Detection of kidney damage by malathion impurities using a microdissection technique.


:O,O,S-Trimethylphosphorothioate (OOS-Me) and O,S,S-trimethylphosphorodithioate (OSS-Me) are impurities in technical grade malathion and related insecticides which have been shown to cause delayed death in rats following a single oral dose of 40-60 mg/kg. In connection with studies on the mode of action of these compounds, work on the microdissection and examination of nephrons was carried out. Nephrons from impurities-treated rats showed swelling, distortion and distension of glomeruli, as well as narrowing of the first part of the proximal tubule (swan neck). These results were similar to those observed from kidney tissue obtained from cadmium-chloride-treated rats and are indicative of OOS-Me and OSS-Me-induced kidney tubule damage.


Toxicol Lett


Toxicology letters


Keadtisuke S,Dheranetra W,Fukuto TR




Has Abstract


1989-04-01 00:00:00














  • CpG-oligodeoxynucleotides may be effective for preventing ionizing radiation induced pulmonary fibrosis.

    abstract::Pulmonary fibrosis is a serious adverse effect of radiotherapy for thoracic tumor, which is believed to be a process that is tightly regulated by the phenotype of the developing Th response after radiation. Here, we will investigate whether CpG-oligodeoxynucleotides (ODN) prevent radiation-induced pulmonary fibrosis b...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Zhang C,Zhao H,Li BL,Fu-Gao,Liu H,Cai JM,Zheng M

    更新日期:2018-08-01 00:00:00

  • The effects of 2,2',4,4',5,5'-hexachlorobiphenyl cotreatment on the disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice.

    abstract::Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. H...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: De Jongh J,DeVito M,Diliberto J,Van den Berg M,Birnbaum L

    更新日期:1995-10-01 00:00:00

  • Alpha-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions.

    abstract::Rat and canine hepatocyte suspensions were exposed to toxic concentrations of ethyl methanesulfonate (EMS) and ionophore A-23187 in the presence and absence of extracellular calcium (Ca2+) and alpha-tocopheryl succinate (alpha-TS). The exogenous administration of alpha-TS (25 microM) completely protected hepatocytes f...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Fariss MW,Merson MH,O'Hara TM

    更新日期:1989-04-01 00:00:00

  • Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: involvement of transcription factor NRF2.

    abstract::Modulation of the cytochrome P450 (CYP) monooxygenase system by cadmium was investigated in male, adult DBA/2J mice treated with a single dose (16 micromol/kg body weight, i.p.) of cadmium chloride (CdCl2). Total CYP content of liver and kidney microsomes decreased maximally (56% and 85%, respectively) 24 and 18 h, re...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Abu-Bakar A,Satarug S,Marks GC,Lang MA,Moore MR

    更新日期:2004-03-21 00:00:00

  • DNA adducts in hamster and rat tracheas exposed to benzo(a)pyrene in vitro.

    abstract::Syrian golden hamsters are much more susceptible than Wistar rats to the induction of tracheal tumors by benzo(a)pyrene (BP). In order to investigate whether this difference is reflected in the pattern of DNA-adduct induction and removal, tracheas from either species were isolated and exposed to BP (5 micrograms/ml) i...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Roggeband R,Wolterbeek AP,van den Berg PT,Baan RA

    更新日期:1994-06-01 00:00:00

  • Is the fear of dioxin cancer more harmful than dioxin?

    abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a proven animal carcinogen. Occupational cohorts with the highest exposures imply that there is a small risk of all cancers combined, but it is difficult to pinpoint the confounding effect of the main chemicals. Studies after major accidents do not unequivocally confirm th...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Tuomisto J,Tuomisto JT

    更新日期:2012-05-05 00:00:00

  • The investigation of the genotoxic effects of fenarimol and propamocarb in mouse bone marrow in vivo.

    abstract::In this study, we aimed to evaluate the genotoxic effects of fungicides fenarimol and propamocarb which are used to protect crops from fungi. For this reason, bone-marrow micronucleus and chromosome aberration tests were carried out in Swiss albino mice. Mice were injected with four different doses of fenarimol and pr...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Aydemir N,Bilaloğlu R

    更新日期:2004-02-28 00:00:00

  • Dibenzofuran induces oxidative stress, disruption of trans-mitochondrial membrane potential (ΔΨm) and G1 arrest in human hepatoma cell line.

    abstract::Dioxins are a class of extremely toxic environmentally persistent pollutant, comprised of halogenated dibenzo-p-dioxins, dibenzofurans and biphenyls. Despite significant human exposure via multiple routes, very little is known about toxicity induced by dibenzofuran (DF). Current study shed lights on the potential toxi...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jaiswal PK,Srivastava S,Gupta J,Thakur IS

    更新日期:2012-10-17 00:00:00

  • Characterisation of glucuronidation and transport in V79 cells co-expressing UGT1A1 and MRP1.

    abstract::The co-ordinated glucuronidation and export of compounds from cells is an important determinant in the detoxification of many compounds in vivo. Many UDP-glucuronosyltransferases (UGTs) and several multidrug resistance proteins (MRPs) have been cloned and individually expressed to assess specificity of glucuronidation...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Cuff RL,Wade LT,Rychlik B,Jedlitschky GA,Burchell B

    更新日期:2001-03-31 00:00:00

  • The organophosphate malathion disturbs gut microbiome development and the quorum-Sensing system.

    abstract::The gut microbiome has tremendous potential to impact health and disease. Various environmental toxicants, including insecticides, have been shown to alter gut microbiome community structures. However, the mechanism that compositionally and functionally regulates gut microbiota remains unclear. Quorum sensing is known...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Gao B,Chi L,Tu P,Bian X,Thomas J,Ru H,Lu K

    更新日期:2018-02-01 00:00:00

  • Combinatory estrogenic effects of bisphenol A in mixtures with alternariol and zearalenone in human endometrial cells.

    abstract::Humans are typically exposed to mixtures of substances, whereby their bioactivity can be significantly altered by co-occurring compounds. Thus, over the last years, research on combinatory effects has gained increasing attention. In particular, several xenoestrogens have been recently reported to interact synergistica...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Aichinger G,Pantazi F,Marko D

    更新日期:2020-02-01 00:00:00

  • Cisplatin transiently up-regulates hHR23 expression through enhanced translational efficiency in A549 adenocarcinoma cells.

    abstract::DNA-damaging agents are commonly used as anticancer therapeutics. Unfortunately, such drugs induced DNA damages as well as DNA repair are important in mediating drug resistance to cancer treatments. To evaluate changes in DNA repair proteins that occur in DNA damage agent treatment, we challenged human A549 lung adeno...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Shen YH,Chen BR,Cherng SH,Chueh PJ,Tan X,Lin YW,Lin JC,Chuang SM

    更新日期:2011-09-10 00:00:00

  • Abrogation of graft-versus-host reaction by dieldrin in mice.

    abstract::Sublethal exposure to the organochlorine pesticide, dieldrin, decreased the T-cell immune response in mice. Indeed, a transient inhibition of the mixed lymphocyte reactivity (MLR) was noted at 7 days after intraperitoneal exposure to 0.6 LD50 dieldrin. The present study was undertaken to further investigate the effect...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Hugo P,Bernier J,Krzystyniak K,Potworowski EF,Fournier M

    更新日期:1988-04-01 00:00:00

  • Role of GABA in the genesis of chemoconvulsant seizures.

    abstract::The direct or indirect interference with GABA-mediated neurotransmission results in convulsive seizure activity in humans and experimental animals. When this convulsant effect is experimentally analyzed, it turns out to be a product of discrete and restricted cerebral sites of drug action. Depending upon the brain cir...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Gale K

    更新日期:1992-12-01 00:00:00

  • Effects of smoking on spontaneous and induced sister chromatid exchanges in lymphocytes.

    abstract::Spontaneous and mitomycin C-induced sister chromatid exchanges (SCEs) in lymphocytes were analyzed in 24 non-smokers and 24 sex- and age-matched smokers. Mean spontaneous SCE frequency for non-smokers was 9.8 SCEs/cell, and that for smokers was 11.5 SCEs/cell. The difference was statistically significant (P less than ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nagaya T,Toriumi H

    更新日期:1985-06-01 00:00:00

  • The effects of intratracheally administered coarse mode particles on respiratory tract infection in mice.

    abstract::Because coarse mode particles are rarely studied in their existing size ranges (greatest mass about 5-7 microns, aerodynamic diameter), we investigated the effects of four such particles, quartz, ferric oxide, calcium carbonate, and sodium feldspar, on host defenses against bacterial pulmonary infection. Mice which re...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Aranyi C,Graf JL,O'Shea WJ,Graham JA,Miller FJ

    更新日期:1983-10-01 00:00:00

  • Vehicle-dependent oral absorption and target tissue dosimetry of chloroform in male rats and female mice.

    abstract::Chloroform-induced toxicity in rodents depends on oral dose regimen. We evaluated the absorption and tissue dosimetry of chloroform after gavage administration in various vehicles to male Fischer 344 rats and female B6C3F1 mice. Animals received a single dose of chloroform in corn oil, water, or aqueous 2% emulphor at...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Dix KJ,Kedderis GL,Borghoff SJ

    更新日期:1997-05-16 00:00:00

  • Involvement of activating ERK1/2 through G protein coupled receptor 30 and estrogen receptor α/β in low doses of bisphenol A promoting growth of Sertoli TM4 cells.

    abstract::Sertoli cells play a pivotal role in supporting proliferation of germ cells and differentiation during spermatogenesis in mammals. Nanomolar concentrations of Bisphenol A (BPA) can significantly stimulate the proliferation of mouse immature Sertoli (TM4) cells. However, mechanisms by which BPA caused these effects wer...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ge LC,Chen ZJ,Liu HY,Zhang KS,Liu H,Huang HB,Zhang G,Wong CK,Giesy JP,Du J,Wang HS

    更新日期:2014-04-07 00:00:00

  • Influence of methylglyoxal on antioxidant enzymes and oxidative damage.

    abstract::The effect of different doses of methylglyoxal (50-400 mg/kg body wt.) were examined using enzymes involved in the antioxidant function, glutathione (GSH) content and lipid peroxidation in the liver and spleen of Swiss albino mice (7-8 week old) after 6, 12 and 24 h. Significant changes were observed predominantly in ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Choudhary D,Chandra D,Kale RK

    更新日期:1997-12-01 00:00:00

  • Testicular toxicity following short-term exposure to tri- and hexavalent chromium: an experimental study in the rat.

    abstract::The effect of tri- and hexavalent chromium after intraperitoneal administration for 5 consecutive days on testicular histopathology and epididymal sperm number was assessed. Treatment with hexavalent chromium induced testicular atrophy and a reduction in epididymal sperm number after 60 days. No effect was seen after ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ernst E

    更新日期:1990-05-01 00:00:00

  • In vivo effect of 7,8-benzoflavone on aryl hydrocarbon hydroxylase activity of mouse liver microsomes.

    abstract::In vivo administration of 3-methylcholanthrene (MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produced much higher hepatic microsomal aryl hydrocarbon hydroxylase (AHH) induction than 7,8-benzoflavone (7,8-BF) in both aromatic hydrocarbon (Ah)-responsive and nonresponsive strains of mice. Simultaneous treatment o...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kiyohara C,Hirohata T

    更新日期:1993-02-01 00:00:00

  • Alterations in the cortical and peripheral somatosensory evoked activity of rats treated with 3-nitropropionic acid.

    abstract::In this study, the action of 3-nitropropionic acid (3-NP) on the parameters of the cortical and peripheral evoked potentials was investigated in rats in different administration schemes (20 mg/kg i.p. during recording or 24 h before, and 5x 15 mg/kg daily 28 days before recording) to elucidate some neurophysiological ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Szabó A,Papp A,Nagymajtényi L,Vezér T

    更新日期:2006-01-25 00:00:00

  • Additive pro-oxidative effects of methylmercury and ebselen in liver from suckling rat pups.

    abstract::Oxidative stress has been pointed as an important molecular mechanism for liver injury in methylmercury (MeHg) poisoning. Ebselen, a seleno-organic compound that possesses anti-oxidant properties, is a useful therapeutic agent used in clinical situations involving oxidative stress. Here, we examined the possible in vi...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Farina M,Soares FA,Zeni G,Souza DO,Rocha JB

    更新日期:2004-02-02 00:00:00

  • Generally recognized as safe (GRAS): history and description.

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    journal_title:Toxicology letters

    pub_type: 历史文章,杂志文章,评审


    authors: Burdock GA,Carabin IG

    更新日期:2004-04-15 00:00:00

  • Defining critical periods for itraconazole-induced cleft palate, limb defects and axial skeletal malformations in the mouse.

    abstract::The main aim of the study was to identify the critical periods of susceptibility for itraconazole-mediated teratogenesis in the mouse. Pregnant ICR (CD-1) mice received a single oral administration of itraconazole at 50 mg/kg b.w., 150 mg/kg b.w. or 250 mg/kg b.w. on gestation day 8, 9, 10, 11 or 12. Control animals w...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Tiboni GM,Marotta F,Del Corso A,Giampietro F

    更新日期:2006-11-01 00:00:00

  • An assessment of the genotoxicity of vanadium.

    abstract::The activities of vanadium oxide (V2O3), vanadyl sulfate (VOSO4) and ammonium metavanadate (NH4VO3) in inducing sister chromatid exchange (SCE) and chromosomal aberrations (CAb) were assayed in Chinese hamster ovary cells. The toxic concentrations (TC50) for these compounds were found to be 25, 23 and 16 micrograms el...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Owusu-Yaw J,Cohen MD,Fernando SY,Wei CI

    更新日期:1990-02-01 00:00:00

  • The effect of different anesthetics on tumor cytotoxicity by natural killer cells.

    abstract::A number of retrospective studies have suggested that choice of anesthetic drugs during surgical tumor resection might affect tumor recurrence/metastasis, or outcome of patients. The recent study showed that volatile anesthetics-based general anesthesia was associated with the worse outcomes than intravenous anestheti...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Tazawa K,Koutsogiannaki S,Chamberlain M,Yuki K

    更新日期:2017-01-15 00:00:00

  • Clinical relevance of ethanol coingestion in patients with GHB/GBL intoxication.

    abstract:OBJECTIVE:Ethanol intake can increase the sedative effects of gamma-hydroxybutyrate/gamma-butyrolactone (GHB/GBL), although the real clinical impact is unknown. We studied the clinical impact of the co-ingestion of ethanol in patients presenting to the Emergency Department (ED) with acute toxicity related to GHB/GBL us...

    journal_title:Toxicology letters

    pub_type: 杂志文章,多中心研究


    authors: Galicia M,Dargan PI,Dines AM,Yates C,Heyerdahl F,Hovda KE,Giraudon I,Euro-DEN Plus Research Group.,Wood DM,Miró Ò,Euro-DEN Plus Research Group.

    更新日期:2019-10-10 00:00:00

  • Identification of aldo-keto reductases as NRF2-target marker genes in human cells.

    abstract::Transcription factor NF-E2-related factor 2 (NRF2) plays a crucial role in the cellular defense against oxidative/electrophilic stress by up-regulating multiple antioxidant genes. Numerous studies with genetically modified animals have demonstrated that Nrf2 is a sensitivity determining factor upon the exposure to env...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jung KA,Choi BH,Nam CW,Song M,Kim ST,Lee JY,Kwak MK

    更新日期:2013-03-27 00:00:00

  • Hepatic and muscle injuries in mice treated with heptachlor.

    abstract::Heptachlor is a major component of the insecticide, chlordane. It is a health hazard but is still in use in some countries of Southeast Asia. To elucidate the toxicity of heptachlor its effects on mice after oral and intraperitoneal administration were studied. A 3-day group, 92-day group and 180-day group were given ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Izushi F,Ogata M

    更新日期:1990-11-01 00:00:00