Unique dose-dependent effects of the human pregnancy hormone estriol on the ratio of blood IgM to IgG in female mice.


:The present study aimed to investigate the dose-dependent modulating effect of estriol (E3), an estrogen predominantly produced during human pregnancy, on antigen‑induced production of specific antibodies in female BALB/c mice. The animals were immunized either with bovine serum albumin (BSA) or the pneumococcal polysaccharide serotype-14 (PPS-14), and the levels of specific serum antibodies were determined using ELISA kits. E3 was found to have very different effects on antigen-induced production of specific antibodies in animals immunized with these two antigens. While E3 stimulated the production of PPS-14-specific antibodies, it suppressed the production of BSA-specific antibodies. The results also demonstrated that the modulating effect of E3 on the production of antigen‑specific antibodies depends on the dose of E3 used. For BSA‑induced antibody production, E3 had a dose‑dependent inhibitory effect, whereas for PPS‑14‑specific antibody (Ab) production, E3 exerted the strongest stimulation at a lower dose, and produced less stimulation at higher doses. E3 caused thymus atrophy in animals immunized with either PPS‑14 or BSA, but only induced spleen atrophy in BSA‑injected mice. These observations suggest that E3 increases the ability of a pregnant female to avoid bacterial infections while decreasing the incidence of autoimmune responses against circulating components from either the fetus or pregnant female.


Mol Med Rep


Ding J,Zhu BT




Has Abstract


2016-01-01 00:00:00












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    authors: Zhang L,Liu J,Zhou F,Wang W,Chen N

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    authors: Vasarmidi E,Sarantoulaki S,Trachalaki A,Margaritopoulos G,Bibaki E,Spandidos DA,Tzanakis N,Antoniou K

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    authors: Carmona B,Guerreiro C,Cravo M,Nobre-Leitão C,Brito M

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    authors: Zhou LN,Cui XJ,Su KX,Wang XH,Guo JH

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    authors: Lyu Y,Zhao H,Ye Y,Liu L,Zhu S,Xia Y,Zou F,Cai S

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    authors: Jung EM,An BS,Kim YK,Jeong YH,Hwang WS,Jeung EB

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    authors: Chen J,Song B,Kong G

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    authors: Hao B,Chen X,Dai D,Zou C,Wu X,Chen J

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    authors: Xu C,Li H,Zhang L,Jia T,Duan L,Lu C

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    authors: Xin JL,Zhang Y,Li Y,Zhang LZ,Lin Y,Zheng LW

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    authors: Wu Y,Zhang Z,Liao X,Qi L,Liu Y,Wang Z

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    authors: Zhou H,Huang J,Zhu L,Cao Y

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    journal_title:Molecular medicine reports

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    authors: Li Y,Zhang X,Wang C,Hu Y,Niu X,Pei D,He Z,Bi Y

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    abstract::The present study aimed to determine the profile of differentially expressed circular RNAs (circRNAs) in infertile patients treated with acupuncture and moxibustion and verify the role of acupuncture and moxibustion in altering endometrial receptivity (ER). High‑throughput RNA sequencing and bioinformatics analysis of...

    journal_title:Molecular medicine reports

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    authors: Shen J,Chen L,Cheng J,Jin X,Mu Y,Li Q,Xia L,Gao Y,Xia Y

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    authors: Liang Z,Li J,Zhao L,Deng Y

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    pub_type: 杂志文章


    authors: Ou S,Liao Y,Shi J,Tang J,Ye Y,Wu F,Wang W,Fei J,Xie F,Bai L

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wang J,Hou J,Lei H,Fu J,Pan Y,Liu J

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    abstract::The clinical significance of microRNA (miR)‑136‑5p in hepatocellular carcinoma (HCC) has not been verified. Therefore, in the current study, the authors aimed to explore miR‑136‑5p expression and its clinical significance in HCC, as well as to investigate its potential target genes function. The authors detected the l...

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    pub_type: 杂志文章,meta分析


    authors: Ding H,Ye ZH,Wen DY,Huang XL,Zeng CM,Mo J,Jiang YQ,Li JJ,Cai XY,Yang H,Chen G

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Yao M,Yang J,Cao L,Zhang L,Qu S,Gao H

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhou H,Yu X,Zhou G

    更新日期:2017-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Xiong HL,Zhou SW,Sun AH,He Y,Li J,Yuan X

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Liu W,Dong M,Bo L,Li C,Liu Q,Li Z,Jin F

    更新日期:2016-01-01 00:00:00

  • Dynamic Nestin expression during hair follicle maturation and the normal hair cycle.

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Chen R,Miao Y,Hu Z

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Dong Y,Gao X,Zhao Y,Wei M,Xu L,Yang G,Liu L

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    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Shu X,Chen F,Peng Q,Lu X,Tian X,Wang Y,Wang G

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