Establishing reference intervals for sex hormones on the analytical platforms Advia Centaur and Immulite 2000XP.


:Reliable reference intervals for sex hormones are indispensable in evaluations of the hypothalamo-pituitary-gonadal axis. This study established reference intervals for estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, and prolactin with the immunoassay platforms Advia Centaur and Immulite 2000XP (Siemens Healthcare, Germany). We recruited healthy men (n=220), women in the follicular (n=139) or luteal (n=87) phases of the menstrual cycle, and postmenopausal women (n=103). Data was analyzed according to CLSI EP28-A3c guidelines. Although reference intervals established with both platforms showed good agreement with ranges quoted by the assay manufacturer, two discrepancies were noted. First, intervals for prolactin in women were influenced by hormonal status, and the partition analysis supported their separation into subgroups based on menstrual cycle. Second, the upper limit for estradiol in the follicular phase was nearly a half of that provided by the manufacturer. This discrepancy was attributed to the stringent definition of the follicular phase (consistently set at days 3-5 after menstruation onset). Our findings suggest that reference values for prolactin should both be gender specific and account for menstrual cycle phase. The results also emphasize that clear-cut selection criteria are required when assembling populations for establishing endocrine reference intervals.


Ann Lab Med


Schüring AN,Kelsch R,Pierściński G,Nofer JR




Has Abstract


2016-01-01 00:00:00














  • Evaluation of the QuantaMatrix Multiplexed Assay Platform for Molecular Diagnosis of Multidrug- and Extensively Drug-Resistant Tuberculosis Using Clinical Strains Isolated in Myanmar.

    abstract:BACKGROUND:Although the incidence of tuberculosis (TB) is decreasing, cases of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB continue to increase. As conventional phenotype drug susceptibility testing (pDST) takes six to eight weeks, molecular assays are widely used to determine drug resistance. ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Chang Y,Kim S,Kim Y,Ei PW,Hwang D,Lee J,Chang CL,Lee H

    更新日期:2020-03-01 00:00:00

  • Evaluation of Xpert Carba-R Assay v.2 to Detect Carbapenemase Genes in Two Hospitals in Korea.

    abstract:BACKGROUND:As the spread of carbapenemase-producing Enterobacteriaceae poses a critical threat to public health, rapid detection of carbapenemase genes is urgently required for prompt initiation of appropriate antimicrobial therapy and infection control. We evaluated the performance of Xpert Carba-R v.2 (Cepheid, USA) ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Byun JH,Kim YA,Kim M,Kim B,Choi JY,Park YS,Yong D

    更新日期:2020-05-01 00:00:00

  • Comparison of total and IgG ABO antibody titers in healthy individuals by using tube and column agglutination techniques.

    abstract:BACKGROUND:Most immune reactions related to transfusion and transplantation are caused by IgM ABO antibodies. However, IgG also plays an important role in these reactions. Therefore, a method to measure antibodies, including IgG, is necessary. We investigated ABO antibody titers of healthy individuals using a column ag...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Park ES,Jo KI,Shin JW,Park R,Choi TY,Bang HI,Chai GR,Yun SG

    更新日期:2014-05-01 00:00:00

  • Plasma Levels and Diagnostic Utility of Macrophage Colony-Stimulating Factor, Matrix Metalloproteinase-9, and Tissue Inhibitor of Metalloproteinases-1 as New Biomarkers of Breast Cancer.

    abstract:BACKGROUND:Macrophage colony-stimulating factor (M-CSF), matrix metalloproteinase-9 (MMP-9), and its specific tissue inhibitor - tissue inhibitor of metalloproteinases-1 (TIMP-1) may play an important role in the pathogenesis and spread of cancer. We investigated the plasma levels of M-CSF, MMP-9, and TIMP-1 in compari...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Ławicki S,Głażewska EK,Sobolewska M,Będkowska GE,Szmitkowski M

    更新日期:2016-05-01 00:00:00

  • Effectiveness of Plasma and Urine Neutrophil Gelatinase-Associated Lipocalin for Predicting Acute Kidney Injury in High-Risk Patients.

    abstract:BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL) is a useful biomarker for acute kidney injury (AKI) prediction. However, studies on whether using both plasma NGAL (PNGAL) and urine NGAL (UNGAL) can improve AKI prediction are limited. We investigated the best approach to predict AKI in high-risk patients wh...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Yi A,Lee CH,Yun YM,Kim H,Moon HW,Hur M

    更新日期:2021-01-01 00:00:00

  • Comparison of ChromID agar and Clostridium difficile selective agar for effective isolation of C. difficile from stool specimens.

    abstract:BACKGROUND:ChromID Clostridium difficile agar (IDCd; bioMérieux SA, France) is a recently developed chromogenic medium for rapid and specific isolation of C. difficile. We compared the performance of IDCd with that of Clostridium difficile Selective Agar (CDSA). METHODS:A total of 530 fresh stool specimens were collec...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Shin BM,Lee EJ

    更新日期:2014-01-01 00:00:00

  • Development of an Automated Image Analyzer for Microvessel Density Measurement in Bone Marrow Biopsies.

    abstract::Angiogenesis is important for the proliferation and survival of multiple myeloma (MM) cells. Bone marrow (BM) microvessel density (MVD) is a useful marker of angiogenesis and an increase in MVD can be used as a marker of poor prognosis in MM patients. We developed an automated image analyzer to assess MVD from images ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Chung Y,Shin S,Shim H,Sohn JY,Lee DE,Lee H,Eom HS,Kim KG,Kong SY

    更新日期:2020-07-01 00:00:00

  • Clinical and microbiological characteristics of six Staphylococcus pettenkoferi isolates from blood samples.

    abstract::Coagulase-negative staphylococci (CoNS) are reported to be the leading cause of nosocomial bloodstream infections. Staphylococcus pettenkoferi is a novel member of CoNS that was first isolated from the human blood and bursitis wound in 2002. We have reported cases of 6 S. pettenkoferi strains isolated from blood speci...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Park S,Chung HS,Lee M

    更新日期:2015-03-01 00:00:00

  • Morning Spot Urine Glucose-to-Creatinine Ratios Predict Overnight Urinary Glucose Excretion in Patients With Type 2 Diabetes.

    abstract:BACKGROUND:With the advent of sodium glucose co-transporter 2 inhibitors to control glucose and treat diabetes, laboratory data aided by either timed or spot glucose levels in the urine could be used as an alternative marker of drug response. The aim of this study was to assess the agreement between overnight urinary g...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Kim SR,Lee YH,Lee SG,Lee SH,Kang ES,Cha BS,Lee HC,Kim JH,Lee BW

    更新日期:2017-01-01 00:00:00

  • Challenges and Considerations in Sequence Variant Interpretation for Mendelian Disorders.

    abstract::In 2015, the American College of Medical Genetics and Genomics (ACMG), together with the Association for Molecular Pathology (AMP), published the latest guidelines for the interpretation of sequence variants, which have been widely adopted into clinical practice. Despite these standardized efforts, the degrees of subj...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章,评审


    authors: Kim YE,Ki CS,Jang MA

    更新日期:2019-09-01 00:00:00

  • In vitro activity of tedizolid against gram-positive bacteria in patients with skin and skin structure infections and hospital-acquired pneumonia: a Korean multicenter study.

    abstract::We compared the activities of tedizolid to those of linezolid and other commonly used antimicrobial agents against gram-positive cocci recovered from patients with skin and skin structure infections (SSSIs) and hospital-acquired pneumonia (HAP) in Korean hospitals. Gram-positive isolates were collected from 356 patien...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Lee Y,Hong SK,Choi S,Im W,Yong D,Lee K

    更新日期:2015-09-01 00:00:00

  • Use of PCR with sequence-specific primers for high-resolution human leukocyte antigen typing of patients with narcolepsy.

    abstract:BACKGROUND:Narcolepsy is a neurologic disorder characterized by excessive daytime sleepiness, symptoms of abnormal rapid eye movement (REM) sleep, and a strong association with HLA-DRB1*1501, -DQA1*0102, and -DQB1*0602. Here, we investigated the clinico-physical characteristics of Korean patients with narcolepsy, their...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Woo HI,Joo EY,Hong SB,Lee KW,Kang ES

    更新日期:2012-01-01 00:00:00

  • A case of IgM deficiency with B cell deficiency detected by ABO discrepancy in a patient with acute osteomyelitis.

    abstract::ABO discrepancy refers to an inconsistency between red cell and serum typings and has various causes, including hypogammaglobulinemia. IgM deficiency is a rare disorder that may accompany several conditions such as infection and autoimmune disorders. Here, we describe a case of IgM deficiency discovered during the eva...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Jung CL,Cha MK,Jun BH,Hong KS

    更新日期:2013-05-01 00:00:00

  • Comparison of red blood cell hemolysis using plasma and serum separation tubes for outpatient specimens.

    abstract:BACKGROUND:To rapidly obtain outpatient results, we use plasma separation tubes (PST) for chemistry analysis. If lactate dehydrogenase measurement is required, serum separation tubes (SST) are used. There has been no evaluation of hemolysis with these tubes. We compared the hemolytic index (HI) obtained by using PST an...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Ko DH,Won D,Jeong TD,Lee W,Chun S,Min WK

    更新日期:2015-03-01 00:00:00

  • Point of care D-dimer testing in the emergency department: a bioequivalence study.

    abstract:BACKGROUND:D-dimer is used widely as a diagnostic aid in low- and moderate-risk patients with suspected venous thromboembolism (VTE). While our laboratory utilizes VIDAS D-dimer analyzer (bioMérieux SA, France), our emergency department (ED) recently procured a D-dimer analyzer AQT90 FLEX (Radiometer Medical ApS, Denma...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Perveen S,Unwin D,Shetty AL

    更新日期:2013-01-01 00:00:00

  • Duffy blood group genotyping in Thai blood donors.

    abstract:BACKGROUND:Duffy (FY) blood group genotyping is important in transfusion medicine because Duffy alloantibodies are associated with delayed hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. In this study, FY allele frequencies in Thai blood donors were determined by in-house PCR with sequen...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Nathalang O,Intharanut K,Siriphanthong K,Nathalang S,Kupatawintu P

    更新日期:2015-11-01 00:00:00

  • Prediction of HLA-DQ in Deceased Donors and its Clinical Significance in Kidney Transplantation.

    abstract:Background:HLA-DQ typing in deceased donors is not mandatory in Korea. Therefore, when patients develop DQ antibodies after kidney transplantation (KT) from deceased donor, it is impossible to determine whether they are donor-specific antibodies (DSA). We developed DQ prediction programs for the HLA gene and evaluated ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Kim SK,Yang JJ,Hwang SH,Sung H,Shin S,Ko SY,Oh HB

    更新日期:2021-03-01 00:00:00

  • Prevalence of blaZ Gene and Performance of Phenotypic Tests to Detect Penicillinase in Staphylococcus aureus Isolates from Japan.

    abstract::Guidelines recommend that clinical laboratories perform phenotypic tests (nitrocefin-based test and penicillin 10-U [P10] or 1-U [P1] zone edge tests) to detect penicillinase in Staphylococcus aureus isolates. This study aimed to assess the prevalence of blaZ encoding penicillinase and perform various phenotypic tests...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Takayama Y,Tanaka T,Oikawa K,Fukano N,Goto M,Takahashi T

    更新日期:2018-03-01 00:00:00

  • Absence of HLA-B*1502 and HLA-A*3101 alleles in 9 Korean patients with antiepileptic drug-induced skin rash: a preliminary study.

    abstract::There have been a number of studies about correlations between HLA genotypes in various ethnic groups and occurrence of various cutaneous adverse drug reactions, ranging in intensity from mild to severe, caused by antiepileptic drugs (AEDs). This is the first report analyzing the HLA genotypes of 9 Korean patients wit...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Song JS,Kang ES,Joo EY,Hong SB,Seo DW,Lee SY

    更新日期:2014-09-01 00:00:00

  • The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases.

    abstract::The platelet-to-lymphocyte ratio (PLR) has emerged as an informative marker revealing shifts in platelet and lymphocyte counts due to acute inflammatory and prothrombotic states. PLR has been extensively examined in neoplastic diseases accompanied by immune suppression and thrombosis, which can be predicted by combine...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章,评审


    authors: Gasparyan AY,Ayvazyan L,Mukanova U,Yessirkepov M,Kitas GD

    更新日期:2019-07-01 00:00:00

  • Immune Checkpoint Programmed Cell Death Protein-1 (PD-1) Expression on Bone Marrow T Cell Subsets in Patients With Plasma Cell Myeloma.

    abstract:Background:Plasma cell myeloma (PCM) is caused by immune dysregulation. We evaluated the expression of immune checkpoint programmed cell death protein-1 (PD-1) on T cell subsets in PCM patients according to disease course and cytogenetic abnormalities. This study aimed to find a target group suitable for therapeutic us...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Lee MY,Park CJ,Cho YU,You E,Jang S,Seo EJ,Lee JH,Yoon DH,Suh C

    更新日期:2021-05-01 00:00:00

  • Comparative Evaluation Between the RealStar Pneumocystis jirovecii PCR Kit and the AmpliSens Pneumocystis jirovecii (carinii)-FRT PCR Kit for Detecting P. jirovecii in Non-HIV Immunocompromised Patients.

    abstract:BACKGROUND:Real-time PCR is more sensitive than microscopic examination for detecting Pneumocystis jirovecii. We compared the performance of two assays for detecting P. jirovecii DNA: the RealStar Pneumocystis jirovecii PCR Kit 1.0 CE (Altona Diagnostics, Hamburg, Germany) and the AmpliSens Pneumocystis jirovecii (cari...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Huh HJ,Lim KR,Ki CS,Huh K,Shim HJ,Song DJ,Kim YJ,Chung DR,Lee NY

    更新日期:2019-03-01 00:00:00

  • The role of cardiac biomarkers in the diagnosis and management of patients presenting with suspected acute coronary syndrome.

    abstract::Myocardial infarction (MI) is the leading cause of death in the developed world. Biomarkers have an essential role in diagnosis, risk stratification, guiding management and clinical decision making in the setting of patients presenting with signs and symptoms of MI. Cardiac troponin (cTn) rose to prominence during the...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章,评审


    authors: Christenson E,Christenson RH

    更新日期:2013-09-01 00:00:00

  • New decision criteria for selecting delta check methods based on the ratio of the delta difference to the width of the reference range can be generally applicable for each clinical chemistry test item.

    abstract:BACKGROUND:Many laboratories use 4 delta check methods: delta difference, delta percent change, rate difference, and rate percent change. However, guidelines regarding decision criteria for selecting delta check methods have not yet been provided. We present new decision criteria for selecting delta check methods for e...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Park SH,Kim SY,Lee W,Chun S,Min WK

    更新日期:2012-09-01 00:00:00

  • Performance Evaluation of the Automated Fluorescent Immunoassay System Rotavirus Assay in Clinical Samples.

    abstract:BACKGROUND:The Automated Fluorescent Immunoassay System (AFIAS) rotavirus assay (Boditech Med Inc., Chuncheon, Korea) is a new rapid antigen test for rotavirus detection. We evaluated the performance of this assay for detecting rotaviruses and their specific genotypes in clinical stool samples. METHODS:AFIAS rotavirus...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Kim JS,Lee SK,Ko DH,Hyun J,Kim HS

    更新日期:2019-01-01 00:00:00

  • Impact of genetic abnormalities on the prognoses and clinical parameters of patients with multiple myeloma.

    abstract:BACKGROUND:We reviewed patients with multiple myeloma (MM) in order to assess the incidence of genetic abnormalities and their associations with clinical parameters, risk groups, and prognosis. METHODS:A total of 130 patients with MM were enrolled. The incidences of genetic abnormalities were determined in all patient...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Jekarl DW,Min CK,Kwon A,Kim H,Chae H,Kim M,Lim J,Kim Y,Han K

    更新日期:2013-07-01 00:00:00

  • Comparison Between Soluble ST2 and High-Sensitivity Troponin I in Predicting Short-Term Mortality for Patients Presenting to the Emergency Department With Chest Pain.

    abstract:BACKGROUND:High-sensitivity cardiac troponin I (hs-cTnI) and the soluble isoform of suppression of tumorigenicity 2 (sST2) are useful prognostic biomarkers in acute coronary syndrome (ACS). The aim of this study was to test the short term prognostic value of sST2 compared with hs-cTnI in patients with chest pain. METH...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Marino R,Magrini L,Orsini F,Russo V,Cardelli P,Salerno G,Hur M,Di Somma S,GREAT NETWORK.

    更新日期:2017-03-01 00:00:00

  • Comparison of sputum and nasopharyngeal swab specimens for molecular diagnosis of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila.

    abstract:BACKGROUND:Differentiation of atypical pathogens is important for community-acquired pneumonia (CAP). In this study, we compared sputum and nasopharyngeal swabs (NPS) for use in detection of Mycoplasma pneumoniae (MP), Chlamydophila pneumoniae (CP), and Legionella pneumophila (LP), using Seeplex PneumoBacter ACE Detect...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Cho MC,Kim H,An D,Lee M,Noh SA,Kim MN,Chong YP,Woo JH

    更新日期:2012-03-01 00:00:00

  • Detection of Serum Antibodies to Hepatitis E Virus Based on HEV Genotype 3 ORF2 Capsid Protein Expressed in Nicotiana benthamiana.

    abstract:BACKGROUND:Hepatitis E virus (HEV) causes epidemics in developing countries and is primarily transmitted through the fecal-oral route. There have been recent reports on the zoonotic spread of the virus, and several animal species, primarily pigs, have been recognized as reservoirs of HEV. Because of its possible spread...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Mazalovska M,Varadinov N,Koynarski T,Minkov I,Teoharov P,Lomonossoff GP,Zahmanova G

    更新日期:2017-07-01 00:00:00

  • Clonal Distribution of Clindamycin-Resistant Erythromycin-Susceptible (CRES) Streptococcus agalactiae in Korea Based on Whole Genome Sequences.

    abstract:BACKGROUND:The clindamycin-resistant erythromycin-susceptible (CRES) phenotype is rare in Streptococcus agalactiae (group B streptococci). We aimed to determine the molecular characteristics of CRES S. agalactiae using whole genome sequencing (WGS). METHODS:Sixty-six S. agalactiae isolates obtained from blood (N=26), ...

    journal_title:Annals of laboratory medicine

    pub_type: 杂志文章


    authors: Takahashi T,Maeda T,Lee S,Lee DH,Kim S

    更新日期:2020-09-01 00:00:00