. Here, we present a digital acoustofluidic method to manipulate cell spheroids and organoids with unprecedented dexterity. By introducing l...

journal_title：Biofabrication

authors： Cai H,Wu Z,Ao Z,Nunez A,Chen B,Jiang L,Bondesson M,Guo F

更新日期：2020-07-01 00:00:00

abstract：:Cell-imprinting technology is a novel method for directing stem cell fate using substrates molded from target cells. Here, we fabricated and studied cell-imprinted substrates for neural priming in human adipose-derived stem cells in the absence of chemical cues. We molded polydimethylsiloxane (PDMS) silicone substrate...

journal_title：Biofabrication

authors： Ghazali ZS,Eskandari M,Bonakdar S,Renaud P,Mashinchian O,Shalileh S,Bonini F,Uckay I,Preynat-Seauve O,Braschler T

更新日期：2020-10-30 00:00:00

abstract：:Nerve tissues contain hierarchically ordered nerve fibers, while each of the nerve fibers has nano-oriented fibrous extracellular matrix and a core-shell structure of tubular myelin sheath with elongated axons encapsulated. Here, we report, for the first time, a ready approach to fabricate biomimetic nerve fibers whic...

journal_title：Biofabrication

authors： Chen S,Wu C,Liu A,Wei D,Xiao Y,Guo Z,Chen L,Zhu Y,Sun J,Luo H,Fan H

更新日期：2020-05-12 00:00:00

abstract：:An ordered cellulose film scaffold, termed a nematic ordered cellulose (NOC) template, had unique surface properties and successfully induced the establishment of a three-dimensional (3D), hierarchical structure of epidermal cells by cell attachment and subsequent culture. Initially, the scaffold surface properties we...

journal_title：Biofabrication

authors： Seyama T,Suh EY,Kondo T

更新日期：2013-06-01 00:00:00