Silkworm ferritin 1 heavy chain homolog is involved in defense against bacterial infection through regulation of haemolymph iron homeostasis.


:Iron functions as a nutrient and a potential toxin in all organisms. It plays a key role in the interaction between microbes and their hosts as well. Microbial infection disrupts iron homeostasis in the host; meanwhile the host endeavors to keep the homeostasis through iron transport and storage. Transferrins and ferritins are the major iron-binding proteins that affect iron distribution in insects. In this study, we investigated a possible involvement of Bombyx mori ferritin 1 (BmFer1) heavy chain homolog in the defense against bacterial infection in the silkworm larvae. The BmFer1 mRNA abundance was up-regulated in hemocytes, but not in fat body, after Pseudomonas aeruginosa or Staphylococcus aureus infection. The infection resulted in elevated iron levels in the hemolymph. Injection of recombinant BmFer1 protein into hemocoel reduced the plasma iron level after infection, limited the bacterial growth in the hemolymph, and resulted in a lower mortality caused by infection. Our study indicated that B. mori ferritin-1 may restrict iron access of the invading bacteria to block their growth as a defense strategy.


Dev Comp Immunol


Otho SA,Chen K,Zhang Y,Wang P,Lu Z




Has Abstract


2016-02-01 00:00:00












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    abstract::We evaluated juvenile, pubescent, reproductive adult, and aged Japanese quail (Coturnix coturnix japonica) to determine if there were age-related differences in immune function with the hypothesis that aged birds would have weaker immune responses. Immune responses were measured using phytohemagglutinin (PHA) skin tes...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Lavoie ET,Sorrell EM,Perez DR,Ottinger MA

    更新日期:2007-01-01 00:00:00

  • Molecular characterization of a heat shock protein 21 (Hsp21) from red swamp crayfish, Procambarus clarkii in response to immune stimulation.

    abstract::Small heat shock proteins are a molecular chaperone and implicated in various physiological and stress processes in animals. However, the immunological functions of Hsp genes remain to elucidate in the crustaceans, particularly in red swamp crayfish, Procambarus clarkii. Here we report the cloning of heat shock protei...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Dai LS,Kausar S,Gul I,Zhou HL,Abbas MN,Deng MJ

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    abstract::The major histocompatibility complex (MHC) includes the most polymorphic genes in vertebrates, and balancing selection has been proposed as a main evolutionary force. Here we present one of the first data sets examining the genetic characteristics of chicken MHC I BFIV molecules in four Chinese native breeds, sourced ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Dai Y,Liu XL,Tang QF,Hu XM,Shen XH,Zhang DJ

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    journal_title:Developmental and comparative immunology

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    authors: Hu B,Chen B,Mao M,Chen M,Liu X,Cui Q,Liu Y,Jiang C

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  • Proteomic analysis of host responses to Marek's disease virus infection in spleens of genetically resistant and susceptible chickens.

    abstract::Resistance to Marek's disease (MD) in chickens is genetically regulated and there are lines of chickens with differential susceptibility or resistance to this disease. The present study was designed to study comparative changes in the spleen proteomes of MD-susceptible B19 and MD-resistant B21 chickens in response to ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Thanthrige-Don N,Parvizi P,Sarson AJ,Shack LA,Burgess SC,Sharif S

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  • Salmon louse rhabdoviruses: Impact on louse development and transcription of selected Atlantic salmon immune genes.

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    pub_type: 杂志文章


    authors: Øvergård AC,Hamre LA,Grotmol S,Nilsen F

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  • Antigenic profiles of endothelial and hemopoietic lineages in murine intraembryonic hemogenic sites.

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Garcia-Porrero JA,Manaia A,Jimeno J,Lasky LL,Dieterlen-Lièvre F,Godin IE

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  • The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish.

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审


    authors: Huising MO,Stet RJ,Savelkoul HF,Verburg-van Kemenade BM

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  • Cloning and functional characterization of rat stimulator of interferon genes (STING) regulated by miR-24.

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Huang Z,Chen X,Yu B,Chen D

    更新日期:2012-07-01 00:00:00

  • IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi.

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Li L,Chen SN,Nie P

    更新日期:2021-01-01 00:00:00

  • Tasmanian devil CD28 and CTLA4 capture CD80 and CD86 from adjacent cells.

    abstract::Immune checkpoint immunotherapy is a pillar of human oncology treatment with potential for non-human species. The first checkpoint immunotherapy approved for human cancers targeted the CTLA4 protein. CTLA4 can inhibit T cell activation by capturing and internalizing CD80 and CD86 from antigen presenting cells, a proce...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Wong C,Darby JM,Murphy PR,Pinfold TL,Lennard PR,Woods GM,Lyons AB,Flies AS

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    abstract::The clip domain serine proteinases (clip-SPs) play critical roles in the signaling processes during embryonic development and in the innate immunity of invertebrates. In the present study, we identified a homolog of the clip-SP, designated as PmClipSP1, by searching the Penaeus monodon EST database (

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Amparyup P,Wiriyaukaradecha K,Charoensapsri W,Tassanakajon A

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  • Arasin 1, a proline-arginine-rich antimicrobial peptide isolated from the spider crab, Hyas araneus.

    abstract::Antimicrobial peptides (AMPs) are considered to play an important role as host-defense molecules in both vertebrates and invertebrates. This work was undertaken to characterize AMPs from hemocyte extracts of the small spider crab, Hyas araneus. A novel proline-arginine-rich AMP of 37 amino acids was isolated and chara...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Stensvåg K,Haug T,Sperstad SV,Rekdal O,Indrevoll B,Styrvold OB

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  • Development of B cells in the gut-associated lymphoid tissue of mid-gestational fetal lambs.

    abstract::Intestinal mucosal immune system development was investigated in fetal lambs from 61 to 110 days (term, 150 days). Fetal small intestine was examined at 400 mm intervals for the presence of IgM(+) cells. The first phase of B cell development was characterised by increase in B cell density throughout the jejunum from 6...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Alitheen N,McClure S,McCullagh P

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  • In vivo and in vitro knockdown of FREP2 gene expression in the snail Biomphalaria glabrata using RNA interference.

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Jiang Y,Loker ES,Zhang SM

    更新日期:2006-01-01 00:00:00

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    abstract::Transfection is a powerful tool useful for studying gene function. Establishing transfection methods that enable highly efficient DNA uptake has become increasingly important. The crayfish hematopoietic tissue (Hpt) cell cultures have been proven to be suitable for studies on immunity and cell differentiation in crust...

    journal_title:Developmental and comparative immunology

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    authors: Shi H,Ruan L,Söderhäll I,Söderhäll K,Xu X

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    abstract::Sea urchins have an innate immune response that functions in the absence of adaptive capabilities. It is mediated, in part, by components of the complement system, an important subsystem of the innate response in mammals. A homologue of complement C3, SpC3, has been identified in adult Strongylocentrotus purpuratus an...

    journal_title:Developmental and comparative immunology

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    authors: Shah M,Brown KM,Smith LC

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Wang L,Liu L,Zhou Y,Zhao X,Xi M,Wei S,Fang R,Ji W,Chen N,Gu Z,Liu X,Wang W,Asim M,Liu X,Lin L

    更新日期:2014-03-01 00:00:00

  • Vaccination with multimeric recombinant VP28 induces high protection against white spot syndrome virus in shrimp.

    abstract::To improve the efficacy of WSSV protection, multimeric (tetrameric) recombinant VP28 (4XrVP28) was produced and tested in comparison with those of monomeric VP28 (1XrVP28). In vitro binding of either 1XrVP28 or 4XrVP28 to shrimp hemocyte surface was evident as early as 10 min after protein inoculation. Similar results...

    journal_title:Developmental and comparative immunology

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    authors: Taengchaiyaphum S,Nakayama H,Srisala J,Khiev R,Aldama-Cano DJ,Thitamadee S,Sritunyalucksana K

    更新日期:2017-11-01 00:00:00

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    abstract::Insects are able to effectively recognize parasitoid eggs or larvae and to eliminate them by formation of a hemocytic capsule. Although the cellular process is now well documented, the genetic aspects of recognition of foreignness and the encapsulation process are still poorly understood. Experiments using the isofema...

    journal_title:Developmental and comparative immunology

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    authors: Carton Y,Boulétreau M

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    abstract::Studies of the innate immune system have recently shown that, in addition to its role in producing the primary response that slows down pathogens, it may also play an important role in initiating and directing the type of response that the adaptive immune system makes. These discoveries have shown a complex web of con...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审


    authors: Dixon B,Stet RJ

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    abstract::Antimicrobial peptides (AMPs) are components of innate immunity found in many forms of life. However, there have been no reports of AMPs in sea star (Phylum Echinodermata). Here we report the isolation and characterization of a novel antimicrobial peptide from the coelomic epithelium extract of the sea star Patiria pe...

    journal_title:Developmental and comparative immunology

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    authors: Kim CH,Go HJ,Oh HY,Park JB,Lee TK,Seo JK,Elphick MR,Park NG

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  • A shrimp pacifastin light chain-like inhibitor: molecular identification and role in the control of the prophenoloxidase system.

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Sangsuriya P,Charoensapsri W,Chomwong S,Senapin S,Tassanakajon A,Amparyup P

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Amen RI,Tijnagel JM,van der Knaap WP,Meuleman EA,de Lange-de Klerk ES,Sminia T

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  • Dual oxidases participate in the regulation of hemolymph microbiota homeostasis in mud crab Scylla paramamosain.

    abstract::Dual oxidases (DUOXs) were originally identified as NADPH oxidases (NOXs), found to be associated with the reactive oxygen species (ROS) hydrogen peroxide (H2O2) production at the plasma membrane and crucial in host biological processes. In this study, SpDUOX1 and SpDUOX2 of mud crab (Scylla paramamosain) were identif...

    journal_title:Developmental and comparative immunology

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    authors: Sun Z,Hao S,Gong Y,Zhang M,Aweya JJ,Tran NT,Zhang Y,Ma H,Li S

    更新日期:2018-12-01 00:00:00

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    abstract::Common carp thrombocytes account for 30-40% of peripheral blood leukocytes and are abundant in the healthy animals' spleen, the thrombopoietic organ. We show that, ex vivo, thrombocytes from healthy carp express a large number of immune-relevant genes, among which several cytokines and Toll-like receptors, clearly poi...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Fink IR,Ribeiro CM,Forlenza M,Taverne-Thiele A,Rombout JH,Savelkoul HF,Wiegertjes GF

    更新日期:2015-06-01 00:00:00

  • Recent advances on the immunobiology of Bithynia spp. hosts of Opisthorchis viverrini.

    abstract::This article reviews the past and present scientific reports regarding Bithynia spp. focusing on the biology, ecology and life cycle of Bithynia snails and their responses to Opisthorchis viverrini infection. Moreover, new data regarding comparative molecular genomics and proteomic approaches have recently revealed no...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审


    authors: Suwannatrai K,Suwannatrai AT,Loukas A,Sotillo J

    更新日期:2020-01-01 00:00:00

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Ohtani M,Hikima J,Hwang SD,Morita T,Suzuki Y,Kato G,Kondo H,Hirono I,Jung TS,Aoki T

    更新日期:2012-04-01 00:00:00

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Liu D,Wang L,Yang L,Qian C,Wei G,Dai L,Li J,Zhu B,Liu C

    更新日期:2015-07-01 00:00:00

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    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Vervelde L,Reemers SS,van Haarlem DA,Post J,Claassen E,Rebel JM,Jansen CA

    更新日期:2013-03-01 00:00:00