Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines.


:The Deciphering the Mechanisms of Developmental Disorders (DMDD) consortium is a research programme set up to identify genes in the mouse, which if mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why disruption of their function has such profound effects on embryo development and survival. The project uses a combination of comprehensive high resolution 3D imaging and tissue histology to identify abnormalities in embryo and placental structures of embryonic lethal lines. The image data we have collected and the phenotypes scored are freely available through the project website ( In this article we describe the web interface to the images that allows the embryo data to be viewed at full resolution in different planes, discuss how to search the database for a phenotype, and our approach to organising the data for an embryo and a mutant line so it is easy to comprehend and intuitive to navigate.


Nucleic Acids Res


Nucleic acids research


Wilson R,McGuire C,Mohun T,DMDD Project.




Has Abstract


2016-01-04 00:00:00














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    abstract::Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL). The HTLV-1 basic leucine zipper protein (HBZ) is expressed in all cases of ATL and is directly associated with virus pathogenicity. The two isoforms of the HBZ protein are synthesized from antisense messenger RNAs (mRN...

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    pub_type: 杂志文章


    authors: Cáceres CJ,Angulo J,Lowy F,Contreras N,Walters B,Olivares E,Allouche D,Merviel A,Pino K,Sargueil B,Thompson SR,López-Lastra M

    更新日期:2018-11-16 00:00:00

  • Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair.

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Kato-Inui T,Takahashi G,Hsu S,Miyaoka Y

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  • Expression of herpes virus thymidine kinase in Neurospora crassa.

    abstract::The expression of thymidine kinase in fungi, which normally lack this enzyme, will greatly aid the study of DNA metabolism and provide useful drug-sensitive phenotypes. The herpes simplex virus type-1 thymidine kinase gene ( tk ) was expressed in Neurospora crassa. tk was expressed as a fusion to N.crassa arg-2 regula...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Sachs MS,Selker EU,Lin B,Roberts CJ,Luo Z,Vaught-Alexander D,Margolin BS

    更新日期:1997-06-15 00:00:00

  • PRISM: a web server and repository for prediction of protein-protein interactions and modeling their 3D complexes.

    abstract::The PRISM web server enables fast and accurate prediction of protein-protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein st...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Baspinar A,Cukuroglu E,Nussinov R,Keskin O,Gursoy A

    更新日期:2014-07-01 00:00:00

  • Structural characterization of a ribonuclease III processing signal.

    abstract::The structure of a ribonuclease III processing signal from bacteriophage T7 was examined by NMR spectroscopy, optical melting, and chemical and enzymatic modification. A 41 nucleotide variant of the T7 R1.1 processing signal has two Watson-Crick base-paired helices separated by an internal loop, consistent with its pr...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


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  • New photoactivatable structural and affinity probes of RNAs: specific features and applications for mapping of spermine binding sites in yeast tRNA(Asp) and interaction of this tRNA with yeast aspartyl-tRNA synthetase.

    abstract::Aryldiazonium salts are shown to be useful as phototriggered structural probes for RNA mapping as well as for footprinting of RNA/protein interaction. In particular the yeast tRNA(Asp)/aspartyl-tRNA synthetase complex is shown to involve the variable loop face and the concave side of the L-shaped nucleic acid bound to...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


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  • Ligation-independent cloning of PCR products (LIC-PCR).

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Aslanidis C,de Jong PJ

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    journal_title:Nucleic acids research

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Putnam WC,Daniher AT,Trawick BN,Bashkin JK

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


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    journal_title:Nucleic acids research

    pub_type: 杂志文章


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    authors: Jia Z,Zhang Y,Li Q,Ye Z,Liu Y,Fu C,Cang X,Wang M,Guan MX

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Hara Y,Onishi Y,Oishi K,Miyazaki K,Fukamizu A,Ishida N

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    pub_type: 杂志文章


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    journal_title:Nucleic acids research

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    pub_type: 杂志文章


    authors: Miyamoto-Sato E,Nemoto N,Kobayashi K,Yanagawa H

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    pub_type: 杂志文章


    authors: Sanyal NK,Kumar U,Roychoudhury M

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Stern DB,Palmer JD

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Kovacheva YS,Tzokov SB,Murray IA,Grasby JA

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Cai Y,Bak RO,Krogh LB,Staunstrup NH,Moldt B,Corydon TJ,Schrøder LD,Mikkelsen JG

    更新日期:2014-02-01 00:00:00

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Heilig R,Muraskowsky R,Kloepfer C,Mandel JL

    更新日期:1982-07-24 00:00:00

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Durland RH,Rao TS,Revankar GR,Tinsley JH,Myrick MA,Seth DM,Rayford J,Singh P,Jayaraman K

    更新日期:1994-08-11 00:00:00

  • Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis.

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Rochat T,Nicolas P,Delumeau O,Rabatinová A,Korelusová J,Leduc A,Bessières P,Dervyn E,Krásny L,Noirot P

    更新日期:2012-10-01 00:00:00

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Burak MJ,Guja KE,Garcia-Diaz M

    更新日期:2015-09-18 00:00:00

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    abstract::Complete genomes of three closely related Gram-positive bacteria Streptococcus pyogenes, Streptococcus pneumoniae and Lactococcus lactis are analyzed for abundances of short DNA sequence motifs (frequent words). The character and extent of frequent words are strikingly different among these genomes. The frequent words...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Mrázek J,Gaynon LH,Karlin S

    更新日期:2002-10-01 00:00:00

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    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Gramates LS,Marygold SJ,Santos GD,Urbano JM,Antonazzo G,Matthews BB,Rey AJ,Tabone CJ,Crosby MA,Emmert DB,Falls K,Goodman JL,Hu Y,Ponting L,Schroeder AJ,Strelets VB,Thurmond J,Zhou P,the FlyBase Consortium.

    更新日期:2017-01-04 00:00:00

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    abstract::The crystal structure of d(CATGGGCCCATG)(2) shows unique stacking patterns of a stable B<-->A-DNA intermediate. We evaluated intrinsic base stacking energies in this crystal structure using an ab initio quantum mechanical method. We found that all crystal base pair steps have stacking energies close to their values in...

    journal_title:Nucleic acids research

    pub_type: 杂志文章


    authors: Poner J,Florián J,Ng HL,Poner JE,Packová N

    更新日期:2000-12-15 00:00:00