Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines.

Abstract:

:The Deciphering the Mechanisms of Developmental Disorders (DMDD) consortium is a research programme set up to identify genes in the mouse, which if mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why disruption of their function has such profound effects on embryo development and survival. The project uses a combination of comprehensive high resolution 3D imaging and tissue histology to identify abnormalities in embryo and placental structures of embryonic lethal lines. The image data we have collected and the phenotypes scored are freely available through the project website (http://dmdd.org.uk). In this article we describe the web interface to the images that allows the embryo data to be viewed at full resolution in different planes, discuss how to search the database for a phenotype, and our approach to organising the data for an embryo and a mutant line so it is easy to comprehend and intuitive to navigate.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Wilson R,McGuire C,Mohun T,DMDD Project.

doi

10.1093/nar/gkv1138

subject

Has Abstract

pub_date

2016-01-04 00:00:00

pages

D855-61

issue

D1

eissn

0305-1048

issn

1362-4962

pii

gkv1138

journal_volume

44

pub_type

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