Acute iron overload leads to hypothalamic-pituitary-gonadal axis abnormalities in female rats.


:Iron plays a critical role in a mammal's physiological processes. However, iron tissue deposits have been shown to act as endocrine disrupters. Studies that evaluate the effect of acute iron overload on hypothalamic-pituitary-gonadal (HPG) axis health are particularly sparse. This study demonstrates that acute iron overload leads to HPG axis abnormalities, including iron accumulation and impairment in reproductive tract morphology. Female rats were treated with iron-dextran (Fe rats) to assess their HPG morphophysiology. The increasing serum iron levels due to iron-dextran treatment were positively correlated with higher iron accumulation in the HPG axis and uterus of Fe rats than in control rats. An increase in the production of superoxide anions was observed in the pituitary, uterus and ovary of Fe rats. Morphophysiological reproductive tract abnormalities, such as abnormal ovarian follicular development and the reduction of serum estrogen levels, were observed in Fe rats. In addition, a significant negative correlation was obtained between ovary superoxide anion and serum estrogen levels. Together, these data provide in vivo evidence that acute iron overload is toxic for the HPG axis, a finding that may be associated with the subsequent development of the risk of reproductive dysfunction.


Toxicol Lett


Toxicology letters


Rossi EM,Marques VB,Nunes Dde O,Carneiro MT,Podratz PL,Merlo E,dos Santos L,Graceli JB




Has Abstract


2016-01-05 00:00:00














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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Coelho MG,Reis PA,Gava VB,Marques PR,Gayer CR,Laranja GA,Felzenswalb I,Sabino KC

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  • A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers.

    abstract::Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two sy...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Wei Z,Fang Y,Gosztyla ML,Li AJ,Huang W,LeClair CA,Simeonov A,Tao D,Xia M

    更新日期:2021-03-01 00:00:00

  • Effects of genistein on the expression of hepatic genes in two rat strains (Sprague-Dawley and Wistar).

    abstract::Information about the effects of phytoestrogens in the liver, the main organ of metabolism, is limited. In this study we have examined the dose dependent effects of the phytoestrogen genistein (GEN) on gene expression in rat liver in comparison to the potent estrogen ethinylestradiol (EE). Special attention was paid t...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Geis RB,Diel P,Degen GH,Vollmer G

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    abstract::Pneumotoxicity of butylated hydroxytoluene (BHT) applied to the skin of CD-1 mice was investigated and compared with that of butylated hydroxyanisole (BHA). To 6 groups of 10 male mice and 10 female mice 0.1 ml of dimethylsulfoxide (DMSO) solutions containing 0, 5, 10, 20, or 30 mg of BHT or 30 mg of BHA were topicall...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Miyakawa Y,Takahashi M,Furukawa F,Toyoda K,Sato H,Hayashi Y

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  • Additive pro-oxidative effects of methylmercury and ebselen in liver from suckling rat pups.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Farina M,Soares FA,Zeni G,Souza DO,Rocha JB

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  • Inter- and intra-individual variation in urinary biomarker concentrations over a 6-day sampling period. Part 1: metals.

    abstract::The aim of the current HBM-study is to further the understanding of the impact of inter- and intra-individual variability in HBM surveys as it may have implications for the design and interpretation of the study outcomes. As spot samples only provide a snapshot in time of the concentrations of chemicals in an individu...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Smolders R,Koch HM,Moos RK,Cocker J,Jones K,Warren N,Levy L,Bevan R,Hays SM,Aylward LL

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yamada YK,Murakami N,Shimizu F,Kubota K

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kromidas L,Trombetta LD,Jamall IS

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  • Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Thiermann H,Eyer F,Felgenhauer N,Pfab R,Zilker T,Eyer P,Worek F

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ahluwalia P,Malik VB

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Wu XR,Xue M,Li XF,Wang Y,Wang J,Han QL,Yi ZC

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Cuff RL,Wade LT,Rychlik B,Jedlitschky GA,Burchell B

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Chen HH,Lin YR,Chan MH

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  • The effect of feeding a diet naturally contaminated with deoxynivalenol (DON) and zearalenone (ZON) on the spleen and liver of sow and fetus from day 35 to 70 of gestation.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Tiemann U,Brüssow KP,Dannenberger D,Jonas L,Pöhland R,Jäger K,Dänicke S,Hagemann E

    更新日期:2008-07-10 00:00:00

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    pub_type: 杂志文章


    authors: Imai T,Takami S,Cho YM,Hirose M,Nishikawa A

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jakobsen K,Eik-Nes KB

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    journal_title:Toxicology letters

    pub_type: 杂志文章


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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Schmeits PC,Volger OL,Zandvliet ET,van Loveren H,Peijnenburg AA,Hendriksen PJ

    更新日期:2013-02-13 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章


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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Li Y,Ding R,Ren X,Wen G,Dong Z,Yao H,Tan Y,Yu H,Wang X,Zhan X,Yao J,Lu Y,Zhang G,Wu X

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Botham PA,Hext PM,Rattray NJ,Walsh ST,Woodcock DR

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nakamoto T,Wagner M,Melvin JE,Bogdanffy MS

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Degraeve N,Chollet MC,Moutschen J

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Guiramand J,Lenoir M,Pujol R,Récasens M

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Hamamichi S,Nishigori H

    更新日期:2001-02-28 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Bai R,Zhang L,Liu Y,Li B,Wang L,Wang P,Autrup H,Beer C,Chen C

    更新日期:2014-04-07 00:00:00

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Zdarova Karasova J,Hepnarova V,Andrys R,Lisa M,Jost P,Muckova L,Pejchal J,Herman D,Jun D,Kassa J,Kuca K

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Pestka JJ,Moorman MA,Warner RL

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Oluwole OS,Onabolu AO,Sowunmi A

    更新日期:2002-09-05 00:00:00