[Serum cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE ) and cytochrome c oxidase (COX) in copper mine miners potentially expose d to hydrogen sulfide].

Abstract:

BACKGROUND:The aim of the study was to evaluate serum levels of the target enzyme for H2S toxicity--cytochrome c oxidase (COX) and enzymes involved in the synthesis of H2S--cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) in copper mine miners. MATERIAL AND METHODS:The initial and basic study was conducted respectively in 237 and 88 miners, working in 2 mining shafts: I--no H2S emissions recorded in the last 10 years (study group A) and II--H2S emissions occurred (study group B). A medical examination was performed and 10 ml of blood was collected from miners immediately after exiting the mine. RESULTS:There were no clinical or biochemical changes typical for H2S toxicity. Sulfhemoglobine was undetectable and there were no changes in the red-ox system. However, in group B, regulatory changes were found; a tendency to higher concentration of CBS and CSE, a higher activity of angiotensin converting enzyme (ACE) compared to group A (p<0.05) and a linear relationship between ACE and CSE (r=0.6927; p<0.001). It has been shown that cigarette smoking decreases COX (p<0.05), however, in miners working in shaft II, the decreased level of COX may result also from the presence of H2S in the gaseous emissions. CONCLUSIONS:COX concentration can be a sensitive indicator of exposure to H2S. The measurements of blood H2S concentrations carried out in workplaces should explain the cause of the changes observed in the COX, CBS and CSE activity. WSTĘP:Celem badań była ocena stężenia mitochondrialnego enzymu docelowego dla toksycznego działania siarkowodoru, tj. oksydazy cytochromu c (COX) oraz enzymów uczestniczących w syntezie endogennego H2S (siarkowodoru) – syntazy β-cystationiny (CBS) i γ-liazy cystationiny (CSE) w surowicy górników kopalni miedzi. MATERIAŁ I METODY:Badanie wstępne przeprowadzono u 237 górników, a zasadnicze u 88 górników zatrudnionych w 2 szybach: I – bez zarejestrowanych emisji H2S w ciągu ostatnich 10 lat (grupa badana A); II – w którym występowały emisje H2S (grupa badana B). U górników przeprowadzono badania lekarskie i bezpośrednio po wyjeździe z kopalni na powierzchnię pobrano od nich po 10 ml krwi żylnej. WYNIKI:Nie stwierdzono żadnych zmian klinicznych ani biochemicznych, typowych dla toksycznego działania siarkowodoru. Stężenie sulfhemoglobiny było nieoznaczalne, nie stwierdzono zmian w układzie oksydo-redukcyjnym. W grupie B wykazano natomiast zmiany regulacyjne, które mogą być wynikiem powtarzanych ekspozycji na H2S. Do tych zmian należy wyższe stężenie CBS i CSE w surowicy, wzrost aktywności enzymu konwertującego angiotensynę (ACE) w porównaniu z grupą A oraz liniowa zależność między ACE a CSE (r = 0,6927; p < 0,001). Wykazano, że palenie papierosów obniża stężenie COX (p < 0,05), jednak u górników zatrudnionych w szybie II obniżenie stężenia COX może wynikać, poza paleniem, także z obecności siarkowodoru w gazach kopalnianych. WNIOSKI:Stężenie COX może być czułym wskaźnikiem ekspozycji na siarkowodór. Pomiary stężenia siarkowodoru we krwi przeprowadzane na stanowiskach pracy powinny wyjaśnić przyczynę zmian w aktywności COX, CBS i CSE.

journal_name

Med Pr

journal_title

Medycyna pracy

authors

Skoczyńska A,Gruszczyński L,Turczyn B,Ścieszka M,Wojakowska A,Pawłowski T,Schmidt E

doi

10.13075/mp.5893.00207

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

539-48

issue

4

eissn

0465-5893

issn

2353-1339

pii

58806

journal_volume

66

pub_type

杂志文章
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    journal_title:Medycyna pracy

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    doi:

    authors: Kubasiewicz M,Starzyński Z

    更新日期:1989-01-01 00:00:00

  • [Various plasma components and whole blood viscosity in patients with the vascular form of vibration disease].

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    authors: Turczyński B,Sroczyński J,Wegiel A

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  • [Mortality rates in industrial cohort studies. II. Standardized relative risk].

    abstract::Presented in the paper are the features of standardized mortality rates (SMR) related to their comparability in different categories of exposure factor as well as features of standardized relative risk (SRR) of the possibility of evaluating the significance of the calculated value of relative risk and possibility of c...

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    doi:

    authors: Szymczak W,Wilczyńska U,Szeszenia-Dabrowska N

    更新日期:1989-01-01 00:00:00

  • [Evaluation of the effectiveness of medical prevention of pneumoconiosis based on studies of its incidence in selected coal mines].

    abstract::In a group of 3,938 persons--pit miners of 3 coal mines--employed over 8 years, full-size X-ray pictures of the chest have been taken and through a special questionnaire information has been collected on the length of employment, workstation, risk of dustiness, exposure to fibrogenic dusts outside the mine. Basing on ...

    journal_title:Medycyna pracy

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    doi:

    authors: Marek K,Kujawska A,Stasiów A,Stachura A,Goniewicz J

    更新日期:1987-01-01 00:00:00

  • [Biomarkers of hepatotoxic effects: their usefulness in occupational medicine].

    abstract::Medical screening and the resultant monitoring of health effects induced by hepatotoxins present in workplaces become of still greater importance in the assessment of occupational health and safety. Health effects of occupational and nonoccupational hepatotoxic factors may be acute, subacute or chronic. Laboratory tes...

    journal_title:Medycyna pracy

    pub_type: 杂志文章,评审

    doi:

    authors: Indulski JA,Lutz W

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  • [Polish asbestos and its fibrogenic effect. II. Identification and fibrogenic effect of fibrous minerals occurring in road stone deposits].

    abstract::Fibrogenic properties of a fibrous mineral occurring in road stone deposits mined at Nasławice at the Lower Silesia have been tested. Diffractometric and infrared absorption spectra tests identified this mineral as antigorite. The content of free crystalline silica was 1.3%. The dust (50 mg) obtained from the test min...

    journal_title:Medycyna pracy

    pub_type: 杂志文章

    doi:

    authors: Woźniak H,Wiecek E

    更新日期:1985-01-01 00:00:00

  • [Glutathione: its biosynthesis, induction agents and concentrations in selected diseases].

    abstract::Glutathione (GSH) is in a constant state of metabolic turnover. Because it is actively synthesized, it also must be degraded. In the first step of GSH synthesis, an amide linkage is formed between cysteine and glutamate catalyzed by gamma-glutamylcysteine synthetase. GSH synthetase catalyzes the reaction between amine...

    journal_title:Medycyna pracy

    pub_type: 杂志文章,评审

    doi:

    authors: Bukowska B

    更新日期:2004-01-01 00:00:00

  • [Occupational cancers in Poland, 1995-2003].

    abstract:BACKGROUND:The aim of this paper is to present current data on the incidence of occupational cancer in Poland. MATERIALS AND METHODS:This work is based on the information collected from forms reporting cases of occupational diseases in 1995-2003, received by the Central Register of Occupational Diseases run by the Nof...

    journal_title:Medycyna pracy

    pub_type: 杂志文章

    doi:

    authors: Wilczyńska U,Szeszenia-Dabrowska N

    更新日期:2005-01-01 00:00:00

  • [Norwegian Teacher Self-Efficacy Scale - Psychometric properties of the Polish version of the scale].

    abstract:BACKGROUND:Self-efficacy refers to different spheres of human functioning and to different tasks, including teaching activity. It is regarded as an important personal resource related to coping with stress. This paper was aimed at presenting psychometric properties of the Norwegian Teachers Self-Efficacy Scale (NTSES),...

    journal_title:Medycyna pracy

    pub_type: 杂志文章

    doi:10.13075/mp.5893.00569

    authors: Baka Ł

    更新日期:2017-10-17 00:00:00

  • [Benzimidazole and its derivatives--from fungicides to designer drugs. A new occupational and environmental hazards].

    abstract::Benzimidazole and benzimidazole derivatives play an important role in controlling various fungal pathogens. The benzimidazoles are also used to treat nematode and trematode infections in humans and animals. It acts by binding to the microtubules and stopping hyphal growth. It also binds to the spindle microtubules and...

    journal_title:Medycyna pracy

    pub_type: 杂志文章,评审

    doi:

    authors: Lutz P

    更新日期:2012-01-01 00:00:00

  • [Concentration of carcinoembryonic antigen, alpha-fetoprotein and beta-subunit of human chorionic gonadotropin in serum of workers employed directly in the production of coke].

    abstract::Serum levels of carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP) and beta-subunit of human chorionic gonadotropin (HCG) in coke oven workers were estimated in order to detect early biological effects of carcinogenesis. CEA, AFP and HCG concentrations were measured in 30 coke oven workers (group I) occupationall...

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    pub_type: 杂志文章

    doi:

    authors: Snit M

    更新日期:1993-01-01 00:00:00

  • [Undergraduate and postgraduate training in occupational hygiene (and medicine) during non-medical studies].

    abstract::It is well known that the employer bears the responsibility for all what is going on in every type of enterprise. Polish high schools (all types) do not provide future managers with full range of education as they do not teach their alumni about occupational medicine and hygiene. Curricula should include classes devot...

    journal_title:Medycyna pracy

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    doi:

    authors: Szozda R

    更新日期:2002-01-01 00:00:00

  • [Application of predictive model to estimate concentrations of chemical substances in the work environment].

    abstract:BACKGROUND:Based on the Estimation and Assessment of Substance Exposure (EASE) predictive model implemented into the European Union System for the Evaluation of Substances (EUSES 2.1.), the exposure to three chosen organic solvents: toluene, ethyl acetate and acetone was estimated and compared with the results of measu...

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    pub_type: 杂志文章

    doi:

    authors: Kupczewska-Dobecka M,Czerczak S,Jakubowski M,Maciaszek P,Janasik B

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  • [Back pain in coal miners of anthracite coal--pilot study results].

    abstract::The objective of the study was to determine the occurrence of a low-back-pain syndrome in coalminers. The pilot study also aimed at the evaluation of the study design and methods, prior to planned full-scale epidemiological assessment of the syndrome in this workforce. In two groups of subjects (204 persons employed i...

    journal_title:Medycyna pracy

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    doi:

    authors: Limburska I,Gaździk TS,Zejda JE

    更新日期:1996-01-01 00:00:00

  • [Changes in blood biochemical parameters during physical exercise and recovery after prior diazepam administration].

    abstract::The study involved 51 healthy males aged 20 -- 24, divided into two groups. Group I (30 subjects) performed exercise on a cycle ergometer with the load increasing according to the following schedule: 1 W/kg for six minutes, 2 W/kg -- six minutes, and 3 W/kg -- six minutes. The remaining 21 subjects (group II) performe...

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    authors: Markiewicz K,Cholewa M,Kojtych A,Radzikowska-Kintzi H,Jakubowski M

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  • [Type D personality, coping with stress and intensity of PTSD symptoms in firefighters].

    abstract:BACKGROUND:Personality traits and coping strategies are regarded as determinants of post-traumatic stress disorder (PTSD) symptoms in persons who have experienced a traumatic event. The purpose of the study was to investigate the relationship between type D personality, coping strategies, and PTSD symptoms. MATERIAL A...

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    doi:

    authors: Ogińiska-Bulik N,Langer I

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  • [Porphyrin equilibrium disorders in subjects exposed to contaminants emitted by nitrogen plants].

    abstract::For purpose of investigating porphyrine balance in people exposed to contaminants emitted by nitric plant, porphobilinogen and coproporphyrin excretion with urine was determined. Methemoglobin level in blood was a basis for evaluating exposure to contaminants. The results obtained were compared with the results of inv...

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    doi:

    authors: Misiewicz A

    更新日期:1978-01-01 00:00:00

  • [Estimation of physical exertion by the AET ergonomic job description].

    abstract::The study has been aimed at showing the advantages of using the AET ergonomic job description for estimation of physical workload, as compared to the traditional methods in which the estimates are made on the basis of the value of energy expenditure, static load and motion monotypicity. From tests on employees at 28 w...

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    authors: Makowiec-Dabrowska T,Radwan-Włodarczyk Z,Koszada-Włodarczyk W

    更新日期:1991-01-01 00:00:00

  • [Dosimetric system for assessing doses received by people occupationally exposed to external sources of ionizing radiation].

    abstract::The current system of dosimetric quantities has been defined by the International Commission on Radiological Protection (ICRP) and the International Commission on Radiation Units and Measurements (ICRU). Complexity of the system implies the physical nature of ionizing radiation, resulting from the presence of differen...

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    authors: Brodecki M,Domienik JU,Zmyślony M

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  • [Noise-induced risks at workstations in Poland and other European Union countries].

    abstract::Noise is one of the most common physical risks in the workplace. Long term exposure to its high levels (above 80-85 dB) can pose a significant threat to health of workers, including hearing loss. Noise can also be a burdensome factor hampering work, causing stress and various health problems. In the European Union abo...

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    doi:

    authors: Augustyńska D,Pleban D,Radosz J

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  • [Studies of lysozyme activity in the saliva of workers in the drug industry].

    abstract::The aim of this study was to examine the lysozyme activity in saliva of pharmaceutic industry workers in whom pathologic changes in the oral cavity were previously diagnosed. The study was carried out in the Pharmaceutic Plant "Polfa" in Stargard Gdański at the departments of sulphonamides, acetylsalicylic acid and va...

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    doi:

    authors: Zajaczkowska-Białowas L,Nowicka J,Kuc B,Sibora P

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  • [Contemporary problems of industrial toxicology].

    abstract::The author presents the present -- day position and developmental trends of industrial toxicology studies, relating this specialty to other hygiene branches, especially to natural environment protection. Disproportions in the development of this line of studies was indicated, as opposed to the progress in technique an...

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    authors: Kowalski Z

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  • [Influence of shift work on the diet and gastrointestinal complains among nurses. A pilot study].

    abstract:BACKGROUND:The work of nurses in hospitals is connected with shift and night work. Numerous publications suggest that shift work is responsible for some gastrointestinal disturbances (heartburn, dyspepsia, loss of appetite, stomach pain). It is not yet conclusive whether shift and night work is responsible for more fre...

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    doi:

    authors: Bilski B

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  • [Effect of chronic exposure to nitrogen dioxide on biogenic amine levels in the brain of guinea pigs].

    abstract::The experiment was carried out on male guinea pigs exposed to NO2 at a constant concentration of 0.1 ppm 24 h daily for 1, 2.5 and 6 months, or NO2 concentration was increased to 0.5 ppm twice daily, between 7:00 and 8:00 AM and 4:00 and 5:00 PM. After the exposure to NO2 was over the animals were killed by decapitati...

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  • [Studies of the effect of environmental factors on the visual system (based on the examination of workers at a precision instrument factory)].

    abstract::The studies involved 254 workers of a Precise Devices Plant. The impact of working conditions (chemical pollutants and lighting) on the sight organ was examined. In the test group a considerable percentage (29.5%) of chronic conjunctivitis was found. The disease results from a long-lasting exposure to dusts of various...

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    authors: Hańczyc P,Lukasik-Czerek A,Piróg M,Zdrojewicz Z,Lasisz B

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  • [Does exogenous melatonin prove to be effective in the prevention and treatment of pathologies associated with shift and night work?].

    abstract::The current data concerning the efficacy of exogenous melatonin treatment, especially with respect to night-shift workers, are presented. Therapy of sleep disorders experienced by night-shift workers is not always successful. To assess the results of melatonin therapy in shift workers, it is essential to perform exten...

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    authors: Bilski B,Perz S,Perz K

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  • [Lipid, collagen and mucopolysaccharide metabolism in workers exposed to occupational noise].

    abstract::In forty-nine workers of steelworks, exposed to noise of 88-112 dBA level, the concentration of total lipids, phospholipids, lipoproteins beta, total cholesterol, triglycerides and free fatty acids was determined. In addition, in the urine collected at night and urine collected within 8 working hours, the concentratio...

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    authors: Sroczyński J,Wegiel A,Wieja A,Kuleszyńska G,Mamczar A,Bresler M

    更新日期:1983-01-01 00:00:00

  • [Relationship between work in nitrogen-processing plants and chronic bronchitis including bronchial hypersensitivity].

    abstract::The examination involved 55 men exposed to NH3, 60 exposed to NO2 and NH3 and 98 controls. Symptoms of chronic cough and (or) expectoration were found in 8 controls and 18 exposed workers. Significant differences refer only to smokers. Bronchial overreactivity was found in 23.5% controls and in 21.1% of those exposed....

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    authors: Gondorowicz K,Rozniecki J

    更新日期:1981-01-01 00:00:00

  • [Variations in body weight as a function of age and smoking in physical workers].

    abstract::The body weight of 181 men performing physical work at an industrial plant was observed for a long time. The rate of excessive body weight was about 20% and varied with age and smoking. In those with excessive body weight during 5 years a significantly higher rate of circulatory system diseases was found. The relative...

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    doi:

    authors: Kocieniewska D

    更新日期:1981-01-01 00:00:00

  • [Vaccination against influenza in medical staff of Warsaw university hospitals and in students of Warsaw Medical University].

    abstract:BACKGROUND:According to CDC recommendations, medical staff should be vaccinated against influenza each year. The objective of this work was to establish the percentage of medical personnel and students vaccinated against influenza in two Warsaw university hospitals and Warsaw Medical University, to evaluate their level...

    journal_title:Medycyna pracy

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    doi:

    authors: Zielonka TM,Lesiński J,Zycińska K,Machowicz R,Wardyn AK

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