Detection of kidney damage by malathion impurities using a microdissection technique.

Abstract:

:O,O,S-Trimethylphosphorothioate (OOS-Me) and O,S,S-trimethylphosphorodithioate (OSS-Me) are impurities in technical grade malathion and related insecticides which have been shown to cause delayed death in rats following a single oral dose of 40-60 mg/kg. In connection with studies on the mode of action of these compounds, work on the microdissection and examination of nephrons was carried out. Nephrons from impurities-treated rats showed swelling, distortion and distension of glomeruli, as well as narrowing of the first part of the proximal tubule (swan neck). These results were similar to those observed from kidney tissue obtained from cadmium-chloride-treated rats and are indicative of OOS-Me and OSS-Me-induced kidney tubule damage.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Keadtisuke S,Dheranetra W,Fukuto TR

doi

10.1016/0378-4274(89)90085-4

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

53-9

issue

1

eissn

0378-4274

issn

1879-3169

pii

0378-4274(89)90085-4

journal_volume

47

pub_type

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