Detection of kidney damage by malathion impurities using a microdissection technique.


:O,O,S-Trimethylphosphorothioate (OOS-Me) and O,S,S-trimethylphosphorodithioate (OSS-Me) are impurities in technical grade malathion and related insecticides which have been shown to cause delayed death in rats following a single oral dose of 40-60 mg/kg. In connection with studies on the mode of action of these compounds, work on the microdissection and examination of nephrons was carried out. Nephrons from impurities-treated rats showed swelling, distortion and distension of glomeruli, as well as narrowing of the first part of the proximal tubule (swan neck). These results were similar to those observed from kidney tissue obtained from cadmium-chloride-treated rats and are indicative of OOS-Me and OSS-Me-induced kidney tubule damage.


Toxicol Lett


Toxicology letters


Keadtisuke S,Dheranetra W,Fukuto TR




Has Abstract


1989-04-01 00:00:00














  • Multi-walled carbon nanotube inhibits CA1 glutamatergic synaptic transmission in rat's hippocampal slices.

    abstract::The purpose of the study was to investigate the neurotoxic effect of multi-walled carbon nanotubes (MWCNTs) on the properties of glutamatergic synaptic transmission in rat's hippocampal slices using whole-cell patch clamp technique. The amplitude and frequency of excitatory postsynaptic current (EPSC) were accessed on...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Chen T,Yang J,Zhang H,Ren G,Yang Z,Zhang T

    更新日期:2014-09-17 00:00:00

  • Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines.

    abstract::Anthocyanins are plant pigments occurring in flowers and berry fruits. Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 s...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kamenickova A,Anzenbacherova E,Pavek P,Soshilov AA,Denison MS,Zapletalova M,Anzenbacher P,Dvorak Z

    更新日期:2013-07-31 00:00:00

  • Zinc- and oxidative property-dependent degradation of pro-caspase-1 and NLRP3 by ziram in mouse macrophages.

    abstract::The NLRP3 inflammasome, composed of caspase-1, NLRP3 and ASC, plays a critical role in the clearance of microbial pathogens. Here, we found that the treatment of mouse macrophages with the zinc-containing dithiocarbamate ziram, a widely used fungicide in agriculture, caused a decrease in pro-caspase-1 and NLRP3 levels...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Muroi M,Tanamoto K

    更新日期:2015-06-15 00:00:00

  • Chronic lead treatment affects dopaminergic control of prolactin secretion in rat pituitary.

    abstract::The effect of lead exposure on dopaminergic mechanisms regulating prolactin (PRL) secretion was studied in rats by measuring dopamine (DA) and dihydroxyphenylacetic acid hypothalamic concentrations and DA receptor density in the hypothalamus and pituitary of lead-exposed animals. [3H]Sulpiride was used as dopamine rec...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Govoni S,Lucchi L,Battaini F,Spano PF,Trabucchi M

    更新日期:1984-03-01 00:00:00

  • Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model.

    abstract::Work with sub-natural levels of deuterium (D) in animals has demonstrated an anti-cancer effect of low D-concentration in water. Our objective was to investigate whether deuterium-depleted water (DDW) can overturn reverse manganese (Mn)-induced reduction in life span, using the Caenorhabditis elegans (C. elegans) as a...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Avila DS,Somlyai G,Somlyai I,Aschner M

    更新日期:2012-06-20 00:00:00

  • Prevention and recovery of CuSO4-induced inhibition of Na+/K+ -ATPase and Mg2+ -ATPase in rat brain synaptosomes by EDTA.

    abstract::Enzymatic activities of Na+/K+-ATPase and Mg2+ -ATPase from rat brain synaptic plasma membrane were studied in the absence and presence of EDTA. The aim of the study was to examine the ability of this strong chelator to prevent and recover the CuSO4-induced inhibition. The influence of experimentally added CuSO4 and E...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Vasić V,Jovanović D,Krstić D,Nikezić G,Horvat A,Vujisić L,Nedeljković N

    更新日期:1999-10-29 00:00:00

  • Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: involvement of transcription factor NRF2.

    abstract::Modulation of the cytochrome P450 (CYP) monooxygenase system by cadmium was investigated in male, adult DBA/2J mice treated with a single dose (16 micromol/kg body weight, i.p.) of cadmium chloride (CdCl2). Total CYP content of liver and kidney microsomes decreased maximally (56% and 85%, respectively) 24 and 18 h, re...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Abu-Bakar A,Satarug S,Marks GC,Lang MA,Moore MR

    更新日期:2004-03-21 00:00:00

  • Egg white-derived peptides prevent cardiovascular disorders induced by mercury in rats: Role of angiotensin-converting enzyme (ACE) and NADPH oxidase.

    abstract::The study aimed to investigate the effects of egg white hydrolysate (EWH) on vascular disorders induced by mercury (Hg). For this, male Wistar rats were treated for 60days: Untreated (saline, i.m.); Mercury (HgCl2, i.m., 1st dose 4.6μg/kg, subsequent doses 0.07μg/kg/day); Hydrolysate (EWH, gavage, 1g/kg/day); Hydrolys...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Rizzetti DA,Martín Á,Corrales P,Fernandez F,Simões MR,Peçanha FM,Vassallo DV,Miguel M,Wiggers GA

    更新日期:2017-11-05 00:00:00

  • Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts.

    abstract::Benzo(a)pyrene (B(a)P), a potent environmental procarcinogen, has been shown to cause cell cycle alternation. However, the mechanisms involved in this effect are not well understood yet. Our current results demonstrated that B(a)P exposure led to cell proliferation and a 33.5% increase in S phase cells as well as a 26...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Gao A,Liu B,Shi X,Jia X,Ye M,Jiao S,You B,Huang C

    更新日期:2007-04-05 00:00:00

  • The investigation of the genotoxic effects of fenarimol and propamocarb in mouse bone marrow in vivo.

    abstract::In this study, we aimed to evaluate the genotoxic effects of fungicides fenarimol and propamocarb which are used to protect crops from fungi. For this reason, bone-marrow micronucleus and chromosome aberration tests were carried out in Swiss albino mice. Mice were injected with four different doses of fenarimol and pr...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Aydemir N,Bilaloğlu R

    更新日期:2004-02-28 00:00:00

  • Preclinical safety profile of disitamab vedotin:a novel anti-HER2 antibody conjugated with MMAE.

    abstract::The HER2 pathway plays a pivotal role in cell proliferation and differentiation, while the receptor overexpression caused by amplification of HER2 gene is associated with the growth of several tumors. Previously published clinical trials have demonstrated that antibody-conjugated drugs (ADCs) remarkably improved clini...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jiang J,Li S,Shan X,Wang L,Ma J,Huang M,Dong L,Chen F

    更新日期:2020-05-15 00:00:00

  • Leptin and IL-8: two novel cytokines screened out in childhood lead exposure.

    abstract::Lead is a toxic heavy metal with many recognized adverse health side effects. The central nervous system is the main target of lead toxicity. Although many studies on lead toxicity were conducted, the mechanism of lead toxicity remains uncertain. One possible attribution is the immature blood-brain barrier that causes...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yang Y,Zhang X,Fu Y,Yang H

    更新日期:2014-06-16 00:00:00

  • Strain differences in susceptibility to di-2-ethylhexyl phthalate-induced testicular atrophy in mice.

    abstract::It is well known that the oral administration of di-2-ethylhexyl phthalate (DEHP) produces severe seminiferous tubular atrophy in rats, but mice are far less sensitive. In the present experiment, we demonstrated that one strain of mice derived from ICR mice, Crj:CD-1, was very sensitive to DEHP-induced testicular inju...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Oishi S

    更新日期:1993-01-01 00:00:00

  • Critical genes as early warning signs: example of vinyl chloride.

    abstract::We have analysed liver angiosarcomas from individuals having been occupationally exposed to vinyl chloride (VC) to identify, in cancer-related genes, lesions which could be VC-specific. Two genetic alterations have been identified: the first one is a GGC --> GAT (Gly --> Asp, Asp13p21) mutation at codon 13 in the Ki-r...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Marion MJ

    更新日期:1998-12-28 00:00:00

  • Ototoxic and nephrotoxic drugs inhibit agonist-induced inositol phosphate formation in rat brain synaptoneurosomes.

    abstract::Neomycin (an aminoglycoside antibiotic), ethacrynate (a loop diuretic), cisplatin (an anticancer drug) and mercuric chloride are chemically unrelated drugs which present similar ototoxic and nephrotoxic properties. We have found that all these molecules inhibit inositol phosphate turnover induced by carbachol or gluta...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Guiramand J,Lenoir M,Pujol R,Récasens M

    更新日期:1990-05-01 00:00:00

  • Renal, hepatic, pulmonary and adrenal tumors induced by prenatal inorganic arsenic followed by dimethylarsinic acid in adulthood in CD1 mice.

    abstract::Inorganic arsenic, an early life carcinogen in humans and mice, can initiate lesions promotable by other agents in later life. The biomethylation product of arsenic, dimethylarsinic acid (DMA), is a multi-site tumor promoter. Thus, pregnant CD1 mice were given drinking water (0 ppm or 85 ppm arsenic) from gestation da...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Tokar EJ,Diwan BA,Waalkes MP

    更新日期:2012-03-07 00:00:00

  • Alterations in the cortical and peripheral somatosensory evoked activity of rats treated with 3-nitropropionic acid.

    abstract::In this study, the action of 3-nitropropionic acid (3-NP) on the parameters of the cortical and peripheral evoked potentials was investigated in rats in different administration schemes (20 mg/kg i.p. during recording or 24 h before, and 5x 15 mg/kg daily 28 days before recording) to elucidate some neurophysiological ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Szabó A,Papp A,Nagymajtényi L,Vezér T

    更新日期:2006-01-25 00:00:00

  • Priming effect of benzo[a]pyrene on monocyte oxidative metabolism: possible mechanisms.

    abstract::Monocytes, separated from human peripheral blood, were preincubated with different polycyclic aromatic hydrocarbons (PAHs) for 24 h and the production of superoxide ions (O*2-) was then measured using as a stimulating agent phorbol 12-myristate 13-acetate. A significantly enhanced O*2- production is only observed when...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Fabiani R,De Bartolomeo A,Rosignoli P,Sebastiani B,Morozzi G

    更新日期:1999-10-29 00:00:00

  • Carp erythrocyte lipids as a potential target for the toxic action of zinc ions.

    abstract::The effects of zinc on the lipid components of carp erythrocytes (Cyprinus carpio L.) were studied on red blood cells exposed to ZnSO4 (0.01-1 mM) for 20 h. The temperatures of the incubation medium were 5 and 20 degrees C for carp collected in winter and summer, respectively. It was observed that increase in the conc...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Teresa G,Anna A,Maria P,Zofia J,Gerard B

    更新日期:2002-06-07 00:00:00

  • Lead given systemically to mice in experimental delay of implantation increases the oxygen consumption of delayed blastocysts.

    abstract::The metabolic activity of pre-implantation blastocysts recovered from delayed mice before and after administration of lead was estimated by measuring their oxygen consumption using a spectrophotometer technique. Normal blastocysts, activated for implantation, increased their oxygen consumption by about 50% compared wi...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nilsson BO,Einarsson B,Magnusson C

    更新日期:1991-05-01 00:00:00

  • Curcumin ameliorates intrahepatic angiogenesis and capillarization of the sinusoids in carbon tetrachloride-induced rat liver fibrosis.

    abstract::Neoangiogenesis and the development of an abnormal angio-architecture in the liver are strongly linked with progressive fibrogenesis. This study aimed to evaluate the ability of curcumin to protect liver fibrosis-associated angiogenesis and capillarization of the sinusoids in experimental rats. Liver fibrosis was indu...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yao Q,Lin Y,Li X,Shen X,Wang J,Tu C

    更新日期:2013-09-12 00:00:00

  • Molecular biology of insecticide resistance.

    abstract::The widespread use of insecticides has amounted to a large scale 'experiment' in natural selection of insects by chemicals of toxicological importance to humans. Specific examples in which the molecular basis of insecticide resistance has been studied in detail are presented here. The biochemical/physiological mechani...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Feyereisen R

    更新日期:1995-12-01 00:00:00

  • Extremely low dose of acrylamide decreases lifespan in Caenorhabditis elegans.

    abstract::The neurotoxic, genotoxic and carcinogenic effects of industrial exposure to acrylamide have been studied in animals and humans for more than 30 years. A recent search for the cause of high background levels of acrylamide in industrially unexposed people revealed that it is formed during the frying or baking of foods ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Hasegawa K,Miwa S,Tsutsumiuchi K,Taniguchi H,Miwa J

    更新日期:2004-09-10 00:00:00

  • Thirteen-week subchronic toxicity study of thiamphenicol in F344 rats.

    abstract::A 13-week subchronic toxicity study of thiamphenicol (TAP) was performed in F344 rats. The minimum lethal dose was estimated to be greater than 10 g/kg body weight, when a single dose of 4-10 g/kg of TAP was given orally. In the subchronic toxicity study, groups of 12 F344 rats of each sex were given solutions contain...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ando J,Ishihara R,Imai S,Takano S,Kitamura T,Takahashi M,Yoshida M,Maekawa A

    更新日期:1997-04-28 00:00:00

  • Genotoxicity--threshold or not? Introduction of cases of industrial chemicals.

    abstract::Many industrially and environmentally important industrial carcinogens display effects that lead them to be viewed and regulated as 'genotoxic compounds'. Some of these chemicals cause experimental tumours only at high or toxic doses. The current view is that non-threshold principles should be applied for risk assessm...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Bolt HM

    更新日期:2003-04-11 00:00:00

  • Differential effects of B- and T-lymphocyte mitogens on cytochrome P450 in mice.

    abstract::Lipopolysaccharide (LPS) is widely used as a B-lymphocyte mitogen and is known to depress expression of the cytochrome P450 (P450). However, there have been no studies regarding to the effects of the other mitogens on the expression of P450. This study investigated the effects of mitogens on the constitutive and induc...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jeong HG

    更新日期:1999-01-11 00:00:00

  • The acetaminophen regioisomer 3'-hydroxyacetanilide inhibits and covalently binds to cytochrome P450 2E1.

    abstract::3'-Hydroxyacetanilide has been previously studied as a nontoxic regioisomer of the analgesic acetaminophen (4'-hydroxyacetanilide). The radiolabeled derivative has been shown to covalently bind to liver proteins at levels similar to that observed with hepatotoxic doses of radiolabeled acetaminophen with no evidence of...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Halmes NC,Samokyszyn VM,Hinton TW,Hinson JA,Pumford NR

    更新日期:1998-01-16 00:00:00

  • Spontaneous neoplasms in aged CD-1 mice.

    abstract::Spontaneous neoplasms in untreated control CD-1 mice (725 males and 725 females) used in carcinogenicity studies were evaluated and tabulated. The most common neoplasms in male mice were alveolar-bronchiolar adenomas (19.3%) followed by hepatocellular adenomas (11.0%), lymphoreticular neoplasms (6.8%), hepatocellular ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Chandra M,Frith CH

    更新日期:1992-06-01 00:00:00

  • Elevation of metallothionein level in preneoplastic lesions during chemical hepatocarcinogenesis of the Fischer 344 rat.

    abstract::Metallothionein (MT) is inducible by various stimuli such as metals and physiological stress. Although elevated MT expression in certain type of tumors has been reported, there are few data available on the roles of MT in tumor formation. In this study, we immunohistochemically examined MT expression in gluthathione S...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Sawaki M,Enomoto K,Hattori A,Tsuzuki N,Sawada N,Mori M

    更新日期:1999-07-30 00:00:00

  • Assessment of tail nerve function in rats chronically exposed to vinyltoluene.

    abstract::In male Sprague-Dawley rats, motor and sensory conduction velocities (MNCV and SNCV) of the tail nerve decreased significantly as a result of oral administration of 400 and 200 mg/kg of 2,5 hexanedione (2,5-HD) once daily, 5 days a week for up to 7 and 15 weeks, respectively; and of whole-body exposure to 300 ppm of v...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Gagnaire F,Nicot T,Zissu D,Bonnet P,de Ceaurriz J

    更新日期:1986-01-01 00:00:00