Acute iron overload leads to hypothalamic-pituitary-gonadal axis abnormalities in female rats.

abstract：:Methamphetamine (METH) is a widely abused psychostimulant. Lactulose is a non-absorbable sugar, which effectively decreases METH-induced neurotoxicity in rat. However, the exact mechanisms need further investigation. In this study, 5-week-old male Sprague Dawley rats received METH (15 mg/kg, 8 intraperitoneal injectio...

journal_title：Toxicology letters

authors： Xie XL,He JT,Wang ZT,Xiao HQ,Zhou WT,Du SH,Xue Y,Wang Q

更新日期：2018-06-01 00:00:00

abstract：:Isolated hepatocytes form thiobarbituric acid (TBA)-reactants, a parameter of lipid peroxidation (LPO), when exposed to cadmium (Cd). Paracetamol (Para) inhibits this response, dependent on time and concentration. Cd-induced SH-group decline, however, and enhanced plasma membrane permeability to Trypan Blue (TB) were ...

journal_title：Toxicology letters

authors： Müller L

更新日期：1983-02-01 00:00:00

abstract：:Pregnant sows were fed a control diet (CON, 0.15 mg deoxynivalenol (DON) and 0.0035 mg zearalenone (ZON) per kg diet) or diet containing 15% of Fusarium toxin contaminated triticale (MYCO, 4.42 mg DON and 0.048 mg ZON per kg diet) during days 35-70 of gestation. All sows were fed in a restricted feeding regimen with t...

journal_title：Toxicology letters

authors： Tiemann U,Brüssow KP,Dannenberger D,Jonas L,Pöhland R,Jäger K,Dänicke S,Hagemann E

更新日期：2008-07-10 00:00:00

abstract：:Sublethal exposure to the organochlorine pesticide, dieldrin, decreased the T-cell immune response in mice. Indeed, a transient inhibition of the mixed lymphocyte reactivity (MLR) was noted at 7 days after intraperitoneal exposure to 0.6 LD50 dieldrin. The present study was undertaken to further investigate the effect...

journal_title：Toxicology letters

authors： Hugo P,Bernier J,Krzystyniak K,Potworowski EF,Fournier M

更新日期：1988-04-01 00:00:00

abstract：:A partially purified toxin fraction and lantadene A were obtained from Lantana camara L. leaves by batch extraction, column chromatography and fractional crystallization. Toxicity was tested in guinea pigs. The total number of chemical entities in the partially purified toxin preparation was 7, the 2 major ones being ...

journal_title：Toxicology letters

authors： Sharma OP,Dawra RK,Makkar HP

更新日期：1987-07-01 00:00:00

abstract：:Long-term (20 days) treatment with methyl mercury (MeHg) increases the total number of benzodiazepine binding sites and decreases essentially the content of cyclic GMP in the cerebellar cortex. In contrast, this treatment fails to modify the content of GABA and cyclic AMP, GAD activity and GABA binding sites in the sa...

journal_title：Toxicology letters

authors： Concas A,Corda MG,Salis M,Mulas ML,Milia A,Corongiu FP,Biggio G

更新日期：1983-08-01 00:00:00

abstract：:The effects of cytochrome P-450 inhibition by alpha-phenyl-alpha-propylbenzeneacetic acid 2-[diethylamino]-ethyl ester hydrochloride (SKF-525A), which inhibits the activity of a number of cytochrome P-450s, on triphenyltin metabolism and toxicity in mice were studied. At 24 h after triphenyltin administration, the tri...

journal_title：Toxicology letters

authors： Ohhira S,Matsui H,Watanabe K

更新日期：2000-11-20 00:00:00

abstract：:Blood-testis barrier (BTB) provides a suitable microenvironment for germ cells that is required for spermatogenesis. Exposure to particulate matter (PM) is recognized to occasion male reproductive impairment, but the mechanism of which remains unclear. Male Sprague-Dawley (SD) rats were used to establish animal models...

journal_title：Toxicology letters

authors： Cao XN,Shen LJ,Wu SD,Yan C,Zhou Y,Xiong G,Wang YC,Liu Y,Liu B,Tang XL,Guo M,Liu DY,Long CL,Sun M,He DW,Lin T,Wei GH

更新日期：2017-01-15 00:00:00

abstract：:The difference between infrared spectra of the nicotinic acetylcholine receptor (nAChR) recorded in the absence and presence of the agonist carbamylcholine (Carb) reveals a complex pattern of positive and negative bands that provides a spectral map of Carb-induced structural change. This spectral map is affected by th...

journal_title：Toxicology letters

authors： Ryan SE,Nguyen HP,Baenziger JE

更新日期：1998-11-23 00:00:00

abstract：:The toxic mechanism of endosulfan, a widely used organochlorine pesticide, was investigated in Saccharomyces cerevisiae and human cell lines. A concentration-dependent inhibition of cell growth was observed when S. cerevisiae was exposed to endosulfan, and its cytotoxicity (IC(50)) was found to be 49 microM and 86 mic...

journal_title：Toxicology letters

authors： Sohn HY,Kwon CS,Kwon GS,Lee JB,Kim E

更新日期：2004-07-15 00:00:00

abstract：:The potential adverse effects of hazardous waste incinerators (HWI) continue to be a subject of worry. The construction of the first and up till now only HWI in Spain finished in 1999. Twenty-six subjects employed at this HWI were divided into three groups: plant, laboratory and administration. Plasma analyses of HCB,...

journal_title：Toxicology letters

authors： Carmen Agramunt M,Domingo A,Domingo JL,Corbella J

更新日期：2003-12-15 00:00:00

abstract：:Toxicogenomics describes the measurement of global gene expression changes in biological samples exposed to toxicants. This new technology promises to greatly facilitate research into toxicant mechanisms, with the possibility of assisting in the detection of compounds with the potential to cause adverse health effects...

journal_title：Toxicology letters

authors： Orphanides G

更新日期：2003-04-11 00:00:00

abstract：:Nitropyrene (1-NP) is classified as Group 2B carcinogen and is one of the main components of diesel exhaust particles (DEP), which are generated from incomplete combustion of automobile engines to cause human cancer or inflammatory diseases. Although many reports on the mutagenesis or carcinogenesis of 1-NP have been ...

journal_title：Toxicology letters

authors： Park EJ,Park K

更新日期：2009-01-30 00:00:00

abstract：:1,3-Dinitrobenzene (DNB) causes testicular injury, particularly to Sertoli cells, and induces apoptosis in the surrounding germinal cells in rodents; however, the mechanisms causing this toxicity are poorly understood. Our studies, using standard and molecular tools, were conducted to better understand the pathogenesi...

journal_title：Toxicology letters

authors： Ludwig S,Tinwell H,Rouquié D,Schorsch F,Pallardy M,Bars R

更新日期：2012-09-03 00:00:00

abstract：:Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes. However, in vivo studies in various, soman poisoned animal species showed a therapeutic effect of oximes, with the exac...

journal_title：Toxicology letters

authors： Worek F,Thiermann H,Wille T

更新日期：2018-09-01 00:00:00

abstract：:Recent epidemiological studies in the United States and in Europe indicate, that the coarse fraction (PM-10) of airborne particulates, smaller than 10 microm and particularly the fine fraction (PM-2.5) smaller than 2.5 microm are responsible for adverse health effects, causing an increasing morbidity and mortality. Fu...

journal_title：Toxicology letters

authors： Hornberg C,Maciuleviciute L,Seemayer NH,Kainka E

更新日期：1998-08-01 00:00:00

abstract：:Nano-materials are currently being used in a variety of fields. One of the concerns associated with their use is their potential to harm human health. In an attempt to identify genes expressed differently in human lung cells (WI-26 VA4) exposed to nanosized (45 nm in diameter) PAMAM (polyamidoamine) dendrimers, we obs...

journal_title：Toxicology letters

authors： Lee JH,Cha KE,Kim MS,Hong HW,Chung DJ,Ryu G,Myung H

更新日期：2009-10-28 00:00:00

abstract：:Furan, a potential human carcinogen, is formed during heat-treatment of food. Previous studies of the genotoxicity of furan have given disparate results. Hence, there is a need for complementary data to clarify the mechanism behind the carcinogenicity of furan. In this study, we have used the flow cytometer-based micr...

journal_title：Toxicology letters

authors： Durling LJ,Svensson K,Abramsson-Zetterberg L

更新日期：2007-02-28 00:00:00

abstract：BACKGROUND:The epithelial to mesenchymal transition (EMT) contributes to fibrosis during silicosis. Zinc finger CCCH-type containing 4 protein (ZC3H4) is a novel CCCH-type zinc finger protein that activates inflammation in pulmonary macrophages during silicosis. However, whether ZC3H4 is involved in EMT during silicosi...

journal_title：Toxicology letters

authors： Jiang R,Zhou Z,Liao Y,Yang F,Cheng Y,Huang J,Wang J,Chen H,Zhu T,Chao J

更新日期：2019-06-01 00:00:00

abstract：:Women over 50 years of age in 32 cadmium(Cd)-polluted and 16 nonpolluted hamlets were studied. Itai-itai disease patients and proteinuria with glucosuria were used as indices of the effect of Cd on health. Unpolished rice samples were collected from 568 households in the same area and analyzed for Cd. The hamlet's ave...

journal_title：Toxicology letters

authors： Nogawa K,Yamada Y,Honda R,Ishizaki M,Tsuritani I,Kawano S,Kato T

更新日期：1983-07-01 00:00:00

abstract：:Although the interest is growing towards glyoxalases and methylglyoxal, their role in metabolism is still an enigma. In this paper, the effects of methylglyoxal in both in vivo and in vitro mammalian systems are reviewed and correlated with its interaction with macromolecules (nucleic acids, proteins). The theories on...

journal_title：Toxicology letters

authors： Kalapos MP

更新日期：1994-07-01 00:00:00

abstract：:Data on occurrence of dioxins (polychlorinated dibenzo-p-dioxins [PCDDs] and dibenzofurans [PCDFs]), dioxin-like PCBs (polychlorinated non-ortho and mono-ortho biphenyls) and non-dioxin-like PCBs (as represented by the so-called indicator-PCBs: congeners 28, 52, 101, 118, 138, 153 and 180) in food products consumed in...

journal_title：Toxicology letters

authors： Baars AJ,Bakker MI,Baumann RA,Boon PE,Freijer JI,Hoogenboom LA,Hoogerbrugge R,van Klaveren JD,Liem AK,Traag WA,de Vries J

更新日期：2004-06-15 00:00:00

abstract：:Betel quid chewing, which contributes high concentration of safrole in saliva, is a popular oral habit in Taiwan. Safrole is a documented rodent hepatocarcinogen, yet its hepatocarcinogenic potential in human is not known. Here, we used LC/ESI-ITMS(n) and LC/QTOF-MS confirmed safrole-dGMP as reference standard to dete...

journal_title：Toxicology letters

authors： Chung YT,Chen CL,Wu CC,Chan SA,Chi CW,Liu TY

更新日期：2008-12-15 00:00:00

abstract：:At the present work, different groups of rainbow trouts have been intraperitoneally treated with a polychlorinated biphenyls commercial mixture (Arochlor-1254) at three doses (5, 20 and 70 mg PCBs/ kg body weight) and they have been sampled at 0 (injection moment), 3, 6 and 9 weeks after xenobiotic exposure. Purificat...

journal_title：Toxicology letters

authors： Pérez-López M,Nóvoa-Valiñas MC,Melgar-Riol MJ

更新日期：2002-12-15 00:00:00

abstract：:Guinea pigs could be immunologically sensitised (as shown by the development of antigen-specific homocytotropic antibodies) to toluene diisocyanate by exposing them for 3 h a day for 5 consecutive days to atmospheres containing free chemical. Pulmonary reactions could be elicited in many of the sensitised animals by c...

journal_title：Toxicology letters

authors： Botham PA,Hext PM,Rattray NJ,Walsh ST,Woodcock DR

更新日期：1988-05-01 00:00:00

abstract：:A quantitative high-content screening (HCS) was suggested for the real-time monitoring of drug-induced mitochondrial dysfunction-mediated hepatotoxicity. This HCS is very advantageous in that it allows simultaneous observation of drug-induced activations of hepatotoxic pathways using hypermulticolor cellular imaging. ...

journal_title：Toxicology letters

authors： Kim JA,Han E,Eun CJ,Tak YK,Song JM

更新日期：2012-10-17 00:00:00

abstract：:Cimetidine, a widely prescribed, potent histamine H2-receptor antagonist, is unrelatedly a mild antiandrogen. Since perinatal androgens are essential for normal masculine imprinting, we wanted to determine if maternally administered cimetidine interfered with the development of the male offspring's sex-dependent, hepa...

journal_title：Toxicology letters

authors： Shapiro BH,Bitar MS

更新日期：1991-01-01 00:00:00

abstract：:Male rats were administered diets containing monobutyl (MBP), mono-iso-butyl (MIBP), monooctyl (MOP) or mono-2-ethylhexyl phthalate (MEHP) for 1 week, and serum lipid compositions were determined. Non-esterified fatty acid was increased and triglycerides and total cholesterol were decreased in all monoester-treated gr...

journal_title：Toxicology letters

authors： Oishi S,Hiraga K

更新日期：1982-11-01 00:00:00

abstract：:Doxorubicin (DOX) is a chemotherapeutic agent of which the medical use is limited due to cardiotoxicity. While acute cardiotoxicity is reversible, chronic cardiotoxicity is persistent or progressive, dose-dependent and irreversible. While DOX mechanisms of action are not fully understood yet, 3 toxicity processes are ...

journal_title：Toxicology letters

authors： Verheijen M,Schrooders Y,Gmuender H,Nudischer R,Clayton O,Hynes J,Niederer S,Cordes H,Kuepfer L,Kleinjans J,Caiment F

更新日期：2018-09-15 00:00:00

abstract：:In addition to evidence that inhalation of ambient particulate matter (PM) can increase cardiopulmonary morbidity and mortality, the brain may also constitute a site adversely effected by the environmental presence of airborne particulate matter. We have examined the association between exposure to PM and adverse CNS ...

journal_title：Toxicology letters

authors： Kleinman MT,Araujo JA,Nel A,Sioutas C,Campbell A,Cong PQ,Li H,Bondy SC

更新日期：2008-05-05 00:00:00