Establishing reference intervals for sex hormones on the analytical platforms Advia Centaur and Immulite 2000XP.


:Reliable reference intervals for sex hormones are indispensable in evaluations of the hypothalamo-pituitary-gonadal axis. This study established reference intervals for estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, and prolactin with the immunoassay platforms Advia Centaur and Immulite 2000XP (Siemens Healthcare, Germany). We recruited healthy men (n=220), women in the follicular (n=139) or luteal (n=87) phases of the menstrual cycle, and postmenopausal women (n=103). Data was analyzed according to CLSI EP28-A3c guidelines. Although reference intervals established with both platforms showed good agreement with ranges quoted by the assay manufacturer, two discrepancies were noted. First, intervals for prolactin in women were influenced by hormonal status, and the partition analysis supported their separation into subgroups based on menstrual cycle. Second, the upper limit for estradiol in the follicular phase was nearly a half of that provided by the manufacturer. This discrepancy was attributed to the stringent definition of the follicular phase (consistently set at days 3-5 after menstruation onset). Our findings suggest that reference values for prolactin should both be gender specific and account for menstrual cycle phase. The results also emphasize that clear-cut selection criteria are required when assembling populations for establishing endocrine reference intervals.


Ann Lab Med


Schüring AN,Kelsch R,Pierściński G,Nofer JR




Has Abstract


2016-01-01 00:00:00














  • Screening PCR Versus Sanger Sequencing: Detection of CALR Mutations in Patients With Thrombocytosis.

    abstract:BACKGROUND:Mutations in calreticulin (CALR) have been reported to be key markers in the molecular diagnosis of myeloid proliferative neoplasms. In most previous reports, CALR mutations were analyzed by using Sanger sequencing. Here, we report a new, rapid, and convenient system for screening CALR mutations without sequ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Jeong JH,Lee HT,Seo JY,Seo YH,Kim KH,Kim MJ,Lee JH,Park J,Hong JS,Park PW,Ahn JY

    更新日期:2016-07-01 00:00:00

  • Effectiveness of Plasma and Urine Neutrophil Gelatinase-Associated Lipocalin for Predicting Acute Kidney Injury in High-Risk Patients.

    abstract:BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL) is a useful biomarker for acute kidney injury (AKI) prediction. However, studies on whether using both plasma NGAL (PNGAL) and urine NGAL (UNGAL) can improve AKI prediction are limited. We investigated the best approach to predict AKI in high-risk patients wh...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Yi A,Lee CH,Yun YM,Kim H,Moon HW,Hur M

    更新日期:2021-01-01 00:00:00

  • Role of plasma exchange in ABO-incompatible kidney transplantation.

    abstract:BACKGROUND:In the past, ABO incompatibility was an absolute contraindication for solid organ transplantation. However, multiple recent trials have suggested strategies for overcoming the reactions between graft antigens and recipient antibodies that cause graft rejection. In this study, we determined the usefulness of ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Yoo S,Lee EY,Huh KH,Kim MS,Kim YS,Kim HO

    更新日期:2012-07-01 00:00:00

  • The first Korean case of candidemia due to Candida dubliniensis.

    abstract::Candidemia due to uncommon Candida spp. appears to be increasing in incidence. C. dubliniensis has been increasingly recovered from individuals not infected with HIV. Identification of C. dubliniensis can be problematic in routine clinical practice due to its phenotypic resemblance to C. albicans. We report the first ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Yu N,Kim HR,Lee MK

    更新日期:2012-05-01 00:00:00

  • Comparison of ChromID agar and Clostridium difficile selective agar for effective isolation of C. difficile from stool specimens.

    abstract:BACKGROUND:ChromID Clostridium difficile agar (IDCd; bioMérieux SA, France) is a recently developed chromogenic medium for rapid and specific isolation of C. difficile. We compared the performance of IDCd with that of Clostridium difficile Selective Agar (CDSA). METHODS:A total of 530 fresh stool specimens were collec...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Shin BM,Lee EJ

    更新日期:2014-01-01 00:00:00

  • New decision criteria for selecting delta check methods based on the ratio of the delta difference to the width of the reference range can be generally applicable for each clinical chemistry test item.

    abstract:BACKGROUND:Many laboratories use 4 delta check methods: delta difference, delta percent change, rate difference, and rate percent change. However, guidelines regarding decision criteria for selecting delta check methods have not yet been provided. We present new decision criteria for selecting delta check methods for e...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Park SH,Kim SY,Lee W,Chun S,Min WK

    更新日期:2012-09-01 00:00:00

  • Antimicrobial resistance patterns and integron carriage of Escherichia coli isolates causing community-acquired infections in Turkey.

    abstract::We aimed to observe antimicrobial resistance patterns and integron carriage of Escherichia coli isolates causing community-acquired infections. Two hundred sixty-eight E. coli strains were obtained from outpatients with various infections at different polyclinics at the 82nd Year of State Hospital in Rize, Turkey. Sus...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Copur-Cicek A,Ozgumus OB,Saral A,Sandalli C

    更新日期:2014-03-01 00:00:00

  • Plasma Levels and Diagnostic Utility of Macrophage Colony-Stimulating Factor, Matrix Metalloproteinase-9, and Tissue Inhibitor of Metalloproteinases-1 as New Biomarkers of Breast Cancer.

    abstract:BACKGROUND:Macrophage colony-stimulating factor (M-CSF), matrix metalloproteinase-9 (MMP-9), and its specific tissue inhibitor - tissue inhibitor of metalloproteinases-1 (TIMP-1) may play an important role in the pathogenesis and spread of cancer. We investigated the plasma levels of M-CSF, MMP-9, and TIMP-1 in compari...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Ławicki S,Głażewska EK,Sobolewska M,Będkowska GE,Szmitkowski M

    更新日期:2016-05-01 00:00:00

  • A Population-Based Genomic Study of Inherited Metabolic Diseases Detected Through Newborn Screening.

    abstract:BACKGROUND:A newborn screening (NBS) program has been utilized to detect asymptomatic newborns with inherited metabolic diseases (IMDs). There have been some bottlenecks such as false-positives and imprecision in the current NBS tests. To overcome these issues, we developed a multigene panel for IMD testing and investi...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Park KJ,Park S,Lee E,Park JH,Park JH,Park HD,Lee SY,Kim JW

    更新日期:2016-11-01 00:00:00

  • Single-color multitarget flow cytometry using monoclonal antibodies labeled with different intensities of the same fluorochrome.

    abstract:BACKGROUND:We developed a single-color multitarget flow cytometry (SM-FC) assay, a single-tube assay with graded mean fluorescence intensities (MFIs). We evaluated the repeatability of SM-FC, and its correlation with multicolor flow cytometry (MFC), to assess its application as a routine FC assay. METHODS:We selected ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Park J,Han K

    更新日期:2012-05-01 00:00:00

  • Application of the Whole Genome-Based Bacterial Identification System, TrueBac ID, Using Clinical Isolates That Were Not Identified With Three Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) Systems.

    abstract:BACKGROUND:Next-generation sequencing is increasingly used for taxonomic identification of pathogenic bacterial isolates. We evaluated the performance of a newly introduced whole genome-based bacterial identification system, TrueBac ID (ChunLab Inc., Seoul, Korea), using clinical isolates that were not identified by th...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Ha SM,Kim CK,Roh J,Byun JH,Yang SJ,Choi SB,Chun J,Yong D

    更新日期:2019-11-01 00:00:00

  • Accessory Gene Regulator Polymorphism and Vancomycin Minimum Inhibitory Concentration in Methicillin-Resistant Staphylococcus aureus.

    abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with a vancomycin minimum inhibitory concentration (MIC) of 2 µg/mL presents a high rate of therapeutic failure in response to vancomycin. In addition, polymorphism in accessory gene regulator (agr) is associated with vancomycin therapeutic effect...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Park MJ,Kim HS,Kim HS,Kim JS,Song W,Kim MY,Lee YK,Kang HJ

    更新日期:2015-07-01 00:00:00

  • Comparison of red blood cell hemolysis using plasma and serum separation tubes for outpatient specimens.

    abstract:BACKGROUND:To rapidly obtain outpatient results, we use plasma separation tubes (PST) for chemistry analysis. If lactate dehydrogenase measurement is required, serum separation tubes (SST) are used. There has been no evaluation of hemolysis with these tubes. We compared the hemolytic index (HI) obtained by using PST an...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Ko DH,Won D,Jeong TD,Lee W,Chun S,Min WK

    更新日期:2015-03-01 00:00:00

  • Stability of pH, Blood Gas Partial Pressure, Hemoglobin Oxygen Saturation Fraction, and Lactate Concentration.

    abstract:BACKGROUND:The storage temperature and time of blood gas samples collected in syringes constitute preanalytical variables that could affect blood gas or lactate concentration measurement results. We analyzed the effect of storage temperature and time delay on arterial or venous blood gas stability related to pH, partia...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Arbiol-Roca A,Imperiali CE,Dot-Bach D,Valero-Politi J,Dastis-Arias M

    更新日期:2020-11-01 00:00:00

  • Development of an Automated Image Analyzer for Microvessel Density Measurement in Bone Marrow Biopsies.

    abstract::Angiogenesis is important for the proliferation and survival of multiple myeloma (MM) cells. Bone marrow (BM) microvessel density (MVD) is a useful marker of angiogenesis and an increase in MVD can be used as a marker of poor prognosis in MM patients. We developed an automated image analyzer to assess MVD from images ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Chung Y,Shin S,Shim H,Sohn JY,Lee DE,Lee H,Eom HS,Kim KG,Kong SY

    更新日期:2020-07-01 00:00:00

  • Biochemical and Genetic Analysis of Seven Korean Individuals With Suspected Metachromatic Leukodystrophy.

    abstract::Metachromatic leukodystrophy (MLD) is an autosomal recessive disease caused by a deficiency in arylsulfatase A (ARSA). However, decreased ARSA activity is also observed in pseudodeficiency (PD). To distinguish between MLD and PD, we performed gene mutation and sulfatide analyses by using dried blood spots (DBSs) from ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Han M,Jun SH,Lee YJ,Eun BL,Lee SJ,Seong MW,Park SS,Song SH,Park HD,Song J

    更新日期:2015-07-01 00:00:00

  • Galectin-3 Reflects the Echocardiographic Grades of Left Ventricular Diastolic Dysfunction.

    abstract:BACKGROUND:The level of Galectin-3 (Gal-3) protein purportedly reflects an ongoing cardiac fibrotic process and has been associated with ventricular remodeling, which is instrumental in the development of heart failure with preserved ejection fraction (HFpEF) syndrome. The aim of this study was to investigate the poten...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Ansari U,Behnes M,Hoffmann J,Natale M,Fastner C,El-Battrawy I,Rusnak J,Kim SH,Lang S,Hoffmann U,Bertsch T,Borggrefe M,Akin I

    更新日期:2018-07-01 00:00:00

  • Evaluation of Xpert Carba-R Assay v.2 to Detect Carbapenemase Genes in Two Hospitals in Korea.

    abstract:BACKGROUND:As the spread of carbapenemase-producing Enterobacteriaceae poses a critical threat to public health, rapid detection of carbapenemase genes is urgently required for prompt initiation of appropriate antimicrobial therapy and infection control. We evaluated the performance of Xpert Carba-R v.2 (Cepheid, USA) ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Byun JH,Kim YA,Kim M,Kim B,Choi JY,Park YS,Yong D

    更新日期:2020-05-01 00:00:00

  • Immune Checkpoint Programmed Cell Death Protein-1 (PD-1) Expression on Bone Marrow T Cell Subsets in Patients With Plasma Cell Myeloma.

    abstract:Background:Plasma cell myeloma (PCM) is caused by immune dysregulation. We evaluated the expression of immune checkpoint programmed cell death protein-1 (PD-1) on T cell subsets in PCM patients according to disease course and cytogenetic abnormalities. This study aimed to find a target group suitable for therapeutic us...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Lee MY,Park CJ,Cho YU,You E,Jang S,Seo EJ,Lee JH,Yoon DH,Suh C

    更新日期:2021-05-01 00:00:00

  • Comparison of total and IgG ABO antibody titers in healthy individuals by using tube and column agglutination techniques.

    abstract:BACKGROUND:Most immune reactions related to transfusion and transplantation are caused by IgM ABO antibodies. However, IgG also plays an important role in these reactions. Therefore, a method to measure antibodies, including IgG, is necessary. We investigated ABO antibody titers of healthy individuals using a column ag...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Park ES,Jo KI,Shin JW,Park R,Choi TY,Bang HI,Chai GR,Yun SG

    更新日期:2014-05-01 00:00:00

  • Delamanid, Bedaquiline, and Linezolid Minimum Inhibitory Concentration Distributions and Resistance-related Gene Mutations in Multidrug-resistant and Extensively Drug-resistant Tuberculosis in Korea.

    abstract:BACKGROUND:Delamanid, bedaquiline, and linezolid have recently been approved for the treatment of multidrug- and extensively drug-resistant (MDR and XDR, respectively) tuberculosis (TB). To use these drugs effectively, drug susceptibility tests, including rapid molecular techniques, are required for accurate diagnosis ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Yang JS,Kim KJ,Choi H,Lee SH

    更新日期:2018-11-01 00:00:00

  • Update on procalcitonin measurements.

    abstract::Procalcitonin (PCT) is used as a biomarker for the diagnosis of sepsis, severe sepsis and septic shock. At the same time, PCT has also been used to guide antibiotic therapy. This review outlines the main indications for PCT measurement and points out possible pitfalls. The classic indications for PCT measurement are: ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章,评审


    authors: Meisner M

    更新日期:2014-07-01 00:00:00

  • Comparison Between Soluble ST2 and High-Sensitivity Troponin I in Predicting Short-Term Mortality for Patients Presenting to the Emergency Department With Chest Pain.

    abstract:BACKGROUND:High-sensitivity cardiac troponin I (hs-cTnI) and the soluble isoform of suppression of tumorigenicity 2 (sST2) are useful prognostic biomarkers in acute coronary syndrome (ACS). The aim of this study was to test the short term prognostic value of sST2 compared with hs-cTnI in patients with chest pain. METH...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Marino R,Magrini L,Orsini F,Russo V,Cardelli P,Salerno G,Hur M,Di Somma S,GREAT NETWORK.

    更新日期:2017-03-01 00:00:00

  • The role of cardiac biomarkers in the diagnosis and management of patients presenting with suspected acute coronary syndrome.

    abstract::Myocardial infarction (MI) is the leading cause of death in the developed world. Biomarkers have an essential role in diagnosis, risk stratification, guiding management and clinical decision making in the setting of patients presenting with signs and symptoms of MI. Cardiac troponin (cTn) rose to prominence during the...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章,评审


    authors: Christenson E,Christenson RH

    更新日期:2013-09-01 00:00:00

  • Clonal spread of carbapenem non-susceptible Acinetobacter baumannii in an intensive care unit in a teaching hospital in China.

    abstract:BACKGROUND:This study was aimed to investigate the genetic diversity and antibiotic resistance profile of the nosocomial infection agent Acinetobacter baumannii from a medical intensive care unit (ICU) in a teaching hospital in Suzhou, China. METHODS:The genetic relationship among A. baumannii isolates in an ICU was i...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Zhong Q,Xu W,Wu Y,Xu H

    更新日期:2012-11-01 00:00:00

  • The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases.

    abstract::The platelet-to-lymphocyte ratio (PLR) has emerged as an informative marker revealing shifts in platelet and lymphocyte counts due to acute inflammatory and prothrombotic states. PLR has been extensively examined in neoplastic diseases accompanied by immune suppression and thrombosis, which can be predicted by combine...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章,评审


    authors: Gasparyan AY,Ayvazyan L,Mukanova U,Yessirkepov M,Kitas GD

    更新日期:2019-07-01 00:00:00

  • Clonal Distribution of Clindamycin-Resistant Erythromycin-Susceptible (CRES) Streptococcus agalactiae in Korea Based on Whole Genome Sequences.

    abstract:BACKGROUND:The clindamycin-resistant erythromycin-susceptible (CRES) phenotype is rare in Streptococcus agalactiae (group B streptococci). We aimed to determine the molecular characteristics of CRES S. agalactiae using whole genome sequencing (WGS). METHODS:Sixty-six S. agalactiae isolates obtained from blood (N=26), ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Takahashi T,Maeda T,Lee S,Lee DH,Kim S

    更新日期:2020-09-01 00:00:00

  • Application of Multigene Panel Sequencing in Patients with Prolonged Rate-corrected QT Interval and No Pathogenic Variants Detected in KCNQ1, KCNH2, and SCN5A.

    abstract::Long QT syndrome (LQTS) is an inherited cardiac disease characterized by a prolonged heart rate-corrected QT (QTc) interval. We investigated the genetic causes in patients with prolonged QTc intervals who were negative for pathogenic variants in three major LQTS-related genes (KCNQ1, KCNH2, and SCN5A). Molecular genet...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Seo SH,Kim SY,Cho SI,Park H,Lee S,Choi JM,Kim MJ,Lee JS,Ahn KJ,Song MK,Bae EJ,Park SS,Seong MW

    更新日期:2018-01-01 00:00:00

  • Evaluation of the QuantaMatrix Multiplexed Assay Platform for Molecular Diagnosis of Multidrug- and Extensively Drug-Resistant Tuberculosis Using Clinical Strains Isolated in Myanmar.

    abstract:BACKGROUND:Although the incidence of tuberculosis (TB) is decreasing, cases of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB continue to increase. As conventional phenotype drug susceptibility testing (pDST) takes six to eight weeks, molecular assays are widely used to determine drug resistance. ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Chang Y,Kim S,Kim Y,Ei PW,Hwang D,Lee J,Chang CL,Lee H

    更新日期:2020-03-01 00:00:00

  • Highly sensitive and novel point-of-care system, aQcare Chlamydia TRF kit for detecting Chlamydia trachomatis by using europium (Eu) (III) chelated nanoparticles.

    abstract:BACKGROUND:The bacterium Chlamydia trachomatis is one of the leading causes of sexually transmitted diseases worldwide. Since no simple and effective tool exists to diagnose C. trachomatis infections, we evaluated a novel point-of-care (POC) test, aQcare Chlamydia TRF kit, which uses europium-chelated nanoparticles and...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Ham JY,Jung J,Hwang BG,Kim WJ,Kim YS,Kim EJ,Cho MY,Hwang MS,Won DI,Suh JS

    更新日期:2015-01-01 00:00:00