Silkworm ferritin 1 heavy chain homolog is involved in defense against bacterial infection through regulation of haemolymph iron homeostasis.


:Iron functions as a nutrient and a potential toxin in all organisms. It plays a key role in the interaction between microbes and their hosts as well. Microbial infection disrupts iron homeostasis in the host; meanwhile the host endeavors to keep the homeostasis through iron transport and storage. Transferrins and ferritins are the major iron-binding proteins that affect iron distribution in insects. In this study, we investigated a possible involvement of Bombyx mori ferritin 1 (BmFer1) heavy chain homolog in the defense against bacterial infection in the silkworm larvae. The BmFer1 mRNA abundance was up-regulated in hemocytes, but not in fat body, after Pseudomonas aeruginosa or Staphylococcus aureus infection. The infection resulted in elevated iron levels in the hemolymph. Injection of recombinant BmFer1 protein into hemocoel reduced the plasma iron level after infection, limited the bacterial growth in the hemolymph, and resulted in a lower mortality caused by infection. Our study indicated that B. mori ferritin-1 may restrict iron access of the invading bacteria to block their growth as a defense strategy.


Dev Comp Immunol


Otho SA,Chen K,Zhang Y,Wang P,Lu Z




Has Abstract


2016-02-01 00:00:00












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    abstract::The rainbow trout caspase 6 gene has been cloned and sequenced. The open reading frame consisted of 906bp, which translated into a protein of 302 amino acids, containing the caspase active site pentapeptide (QACRG) and the caspase family signature (HADADCFVCVFLSHG). Amino acids involved in catalysis and those known to...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Laing KJ,Holland J,Bonilla S,Cunningham C,Secombes CJ

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    journal_title:Developmental and comparative immunology

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    authors: Zhang Y,Zhang H,Kong Y,Feng L

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    authors: Kawaguchi S,Muramatsu S,Mitsuhashi S

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    journal_title:Developmental and comparative immunology

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    authors: Ottaviani E,Franchini A,Mandrioli M,Saxena A,Hanukoglu A,Hanukoglu I

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    journal_title:Developmental and comparative immunology

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    journal_title:Developmental and comparative immunology

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    authors: Zhang Z,Zhu S

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    authors: Guan GK,Liu QH,Li C,Huang J

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    authors: Partula S,Charlemagne J

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