[Serum cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE ) and cytochrome c oxidase (COX) in copper mine miners potentially expose d to hydrogen sulfide].

Abstract:

BACKGROUND:The aim of the study was to evaluate serum levels of the target enzyme for H2S toxicity--cytochrome c oxidase (COX) and enzymes involved in the synthesis of H2S--cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) in copper mine miners. MATERIAL AND METHODS:The initial and basic study was conducted respectively in 237 and 88 miners, working in 2 mining shafts: I--no H2S emissions recorded in the last 10 years (study group A) and II--H2S emissions occurred (study group B). A medical examination was performed and 10 ml of blood was collected from miners immediately after exiting the mine. RESULTS:There were no clinical or biochemical changes typical for H2S toxicity. Sulfhemoglobine was undetectable and there were no changes in the red-ox system. However, in group B, regulatory changes were found; a tendency to higher concentration of CBS and CSE, a higher activity of angiotensin converting enzyme (ACE) compared to group A (p<0.05) and a linear relationship between ACE and CSE (r=0.6927; p<0.001). It has been shown that cigarette smoking decreases COX (p<0.05), however, in miners working in shaft II, the decreased level of COX may result also from the presence of H2S in the gaseous emissions. CONCLUSIONS:COX concentration can be a sensitive indicator of exposure to H2S. The measurements of blood H2S concentrations carried out in workplaces should explain the cause of the changes observed in the COX, CBS and CSE activity. WSTĘP:Celem badań była ocena stężenia mitochondrialnego enzymu docelowego dla toksycznego działania siarkowodoru, tj. oksydazy cytochromu c (COX) oraz enzymów uczestniczących w syntezie endogennego H2S (siarkowodoru) – syntazy β-cystationiny (CBS) i γ-liazy cystationiny (CSE) w surowicy górników kopalni miedzi. MATERIAŁ I METODY:Badanie wstępne przeprowadzono u 237 górników, a zasadnicze u 88 górników zatrudnionych w 2 szybach: I – bez zarejestrowanych emisji H2S w ciągu ostatnich 10 lat (grupa badana A); II – w którym występowały emisje H2S (grupa badana B). U górników przeprowadzono badania lekarskie i bezpośrednio po wyjeździe z kopalni na powierzchnię pobrano od nich po 10 ml krwi żylnej. WYNIKI:Nie stwierdzono żadnych zmian klinicznych ani biochemicznych, typowych dla toksycznego działania siarkowodoru. Stężenie sulfhemoglobiny było nieoznaczalne, nie stwierdzono zmian w układzie oksydo-redukcyjnym. W grupie B wykazano natomiast zmiany regulacyjne, które mogą być wynikiem powtarzanych ekspozycji na H2S. Do tych zmian należy wyższe stężenie CBS i CSE w surowicy, wzrost aktywności enzymu konwertującego angiotensynę (ACE) w porównaniu z grupą A oraz liniowa zależność między ACE a CSE (r = 0,6927; p < 0,001). Wykazano, że palenie papierosów obniża stężenie COX (p < 0,05), jednak u górników zatrudnionych w szybie II obniżenie stężenia COX może wynikać, poza paleniem, także z obecności siarkowodoru w gazach kopalnianych. WNIOSKI:Stężenie COX może być czułym wskaźnikiem ekspozycji na siarkowodór. Pomiary stężenia siarkowodoru we krwi przeprowadzane na stanowiskach pracy powinny wyjaśnić przyczynę zmian w aktywności COX, CBS i CSE.

journal_name

Med Pr

journal_title

Medycyna pracy

authors

Skoczyńska A,Gruszczyński L,Turczyn B,Ścieszka M,Wojakowska A,Pawłowski T,Schmidt E

doi

10.13075/mp.5893.00207

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

539-48

issue

4

eissn

0465-5893

issn

2353-1339

pii

58806

journal_volume

66

pub_type

杂志文章
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  • [Exposure to selected aldehydes among municipal transport bus drivers].

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    authors: Brzeźnicki S,Gromiec J

    更新日期:2002-01-01 00:00:00

  • [Measurement of the temporary auditory threshold shift (TTS) for evaluation of the degree of noise hazard].

    abstract::Long-term investigations of noise in coal mines enhanced the need to take measurements at work stations posing high risk of methane explosion. To facilitate evaluation of noise hazard at the workplace in coal mines, attempts have been made to apply TTS measurements. Measurements of TTS taken within 3 to 5 minutes afte...

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    authors: Lipowczan A,Sułkowski W,Tengler M

    更新日期:1983-01-01 00:00:00

  • [Quantitative methods of cancer risk assessment in exposure to chemicals].

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    authors: Szymczak W

    更新日期:2009-01-01 00:00:00

  • [Costs and benefits of medical prevention in small enterprises].

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    authors: Rydlewska-Liszkowska I,Jugo B,Kacprzak E

    更新日期:1997-01-01 00:00:00

  • [Acquired color vision disturbances as a sensitive marker of chronic exposure to petroleum derivatives].

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    doi:

    authors: Zdzieszyńska M,Goś R

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  • [Liver angiosarcoma in a male exposed to vinyl chloride over 22 years].

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    doi:

    authors: Moszczyński P,Moszczyński P Jr,Zabiínski Z

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  • [The management of obstructive sleep apnea syndrome in drivers - recommendations of the Polish Society Of Occupational Medicine, The Polish Respiratory Society, The Nofer Institute of Occupational Medicine in Lodz and The Polish Sleep Research Society].

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  • [Does exogenous melatonin prove to be effective in the prevention and treatment of pathologies associated with shift and night work?].

    abstract::The current data concerning the efficacy of exogenous melatonin treatment, especially with respect to night-shift workers, are presented. Therapy of sleep disorders experienced by night-shift workers is not always successful. To assess the results of melatonin therapy in shift workers, it is essential to perform exten...

    journal_title:Medycyna pracy

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    doi:

    authors: Bilski B,Perz S,Perz K

    更新日期:2005-01-01 00:00:00

  • Occupational exposure to antineoplastic drugs in hospital environments: potential risk associated with contact with cyclophosphamide- and ifosfamide-contaminated surfaces.

    abstract:BACKGROUND:Cyclophosphamide (CP) and ifosfamide (IP) contaminations have been detected in hospital environments. This study was conducted to determine if there was any contamination in the spaces (floors and door handles) between the hospital exit and the antineoplastic drugs (ADs) preparation and administration units....

    journal_title:Medycyna pracy

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    doi:10.13075/mp.5893.00931

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  • [Concentration of serum iron and transferrin saturation with iron as indices of changes resulting from chronic exposure to chemicals in industry].

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    doi:

    authors: Prazanowski M

    更新日期:1978-01-01 00:00:00

  • [Chronic fatigue syndrome: its importance in occupational medicine].

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    authors: Wiszniewska M,Walusiak J,Wittczak T,Pałczyński C

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  • [Evaluation of the nervous system in workers as needed for preventive examinations. Methodology. I. Subjective examinations].

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    authors: Polakowska B

    更新日期:1994-01-01 00:00:00

  • [Emotional self-control, coping with stress and psycho-physical well-being of prison officers].

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  • [Petroleum substances--human health hazards. I. Classification of petroleum substances on the list of dangerous substances and assessment of existing hazards].

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    authors: Konieczko K

    更新日期:2006-01-01 00:00:00

  • [Evaluation of the cancer risk among men exposed to occupational asbestos dust based on cohort studies].

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    authors: Szeszenia-Dabrowska N,Wilczyńska U,Kaczmarek T,Szymczak W

    更新日期:1991-01-01 00:00:00

  • [Incidence of urinary tract diseases among workers in the Masovian Refining and Petrochemical Plants in Płock 1978-1981].

    abstract::The studies were aimed at estimation of the incidence rate of genito-urinary tract diseases among employees of the Mazovian Refining and Petrochemical Plants in Płock. In 1978-1981, 873 employees were examined, including 244 females and 629 males. Most of them, namely 572 (65%), were employed in those plants for more ...

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    doi:

    authors: Miekoś E,Leńko Z,Monita W,Lesiewicz H,Jazdzewski B,Zajgner J,Pawlak C,Kozłowski R

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  • [Effect of professional work and environmental factors on arterial blood pressure].

    abstract::Polish population is characterized by a high prevalence of cardiovascular diseases, including arterial hypertension. At present, the studies on the factors favouring the development of hypertension are carried out in many countries. The results of recent studies concerning the association between work and arterial hyp...

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    authors: Kawecka-Jaszcz K

    更新日期:1991-01-01 00:00:00

  • [Asbestos substitutes and their biological effects. 3. Carcinogenic effects of synthetic amphiboles in animal experiments].

    abstract::This work presents the results of the test performed on rats to evaluate the carcinogenic effect of 4 synthetic amphiboles compared to that of the natural amphibole--crocidolite. The dose of the magnesium amphibole (Na2Mg6Si8(OH)2) administered to the animals contained 240 x 10(6) respirable fibres; the corresponding ...

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    authors: Woźniak H,Wiecek E,Stetkiewicz J,Lao I,Krajnow A,Roszkowicz A

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  • [Analysis of occupational exposure of healthcare workers in the years 1998-2013 for bloodborne pathogens on the example of the hospital of the surgical profile].

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  • [Biological hazards in air at municipal waste landfills].

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    authors: Buczyńska A,Cyprowski M,Szadkowska-Stańczyk I

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  • [Screening methods for the detection of alpha-1-antitrypsin deficiency in blood serum].

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    更新日期:1977-01-01 00:00:00

  • [Estimation of the restricted area related to the limitation of exposure of the general public to electromagnetic fields in the vicinity of microwave relay antenna systems].

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  • [Do the requirements included in the regulation on health and safety at school effectively prevent children from carrying too heavy schoolbags?]

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    authors: Rogaczewska T,Gromiec J,Woźniczka M

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    authors: Gdulewicz T,Dawydzik L,Indulski J,Włodarczyk C

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